IL122184A - Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure - Google Patents

Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure

Info

Publication number
IL122184A
IL122184A IL12218496A IL12218496A IL122184A IL 122184 A IL122184 A IL 122184A IL 12218496 A IL12218496 A IL 12218496A IL 12218496 A IL12218496 A IL 12218496A IL 122184 A IL122184 A IL 122184A
Authority
IL
Israel
Prior art keywords
imines
hydrogenation
elevated pressure
hydrogen iodide
iridium catalyst
Prior art date
Application number
IL12218496A
Other languages
English (en)
Other versions
IL122184A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL122184A0 publication Critical patent/IL122184A0/xx
Publication of IL122184A publication Critical patent/IL122184A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
IL12218496A 1995-06-08 1996-06-04 Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure IL122184A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168595 1995-06-08
PCT/EP1996/002419 WO1996041793A1 (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines

Publications (2)

Publication Number Publication Date
IL122184A0 IL122184A0 (en) 1998-04-05
IL122184A true IL122184A (en) 2000-02-29

Family

ID=4216210

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12218496A IL122184A (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines in the presence of hydrogen iodide using an iridium catalyst at elevated pressure

Country Status (26)

Country Link
US (1) US5886225A (xx)
EP (1) EP0830337B1 (xx)
JP (1) JP4128623B2 (xx)
KR (1) KR100470884B1 (xx)
CN (1) CN1176900C (xx)
AR (1) AR002359A1 (xx)
AT (1) ATE187957T1 (xx)
AU (1) AU710870B2 (xx)
BR (1) BR9609159A (xx)
CA (1) CA2220999C (xx)
CZ (1) CZ287315B6 (xx)
DE (1) DE69605794T2 (xx)
DK (1) DK0830337T3 (xx)
EA (1) EA000498B1 (xx)
ES (1) ES2141512T3 (xx)
GR (1) GR3032521T3 (xx)
HR (1) HRP960253B1 (xx)
HU (1) HU229337B1 (xx)
IL (1) IL122184A (xx)
PL (1) PL183317B1 (xx)
PT (1) PT830337E (xx)
SK (1) SK281568B6 (xx)
TW (1) TW346482B (xx)
UA (1) UA51652C2 (xx)
WO (1) WO1996041793A1 (xx)
ZA (1) ZA964832B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2150464C1 (ru) * 1994-02-02 2000-06-10 Новартис Аг Способ гидрогенизации иминов и способ получения амина
US6228971B1 (en) * 1999-06-21 2001-05-08 Ppg Industries Ohio, Inc. Polymeric imine functional compositions and their use in film-forming compositions
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
MX2010009162A (es) 2008-02-22 2010-12-21 Radius Health Inc Moduladores selectivos del receptor de androgeno.
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
CA2788907A1 (en) 2010-02-04 2011-08-11 Radius Health, Inc. Selective androgen receptor modulators
MX342898B (es) 2010-05-12 2016-10-18 Radius Health Inc * Regimen terapéutico de la sal de diclorhidrato del (r) -6-(2-(etil (4-2(etilamino) etil) bencil) amino)-4-metoxifenil)-5, 6,7,8-tetrahidronaftaleno-2-ol.
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
ES2550319T3 (es) 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
CN102153589B (zh) 2011-02-28 2013-01-02 大连多相触媒有限公司 一种亚胺的不对称加氢催化剂及其合成方法和应用
US9199930B2 (en) 2012-09-06 2015-12-01 Council Of Scientific And Industrial Research Process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline
SI3122426T1 (sl) 2014-03-28 2023-04-28 Duke University Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
LT3474841T (lt) 2016-06-22 2022-06-10 Ellipses Pharma Ltd Ar+ krūties vėžio gydymo būdai
LT3565542T (lt) 2017-01-05 2024-07-10 Radius Pharmaceuticals, Inc. Polimorfinės rad1901-2hcl formos
CN112423844B (zh) 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
CN110305025B (zh) * 2019-07-23 2022-05-06 衢州学院 一种由亚胺催化氢化合成苄胺类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0256982B1 (de) * 1986-08-04 1991-08-28 Ciba-Geigy Ag Verfahren zur Herstellung von optisch aktiven sekundären Arylaminen
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
US5112999A (en) * 1989-09-18 1992-05-12 Ciba-Geigy Corporation Iridium complexes, process for their preparation and their use
EP0564406B1 (de) * 1992-04-02 1999-05-06 Novartis AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
AU1575495A (en) * 1994-02-02 1995-08-21 Ciba-Geigy Ag Hydrogenation catalyst, process for the preparation thereof and hydrogenation process

Also Published As

Publication number Publication date
SK168197A3 (en) 1998-05-06
GR3032521T3 (en) 2000-05-31
AU6221896A (en) 1997-01-09
JPH11507917A (ja) 1999-07-13
PL183317B1 (pl) 2002-06-28
CA2220999C (en) 2008-01-29
WO1996041793A1 (en) 1996-12-27
HUP9802307A3 (en) 1999-03-29
IL122184A0 (en) 1998-04-05
EP0830337A1 (en) 1998-03-25
PT830337E (pt) 2000-05-31
EP0830337B1 (en) 1999-12-22
KR100470884B1 (ko) 2005-06-22
BR9609159A (pt) 1999-05-04
CN1187183A (zh) 1998-07-08
US5886225A (en) 1999-03-23
CZ287315B6 (en) 2000-10-11
CN1176900C (zh) 2004-11-24
KR19990021908A (ko) 1999-03-25
DK0830337T3 (da) 2000-06-13
AR002359A1 (es) 1998-03-11
ES2141512T3 (es) 2000-03-16
HU229337B1 (en) 2013-11-28
UA51652C2 (uk) 2002-12-16
CZ391997A3 (cs) 1998-03-18
TW346482B (en) 1998-12-01
JP4128623B2 (ja) 2008-07-30
AU710870B2 (en) 1999-09-30
EA199700424A1 (ru) 1999-02-25
EA000498B1 (ru) 1999-08-26
SK281568B6 (sk) 2001-05-10
HUP9802307A2 (hu) 1999-02-01
DE69605794T2 (de) 2000-07-20
ZA964832B (en) 1996-12-09
HRP960253B1 (en) 2000-10-31
PL323946A1 (en) 1998-04-27
DE69605794D1 (de) 2000-01-27
CA2220999A1 (en) 1996-12-27
HRP960253A2 (en) 1997-10-31
ATE187957T1 (de) 2000-01-15

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