EA199700424A1 - Способ гидрирования иминов - Google Patents

Способ гидрирования иминов

Info

Publication number
EA199700424A1
EA199700424A1 EA199700424A EA199700424A EA199700424A1 EA 199700424 A1 EA199700424 A1 EA 199700424A1 EA 199700424 A EA199700424 A EA 199700424A EA 199700424 A EA199700424 A EA 199700424A EA 199700424 A1 EA199700424 A1 EA 199700424A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imine
hydration
imins
hydrogenating
reaction mixture
Prior art date
Application number
EA199700424A
Other languages
English (en)
Other versions
EA000498B1 (ru
Inventor
Ганс-Питер Ялетт
Феликс Шпиндель
Рейнхард Георг Ханрайх
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA199700424A1 publication Critical patent/EA199700424A1/ru
Publication of EA000498B1 publication Critical patent/EA000498B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Способ гидрирования иминов водородом при повышенном давлении в присутствии иридиевых катализаторов и с инертным растворителем или без него, в котором реакционная смесь содержит йодистый водород.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700424A 1995-06-08 1996-06-04 Способ гидрирования иминов EA000498B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168595 1995-06-08
PCT/EP1996/002419 WO1996041793A1 (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines

Publications (2)

Publication Number Publication Date
EA199700424A1 true EA199700424A1 (ru) 1999-02-25
EA000498B1 EA000498B1 (ru) 1999-08-26

Family

ID=4216210

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700424A EA000498B1 (ru) 1995-06-08 1996-06-04 Способ гидрирования иминов

Country Status (26)

Country Link
US (1) US5886225A (ru)
EP (1) EP0830337B1 (ru)
JP (1) JP4128623B2 (ru)
KR (1) KR100470884B1 (ru)
CN (1) CN1176900C (ru)
AR (1) AR002359A1 (ru)
AT (1) ATE187957T1 (ru)
AU (1) AU710870B2 (ru)
BR (1) BR9609159A (ru)
CA (1) CA2220999C (ru)
CZ (1) CZ287315B6 (ru)
DE (1) DE69605794T2 (ru)
DK (1) DK0830337T3 (ru)
EA (1) EA000498B1 (ru)
ES (1) ES2141512T3 (ru)
GR (1) GR3032521T3 (ru)
HR (1) HRP960253B1 (ru)
HU (1) HU229337B1 (ru)
IL (1) IL122184A (ru)
PL (1) PL183317B1 (ru)
PT (1) PT830337E (ru)
SK (1) SK281568B6 (ru)
TW (1) TW346482B (ru)
UA (1) UA51652C2 (ru)
WO (1) WO1996041793A1 (ru)
ZA (1) ZA964832B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU677753B2 (en) * 1994-02-02 1997-05-01 Syngenta Participations Ag Process for the hydrogenation of imines
US6228971B1 (en) * 1999-06-21 2001-05-08 Ppg Industries Ohio, Inc. Polymeric imine functional compositions and their use in film-forming compositions
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
US8067448B2 (en) 2008-02-22 2011-11-29 Radius Health, Inc. Selective androgen receptor modulators
CA2788907A1 (en) 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
WO2011143469A1 (en) 2010-05-12 2011-11-17 Radius Health,Inc Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
ES2550319T3 (es) 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
CN102153589B (zh) 2011-02-28 2013-01-02 大连多相触媒有限公司 一种亚胺的不对称加氢催化剂及其合成方法和应用
EP2892877B1 (en) 2012-09-06 2017-06-21 Council of Scientific and Industrial Research Process for the preparation of (s)-2-ethyl-n-(1-methoxypropan -2-yl)-6-methyl aniline
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
DK3122426T3 (da) 2014-03-28 2023-04-03 Univ Duke Behandling af brystcancer ved anvendelse af selektive østrogenreceptormodulatorer
EP4066827A1 (en) 2016-06-22 2022-10-05 Ellipses Pharma Ltd Ar+ breast cancer treatment methods
MX2019007748A (es) 2017-01-05 2019-09-09 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
CN110305025B (zh) * 2019-07-23 2022-05-06 衢州学院 一种由亚胺催化氢化合成苄胺类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE66666T1 (de) * 1986-08-04 1991-09-15 Ciba Geigy Ag Verfahren zur herstellung von optisch aktiven sekundaeren arylaminen.
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
DE59009835D1 (de) * 1989-09-18 1995-12-07 Ciba Geigy Ag Iridiumkomplexe, Verfahren zu deren Herstellung und deren Verwendung.
EP0564406B1 (de) * 1992-04-02 1999-05-06 Novartis AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
CN1139930A (zh) * 1994-02-02 1997-01-08 希巴-盖吉股份公司 加氢催化剂及其制备方法和加氢方法

Also Published As

Publication number Publication date
HRP960253B1 (en) 2000-10-31
KR19990021908A (ko) 1999-03-25
BR9609159A (pt) 1999-05-04
CN1176900C (zh) 2004-11-24
PL323946A1 (en) 1998-04-27
EP0830337B1 (en) 1999-12-22
ES2141512T3 (es) 2000-03-16
CA2220999C (en) 2008-01-29
ATE187957T1 (de) 2000-01-15
EP0830337A1 (en) 1998-03-25
PL183317B1 (pl) 2002-06-28
UA51652C2 (ru) 2002-12-16
AR002359A1 (es) 1998-03-11
AU6221896A (en) 1997-01-09
EA000498B1 (ru) 1999-08-26
GR3032521T3 (en) 2000-05-31
DE69605794T2 (de) 2000-07-20
HUP9802307A2 (hu) 1999-02-01
HRP960253A2 (en) 1997-10-31
IL122184A0 (en) 1998-04-05
JP4128623B2 (ja) 2008-07-30
CN1187183A (zh) 1998-07-08
KR100470884B1 (ko) 2005-06-22
CA2220999A1 (en) 1996-12-27
SK281568B6 (sk) 2001-05-10
WO1996041793A1 (en) 1996-12-27
ZA964832B (en) 1996-12-09
IL122184A (en) 2000-02-29
PT830337E (pt) 2000-05-31
CZ287315B6 (en) 2000-10-11
US5886225A (en) 1999-03-23
CZ391997A3 (cs) 1998-03-18
DE69605794D1 (de) 2000-01-27
HUP9802307A3 (en) 1999-03-29
HU229337B1 (en) 2013-11-28
SK168197A3 (en) 1998-05-06
DK0830337T3 (da) 2000-06-13
AU710870B2 (en) 1999-09-30
TW346482B (en) 1998-12-01
JPH11507917A (ja) 1999-07-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): TM

MK4A Patent expired

Designated state(s): RU