DE68916537D1 - Herstellung eines insulinähnlichen, wachstümsfaktor bindenden proteins. - Google Patents
Herstellung eines insulinähnlichen, wachstümsfaktor bindenden proteins.Info
- Publication number
- DE68916537D1 DE68916537D1 DE68916537T DE68916537T DE68916537D1 DE 68916537 D1 DE68916537 D1 DE 68916537D1 DE 68916537 T DE68916537 T DE 68916537T DE 68916537 T DE68916537 T DE 68916537T DE 68916537 D1 DE68916537 D1 DE 68916537D1
- Authority
- DE
- Germany
- Prior art keywords
- insulin
- growth factor
- binding protein
- production
- factor binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/171,623 US5258287A (en) | 1988-03-22 | 1988-03-22 | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
PCT/US1989/000983 WO1989009268A1 (en) | 1988-03-22 | 1989-03-10 | Production of insulin-like growth factor binding protein |
Publications (3)
Publication Number | Publication Date |
---|---|
DE68916537D1 true DE68916537D1 (de) | 1994-08-04 |
DE68916537T2 DE68916537T2 (de) | 1995-01-19 |
DE68916537T3 DE68916537T3 (de) | 2003-11-27 |
Family
ID=22624500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68916537T Expired - Lifetime DE68916537T3 (de) | 1988-03-22 | 1989-03-10 | Herstellung eines insulinähnlichen, wachstümsfaktor bindenden proteins. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5258287A (de) |
EP (1) | EP0406272B2 (de) |
JP (2) | JP3577311B2 (de) |
AT (1) | ATE107958T1 (de) |
CA (1) | CA1340703C (de) |
DE (1) | DE68916537T3 (de) |
HK (1) | HK1007335A1 (de) |
NZ (1) | NZ228350A (de) |
WO (1) | WO1989009268A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2687995B2 (ja) | 1980-04-03 | 1997-12-08 | バイオゲン インコーポレイテッド | Dna配列、組替えdna分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法 |
US5200509A (en) * | 1987-04-06 | 1993-04-06 | Celtrix Pharmaceuticals, Inc. | Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides |
US5693760A (en) | 1988-04-14 | 1997-12-02 | Incyte Pharmaceuticals, Inc. | Method of causing selective immunosuppression using HL-60 related lectins |
US5633148A (en) * | 1988-04-14 | 1997-05-27 | Incyte Pharmaceuticals, Inc. | Unique lectins |
US6465423B1 (en) | 1988-07-15 | 2002-10-15 | Central Sydney Area Health Service | Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex |
ATE125268T1 (de) * | 1988-07-15 | 1995-08-15 | Cent Sydney Area Health Serv | Säureempfindliche subeinheit eines insulinähnlichen wachstumfaktors-bindeprotein- komplexes. |
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
SE8904361D0 (sv) * | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
SE9002732D0 (sv) * | 1990-08-24 | 1990-08-24 | Kabivitrum Ab | Product containing growth factor |
JPH06503711A (ja) * | 1990-08-28 | 1994-04-28 | カイロン コーポレイション | 新規インシュリン様成長因子結合タンパク質(igfbp―4) |
US5212074A (en) * | 1990-08-28 | 1993-05-18 | Chiron Corporation | Genetic material encoding new insulin-like growth factor binding protein igfbp-6 |
US20050209121A1 (en) * | 1990-12-05 | 2005-09-22 | Novozymes A/S | Proteins with changed epitopes and methods for the production thereof |
US6967080B1 (en) * | 1990-12-05 | 2005-11-22 | Novozymes A/S | Proteins with changed epitopes and methods for the production thereof |
FI86777C (fi) * | 1990-12-31 | 1992-10-12 | Medix Biochemica Ab Oy | Foerfarande foer diagnosticering av bristningen av fosterhinnorna samt reagensfoerpackning foer anvaendning daervid |
DE69233155T2 (de) | 1991-01-08 | 2004-06-03 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Insulinartigen wachstumsfaktor bindendes protein |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
FI94181C (fi) | 1992-06-29 | 1995-07-25 | Medix Biochemica Ab Oy | Diagnostinen menetelmä synnytysajankohdan ennustamiseksi sekä siihen käytettävä reagenssipakkaus |
DE69333063T2 (de) | 1992-11-04 | 2004-05-13 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Vekürztes insulinähnlichen wachstumsfaktor-bindendes protein mit mitogener aktivität |
AU5608594A (en) * | 1992-11-16 | 1994-06-08 | Incyte Pharmaceuticals, Inc. | Method of causing selective immunosuppression using hl-60-related lectins |
US6406679B1 (en) | 1992-11-16 | 2002-06-18 | Incyte Pharmaceuticals, Inc. | Use of HL-60-related lectins in drug delivery and detection of lectin-expressing cells |
EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
US5585237A (en) * | 1993-10-25 | 1996-12-17 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from recombinant DNA |
JPH09509140A (ja) * | 1993-11-15 | 1997-09-16 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 神経学的障害の治療方法 |
WO1996000240A1 (fr) * | 1994-06-27 | 1996-01-04 | Snow Brand Milk Products Co., Ltd. | Nouvelle proteine et procede pour sa fabrication |
US5789547A (en) * | 1995-06-07 | 1998-08-04 | Celtrix Pharmaceuticals, Inc. | Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding |
AR048563A1 (es) * | 1996-09-16 | 2006-05-10 | Univ Dalhousie | Metodos para el tratamiento de la enfermedad renal poliquistica en un mamifero, la insuficiencia renal, el desarrollo glomerular y de los rinones y proteger de la toxicidad por hormonas esteroides y uso de la igf- i para la fabricacion de una composicion farmaceutica. |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US5914390A (en) * | 1997-05-12 | 1999-06-22 | Celtrix Pharmaceuticals, Inc. | Methods for increasing yields of recombinant proteins |
US6068993A (en) * | 1997-07-02 | 2000-05-30 | Biobras Sa | Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
US6417330B1 (en) * | 1998-06-01 | 2002-07-09 | Celtrix Pharmaceuticals, Inc. | Insulin-like growth factor binding protein variants |
PT1141014E (pt) | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
DK1141015T3 (da) | 1999-01-06 | 2010-01-25 | Genentech Inc | Insulin-lignende vækstfaktor (IGF) I-mutantvarianter |
EP1282437B1 (de) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Behandlung von knorpelerkrankungen |
US20030035788A1 (en) * | 2000-09-19 | 2003-02-20 | Desmond Mascarenhas | Method for use of IGF-binding protein for selective sensitization of target cells in vivo |
AU2002248609B2 (en) | 2001-03-14 | 2007-03-01 | Genentech, Inc. | IGF antagonist peptides |
AU2002363322A1 (en) * | 2001-10-26 | 2003-05-19 | Large Scale Biology Corporation | Endothelial cell derived hemotopoietic growth factor |
CA2538342C (en) | 2003-09-12 | 2013-01-08 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency |
EP1670822A2 (de) | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf-bindende proteine |
JP2006258673A (ja) * | 2005-03-18 | 2006-09-28 | Fisheries Research Agency | 魚類のigf−i濃度の測定方法及びその方法に用いる測定キット |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
US8999916B2 (en) | 2010-03-31 | 2015-04-07 | Agency For Science, Technology And Research | Crosslinked peptide hydrogels |
US9067084B2 (en) * | 2010-03-31 | 2015-06-30 | Agency For Science, Technology And Research | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
US9687591B2 (en) | 2010-03-31 | 2017-06-27 | Agency For Science, Technology And Research | Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes |
US9120841B2 (en) | 2012-09-28 | 2015-09-01 | Agency For Science, Technology And Research | Amphiphilic linear peptidepeptoid and hydrogel comprising the same |
CN110248672A (zh) * | 2017-02-06 | 2019-09-17 | 中央研究院 | 重组蛋白及其用途 |
JP2020533344A (ja) | 2017-09-11 | 2020-11-19 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 慢性肺疾患を治療するための方法および組成物 |
CA3194764A1 (en) | 2020-10-19 | 2022-04-28 | Oak Hill Bio Limited | Compositions suitable for use in neonates |
WO2023139115A1 (en) | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions and methods for reducing oxidation of igf‐1/igfbp |
WO2023242439A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Vascular stabilisation (preterm infants) |
WO2023242442A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Method of maturing/differentiating neurons and/or modulating the vagus nerve |
WO2023242440A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Treament of lungs in infants |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
US4853330A (en) * | 1983-04-07 | 1989-08-01 | Genentech, Inc. | Human tissue plasminogen activator |
US5010002A (en) * | 1983-01-19 | 1991-04-23 | Genentech, Inc. | Human t-PA production using vectors coding DHFR protein |
US5028531A (en) * | 1984-03-19 | 1991-07-02 | Fujisawa Pharmaceutical Company, Ltd. | IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof |
US4879231A (en) * | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4886747A (en) * | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
US5089396A (en) * | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
US4868113A (en) * | 1986-03-03 | 1989-09-19 | Rorer Biotechnology, Inc. | Recombinant DNA vector encoding human endothelial cell growth factor |
GB8610600D0 (en) * | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
US5200509A (en) * | 1987-04-06 | 1993-04-06 | Celtrix Pharmaceuticals, Inc. | Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides |
DE3881801T2 (de) * | 1987-04-06 | 1993-12-23 | Celtrix Pharma | Menschliche somatomedin-träger-protein-untereinheiten und verfahren zu ihrer herstellung. |
EP0321196A3 (de) * | 1987-12-18 | 1990-07-18 | Mycogen Plant Science, Inc. | Transkriptionsaktivator des 780 T-DNA-Gens |
DK131988A (da) * | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
JPH03504597A (ja) * | 1988-04-12 | 1991-10-09 | シナージェン,インコーポレーテッド | インスリン様成長因子活性の強化および阻害方法 |
GB8826451D0 (en) * | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
US5098833A (en) * | 1989-02-23 | 1992-03-24 | Genentech, Inc. | DNA sequence encoding a functional domain of a lymphocyte homing receptor |
-
1988
- 1988-03-22 US US07/171,623 patent/US5258287A/en not_active Expired - Lifetime
-
1989
- 1989-03-10 DE DE68916537T patent/DE68916537T3/de not_active Expired - Lifetime
- 1989-03-10 AT AT89903593T patent/ATE107958T1/de not_active IP Right Cessation
- 1989-03-10 WO PCT/US1989/000983 patent/WO1989009268A1/en active IP Right Grant
- 1989-03-10 EP EP89903593A patent/EP0406272B2/de not_active Expired - Lifetime
- 1989-03-10 JP JP50336989A patent/JP3577311B2/ja not_active Expired - Lifetime
- 1989-03-15 NZ NZ228350A patent/NZ228350A/en unknown
- 1989-03-22 CA CA000594536A patent/CA1340703C/en not_active Expired - Lifetime
-
1993
- 1993-01-13 US US08/003,710 patent/US5328891A/en not_active Expired - Lifetime
-
1998
- 1998-06-25 HK HK98106562A patent/HK1007335A1/xx not_active IP Right Cessation
-
2004
- 2004-02-25 JP JP2004049408A patent/JP3985015B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH03505397A (ja) | 1991-11-28 |
EP0406272B1 (de) | 1994-06-29 |
EP0406272B2 (de) | 2002-07-24 |
AU3217889A (en) | 1989-10-16 |
DE68916537T2 (de) | 1995-01-19 |
HK1007335A1 (en) | 1999-04-09 |
JP3577311B2 (ja) | 2004-10-13 |
WO1989009268A1 (en) | 1989-10-05 |
JP2004256541A (ja) | 2004-09-16 |
ATE107958T1 (de) | 1994-07-15 |
DE68916537T3 (de) | 2003-11-27 |
US5328891A (en) | 1994-07-12 |
CA1340703C (en) | 1999-08-10 |
EP0406272A1 (de) | 1991-01-09 |
AU629820B2 (en) | 1992-10-15 |
US5258287A (en) | 1993-11-02 |
NZ228350A (en) | 1992-03-26 |
JP3985015B2 (ja) | 2007-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings |