KR890008317A - 유전학적 조작에 의한 응고억제성 단백질 pp4의 제조방법 - Google Patents

유전학적 조작에 의한 응고억제성 단백질 pp4의 제조방법 Download PDF

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Publication number
KR890008317A
KR890008317A KR1019880014311A KR880014311A KR890008317A KR 890008317 A KR890008317 A KR 890008317A KR 1019880014311 A KR1019880014311 A KR 1019880014311A KR 880014311 A KR880014311 A KR 880014311A KR 890008317 A KR890008317 A KR 890008317A
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KR
South Korea
Prior art keywords
dna
diagnostic aid
dna according
genetic manipulation
diagnostic
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KR1019880014311A
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English (en)
Inventor
그룬트만 울리흐
아벨 칼-요세프
큅퍼 한스
Original Assignee
필립 스타인, 헤리베르트 부크
베링베르케 아크티엔게젤샤프트
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Application filed by 필립 스타인, 헤리베르트 부크, 베링베르케 아크티엔게젤샤프트 filed Critical 필립 스타인, 헤리베르트 부크
Publication of KR890008317A publication Critical patent/KR890008317A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Abstract

내용 없음

Description

유전학적 조작에 의한 응고억제성 단백질 PP4의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
도면은 PP4를 암호화하는 cDNA 서열의 제한지도를 도시한 것이다.

Claims (14)

  1. 응고억제성 단백질 PP4를 암호화하고 표 1 에 나타낸 암호화쇄를 함유하는 DNA 서열.
  2. 엄격한 조건하에서, 제 1 항에 따른 DNA와 하이브리드화되는 DNA 또는 RNA.
  3. 표 1 에 나타낸 아미노산 서열을 암호화하는 DNA 서열.
  4. 제 1 항. 2항 또는 3항에 따른 DNA를 함유하는 유전자 구조물.
  5. 제 1 내지 4항중 한 항 이상에 따른 DNA를 함유하는 벡터.
  6. 제 1 항, 2항, 3항 또는 4항에 따른 DNA를 함유하는 형질환된 세포.
  7. 유전학적 조작에 의해 수득가능하고 표 1 에 나타낸 아미노산 서열을 함유하는 PP4.
  8. 제 1 항, 3항 또는 4항(여기에서, 4항은 1항 및 3항에만 관련된다)에 따른 cDNA를, 발현시스템내에 삽입시키고, 여기에서 발현시킴을 특징으로 하는, PP4의 제조방법.
  9. PP4에 대하여 특이적이고, 유전학적 조작에 의해 제조된 PP4로부터, 또는 항원 활성을 지니는 PP4의 일부로 부터 수득되는 폴리클로날 또는 모노클로날 항체.
  10. 제 1 항, 2항. 3항 또는 4항에 따른 DNA의 전부 또는 일부를 함유하는 진단용 보조제.
  11. 제 1 항에 따른 DNA와 상보적인 DNA 또는 RNA의 전부 또는 일부를 함유하는 진단용 보조제.
  12. 제 9 항에 따른 항체를 함유하는 진단용 보조제.
  13. 체액, 조직, 또는 이로부터 수득된 핵산을 제 10 항, 11항 또는 12항에 따른 진단용 보조제와 접촉시킴을 특징으로하는 진단방법.
  14. 제 8 항에 따라 제조된 PP4를 함유하는 약학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880014311A 1987-11-03 1988-11-01 유전학적 조작에 의한 응고억제성 단백질 pp4의 제조방법 KR890008317A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3737239.4 1987-11-03
DE19873737239 DE3737239A1 (de) 1987-11-03 1987-11-03 Gentechnische herstellung von anticoagulatorischem protein pp4

Publications (1)

Publication Number Publication Date
KR890008317A true KR890008317A (ko) 1989-07-10

Family

ID=6339665

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880014311A KR890008317A (ko) 1987-11-03 1988-11-01 유전학적 조작에 의한 응고억제성 단백질 pp4의 제조방법

Country Status (8)

Country Link
EP (1) EP0318703A1 (ko)
JP (1) JPH01165386A (ko)
KR (1) KR890008317A (ko)
AU (1) AU2458988A (ko)
DE (1) DE3737239A1 (ko)
DK (1) DK610288A (ko)
FI (1) FI885024A (ko)
PT (1) PT88912B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3533516A1 (de) * 1984-09-21 1986-04-03 Boehringer Ingelheim KG, 6507 Ingelheim Blutgerinnungshemmende proteine, verfahren zur herstellung sowie deren verwendung
DK0409052T3 (da) * 1989-07-15 1993-06-07 Boehringer Ingelheim Int Middel, der indeholder et antikoagulans
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
DE4012341A1 (de) * 1990-04-18 1991-10-24 Behringwerke Ag Monoklonale antikoerper gegen pp4, verfahren zu ihrer herstellung und ihre verwendung
EP0672136B1 (en) * 1992-07-08 2000-03-08 N.V. Innogenetics S.A. Polypeptides, derived from endonexin 2, having hepatitis b virus receptor activity and their use in diagnostic and pharmaceutical compositions
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
DE69527505D1 (de) * 1994-11-11 2002-08-29 Noboru Kaneko Monoklonaler antikörper gegen antiannexin-v, verfahren zu seiner herstellung und seiner verwendung
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
ES2286247T3 (es) 2001-02-21 2007-12-01 Alavita Pharmaceuticals, Inc. Proteinas anexinicas modificacdas y tratamiento de la trombosis.
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3315000A1 (de) * 1983-04-26 1984-10-31 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
JPH0826078B2 (ja) * 1984-01-12 1996-03-13 カイロン コーポレイション フアクタ−ｖ▲ｉｉｉ▼ｃ組成物
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
DE3643182A1 (de) * 1986-12-18 1988-06-30 Behringwerke Ag Arzneimittel enthaltend das gewebeprotein pp4, verfahren zur herstellung von pp4 und zu seiner pasteurisierung sowie die verwendung von pp4

Also Published As

Publication number Publication date
DE3737239A1 (de) 1989-10-12
FI885024A (fi) 1989-05-04
PT88912A (pt) 1988-12-01
FI885024A0 (fi) 1988-11-01
AU2458988A (en) 1989-05-04
PT88912B (pt) 1993-01-29
EP0318703A1 (de) 1989-06-07
DK610288D0 (da) 1988-11-02
DK610288A (da) 1989-05-04
JPH01165386A (ja) 1989-06-29

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