ES2141512T3 - Procedimiento para la hidrogenacion de iminas. - Google Patents

Procedimiento para la hidrogenacion de iminas.

Info

Publication number
ES2141512T3
ES2141512T3 ES96920786T ES96920786T ES2141512T3 ES 2141512 T3 ES2141512 T3 ES 2141512T3 ES 96920786 T ES96920786 T ES 96920786T ES 96920786 T ES96920786 T ES 96920786T ES 2141512 T3 ES2141512 T3 ES 2141512T3
Authority
ES
Spain
Prior art keywords
iminas
hydrogenation
procedure
hydrogen
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96920786T
Other languages
English (en)
Inventor
Hans-Peter Jalett
Felix Spindler
Reinhard Georg Hanreich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2141512T3 publication Critical patent/ES2141512T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA HIDROGENACION DE IMINAS CON HIDROGENO BAJO UNA PRESION ELEVADA EN PRESENCIA DE CATALIZADORES DE IRIDIO Y CON LA PRESENCIA O NO DE UN DISOLVENTE INERTE, EN EL CUAL LA MEZCLA DE REACCION CONTIENE YODURO DE HIDROGENO.
ES96920786T 1995-06-08 1996-06-04 Procedimiento para la hidrogenacion de iminas. Expired - Lifetime ES2141512T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH168595 1995-06-08

Publications (1)

Publication Number Publication Date
ES2141512T3 true ES2141512T3 (es) 2000-03-16

Family

ID=4216210

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96920786T Expired - Lifetime ES2141512T3 (es) 1995-06-08 1996-06-04 Procedimiento para la hidrogenacion de iminas.

Country Status (26)

Country Link
US (1) US5886225A (es)
EP (1) EP0830337B1 (es)
JP (1) JP4128623B2 (es)
KR (1) KR100470884B1 (es)
CN (1) CN1176900C (es)
AR (1) AR002359A1 (es)
AT (1) ATE187957T1 (es)
AU (1) AU710870B2 (es)
BR (1) BR9609159A (es)
CA (1) CA2220999C (es)
CZ (1) CZ287315B6 (es)
DE (1) DE69605794T2 (es)
DK (1) DK0830337T3 (es)
EA (1) EA000498B1 (es)
ES (1) ES2141512T3 (es)
GR (1) GR3032521T3 (es)
HR (1) HRP960253B1 (es)
HU (1) HU229337B1 (es)
IL (1) IL122184A (es)
PL (1) PL183317B1 (es)
PT (1) PT830337E (es)
SK (1) SK281568B6 (es)
TW (1) TW346482B (es)
UA (1) UA51652C2 (es)
WO (1) WO1996041793A1 (es)
ZA (1) ZA964832B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9505836A (pt) * 1994-02-02 1996-02-27 Ciba Geigy Ag Processo para a hidrogenaçao de iminas
US6228971B1 (en) * 1999-06-21 2001-05-08 Ppg Industries Ohio, Inc. Polymeric imine functional compositions and their use in film-forming compositions
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
EP2260028B1 (en) 2008-02-22 2014-05-07 Radius Health, Inc. Selective androgen receptor modulators
AU2011212813B2 (en) 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
EP3106159A1 (en) 2010-05-12 2016-12-21 Radius Health, Inc. Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
ES2550319T3 (es) 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
CN102153589B (zh) 2011-02-28 2013-01-02 大连多相触媒有限公司 一种亚胺的不对称加氢催化剂及其合成方法和应用
US9199930B2 (en) 2012-09-06 2015-12-01 Council Of Scientific And Industrial Research Process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline
EP4035664A3 (en) 2014-03-28 2022-11-30 Duke University Treating cancer using selective estrogen receptor modulators
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
AU2017281038B2 (en) 2016-06-22 2021-09-09 Ellipses Pharma Ltd AR+ breast cancer treatment methods
AU2018205285C9 (en) 2017-01-05 2024-05-23 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
CN112423844A (zh) 2018-07-04 2021-02-26 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
CN110305025B (zh) * 2019-07-23 2022-05-06 衢州学院 一种由亚胺催化氢化合成苄胺类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE66666T1 (de) * 1986-08-04 1991-09-15 Ciba Geigy Ag Verfahren zur herstellung von optisch aktiven sekundaeren arylaminen.
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
EP0419409B1 (de) * 1989-09-18 1995-11-02 Ciba-Geigy Ag Iridiumkomplexe, Verfahren zu deren Herstellung und deren Verwendung
DE59309554D1 (de) * 1992-04-02 1999-06-10 Novartis Ag Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
ES2137494T3 (es) * 1994-02-02 1999-12-16 Novartis Ag Catalizador de hidrogenacion, procedimiento para la preparacion del mismo y procedimiento de hidrogenacion.

Also Published As

Publication number Publication date
PL183317B1 (pl) 2002-06-28
EP0830337B1 (en) 1999-12-22
CN1187183A (zh) 1998-07-08
DK0830337T3 (da) 2000-06-13
WO1996041793A1 (en) 1996-12-27
PL323946A1 (en) 1998-04-27
ATE187957T1 (de) 2000-01-15
EA199700424A1 (ru) 1999-02-25
HUP9802307A3 (en) 1999-03-29
TW346482B (en) 1998-12-01
KR100470884B1 (ko) 2005-06-22
IL122184A (en) 2000-02-29
PT830337E (pt) 2000-05-31
DE69605794D1 (de) 2000-01-27
IL122184A0 (en) 1998-04-05
AR002359A1 (es) 1998-03-11
CA2220999A1 (en) 1996-12-27
ZA964832B (en) 1996-12-09
UA51652C2 (uk) 2002-12-16
CZ391997A3 (cs) 1998-03-18
JP4128623B2 (ja) 2008-07-30
BR9609159A (pt) 1999-05-04
HRP960253B1 (en) 2000-10-31
AU710870B2 (en) 1999-09-30
GR3032521T3 (en) 2000-05-31
CZ287315B6 (en) 2000-10-11
AU6221896A (en) 1997-01-09
KR19990021908A (ko) 1999-03-25
US5886225A (en) 1999-03-23
JPH11507917A (ja) 1999-07-13
EP0830337A1 (en) 1998-03-25
CA2220999C (en) 2008-01-29
HRP960253A2 (en) 1997-10-31
DE69605794T2 (de) 2000-07-20
CN1176900C (zh) 2004-11-24
SK281568B6 (sk) 2001-05-10
HU229337B1 (en) 2013-11-28
SK168197A3 (en) 1998-05-06
EA000498B1 (ru) 1999-08-26
HUP9802307A2 (hu) 1999-02-01

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