ATE283288T1 - Mutantes hämoglobin mit niedriger affinität für sauerstoff - Google Patents

Mutantes hämoglobin mit niedriger affinität für sauerstoff

Info

Publication number
ATE283288T1
ATE283288T1 AT96915428T AT96915428T ATE283288T1 AT E283288 T1 ATE283288 T1 AT E283288T1 AT 96915428 T AT96915428 T AT 96915428T AT 96915428 T AT96915428 T AT 96915428T AT E283288 T1 ATE283288 T1 AT E283288T1
Authority
AT
Austria
Prior art keywords
oxygen
mutant hemoglobin
hemoglobin
low affinity
mutant
Prior art date
Application number
AT96915428T
Other languages
English (en)
Inventor
Chien Ho
Hyun-Won Kim
Tong-Jian Shen
Original Assignee
Univ Carnegie Mellon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Carnegie Mellon filed Critical Univ Carnegie Mellon
Application granted granted Critical
Publication of ATE283288T1 publication Critical patent/ATE283288T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AT96915428T 1995-05-01 1996-04-30 Mutantes hämoglobin mit niedriger affinität für sauerstoff ATE283288T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/432,071 US5843888A (en) 1995-05-01 1995-05-01 Low oxygen affinity mutant hemoglobin
PCT/US1996/006075 WO1996034974A1 (en) 1995-05-01 1996-04-30 Low oxygen affinity mutant hemoglobin

Publications (1)

Publication Number Publication Date
ATE283288T1 true ATE283288T1 (de) 2004-12-15

Family

ID=23714638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96915428T ATE283288T1 (de) 1995-05-01 1996-04-30 Mutantes hämoglobin mit niedriger affinität für sauerstoff

Country Status (8)

Country Link
US (1) US5843888A (de)
EP (1) EP0826064B1 (de)
JP (1) JP3170289B2 (de)
CN (1) CN1159450C (de)
AT (1) ATE283288T1 (de)
AU (1) AU5720596A (de)
DE (1) DE69633918D1 (de)
WO (1) WO1996034974A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998050430A2 (en) * 1997-05-02 1998-11-12 Somatogen, Inc. Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
US6486123B1 (en) 2000-06-21 2002-11-26 Carnegie Mellon University Low oxygen affinity mutant hemoglobins
US20070066548A1 (en) * 2003-03-14 2007-03-22 Albert Einstein College Of Medicine Of Yeshiva University Globin variant gene methods and compositions
US8551536B2 (en) 2007-08-31 2013-10-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitrite and nitrite-metheme therapy to detoxify stroma-free hemoglobin based blood substitutes
JP2016027326A (ja) * 2014-06-26 2016-02-18 アークレイ株式会社 測定方法、測定装置および溶離液
WO2019018403A1 (en) 2017-07-18 2019-01-24 Virtech Bio, Llc BLOOD SUBSTITUTES COMPRISING HEMOGLOBIN AND METHODS OF MAKING
CN111989568B (zh) * 2018-04-18 2024-05-28 积水医疗株式会社 血红蛋白分析方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013662A (en) * 1985-09-20 1991-05-07 Cetus Corporation Bacterial methionine n-terminal peptidase
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
US4870017A (en) * 1985-09-20 1989-09-26 Cetus Corporation Bacterial methionine N-terminal peptidase
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US5173426A (en) * 1989-10-06 1992-12-22 Yale University DNAs encoding genetically engineered low oxygen affinity mutants of human hemoglobin
US5239061A (en) * 1990-06-20 1993-08-24 Research Corporation Technologies, Inc. Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin

Also Published As

Publication number Publication date
JPH11506314A (ja) 1999-06-08
EP0826064B1 (de) 2004-11-24
JP3170289B2 (ja) 2001-05-28
WO1996034974A1 (en) 1996-11-07
AU5720596A (en) 1996-11-21
US5843888A (en) 1998-12-01
CN1159450C (zh) 2004-07-28
DE69633918D1 (de) 2004-12-30
CN1183120A (zh) 1998-05-27
EP0826064A4 (de) 1998-11-18
EP0826064A1 (de) 1998-03-04

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