ES8607024A1 - Anticuerpos monoclonales - Google Patents

Anticuerpos monoclonales

Info

Publication number
ES8607024A1
ES8607024A1 ES527730A ES527730A ES8607024A1 ES 8607024 A1 ES8607024 A1 ES 8607024A1 ES 527730 A ES527730 A ES 527730A ES 527730 A ES527730 A ES 527730A ES 8607024 A1 ES8607024 A1 ES 8607024A1
Authority
ES
Spain
Prior art keywords
lupus erythematosus
systemic lupus
patients
native dna
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527730A
Other languages
English (en)
Other versions
ES527730A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeshiva University
Original Assignee
Yeshiva University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeshiva University filed Critical Yeshiva University
Publication of ES8607024A1 publication Critical patent/ES8607024A1/es
Publication of ES527730A0 publication Critical patent/ES527730A0/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SINTESIS DE ANTICUERPOS MONOCLONALES ANTIIDIOTIPICOS. COMPRENDE: A) OBTENER LINFOCITOS, ESPECIFICAMENTE SENSIBILIZADOS AL ANTICUERPO ANTI-ADN NATIVO INMUNIZADO DE UN RATON CON ANTICUERPO ANTI-ADN HUMANO Y AISLANDO LAS CELULAS DEL BAZO DEL ANIMAL; B) FUNDIR LOS LINFOCITOS CON ASOCIADOS DE FUSION PARA FORMAR HIBRIDOMAS; C) SELECCIONAR LOS HIBRIDOMAS QUE SEGREGAN ANTICUERPO ANTI-ADN NATIVO HUMANO PROCEDENTE DE DOS INDIVIDUOS GENETICAMENTE NO IDENTICOS; D) CLONAR LOS HIBRIDOMAS SELECCIONADOS; Y E) RECUPERAR LOS ANTICUERPOS MONOCLONALES CAPACES DE REACCIONAR CON UN IDIOTIPO COMPARTIDO DE ANTICUERPO ANTI-ADN NATIVO HUMANO. SIENDO: EL ASOCIADO DE FUSION UNA CELULA DE MIELOMA TIPO X63AG8.653. SE UTILIZAN COMO REACTIVOS DE DIAGNOSTICO EN LA DETERMINACION DE LA DOLENCIA LUPUS ERITEMATOSUS SISTEMICO.
ES527730A 1982-12-03 1983-12-02 Anticuerpos monoclonales Expired ES8607024A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44671882A 1982-12-03 1982-12-03
US06/552,290 US4692416A (en) 1982-12-03 1983-11-16 Monoclonal antibodies reactive with shared idiotypes on human antibodies to native DNA from patients with systemic lupus erythematosus

Publications (2)

Publication Number Publication Date
ES8607024A1 true ES8607024A1 (es) 1986-06-16
ES527730A0 ES527730A0 (es) 1986-06-16

Family

ID=27034715

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527730A Expired ES8607024A1 (es) 1982-12-03 1983-12-02 Anticuerpos monoclonales

Country Status (11)

Country Link
US (1) US4692416A (es)
EP (1) EP0113431B1 (es)
AU (1) AU566246B2 (es)
CA (1) CA1215009A (es)
DE (1) DE3382009D1 (es)
DK (1) DK557383A (es)
ES (1) ES8607024A1 (es)
FI (1) FI834424A (es)
IL (1) IL70366A (es)
NO (1) NO163039C (es)
NZ (1) NZ206467A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536479A (en) * 1983-03-22 1985-08-20 E. I. Du Pont De Nemours And Company Use of anti-idiotype antibodies in immunoassays
US4731237A (en) * 1983-11-07 1988-03-15 The Wistar Institute Immune response to virus induced by anti-idiotype antibodies
EP0141783B2 (en) * 1983-11-07 1993-06-16 The Wistar Institute Immune response to tumours and viruses induced by anti-idiotype antibodies
JPS61205862A (ja) * 1985-03-08 1986-09-12 Shionogi & Co Ltd アレルゲン特異ＩｇＧ抗体測定用試薬
US4865970A (en) * 1986-02-28 1989-09-12 Hoffmann-La Roche Inc. Method of detecting ribosomal protein antibodies in systemic lupus erythematosus
DE3609271A1 (de) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper
WO1988007058A1 (en) * 1987-03-16 1988-09-22 Biosolutions Pty. Ltd. Anti-paratopic antibody as an immunogen
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
PT89107A (pt) * 1987-11-30 1989-11-30 Idec Pharma Corp Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas
US6232444B1 (en) 1990-01-29 2001-05-15 The Regents Of The University Of California Conserved anti-DNA antibody idiotype associated with nephritis in murine and human lupus
EP0535032A1 (en) * 1990-06-08 1993-04-07 Symbicom Ab Therapy and prophylaxis of autoimmune diseases
US7888458B1 (en) 1993-11-30 2011-02-15 John B. Harley Diagnostics and therapy of epstein-barr virus in autoimmune disorders
WO1996037225A1 (en) * 1995-05-25 1996-11-28 Oklahoma Medical Research Foundation Method for treatment of sle
US7273613B1 (en) 1997-01-13 2007-09-25 The Board of Regents, The University of Oklahoma Diagnostics and therapy of Epstein-Barr virus in autoimmune disorders
TWI434855B (zh) * 2006-11-21 2014-04-21 Hoffmann La Roche 結合物及其在免疫分析中作為參考標準之用途
WO2009014476A1 (en) * 2007-07-24 2009-01-29 Iss Immune System Stimulation Ab Method and means for prediction of systemic lupus erythematosus susceptibility
US8283408B2 (en) 2010-02-26 2012-10-09 Hexcel Corporation Thermoplastic-toughened cyanate ester resin composites with low heat release properties

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234563A (en) * 1978-06-02 1980-11-18 American Hospital Supply Corporation Insolubilized deoxyribonucleic acid (DNA)
US4493899A (en) * 1981-10-16 1985-01-15 City Of Hope Method of testing for particular antibodies in the serum of a patient
DE3364347D1 (en) * 1982-04-09 1986-08-07 Fujirebio Kk Anti immune complex antibody and preparation thereof
US4487830A (en) * 1982-05-14 1984-12-11 American Hoechst Corporation Enzyme/immunofluorescent assay for autoantibodies

Also Published As

Publication number Publication date
US4692416A (en) 1987-09-08
DK557383D0 (da) 1983-12-02
EP0113431A3 (en) 1986-08-27
IL70366A (en) 1987-11-30
NO163039B (no) 1989-12-11
EP0113431A2 (en) 1984-07-18
FI834424A (fi) 1984-06-04
FI834424A0 (fi) 1983-12-02
NO163039C (no) 1990-03-21
ES527730A0 (es) 1986-06-16
AU2171283A (en) 1984-06-07
CA1215009A (en) 1986-12-09
NO834434L (no) 1984-06-04
DE3382009D1 (de) 1991-01-03
NZ206467A (en) 1986-11-12
AU566246B2 (en) 1987-10-15
EP0113431B1 (en) 1990-11-22
DK557383A (da) 1984-06-04
IL70366A0 (en) 1984-03-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203