IL122184A - Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure - Google Patents

Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure

Info

Publication number
IL122184A
IL122184A IL12218496A IL12218496A IL122184A IL 122184 A IL122184 A IL 122184A IL 12218496 A IL12218496 A IL 12218496A IL 12218496 A IL12218496 A IL 12218496A IL 122184 A IL122184 A IL 122184A
Authority
IL
Israel
Prior art keywords
imines
hydrogenation
elevated pressure
hydrogen iodide
iridium catalyst
Prior art date
Application number
IL12218496A
Other languages
English (en)
Other versions
IL122184A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL122184A0 publication Critical patent/IL122184A0/xx
Publication of IL122184A publication Critical patent/IL122184A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
IL12218496A 1995-06-08 1996-06-04 Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure IL122184A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168595 1995-06-08
PCT/EP1996/002419 WO1996041793A1 (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines

Publications (2)

Publication Number Publication Date
IL122184A0 IL122184A0 (en) 1998-04-05
IL122184A true IL122184A (en) 2000-02-29

Family

ID=4216210

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12218496A IL122184A (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure

Country Status (26)

Country Link
US (1) US5886225A (es)
EP (1) EP0830337B1 (es)
JP (1) JP4128623B2 (es)
KR (1) KR100470884B1 (es)
CN (1) CN1176900C (es)
AR (1) AR002359A1 (es)
AT (1) ATE187957T1 (es)
AU (1) AU710870B2 (es)
BR (1) BR9609159A (es)
CA (1) CA2220999C (es)
CZ (1) CZ287315B6 (es)
DE (1) DE69605794T2 (es)
DK (1) DK0830337T3 (es)
EA (1) EA000498B1 (es)
ES (1) ES2141512T3 (es)
GR (1) GR3032521T3 (es)
HR (1) HRP960253B1 (es)
HU (1) HU229337B1 (es)
IL (1) IL122184A (es)
PL (1) PL183317B1 (es)
PT (1) PT830337E (es)
SK (1) SK281568B6 (es)
TW (1) TW346482B (es)
UA (1) UA51652C2 (es)
WO (1) WO1996041793A1 (es)
ZA (1) ZA964832B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK281759B6 (sk) * 1994-02-02 2001-07-10 Novartis Ag Spôsob hydrogenácie imínov
US6228971B1 (en) * 1999-06-21 2001-05-08 Ppg Industries Ohio, Inc. Polymeric imine functional compositions and their use in film-forming compositions
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
WO2009105214A2 (en) 2008-02-22 2009-08-27 Radius Health, Inc. Selective androgen receptor modulators
JP5964756B2 (ja) 2010-02-04 2016-08-03 ラジウス ヘルス，インコーポレイテッド 選択的アンドロゲン受容体モジュレーター
LT2568806T (lt) 2010-05-12 2016-09-26 Radius Health, Inc. Terapiniai režimai
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
JP5965909B2 (ja) 2010-09-28 2016-08-10 ラジウス ヘルス，インコーポレイテッド 選択的アンドロゲン受容体モジュレーター
CN102153589B (zh) 2011-02-28 2013-01-02 大连多相触媒有限公司 一种亚胺的不对称加氢催化剂及其合成方法和应用
WO2014037962A1 (en) 2012-09-06 2014-03-13 Council Of Scientific And Industrial Research Process for the preparation of (s)-2-ethyl-n-(1-methoxypropan -2-yl)-6-methyl aniline
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
EP3834824A1 (en) 2014-03-28 2021-06-16 Duke University Method of treating cancer using selective estrogen receptor modulators
KR102397890B1 (ko) 2016-06-22 2022-05-12 일립시스 파마 리미티드 Ar+ 유방암 치료 방법
WO2018129419A1 (en) 2017-01-05 2018-07-12 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
CN110305025B (zh) * 2019-07-23 2022-05-06 衢州学院 一种由亚胺催化氢化合成苄胺类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3772487D1 (de) * 1986-08-04 1991-10-02 Ciba Geigy Ag Verfahren zur herstellung von optisch aktiven sekundaeren arylaminen.
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
EP0419409B1 (de) * 1989-09-18 1995-11-02 Ciba-Geigy Ag Iridiumkomplexe, Verfahren zu deren Herstellung und deren Verwendung
DE59309554D1 (de) * 1992-04-02 1999-06-10 Novartis Ag Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
DE69512765T2 (de) * 1994-02-02 2000-06-29 Novartis Ag Hydrierungskatalysator, verfahren zu seiner herstellung und hydrierungsverfahren

Also Published As

Publication number Publication date
AR002359A1 (es) 1998-03-11
JP4128623B2 (ja) 2008-07-30
WO1996041793A1 (en) 1996-12-27
BR9609159A (pt) 1999-05-04
HUP9802307A2 (hu) 1999-02-01
AU6221896A (en) 1997-01-09
HRP960253A2 (en) 1997-10-31
JPH11507917A (ja) 1999-07-13
EA199700424A1 (ru) 1999-02-25
HUP9802307A3 (en) 1999-03-29
EP0830337B1 (en) 1999-12-22
PL183317B1 (pl) 2002-06-28
AU710870B2 (en) 1999-09-30
PL323946A1 (en) 1998-04-27
CZ287315B6 (en) 2000-10-11
CA2220999A1 (en) 1996-12-27
EP0830337A1 (en) 1998-03-25
SK281568B6 (sk) 2001-05-10
CN1187183A (zh) 1998-07-08
UA51652C2 (uk) 2002-12-16
TW346482B (en) 1998-12-01
HU229337B1 (en) 2013-11-28
EA000498B1 (ru) 1999-08-26
CZ391997A3 (cs) 1998-03-18
SK168197A3 (en) 1998-05-06
DK0830337T3 (da) 2000-06-13
GR3032521T3 (en) 2000-05-31
DE69605794D1 (de) 2000-01-27
IL122184A0 (en) 1998-04-05
CN1176900C (zh) 2004-11-24
ES2141512T3 (es) 2000-03-16
KR100470884B1 (ko) 2005-06-22
CA2220999C (en) 2008-01-29
HRP960253B1 (en) 2000-10-31
ATE187957T1 (de) 2000-01-15
US5886225A (en) 1999-03-23
KR19990021908A (ko) 1999-03-25
DE69605794T2 (de) 2000-07-20
ZA964832B (en) 1996-12-09
PT830337E (pt) 2000-05-31

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Legal Events

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