KR890007750A - 인간 조직 인자 억제제의 dna 클론 - Google Patents

인간 조직 인자 억제제의 dna 클론 Download PDF

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Publication number
KR890007750A
KR890007750A KR1019880009237A KR880009237A KR890007750A KR 890007750 A KR890007750 A KR 890007750A KR 1019880009237 A KR1019880009237 A KR 1019880009237A KR 880009237 A KR880009237 A KR 880009237A KR 890007750 A KR890007750 A KR 890007750A
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South Korea
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human tissue
tissue factor
factor inhibitor
dna clone
protein
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KR1019880009237A
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KR930000274B1 (ko
Inventor
존 브로우즈 2세 조즈
구사노 크렛스머 구니꼬
체인 운 세
Original Assignee
아놀드 하비 콜
몬산토 캄파니
에드워드 레스리 멕코르디
워싱턴 유니버시티
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22410671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR890007750(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/123,753 external-priority patent/US4966852A/en
Application filed by 아놀드 하비 콜, 몬산토 캄파니, 에드워드 레스리 멕코르디, 워싱턴 유니버시티 filed Critical 아놀드 하비 콜
Publication of KR890007750A publication Critical patent/KR890007750A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

인간 조직 인자 억제제의 DNA의 클론
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 125 I - 제Xa인자로 표지된 λgtll클론의 방사선 사진이고,
제2도는 P9삽입자(inserts)의 부분적인 제한지도와 삽입순서에 대한 것이며,
제3도는 인간 TFI cDNA의 뉴클레오타이드 서열과 번역된 아미노산 서열에 관한 것이며,

Claims (6)

  1. 제2도의 제한 지도에 표현된 바와같은 특징을 갖는 λP9의 인간조직 인자 억제제 cDNA클론.
  2. 제3도의 뉴클레오타이드 서열을 갖는 인간 조직 인자 억제제의 cDNA.
  3. 제3도의 단백질 아미노산 서열을 갖는 인간 조직 인자 억제제.
  4. 제3항에 있어서, 단백질은 비글리코실화 된것임을 특징으로 하는 인간 조직 인자 억제제.
  5. 제3항에 있어서, 단배질은 글리로실화 된것임을 특징으로 하는 인간 조직 인자 억제제.
  6. 인간 조직 인자 억제제를 암호화하는 서열로구성된 DNA 서열.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880009237A 1987-11-23 1988-07-22 인간 조직 인자 억제제의 dna의 클론. KR930000274B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US123753 1987-11-23
US123,753 1987-11-23
US07/123,753 US4966852A (en) 1987-07-23 1987-11-23 DNA clone of human tissue factor inhibitor

Publications (2)

Publication Number Publication Date
KR890007750A true KR890007750A (ko) 1989-07-05
KR930000274B1 KR930000274B1 (ko) 1993-01-14

Family

ID=22410671

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880009237A KR930000274B1 (ko) 1987-11-23 1988-07-22 인간 조직 인자 억제제의 dna의 클론.

Country Status (15)

Country Link
EP (1) EP0318451B1 (ko)
JP (5) JP2836823B2 (ko)
KR (1) KR930000274B1 (ko)
AT (1) ATE111518T1 (ko)
AU (1) AU604139B2 (ko)
CA (1) CA1341223C (ko)
DE (1) DE3851511T2 (ko)
DK (1) DK173536B1 (ko)
ES (1) ES2063769T3 (ko)
FI (1) FI93365C (ko)
IE (1) IE65393B1 (ko)
IL (1) IL87171A (ko)
NO (2) NO310466B1 (ko)
NZ (1) NZ225535A (ko)
PT (1) PT88076B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
EP0439442B1 (en) * 1990-01-25 1996-03-06 Washington University Factor x-laci hybrid protein
CA2049873C (en) * 1990-08-27 2001-12-04 Tze-Chein Wun Anticoagulant combination of laci and sulfated polysaccharides
DK261490D0 (da) * 1990-10-31 1990-10-31 Novo Nordisk As New pharmaceutical compound
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO2003055442A2 (en) 2001-10-15 2003-07-10 Chiron Corporation Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi)
EP2298278B1 (en) 2002-06-07 2015-11-11 Dyax Corp. Prevention and reduction of blood loss and inflammatory response
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EP1981519B1 (en) 2005-12-29 2017-12-27 Dyax Corp. Protease inhibition
JP5739816B2 (ja) 2008-12-19 2015-06-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Ｔｆｐｉインヒビターおよび使用法
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
LT2521568T (lt) 2010-01-06 2018-12-10 Dyax Corp. Plazmos kalikreiną surišantys baltymai
WO2011115712A2 (en) 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use
BR112013017080A8 (pt) 2011-01-06 2023-05-09 Dyax Corp Anticorpo ou fragmento funcional do mesmo que se liga a forma ativa de calicreína do plasma humano, composiçao farmacêutica e método de detecçao de calicreína do plasma em um paciente
WO2012171996A1 (en) 2011-06-15 2012-12-20 F. Hoffmann-La Roche Ag Anti-human epo receptor antibodies and methods of use
WO2013141965A1 (en) 2012-03-21 2013-09-26 Baxter International Inc. Tfpi inhibitors and methods of use
BR112018011622A2 (pt) 2015-12-11 2018-11-27 Dyax Corp método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor

Also Published As

Publication number Publication date
ATE111518T1 (de) 1994-09-15
AU604139B2 (en) 1990-12-06
JP2005306875A (ja) 2005-11-04
EP0318451B1 (en) 1994-09-14
JP2004201696A (ja) 2004-07-22
DE3851511T2 (de) 1995-03-30
DE3851511D1 (de) 1994-10-20
NO20013608D0 (no) 2001-07-20
NZ225535A (en) 1990-11-27
FI93365C (fi) 1995-03-27
JP3565714B2 (ja) 2004-09-15
CA1341223C (en) 2001-05-01
FI883487A (fi) 1989-05-24
DK173536B1 (da) 2001-02-05
FI93365B (fi) 1994-12-15
DK413488A (da) 1989-05-24
JP2002097200A (ja) 2002-04-02
JP4025035B2 (ja) 2007-12-19
JP2836823B2 (ja) 1998-12-14
IL87171A0 (en) 1988-12-30
KR930000274B1 (ko) 1993-01-14
EP0318451A2 (en) 1989-05-31
NO883270D0 (no) 1988-07-22
ES2063769T3 (es) 1995-01-16
JPH01165383A (ja) 1989-06-29
IE882243L (en) 1989-05-23
PT88076A (pt) 1988-08-01
EP0318451A3 (en) 1990-03-28
NO20013608L (no) 1989-05-24
IL87171A (en) 1995-08-31
AU1928788A (en) 1989-05-25
DK413488D0 (da) 1988-07-22
NO883270L (no) 1989-05-24
PT88076B (pt) 1993-01-29
IE65393B1 (en) 1995-10-18
JPH1175875A (ja) 1999-03-23
FI883487A0 (fi) 1988-07-22
NO310466B1 (no) 2001-07-09

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