ES8607024A1 - Anticuerpos monoclonales - Google Patents
Anticuerpos monoclonalesInfo
- Publication number
- ES8607024A1 ES8607024A1 ES527730A ES527730A ES8607024A1 ES 8607024 A1 ES8607024 A1 ES 8607024A1 ES 527730 A ES527730 A ES 527730A ES 527730 A ES527730 A ES 527730A ES 8607024 A1 ES8607024 A1 ES 8607024A1
- Authority
- ES
- Spain
- Prior art keywords
- lupus erythematosus
- systemic lupus
- patients
- native dna
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/104—Lupus erythematosus [SLE]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/824—Immunological separation techniques
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SINTESIS DE ANTICUERPOS MONOCLONALES ANTIIDIOTIPICOS. COMPRENDE: A) OBTENER LINFOCITOS, ESPECIFICAMENTE SENSIBILIZADOS AL ANTICUERPO ANTI-ADN NATIVO INMUNIZADO DE UN RATON CON ANTICUERPO ANTI-ADN HUMANO Y AISLANDO LAS CELULAS DEL BAZO DEL ANIMAL; B) FUNDIR LOS LINFOCITOS CON ASOCIADOS DE FUSION PARA FORMAR HIBRIDOMAS; C) SELECCIONAR LOS HIBRIDOMAS QUE SEGREGAN ANTICUERPO ANTI-ADN NATIVO HUMANO PROCEDENTE DE DOS INDIVIDUOS GENETICAMENTE NO IDENTICOS; D) CLONAR LOS HIBRIDOMAS SELECCIONADOS; Y E) RECUPERAR LOS ANTICUERPOS MONOCLONALES CAPACES DE REACCIONAR CON UN IDIOTIPO COMPARTIDO DE ANTICUERPO ANTI-ADN NATIVO HUMANO. SIENDO: EL ASOCIADO DE FUSION UNA CELULA DE MIELOMA TIPO X63AG8.653. SE UTILIZAN COMO REACTIVOS DE DIAGNOSTICO EN LA DETERMINACION DE LA DOLENCIA LUPUS ERITEMATOSUS SISTEMICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44671882A | 1982-12-03 | 1982-12-03 | |
US06/552,290 US4692416A (en) | 1982-12-03 | 1983-11-16 | Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8607024A1 true ES8607024A1 (es) | 1986-06-16 |
ES527730A0 ES527730A0 (es) | 1986-06-16 |
Family
ID=27034715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527730A Expired ES8607024A1 (es) | 1982-12-03 | 1983-12-02 | Anticuerpos monoclonales |
Country Status (11)
Country | Link |
---|---|
US (1) | US4692416A (es) |
EP (1) | EP0113431B1 (es) |
AU (1) | AU566246B2 (es) |
CA (1) | CA1215009A (es) |
DE (1) | DE3382009D1 (es) |
DK (1) | DK557383A (es) |
ES (1) | ES8607024A1 (es) |
FI (1) | FI834424A (es) |
IL (1) | IL70366A (es) |
NO (1) | NO163039C (es) |
NZ (1) | NZ206467A (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4536479A (en) * | 1983-03-22 | 1985-08-20 | E. I. Du Pont De Nemours And Company | Use of anti-idiotype antibodies in immunoassays |
US4731237A (en) * | 1983-11-07 | 1988-03-15 | The Wistar Institute | Immune response to virus induced by anti-idiotype antibodies |
EP0141783B2 (en) * | 1983-11-07 | 1993-06-16 | The Wistar Institute | Immune response to tumours and viruses induced by anti-idiotype antibodies |
JPS61205862A (ja) * | 1985-03-08 | 1986-09-12 | Shionogi & Co Ltd | アレルゲン特異IgG抗体測定用試薬 |
US4865970A (en) * | 1986-02-28 | 1989-09-12 | Hoffmann-La Roche Inc. | Method of detecting ribosomal protein antibodies in systemic lupus erythematosus |
DE3609271A1 (de) * | 1986-03-19 | 1987-09-24 | Boehringer Mannheim Gmbh | Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper |
WO1988007058A1 (en) * | 1987-03-16 | 1988-09-22 | Biosolutions Pty. Ltd. | Anti-paratopic antibody as an immunogen |
US5428132A (en) * | 1987-10-11 | 1995-06-27 | United States Of America | Conjugate and method for integration of foreign DNA into cells |
PT89107A (pt) * | 1987-11-30 | 1989-11-30 | Idec Pharma Corp | Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas |
US6232444B1 (en) | 1990-01-29 | 2001-05-15 | The Regents Of The University Of California | Conserved anti-DNA antibody idiotype associated with nephritis in murine and human lupus |
EP0535032A1 (en) * | 1990-06-08 | 1993-04-07 | Symbicom Ab | Therapy and prophylaxis of autoimmune diseases |
US7888458B1 (en) | 1993-11-30 | 2011-02-15 | John B. Harley | Diagnostics and therapy of epstein-barr virus in autoimmune disorders |
WO1996037225A1 (en) * | 1995-05-25 | 1996-11-28 | Oklahoma Medical Research Foundation | Method for treatment of sle |
US7273613B1 (en) | 1997-01-13 | 2007-09-25 | The Board of Regents, The University of Oklahoma | Diagnostics and therapy of Epstein-Barr virus in autoimmune disorders |
TWI434855B (zh) * | 2006-11-21 | 2014-04-21 | Hoffmann La Roche | 結合物及其在免疫分析中作為參考標準之用途 |
WO2009014476A1 (en) * | 2007-07-24 | 2009-01-29 | Iss Immune System Stimulation Ab | Method and means for prediction of systemic lupus erythematosus susceptibility |
US8283408B2 (en) | 2010-02-26 | 2012-10-09 | Hexcel Corporation | Thermoplastic-toughened cyanate ester resin composites with low heat release properties |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4234563A (en) * | 1978-06-02 | 1980-11-18 | American Hospital Supply Corporation | Insolubilized deoxyribonucleic acid (DNA) |
US4493899A (en) * | 1981-10-16 | 1985-01-15 | City Of Hope | Method of testing for particular antibodies in the serum of a patient |
DE3364347D1 (en) * | 1982-04-09 | 1986-08-07 | Fujirebio Kk | Anti immune complex antibody and preparation thereof |
US4487830A (en) * | 1982-05-14 | 1984-12-11 | American Hoechst Corporation | Enzyme/immunofluorescent assay for autoantibodies |
-
1983
- 1983-11-16 US US06/552,290 patent/US4692416A/en not_active Expired - Lifetime
- 1983-11-25 AU AU21712/83A patent/AU566246B2/en not_active Ceased
- 1983-12-01 DE DE8383112090T patent/DE3382009D1/de not_active Expired - Fee Related
- 1983-12-01 CA CA000442334A patent/CA1215009A/en not_active Expired
- 1983-12-01 EP EP83112090A patent/EP0113431B1/en not_active Expired - Lifetime
- 1983-12-02 ES ES527730A patent/ES8607024A1/es not_active Expired
- 1983-12-02 FI FI834424A patent/FI834424A/fi not_active Application Discontinuation
- 1983-12-02 DK DK557383A patent/DK557383A/da not_active Application Discontinuation
- 1983-12-02 NO NO834434A patent/NO163039C/no unknown
- 1983-12-02 IL IL70366A patent/IL70366A/xx unknown
- 1983-12-02 NZ NZ206467A patent/NZ206467A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US4692416A (en) | 1987-09-08 |
DK557383D0 (da) | 1983-12-02 |
EP0113431A3 (en) | 1986-08-27 |
IL70366A (en) | 1987-11-30 |
NO163039B (no) | 1989-12-11 |
EP0113431A2 (en) | 1984-07-18 |
FI834424A (fi) | 1984-06-04 |
FI834424A0 (fi) | 1983-12-02 |
NO163039C (no) | 1990-03-21 |
ES527730A0 (es) | 1986-06-16 |
AU2171283A (en) | 1984-06-07 |
CA1215009A (en) | 1986-12-09 |
NO834434L (no) | 1984-06-04 |
DE3382009D1 (de) | 1991-01-03 |
NZ206467A (en) | 1986-11-12 |
AU566246B2 (en) | 1987-10-15 |
EP0113431B1 (en) | 1990-11-22 |
DK557383A (da) | 1984-06-04 |
IL70366A0 (en) | 1984-03-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8607024A1 (es) | Anticuerpos monoclonales | |
AR243931A1 (es) | Antigeno purificado,conjunto de reactivos para la deteccion de anticuerpos anti-hiv-2 en un fluido biologico que comprende dichos antigenos,anticuerpos,hibridomas y procedimientos. | |
IT8320550A0 (it) | Procedimento di purificazione peraffinita' in cui si impiegano anticorpi monoclonali. | |
ES2124209T3 (es) | Anticuerpos monoclonales mejorados reactivos con caquectina. | |
DE3382283D1 (de) | Monoklonale antikoerper spezifisch gegen das karzinoembryonische antigen. | |
ATE94205T1 (de) | Monoklonale antikoerper gegen melanoma-assoziierte antigene, hybridzellinien, die diese antikoerper produzieren, und ihre verwendung. | |
OA08485A (fr) | Monoclonal antibodies and antigen for human non-small cell lung carcinoma and certain other human carcinomas. | |
KR100215606B1 (en) | Toxoplasma gondii antigens, the preparation thereof and the diagnostic agent containing them | |
DK0687295T3 (da) | Human B-lymfoblastoidcellelinje, der secernerer anti-gangliosid-antistof | |
DE3586216D1 (de) | Brusttumorassoziiertes antigen und monoklonale antikoerper dazu. | |
GB2182949A (en) | Monoclonal antibodies and antigens for human non-small cell lung carcinomas | |
GB2083836A (en) | Monoclonal antibody | |
FR2560212B1 (fr) | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps | |
AU6828387A (en) | Assay for human breast cancer | |
DK0454782T3 (da) | Cancer-beslægtet haptaglobin (Hpr.) | |
NO873774D0 (no) | Monoklonale eller polyklonale antistoffer. | |
EP0109434A4 (en) | IN VITRO DIAGNOSTICS METHODS USING MONOCLONAL ANTIBODIES AGAINST PROTEINS OF CONNECTIVE TISSUES. | |
DE3585049D1 (de) | Monoklonale antikoerper. | |
NO173831C (no) | Nye monoklonale antistoffer mot IFN-omega, hybridomer til fremstilling derav og anvendelse for rensing samt paavisning eller kvantitativ bestemmelse av IFN-omega, og sett for bruk ved paavisningen | |
DE3785795D1 (de) | Monoklonale anti-menschliche magenkrebs-antikoerper. | |
EP0248147A3 (en) | Method of determining the presence of cancer cells | |
EP0272113A3 (en) | Anti-human cancer monoclonal antibodies | |
AU582129B2 (en) | Circulating antigens of dirofilaria immitis,monoclonal antibodies specific therefor and methods of preparing such antibodies and detecting such antigens | |
MX9704717A (es) | Antigeno, anticuerpos y ensayo de diagnostico para la enfermedad de alzheimer. | |
EP0117705A3 (en) | Monoclonal antibody specific for monocytes and blast cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |