ATE111518T1 - Dna-klon für menschlichen gewebefaktorinhibitor. - Google Patents

Dna-klon für menschlichen gewebefaktorinhibitor.

Info

Publication number
ATE111518T1
ATE111518T1 AT88870127T AT88870127T ATE111518T1 AT E111518 T1 ATE111518 T1 AT E111518T1 AT 88870127 T AT88870127 T AT 88870127T AT 88870127 T AT88870127 T AT 88870127T AT E111518 T1 ATE111518 T1 AT E111518T1
Authority
AT
Austria
Prior art keywords
human tissue
tissue factor
factor inhibitor
dna clone
tfi
Prior art date
Application number
AT88870127T
Other languages
English (en)
Inventor
George John Broze Jr
Kuniko Kusano Kretzmer
Tze-Chein Wun
Original Assignee
Monsanto Co
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22410671&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE111518(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/123,753 external-priority patent/US4966852A/en
Application filed by Monsanto Co, Univ Washington filed Critical Monsanto Co
Application granted granted Critical
Publication of ATE111518T1 publication Critical patent/ATE111518T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT88870127T 1987-11-23 1988-07-22 Dna-klon für menschlichen gewebefaktorinhibitor. ATE111518T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/123,753 US4966852A (en) 1987-07-23 1987-11-23 DNA clone of human tissue factor inhibitor

Publications (1)

Publication Number Publication Date
ATE111518T1 true ATE111518T1 (de) 1994-09-15

Family

ID=22410671

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88870127T ATE111518T1 (de) 1987-11-23 1988-07-22 Dna-klon für menschlichen gewebefaktorinhibitor.

Country Status (15)

Country Link
EP (1) EP0318451B1 (de)
JP (5) JP2836823B2 (de)
KR (1) KR930000274B1 (de)
AT (1) ATE111518T1 (de)
AU (1) AU604139B2 (de)
CA (1) CA1341223C (de)
DE (1) DE3851511T2 (de)
DK (1) DK173536B1 (de)
ES (1) ES2063769T3 (de)
FI (1) FI93365C (de)
IE (1) IE65393B1 (de)
IL (1) IL87171A (de)
NO (2) NO310466B1 (de)
NZ (1) NZ225535A (de)
PT (1) PT88076B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378614A (en) * 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
ES2086521T3 (es) * 1990-01-25 1996-07-01 Univ Washington Proteina hibrida laci-factor x.
PT98779B (pt) * 1990-08-27 1999-06-30 Monsanto Co Processo para a preparacao de uma composicao anticoagulante contendo inibidor sulfatados e metodos para a sua utilizacao
DK261490D0 (da) * 1990-10-31 1990-10-31 Novo Nordisk As New pharmaceutical compound
US5346991A (en) * 1991-06-13 1994-09-13 Genentech, Inc. Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US6063764A (en) * 1992-06-01 2000-05-16 Washington University & Chiron Corp. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US20030171292A1 (en) 1992-06-01 2003-09-11 Creasey Abla A. Method for using lipoprotein associated coagulation inhibitor to treat sepsis
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
HUP0501111A2 (en) 2001-10-15 2007-12-28 Chiron Corp Treatment of severe pneumonia by administration of tissue factor pathway inhibitor
DK1941867T3 (da) 2002-06-07 2012-01-02 Dyax Corp Polypeptid med modificeret Kunitz domæne
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
PT1981519T (pt) 2005-12-29 2018-02-23 Dyax Corp Inibição de protéases
CN102348462B (zh) 2008-12-19 2015-06-17 巴克斯特国际公司 Tfpi抑制剂和使用方法
WO2010080833A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
CA3168591A1 (en) 2010-01-06 2011-07-14 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
CN105566490A (zh) 2010-03-19 2016-05-11 巴克斯特国际公司 Tfpi抑制剂及使用方法
KR102502293B1 (ko) 2011-01-06 2023-02-21 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
AR086924A1 (es) 2011-06-15 2014-01-29 Hoffmann La Roche Anticuerpos anti-receptor de epo humano y los metodos para su utilizacion
AU2013235741C1 (en) 2012-03-21 2017-12-21 Takeda Pharmaceutical Company Limited TFPI inhibitors and methods of use
NZ744233A (en) 2015-12-11 2023-11-24 Takeda Pharmaceuticals Co Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
IL87172A (en) * 1987-07-23 1994-12-29 Univ Washington A method of inhibiting the isolation of a purer tissue factor

Also Published As

Publication number Publication date
EP0318451A3 (en) 1990-03-28
DK173536B1 (da) 2001-02-05
PT88076B (pt) 1993-01-29
NO20013608D0 (no) 2001-07-20
FI883487A (fi) 1989-05-24
KR890007750A (ko) 1989-07-05
IE65393B1 (en) 1995-10-18
NO883270L (no) 1989-05-24
DE3851511T2 (de) 1995-03-30
JPH01165383A (ja) 1989-06-29
EP0318451B1 (de) 1994-09-14
ES2063769T3 (es) 1995-01-16
AU1928788A (en) 1989-05-25
EP0318451A2 (de) 1989-05-31
NO310466B1 (no) 2001-07-09
JP2836823B2 (ja) 1998-12-14
NO883270D0 (no) 1988-07-22
CA1341223C (en) 2001-05-01
DK413488A (da) 1989-05-24
JP2004201696A (ja) 2004-07-22
JPH1175875A (ja) 1999-03-23
PT88076A (pt) 1988-08-01
IL87171A0 (en) 1988-12-30
FI883487A0 (fi) 1988-07-22
JP4025035B2 (ja) 2007-12-19
FI93365C (fi) 1995-03-27
AU604139B2 (en) 1990-12-06
JP3565714B2 (ja) 2004-09-15
IL87171A (en) 1995-08-31
IE882243L (en) 1989-05-23
DE3851511D1 (de) 1994-10-20
KR930000274B1 (ko) 1993-01-14
NO20013608L (no) 1989-05-24
JP2005306875A (ja) 2005-11-04
FI93365B (fi) 1994-12-15
DK413488D0 (da) 1988-07-22
NZ225535A (en) 1990-11-27
JP2002097200A (ja) 2002-04-02

Similar Documents

Publication Publication Date Title
ATE111518T1 (de) Dna-klon für menschlichen gewebefaktorinhibitor.
ATE142258T1 (de) Menschlicher gefässpermeabilitätsfaktor
AR227252A1 (es) Procedimiento para la fabricacion de un aglutinante para tejidos a base de proteinas humanas o animales
BR8707937A (pt) Protese para osteosintese
DK450887A (da) Kirurgisk klammepistol
AR227194A1 (es) Procedimiento para la fabricacion de un preparado activador de la coagulacion de la sangre a base de proteinas humanas
DE3578611D1 (de) Instrumente zur behandlung von verformten naegeln bei menschlichen patienten.
BR1100464A (pt) Inibidor de fator tecidual humano
ATE140962T1 (de) Dns-klone von menschlichem thrombomodulin
IT8448082A0 (it) Composto farmaceutico a base di dii droergotossina per il trattamento dell'ipertensione
EP0272609A3 (en) Amino acid sequence of human alpha2-plasmin inhibitor and cdna and genomic dna encoding said amino acid sequence
IT8819400A0 (it) Composizioni aminoacidiche perfezionate per il trattamento specifico delle insufficienze multiple d'organo.
IT8719433A0 (it) Procedimento per la preparazione di alfafetoproteina umana.
IT1212555B (it) Composizione a base di dobesilato di calcio per il trattamento di malattie cardiache
IE860985L (en) Human anti-inflammatory phospholipase inhibitor protein
IT8867135A0 (it) Protesi ad espansione endoluminale particolarmente per il trattamentodi patologie vascolari
NO914588D0 (no) Enzymkatalysert fremgangsmaate for fremstilling av n-acyl-aminosyrer og n-acyl-aminosyreamider

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time