ES2017122A6 - Procedimiento de preparacion de proteina de ligado de heparina. - Google Patents
Procedimiento de preparacion de proteina de ligado de heparina.Info
- Publication number
- ES2017122A6 ES2017122A6 ES8901356A ES8901356A ES2017122A6 ES 2017122 A6 ES2017122 A6 ES 2017122A6 ES 8901356 A ES8901356 A ES 8901356A ES 8901356 A ES8901356 A ES 8901356A ES 2017122 A6 ES2017122 A6 ES 2017122A6
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- processes
- producing
- well
- binding proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE PROTEINA DE LIGADO DE HEPARINA, QUE TIENE, EN ESTADO GLICOSILADO, UN PESO MOLECULAR APARENTE DE APROXIMADAMENTE 28 KDA, DETERMINADO POR ELECTROFORESIS EN GEL DE POLIACRILAMIDA DE SOLUCION DE DODECILSULFONATO SODICO (SDS-PAGE), BASADO EN LA EXTRACCION DE TROMBOCITOS Y LA PURIFICACION DEL EXTRACTO DE CROMATOGRAFIA SOBRE HEPARINA-SEFAROSA Y CROMATOGRAFIA LIQUIDA DE ALTO RENDIMIENTO (HPLC) DE FASE INVERSA. TAL METODO CROMATOGRAFICO COMPRENDE ELUCION EN GRADIENTE CON NACL DED 0,5 M HASTA 3 M DE UNA COLUMNA A TRAVES DE LA CUAL SE HA VERTIDO PRIMERAMENTE UN EXTRACTO DE LAS PLAQUETAS SANGUINEAS. LA PROTEINA OBTENIDA PRESENTA PROPIEDADES ANGIOGENAS IN VIVO Y SE APLICA A LA PREPARACION DE FARMACOS PARA EL TRATAMIENTO TOPICO DE LESIONES EXTERNAS EN MAMIFEROS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK145388A DK145388D0 (da) | 1988-03-17 | 1988-03-17 | Heparin-bindende protein |
DK73789A DK73789D0 (da) | 1989-02-17 | 1989-02-17 | Heparin-bindende protein |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2017122A6 true ES2017122A6 (es) | 1991-01-01 |
Family
ID=26064553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8901356A Expired - Lifetime ES2017122A6 (es) | 1988-03-17 | 1989-03-17 | Procedimiento de preparacion de proteina de ligado de heparina. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0409858B1 (es) |
JP (1) | JP2846385B2 (es) |
AU (1) | AU617795B2 (es) |
DE (1) | DE68911297T2 (es) |
ES (1) | ES2017122A6 (es) |
FI (1) | FI101626B (es) |
HU (1) | HU219883B (es) |
IE (1) | IE61947B1 (es) |
IL (1) | IL89661A (es) |
NO (1) | NO179588C (es) |
NZ (2) | NZ228370A (es) |
WO (1) | WO1989008666A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
DE69033668T2 (de) | 1989-01-31 | 2001-04-12 | Jeffrey S Rubin | Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor |
US7026291B1 (en) | 1989-01-31 | 2006-04-11 | The United States Of America As Represented By The Department Of Health And Human Services | Epithelial cell specific growth factor, keratinocyte growth factor (KGF) |
US5198423A (en) * | 1989-05-26 | 1993-03-30 | Takara Shuzo Co., Ltd. | Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin |
US5607916A (en) * | 1989-07-05 | 1997-03-04 | The Board Of Regents Of The University Of Oklahoma | Method and composition for the treatment of septic shock |
DE69132530D1 (de) * | 1990-10-16 | 2001-03-15 | Childrens Medical Center | Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf) |
DK261490D0 (da) | 1990-10-31 | 1990-10-31 | Novo Nordisk As | New pharmaceutical compound |
AU2658092A (en) * | 1991-09-12 | 1993-04-05 | Novo Nordisk A/S | A method of screening for inhibitors of heparin-binding protein |
NZ332683A (en) * | 1994-04-21 | 2001-06-29 | Novo Nordisk As | Use of heparin binding protein to prevent or treat sepsis |
US5939390A (en) * | 1995-03-09 | 1999-08-17 | Novo Nordisk A/S | Pharmaceutical composition |
EP0871721A1 (en) * | 1995-03-09 | 1998-10-21 | Novo Nordisk A/S | A protein-lipid conjugate, consisting of heparin binding protein (hbp) and a ceramide analogue, and its pharmaceutical use in treatment of conditions involving stress injury to cells |
AU6670198A (en) * | 1997-02-28 | 1998-09-18 | The Texas A & M University System | Heparan sulfate/heparin interacting protein compositions and methods of use |
CA2407714A1 (en) * | 1999-04-29 | 2000-11-09 | Leukotech A/S | Expression of heparin-binding protein in recombinant mammalian cells |
WO2003080660A2 (en) * | 2002-03-27 | 2003-10-02 | Leukotech A/S | Method for the preparation of recombinant mammalian heparin-binding protein (hbp) |
WO2006036002A1 (ja) * | 2004-09-28 | 2006-04-06 | Kurume University | 新規骨転移マーカーペプチドおよびそれを用いた骨転移の診断方法 |
CN112647358A (zh) * | 2020-12-07 | 2021-04-13 | 静宁县恒达有限责任公司 | 一种磷硼杂链预聚物嵌段聚氨酯水性防潮阻燃纸箱覆膜剂及其制备方法与应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989000198A1 (en) * | 1987-07-07 | 1989-01-12 | Biotechnology Research Associates, J.V. | Recombinant fibroblast growth factors |
JPS62270597A (ja) * | 1986-03-07 | 1987-11-24 | プレジデント・アンド・フエロウズ・オブ・ハ−バ−ド・カレジ | ヒト種類1ヘパリン結合性成長因子 |
US4883751A (en) * | 1986-05-28 | 1989-11-28 | New York University | Specific immunoassay for heparin |
EP0364481A4 (en) * | 1987-06-18 | 1992-01-22 | Monash University | Growth factors |
-
1989
- 1989-03-17 AU AU33462/89A patent/AU617795B2/en not_active Ceased
- 1989-03-17 JP JP1503563A patent/JP2846385B2/ja not_active Expired - Fee Related
- 1989-03-17 EP EP89904014A patent/EP0409858B1/en not_active Expired - Lifetime
- 1989-03-17 WO PCT/DK1989/000059 patent/WO1989008666A1/en active IP Right Grant
- 1989-03-17 NZ NZ228370A patent/NZ228370A/en unknown
- 1989-03-17 DE DE89904014T patent/DE68911297T2/de not_active Expired - Fee Related
- 1989-03-17 IL IL8966189A patent/IL89661A/en not_active IP Right Cessation
- 1989-03-17 ES ES8901356A patent/ES2017122A6/es not_active Expired - Lifetime
- 1989-03-17 HU HU118/89A patent/HU219883B/hu not_active IP Right Cessation
- 1989-03-17 IE IE86489A patent/IE61947B1/en not_active IP Right Cessation
-
1990
- 1990-09-14 FI FI904546A patent/FI101626B/fi not_active IP Right Cessation
- 1990-09-14 NO NO904024A patent/NO179588C/no not_active IP Right Cessation
-
1992
- 1992-05-26 NZ NZ243844A patent/NZ243844A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI101626B1 (fi) | 1998-07-31 |
IL89661A (en) | 1999-05-09 |
IE61947B1 (en) | 1994-11-30 |
NO904024D0 (no) | 1990-09-14 |
HU892118D0 (en) | 1991-05-28 |
NO179588C (no) | 1996-11-06 |
AU3346289A (en) | 1989-10-05 |
EP0409858A1 (en) | 1991-01-30 |
WO1989008666A1 (en) | 1989-09-21 |
IE890864L (en) | 1989-09-17 |
HU219883B (hu) | 2001-08-28 |
EP0409858B1 (en) | 1993-12-08 |
NO904024L (no) | 1990-11-13 |
NZ243844A (en) | 1994-01-26 |
FI904546A0 (fi) | 1990-09-14 |
DE68911297D1 (de) | 1994-01-20 |
DE68911297T2 (de) | 1994-03-31 |
JPH03504919A (ja) | 1991-10-31 |
NZ228370A (en) | 1994-01-26 |
JP2846385B2 (ja) | 1999-01-13 |
NO179588B (no) | 1996-07-29 |
HUT58107A (en) | 1992-01-28 |
AU617795B2 (en) | 1991-12-05 |
FI101626B (fi) | 1998-07-31 |
IL89661A0 (en) | 1989-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted |