DK173536B1 - cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein - Google Patents
cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein Download PDFInfo
- Publication number
- DK173536B1 DK173536B1 DK198804134A DK413488A DK173536B1 DK 173536 B1 DK173536 B1 DK 173536B1 DK 198804134 A DK198804134 A DK 198804134A DK 413488 A DK413488 A DK 413488A DK 173536 B1 DK173536 B1 DK 173536B1
- Authority
- DK
- Denmark
- Prior art keywords
- tfi
- sequence
- cdna
- protein
- tissue factor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK200001612A DK174754B1 (da) | 1987-11-23 | 2000-10-27 | Humane vævsfaktorinhibitor (TFI), antistof med bindingsspecificitet herfor, fremgangsmåde til anvendelse af en TFI-peptid-kolonne til at oprense et antistof og fremgangsmåder til detektion af TFI eller et polypeptid omfattende.... |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12375387 | 1987-11-23 | ||
US07/123,753 US4966852A (en) | 1987-07-23 | 1987-11-23 | DNA clone of human tissue factor inhibitor |
Publications (3)
Publication Number | Publication Date |
---|---|
DK413488D0 DK413488D0 (da) | 1988-07-22 |
DK413488A DK413488A (da) | 1989-05-24 |
DK173536B1 true DK173536B1 (da) | 2001-02-05 |
Family
ID=22410671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198804134A DK173536B1 (da) | 1987-11-23 | 1988-07-22 | cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0318451B1 (ko) |
JP (5) | JP2836823B2 (ko) |
KR (1) | KR930000274B1 (ko) |
AT (1) | ATE111518T1 (ko) |
AU (1) | AU604139B2 (ko) |
CA (1) | CA1341223C (ko) |
DE (1) | DE3851511T2 (ko) |
DK (1) | DK173536B1 (ko) |
ES (1) | ES2063769T3 (ko) |
FI (1) | FI93365C (ko) |
IE (1) | IE65393B1 (ko) |
IL (1) | IL87171A (ko) |
NO (2) | NO310466B1 (ko) |
NZ (1) | NZ225535A (ko) |
PT (1) | PT88076B (ko) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5378614A (en) * | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
DK408089D0 (da) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
EP0439442B1 (en) * | 1990-01-25 | 1996-03-06 | Washington University | Factor x-laci hybrid protein |
CA2049873C (en) * | 1990-08-27 | 2001-12-04 | Tze-Chein Wun | Anticoagulant combination of laci and sulfated polysaccharides |
DK261490D0 (da) * | 1990-10-31 | 1990-10-31 | Novo Nordisk As | New pharmaceutical compound |
US5346991A (en) * | 1991-06-13 | 1994-09-13 | Genentech, Inc. | Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders |
US5276015A (en) * | 1992-03-18 | 1994-01-04 | Washington University | Method of inhibiting microvascular thrombosis |
US20030171292A1 (en) | 1992-06-01 | 2003-09-11 | Creasey Abla A. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
WO2003055442A2 (en) | 2001-10-15 | 2003-07-10 | Chiron Corporation | Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi) |
EP2298278B1 (en) | 2002-06-07 | 2015-11-11 | Dyax Corp. | Prevention and reduction of blood loss and inflammatory response |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
EP1981519B1 (en) | 2005-12-29 | 2017-12-27 | Dyax Corp. | Protease inhibition |
JP5739816B2 (ja) | 2008-12-19 | 2015-06-24 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Tfpiインヒビターおよび使用法 |
AU2010203712A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
LT2521568T (lt) | 2010-01-06 | 2018-12-10 | Dyax Corp. | Plazmos kalikreiną surišantys baltymai |
WO2011115712A2 (en) | 2010-03-19 | 2011-09-22 | Baxter International Inc | Tfpi inhibitors and methods of use |
BR112013017080A8 (pt) | 2011-01-06 | 2023-05-09 | Dyax Corp | Anticorpo ou fragmento funcional do mesmo que se liga a forma ativa de calicreína do plasma humano, composiçao farmacêutica e método de detecçao de calicreína do plasma em um paciente |
WO2012171996A1 (en) | 2011-06-15 | 2012-12-20 | F. Hoffmann-La Roche Ag | Anti-human epo receptor antibodies and methods of use |
WO2013141965A1 (en) | 2012-03-21 | 2013-09-26 | Baxter International Inc. | Tfpi inhibitors and methods of use |
BR112018011622A2 (pt) | 2015-12-11 | 2018-11-27 | Dyax Corp | método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775624A (en) * | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
IL87172A (en) * | 1987-07-23 | 1994-12-29 | Univ Washington | A method of inhibiting the isolation of a purer tissue factor |
-
1988
- 1988-07-21 IL IL8717188A patent/IL87171A/en not_active IP Right Cessation
- 1988-07-22 IE IE224388A patent/IE65393B1/en not_active IP Right Cessation
- 1988-07-22 DE DE3851511T patent/DE3851511T2/de not_active Expired - Lifetime
- 1988-07-22 FI FI883487A patent/FI93365C/fi active IP Right Grant
- 1988-07-22 NZ NZ225535A patent/NZ225535A/en unknown
- 1988-07-22 KR KR1019880009237A patent/KR930000274B1/ko not_active IP Right Cessation
- 1988-07-22 CA CA000572753A patent/CA1341223C/en not_active Expired - Fee Related
- 1988-07-22 PT PT88076A patent/PT88076B/pt not_active IP Right Cessation
- 1988-07-22 EP EP88870127A patent/EP0318451B1/en not_active Expired - Lifetime
- 1988-07-22 DK DK198804134A patent/DK173536B1/da not_active IP Right Cessation
- 1988-07-22 ES ES88870127T patent/ES2063769T3/es not_active Expired - Lifetime
- 1988-07-22 AT AT88870127T patent/ATE111518T1/de not_active IP Right Cessation
- 1988-07-22 JP JP63183423A patent/JP2836823B2/ja not_active Expired - Lifetime
- 1988-07-22 AU AU19287/88A patent/AU604139B2/en not_active Expired
- 1988-07-22 NO NO19883270A patent/NO310466B1/no not_active IP Right Cessation
-
1998
- 1998-05-25 JP JP18131998A patent/JP3565714B2/ja not_active Expired - Lifetime
-
2001
- 2001-07-20 NO NO20013608A patent/NO20013608D0/no not_active Application Discontinuation
- 2001-07-26 JP JP2001226122A patent/JP4025035B2/ja not_active Expired - Lifetime
-
2004
- 2004-04-15 JP JP2004120081A patent/JP2004201696A/ja active Pending
-
2005
- 2005-04-22 JP JP2005124415A patent/JP2005306875A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK173536B1 (da) | cDNA-sekvens, som koder for modent humant vævsfaktorinhibitor-protein | |
US4966852A (en) | DNA clone of human tissue factor inhibitor | |
Wun et al. | Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. | |
US7060805B2 (en) | Methods for isolating tissue factor inhibitor | |
Hunt et al. | A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha1-proteinase inhibitor | |
Sommer et al. | cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily | |
Freije et al. | Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva | |
AU711113B2 (en) | Novel serpin derived from human hypothalamus | |
US6025143A (en) | Antibodies directed against peptides derived from the SMR1 polypeptide | |
Shen et al. | Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA | |
DK174754B1 (da) | Humane vævsfaktorinhibitor (TFI), antistof med bindingsspecificitet herfor, fremgangsmåde til anvendelse af en TFI-peptid-kolonne til at oprense et antistof og fremgangsmåder til detektion af TFI eller et polypeptid omfattende.... | |
DK175431B1 (da) | Antistoffer som binder fragmenter af vævsfaktorinhibitor (TFI), sammensætninger omfattende disse antistoffer, og fremgangsmåde til anvendelse af en immunoaffinitetsmatrix omfattende et sådant antistof til at oprense et polypeptid fra et biologisk fluidum | |
Lai et al. | Purification and characterization of a trypsin inhibitor from mouse seminal vesicle secretion | |
OHLSSON | Chemistry and Biology of Secretory Leukoprotease Inhibitor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
Country of ref document: DK |