DE3856069D1 - Cdna, die für peptidyl-glycin alphaamidierende monooxygenase (pam) codiert - Google Patents

Cdna, die für peptidyl-glycin alphaamidierende monooxygenase (pam) codiert

Info

Publication number
DE3856069D1
DE3856069D1 DE3856069T DE3856069T DE3856069D1 DE 3856069 D1 DE3856069 D1 DE 3856069D1 DE 3856069 T DE3856069 T DE 3856069T DE 3856069 T DE3856069 T DE 3856069T DE 3856069 D1 DE3856069 D1 DE 3856069D1
Authority
DE
Germany
Prior art keywords
pam
alphaamidating
glycin
monooxygenase
peptidyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3856069T
Other languages
English (en)
Inventor
Henry Keutmann
Peter Zmbh Universit Schofield
Henry Rodriguez
Betty Eipper
Richard Mains
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
General Hospital Corp
Johns Hopkins University
Original Assignee
Genentech Inc
General Hospital Corp
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22257394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3856069(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc, General Hospital Corp, Johns Hopkins University filed Critical Genentech Inc
Application granted granted Critical
Publication of DE3856069D1 publication Critical patent/DE3856069D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003—Peptidylglycine monooxygenase (1.14.17.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE3856069T 1987-09-15 1988-09-14 Cdna, die für peptidyl-glycin alphaamidierende monooxygenase (pam) codiert Expired - Lifetime DE3856069D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/096,447 US6255067B1 (en) 1987-09-15 1987-09-15 cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)
PCT/US1988/003172 WO1989002460A1 (en) 1987-09-15 1988-09-14 cDNA ENCODING PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE (PAM)

Publications (1)

Publication Number Publication Date
DE3856069D1 true DE3856069D1 (de) 1997-12-18

Family

ID=22257394

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3856069T Expired - Lifetime DE3856069D1 (de) 1987-09-15 1988-09-14 Cdna, die für peptidyl-glycin alphaamidierende monooxygenase (pam) codiert

Country Status (6)

Country Link
US (1) US6255067B1 (de)
EP (1) EP0382766B1 (de)
JP (1) JPH03501205A (de)
AT (1) ATE160172T1 (de)
DE (1) DE3856069D1 (de)
WO (1) WO1989002460A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US5871995A (en) * 1989-08-15 1999-02-16 Shiseido Company, Ltd. Purified enzymes participating in C-terminal amidation
EP0448513A3 (en) * 1990-03-21 1991-12-27 Japat Ltd Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof
ES2079054T3 (es) * 1990-06-01 1996-01-01 Ciba Geigy Ag Peptidilhidroxiglicina n-c-liasa y adn codificante de la misma.
GB9213215D0 (en) * 1992-06-20 1992-08-05 Wellcome Found Peptides
DE102004058306A1 (de) * 2004-12-01 2006-07-27 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden
US9096843B2 (en) 2009-12-01 2015-08-04 Novo Nordisk A/S Peptidyl α-hydroxyglycine α-amidating lyases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2704084A (en) * 1983-04-19 1984-10-25 Genex Corp. Cloned ovine growth hormone genes
US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
JP2598050B2 (ja) 1987-07-17 1997-04-09 サントリー株式会社 Ｃ−末端α−アミド化酵素
WO2001059081A2 (en) * 2000-02-09 2001-08-16 Millennium Pharmaceuticals, Inc. Methods for using 20893, a human protein kinase

Also Published As

Publication number Publication date
ATE160172T1 (de) 1997-11-15
EP0382766B1 (de) 1997-11-12
EP0382766A1 (de) 1990-08-22
JPH03501205A (ja) 1991-03-22
US6255067B1 (en) 2001-07-03
WO1989002460A1 (en) 1989-03-23

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