KR890008316A - 항응고성 단백질 pp4-x, 및 이의 제조방법 및 용도 - Google Patents

항응고성 단백질 pp4-x, 및 이의 제조방법 및 용도 Download PDF

Info

Publication number
KR890008316A
KR890008316A KR1019880014310A KR880014310A KR890008316A KR 890008316 A KR890008316 A KR 890008316A KR 1019880014310 A KR1019880014310 A KR 1019880014310A KR 880014310 A KR880014310 A KR 880014310A KR 890008316 A KR890008316 A KR 890008316A
Authority
KR
South Korea
Prior art keywords
dna
diagnostic aid
amino acid
acid sequence
protein
Prior art date
Application number
KR1019880014310A
Other languages
English (en)
Inventor
그룬트만 울리히
아벨 칼-조새프
아만 에곤
Original Assignee
필립 스타인, 헤리베르트버그
베링베르케 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 필립 스타인, 헤리베르트버그, 베링베르케 아크티엔게젤샤프트 filed Critical 필립 스타인, 헤리베르트버그
Publication of KR890008316A publication Critical patent/KR890008316A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos
    • Y10S530/851—Placenta; amniotic fluid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

항응고성 단백질 PP4-X, 및 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 PP4-X를 암호화하는 cDNA 서열의 제한지도(map)을 나타내는 것이다.

Claims (16)

  1. 표 1 에 나타낸 아미노산 서열을 갖는 PP4-X.
  2. PP4-X를 암호화하며 표 1 에 나타낸 암호화 본쇄를 함유하는 DNA 서열.
  3. 엄격한 조건하에서 제 2 항에서 청구한 DNA와 하이브리드화화는 DNA.
  4. 표 1 에 나타낸 아미노산 서열을 암호화하는 DNA 서열.
  5. 제 2 항, 제 3 항 및 제 4 항중 어느 한 항에서 청구한 DNA를 함유하는 유전자 구조물.
  6. 제 2 항 내지 제 5 항중 어느 한 항에서 청구한 DNA 서열을 함유하는 백터.
  7. 제 2 항 내지 제 5 항중 어느 한 항에서 청구한 DNA를 함유하는 형질전환된 세포.
  8. 세균, 효모 또는 동물의 세포에서 제 2 항, 제 4 항 및 제 5 항중 어느 한 항에서 청구한 DNA 서열의 발현에 의해 수득된 PP4-X.
  9. 제 2 항, 제 4 항, 제 5 항 및 제 6 항중 어느 한 항에서 청구한 cDNA를 발현계에 삽입한후, 여기서 이의 발현을 일으키는 것을 특징으로 하여, PP4-X를 제조하는 방법.
  10. PP4-X 활성을 가지며 표 1 에 나타낸 아미노산 서열 또는 이의 일부분을 함유하는 단백질, 및 이 단백질의 돌연변이체 및 변이체.
  11. PP4-X 특이성이며 항원성 활성을 갖는 PP4-X 또는 이의 일부분으로부터 수득되는 폴리클로날 또는 모노클로날 항체.
  12. 제 1 항, 제 8 항 및 제 10 항중 어느 한 항에서 청구한 항원을 함유하는 진단용 보조제.
  13. 제11항에서 청구한 항체를 함유하는 진단용 보조제.
  14. 제 2 항, 제 3 항, 제 4 항 및 제 5 항중 어느 한 한에서 청구한 DNA를 전체적으로 또는 부분적으로 함유하는 진단용 보조제.
  15. 제 2 항에서 청구한 DNA에 상보적인 RNA를 전체적으로 또는 부분적으로 함유하는 진단용 보조제.
  16. 제 1 항, 제 8 항 및 제 10 항중 어느 한 항에서 청구한 단백질을 함유하는 약제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880014310A 1987-11-03 1988-11-01 항응고성 단백질 pp4-x, 및 이의 제조방법 및 용도 KR890008316A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873737237 DE3737237A1 (de) 1987-11-03 1987-11-03 Anticoagulatorisches protein pp4-x, seine herstellung und verwendung
DEP3737237.8 1987-11-03

Publications (1)

Publication Number Publication Date
KR890008316A true KR890008316A (ko) 1989-07-10

Family

ID=6339663

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880014310A KR890008316A (ko) 1987-11-03 1988-11-01 항응고성 단백질 pp4-x, 및 이의 제조방법 및 용도

Country Status (11)

Country Link
US (1) US5202419A (ko)
EP (1) EP0315081B1 (ko)
JP (1) JPH01165387A (ko)
KR (1) KR890008316A (ko)
AT (1) ATE109509T1 (ko)
AU (1) AU613676B2 (ko)
DE (2) DE3737237A1 (ko)
DK (1) DK610488A (ko)
ES (1) ES2056872T3 (ko)
FI (1) FI885025A (ko)
PT (1) PT88913B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330396B1 (en) * 1988-02-26 1995-06-21 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing lipocortins III, IV, V & VI
DE3939169A1 (de) * 1989-11-27 1991-05-29 Behringwerke Ag Verfahren zur reinigung von lipocortinen
DE4012341A1 (de) * 1990-04-18 1991-10-24 Behringwerke Ag Monoklonale antikoerper gegen pp4, verfahren zu ihrer herstellung und ihre verwendung
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5968477A (en) * 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3315000A1 (de) * 1983-04-26 1984-10-31 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
AU601676B2 (en) * 1985-01-10 1990-09-20 Biogen, Inc. Dna sequences recombinant dna molecules and processes for producing human lipocorton-like polypeptides
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
EP0300030A1 (en) * 1987-02-06 1989-01-25 Zymogenetics, Inc. Human proteins having anticoagulant and anti-inflammatory activity
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity

Also Published As

Publication number Publication date
AU2459188A (en) 1989-05-04
EP0315081A3 (en) 1990-05-30
DK610488D0 (da) 1988-11-02
ATE109509T1 (de) 1994-08-15
FI885025A (fi) 1989-05-04
DE3850933D1 (de) 1994-09-08
FI885025A0 (fi) 1988-11-01
EP0315081B1 (de) 1994-08-03
PT88913A (pt) 1988-12-01
DE3737237A1 (de) 1989-05-18
ES2056872T3 (es) 1994-10-16
AU613676B2 (en) 1991-08-08
DK610488A (da) 1989-05-04
EP0315081A2 (de) 1989-05-10
PT88913B (pt) 1993-01-29
JPH01165387A (ja) 1989-06-29
US5202419A (en) 1993-04-13

Similar Documents

Publication Publication Date Title
Mihaesco et al. Papain digestion fragments of human IgM globulins
AU5909386A (en) Diagnostic reagents based on unique sequences within the variable region of the t cell receptor and uses thereof
KR890000517A (ko) 하이브리드 단백질 c 및 이의 제조방법
KR910012244A (ko) 톡소플라스마 곤디 항원, 이의 제조방법 및 이의 용도
DE240975T1 (de) Menschliches gamma-interferon-spezifisches rezeptorprotein, antikoerper gegen dieses protein, verfahren zur herstellung dieses proteins und dieses antikoerpers und dieses protein und diesen antikoerper enthaltende zusammensetzungen.
HUP0002472A2 (hu) Izolált dendritikus sejtmembrán-fehérje gének
HANSMA The immobilization antigen of Paramecium aurelia is a single polypeptide chain
ATE24018T1 (de) Polysaccharid-antigen aus streptococcus und impfstoffe.
KR890008317A (ko) 유전학적 조작에 의한 응고억제성 단백질 pp4의 제조방법
ES8607024A1 (es) Anticuerpos monoclonales
KR900004935A (ko) 슈도 모나즈 아에루기노사의 지질단백질 i(ompi)
ES2032447T3 (es) Nuevos anticuerpos monoclonales y su produccion y uso.
EP0074240A3 (en) Antibodies specific to endotoxins
KR890008316A (ko) 항응고성 단백질 pp4-x, 및 이의 제조방법 및 용도
Thalhamer et al. Passive immunization: a method of enhancing the immune response against antigen mixtures
Brenner The mechanism of gene action
EP0293827A3 (en) Assay for leishmaniasis
Goodman On the emergence of intraspecific differences in the protein antigens of human beings
US4269765A (en) Immune serum for diagnosis of cancer and preparation thereof
Heidelberger Some contributions of immunochemistry to biochemistry and biology
KR890002402A (ko) 인간의 유두종바이러스형 41, 이의 dna 및 이로부터 코드화된 단백질
KR930703445A (ko) 톡소플라스마 곤디(toxoplasma gondii)의 단백질 항원의 클로닝 및 발현
Elliott et al. The incidence of antigen J in cattle and the production of anti-J by isoimmunization
Mitchell et al. IgM antibody-I: Heterogeneity of the component chains of equine anti-lactose antibody
KR900009987A (ko) 태반 단백질 11(PP11)을 암호화하는 cDNA, 이의 분리방법 및 용도

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application