NO20013608L - DNA-klon for human vevsfaktorinhibitor - Google Patents

DNA-klon for human vevsfaktorinhibitor

Info

Publication number
NO20013608L
NO20013608L NO20013608A NO20013608A NO20013608L NO 20013608 L NO20013608 L NO 20013608L NO 20013608 A NO20013608 A NO 20013608A NO 20013608 A NO20013608 A NO 20013608A NO 20013608 L NO20013608 L NO 20013608L
Authority
NO
Norway
Prior art keywords
human tissue
tissue factor
factor inhibitor
dna clone
tfi
Prior art date
Application number
NO20013608A
Other languages
English (en)
Other versions
NO20013608D0 (no
Inventor
Jr George John Broze
Kuniko Kusano Kretzmer
Tze-Chein Wun
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22410671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20013608(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/123,753 external-priority patent/US4966852A/en
Publication of NO20013608L publication Critical patent/NO20013608L/no
Application filed by Univ Washington filed Critical Univ Washington
Publication of NO20013608D0 publication Critical patent/NO20013608D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1432 basepar stor innføyelse i human vevsfaktorinhibitorklon A.P9 som vist i fig. 3. cDNA for humanvevsfaktor- inhibitor med nukleotidsekvensen som vist i fig. 3 som koder for human vevsfaktorinhibitor med aminosyre- sekvensen vist i fig. 3. Human vevsfaktorinhibitor fremstilt ved hjelp av gentekniske fremgangsmåter i en vertscelle som ikke en HepG2-hepatomcelle, hvor den humane vevsfaktorinhibitor er i hoved-sakelig ren form, bortsett fra dens naturlige forekommende blandinger, og har proteinaminosyresekvensen som vist i fig. 3. Rekombinant polypeptidfremstil- ling i en vertscelle, som omfatter aminosyresekvensen til moden vevs- faktorinhibitor (TFI) som vist i fig. 3 . Ekspresjonsvektor, vertscelle og fremgangsmåte for fremstilling av et vevsfaktorinhibitorpolypeptid. Isolert og renset antistoff med en bindingsspesifisitet for vevs- faktorinhibitor (TFI) og preparat som omfatter antistoffet.
NO20013608A 1987-11-23 2001-07-20 DNA-klon for human vevsfaktorinhibitor NO20013608D0 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/123,753 US4966852A (en) 1987-07-23 1987-11-23 DNA clone of human tissue factor inhibitor

Publications (2)

Publication Number Publication Date
NO20013608L true NO20013608L (no) 1989-05-24
NO20013608D0 NO20013608D0 (no) 2001-07-20

Family

ID=22410671

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19883270A NO310466B1 (no) 1987-11-23 1988-07-22 cDNA-sekvens som koder for modent humanvevsfaktorinhibitorprotein
NO20013608A NO20013608D0 (no) 1987-11-23 2001-07-20 DNA-klon for human vevsfaktorinhibitor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19883270A NO310466B1 (no) 1987-11-23 1988-07-22 cDNA-sekvens som koder for modent humanvevsfaktorinhibitorprotein

Country Status (15)

Country Link
EP (1) EP0318451B1 (no)
JP (5) JP2836823B2 (no)
KR (1) KR930000274B1 (no)
AT (1) ATE111518T1 (no)
AU (1) AU604139B2 (no)
CA (1) CA1341223C (no)
DE (1) DE3851511T2 (no)
DK (1) DK173536B1 (no)
ES (1) ES2063769T3 (no)
FI (1) FI93365C (no)
IE (1) IE65393B1 (no)
IL (1) IL87171A (no)
NO (2) NO310466B1 (no)
NZ (1) NZ225535A (no)
PT (1) PT88076B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
ES2086521T3 (es) * 1990-01-25 1996-07-01 Univ Washington Proteina hibrida laci-factor x.
PT98779B (pt) * 1990-08-27 1999-06-30 Monsanto Co Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao
DK261490D0 (da) * 1990-10-31 1990-10-31 Novo Nordisk As New pharmaceutical compound
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
IL161408A0 (en) 2001-10-15 2004-09-27 Chiron Corp Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi)
ATE477020T1 (de) 2002-06-07 2010-08-15 Dyax Corp Prevention und verringerung von ischemia
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
HUE038243T2 (hu) 2005-12-29 2018-10-29 Dyax Corp Proteáz gátlás
SI2379096T1 (sl) 2008-12-19 2020-03-31 Baxalta GmbH Zaviralci TFPI in postopki uporabe
EP2385843A4 (en) 2009-01-06 2013-02-27 Dyax Corp TREATMENT OF MUZOSITIS WITH CALLICINE INHIBITORS
CA3168591A1 (en) 2010-01-06 2011-07-14 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
WO2011115712A2 (en) 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use
JP2014506257A (ja) 2011-01-06 2014-03-13 ダイアックス コーポレーション 血漿カリクレイン結合タンパク質
WO2012171996A1 (en) * 2011-06-15 2012-12-20 F. Hoffmann-La Roche Ag Anti-human epo receptor antibodies and methods of use
DK2827883T3 (da) 2012-03-21 2019-07-29 Baxalta GmbH Tfpi-inhibitorer og fremgangsmåder til anvendelse
EP3387018A1 (en) 2015-12-11 2018-10-17 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor

Also Published As

Publication number Publication date
NZ225535A (en) 1990-11-27
NO310466B1 (no) 2001-07-09
CA1341223C (en) 2001-05-01
EP0318451B1 (en) 1994-09-14
PT88076B (pt) 1993-01-29
FI883487A0 (fi) 1988-07-22
JPH01165383A (ja) 1989-06-29
KR930000274B1 (ko) 1993-01-14
FI883487A (fi) 1989-05-24
ATE111518T1 (de) 1994-09-15
JP2005306875A (ja) 2005-11-04
FI93365C (fi) 1995-03-27
DE3851511D1 (de) 1994-10-20
NO20013608D0 (no) 2001-07-20
NO883270L (no) 1989-05-24
JPH1175875A (ja) 1999-03-23
IL87171A0 (en) 1988-12-30
IE65393B1 (en) 1995-10-18
DK413488D0 (da) 1988-07-22
DK413488A (da) 1989-05-24
FI93365B (fi) 1994-12-15
AU604139B2 (en) 1990-12-06
JP4025035B2 (ja) 2007-12-19
EP0318451A3 (en) 1990-03-28
KR890007750A (ko) 1989-07-05
JP2002097200A (ja) 2002-04-02
DE3851511T2 (de) 1995-03-30
JP3565714B2 (ja) 2004-09-15
JP2836823B2 (ja) 1998-12-14
IE882243L (en) 1989-05-23
EP0318451A2 (en) 1989-05-31
DK173536B1 (da) 2001-02-05
JP2004201696A (ja) 2004-07-22
PT88076A (pt) 1988-08-01
NO883270D0 (no) 1988-07-22
AU1928788A (en) 1989-05-25
ES2063769T3 (es) 1995-01-16
IL87171A (en) 1995-08-31

Similar Documents

Publication Publication Date Title
FI883487A0 (fi) Ihmisen kudostekijäinhibiittorin DNA-klooni
ATE142258T1 (de) Menschlicher gefässpermeabilitätsfaktor
BR8707937A (pt) Protese para osteosintese
DK450887A (da) Kirurgisk klammepistol
AR227252A1 (es) Procedimiento para la fabricacion de un aglutinante para tejidos a base de proteinas humanas o animales
BR8807112A (pt) Forceps cirurgico
BR1100464A (pt) Inibidor de fator tecidual humano
ATE140962T1 (de) Dns-klone von menschlichem thrombomodulin
IT8719433A0 (it) Procedimento per la preparazione di alfafetoproteina umana.
IT1212555B (it) Composizione a base di dobesilato di calcio per il trattamento di malattie cardiache
IT8819400A0 (it) Composizioni aminoacidiche perfezionate per il trattamento specifico delle insufficienze multiple d'organo.
NO914588L (no) Enzymkatalysert fremgangsmaate for fremstilling av n-acyl-aminosyrer og n-acyl-aminosyreamider
IE860985L (en) Human anti-inflammatory phospholipase inhibitor protein
IT8867135A0 (it) Protesi ad espansione endoluminale particolarmente per il trattamentodi patologie vascolari
IT8547715A0 (it) Apparecchio e procedimento per la fabbricazione di protesi dentarie
SE8605216L (sv) Ny medicinsk anvendning
KR870000729U (ko) 양말 토우부용 봉합기

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application