IL122184A - Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure - Google Patents

Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure

Info

Publication number
IL122184A
IL122184A IL12218496A IL12218496A IL122184A IL 122184 A IL122184 A IL 122184A IL 12218496 A IL12218496 A IL 12218496A IL 12218496 A IL12218496 A IL 12218496A IL 122184 A IL122184 A IL 122184A
Authority
IL
Israel
Prior art keywords
imines
hydrogenation
elevated pressure
hydrogen iodide
iridium catalyst
Prior art date
Application number
IL12218496A
Other languages
English (en)
Other versions
IL122184A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL122184A0 publication Critical patent/IL122184A0/xx
Publication of IL122184A publication Critical patent/IL122184A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
IL12218496A 1995-06-08 1996-06-04 Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure IL122184A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168595 1995-06-08
PCT/EP1996/002419 WO1996041793A1 (fr) 1995-06-08 1996-06-04 Procede d'hydrogenation des imines

Publications (2)

Publication Number Publication Date
IL122184A0 IL122184A0 (en) 1998-04-05
IL122184A true IL122184A (en) 2000-02-29

Family

ID=4216210

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12218496A IL122184A (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure

Country Status (26)

Country Link
US (1) US5886225A (fr)
EP (1) EP0830337B1 (fr)
JP (1) JP4128623B2 (fr)
KR (1) KR100470884B1 (fr)
CN (1) CN1176900C (fr)
AR (1) AR002359A1 (fr)
AT (1) ATE187957T1 (fr)
AU (1) AU710870B2 (fr)
BR (1) BR9609159A (fr)
CA (1) CA2220999C (fr)
CZ (1) CZ287315B6 (fr)
DE (1) DE69605794T2 (fr)
DK (1) DK0830337T3 (fr)
EA (1) EA000498B1 (fr)
ES (1) ES2141512T3 (fr)
GR (1) GR3032521T3 (fr)
HR (1) HRP960253B1 (fr)
HU (1) HU229337B1 (fr)
IL (1) IL122184A (fr)
PL (1) PL183317B1 (fr)
PT (1) PT830337E (fr)
SK (1) SK281568B6 (fr)
TW (1) TW346482B (fr)
UA (1) UA51652C2 (fr)
WO (1) WO1996041793A1 (fr)
ZA (1) ZA964832B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100355255B1 (ko) * 1994-02-02 2002-12-31 노바티스 아게 이민의수소화방법
US6228971B1 (en) * 1999-06-21 2001-05-08 Ppg Industries Ohio, Inc. Polymeric imine functional compositions and their use in film-forming compositions
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
MX2010009162A (es) 2008-02-22 2010-12-21 Radius Health Inc Moduladores selectivos del receptor de androgeno.
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
EP2531029B1 (fr) 2010-02-04 2016-10-19 Radius Health, Inc. Modulateurs sélectifs du récepteur des androgènes
ME02474B (fr) 2010-05-12 2017-02-20 Radius Health Inc Schémas thérapeutiques
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
BR112013007685B1 (pt) 2010-09-28 2021-11-09 Radius Pharmaceuticals, Inc Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto
CN102153589B (zh) 2011-02-28 2013-01-02 大连多相触媒有限公司 一种亚胺的不对称加氢催化剂及其合成方法和应用
WO2014037962A1 (fr) 2012-09-06 2014-03-13 Council Of Scientific And Industrial Research Procédé de préparation de (s)-2-éthyl-n-(1-méthoxypropan-2-yl)-6-méthylaniline
EP4035664A3 (fr) 2014-03-28 2022-11-30 Duke University Traitement du cancer faisant intervenir des modulateurs sélectifs des récepteurs des strogènes
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
RU2769527C2 (ru) 2016-06-22 2022-04-01 Эллипсес Фарма Лтд Способы лечения ar+ рака молочной железы
KR102322802B1 (ko) 2017-01-05 2021-11-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
US11643385B2 (en) 2018-07-04 2023-05-09 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
CN110305025B (zh) * 2019-07-23 2022-05-06 衢州学院 一种由亚胺催化氢化合成苄胺类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994615A (en) * 1986-08-04 1991-02-19 Ciba-Geigy Corporation Process for the preparation of optically active secondary arylamines
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
DE59009835D1 (de) * 1989-09-18 1995-12-07 Ciba Geigy Ag Iridiumkomplexe, Verfahren zu deren Herstellung und deren Verwendung.
SG42936A1 (en) * 1992-04-02 1997-10-17 Ciba Geigy Ag Ferrocenyl diphosphines as ligands for homogeneous catalysts
JPH09508400A (ja) * 1994-02-02 1997-08-26 チバ−ガイギー アクチエンゲゼルシャフト 水素化触媒、その調製方法および水素化方法

Also Published As

Publication number Publication date
US5886225A (en) 1999-03-23
CZ287315B6 (en) 2000-10-11
KR100470884B1 (ko) 2005-06-22
WO1996041793A1 (fr) 1996-12-27
CN1176900C (zh) 2004-11-24
DE69605794D1 (de) 2000-01-27
TW346482B (en) 1998-12-01
CA2220999C (fr) 2008-01-29
CZ391997A3 (cs) 1998-03-18
IL122184A0 (en) 1998-04-05
AR002359A1 (es) 1998-03-11
CA2220999A1 (fr) 1996-12-27
AU710870B2 (en) 1999-09-30
JPH11507917A (ja) 1999-07-13
EA000498B1 (ru) 1999-08-26
EP0830337A1 (fr) 1998-03-25
HRP960253B1 (en) 2000-10-31
ES2141512T3 (es) 2000-03-16
HUP9802307A2 (hu) 1999-02-01
EP0830337B1 (fr) 1999-12-22
GR3032521T3 (en) 2000-05-31
CN1187183A (zh) 1998-07-08
BR9609159A (pt) 1999-05-04
PT830337E (pt) 2000-05-31
UA51652C2 (uk) 2002-12-16
SK168197A3 (en) 1998-05-06
EA199700424A1 (ru) 1999-02-25
PL323946A1 (en) 1998-04-27
DK0830337T3 (da) 2000-06-13
PL183317B1 (pl) 2002-06-28
HU229337B1 (en) 2013-11-28
KR19990021908A (ko) 1999-03-25
HUP9802307A3 (en) 1999-03-29
ZA964832B (en) 1996-12-09
SK281568B6 (sk) 2001-05-10
DE69605794T2 (de) 2000-07-20
JP4128623B2 (ja) 2008-07-30
AU6221896A (en) 1997-01-09
HRP960253A2 (en) 1997-10-31
ATE187957T1 (de) 2000-01-15

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