IL118474A - Benzimideol derivatives and pharmaceutical preparations containing them - Google Patents
Benzimideol derivatives and pharmaceutical preparations containing themInfo
- Publication number
- IL118474A IL118474A IL11847496A IL11847496A IL118474A IL 118474 A IL118474 A IL 118474A IL 11847496 A IL11847496 A IL 11847496A IL 11847496 A IL11847496 A IL 11847496A IL 118474 A IL118474 A IL 118474A
- Authority
- IL
- Israel
- Prior art keywords
- group
- carbon atoms
- reaction
- compound according
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13509795 | 1995-06-01 | ||
JP4584596 | 1996-03-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL118474A0 IL118474A0 (en) | 1996-09-12 |
IL118474A true IL118474A (en) | 2001-08-08 |
Family
ID=26385935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11847496A IL118474A (en) | 1995-06-01 | 1996-05-30 | Benzimideol derivatives and pharmaceutical preparations containing them |
Country Status (21)
Country | Link |
---|---|
US (1) | US5886014A (xx) |
EP (1) | EP0745600B1 (xx) |
JP (2) | JP2976885B2 (xx) |
KR (2) | KR100485425B1 (xx) |
CN (1) | CN1066729C (xx) |
AT (1) | ATE207489T1 (xx) |
AU (1) | AU712390B2 (xx) |
CA (1) | CA2177858C (xx) |
CZ (1) | CZ293016B6 (xx) |
DE (1) | DE69616151T2 (xx) |
DK (1) | DK0745600T3 (xx) |
ES (1) | ES2164841T3 (xx) |
HK (2) | HK1002280A1 (xx) |
HU (1) | HU225778B1 (xx) |
IL (1) | IL118474A (xx) |
MX (1) | MX9602122A (xx) |
NO (1) | NO308744B1 (xx) |
NZ (1) | NZ286716A (xx) |
PT (1) | PT745600E (xx) |
RU (1) | RU2125048C1 (xx) |
TW (1) | TW449594B (xx) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
EP0783888A1 (en) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
IL120264A0 (en) * | 1996-02-29 | 1997-06-10 | Pfizer | Method of reducing tissue damage associated with non-cardiac ischemia |
IL120443A (en) * | 1996-03-18 | 2000-07-16 | Sankyo Co | Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis |
US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
AU710249B2 (en) * | 1996-05-31 | 1999-09-16 | Sankyo Company Limited | Autoimmune disease therapeutic agent |
CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
KR100579765B1 (ko) * | 1996-07-01 | 2006-12-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도 |
US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
USRE39266E1 (en) | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US6313113B1 (en) | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
DE69716592T2 (de) * | 1997-05-02 | 2003-06-26 | Dr. Reddy's Laboratories Ltd., Hyderabad | Neue heterozyklische verbindungen mit antidiabetischen, hypolipiddaemischen und blutdrucksenkenden eigenschaften, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten |
US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
BR9813848B1 (pt) * | 1997-10-08 | 2011-07-12 | composto heterocìclico fundido substituìdo, uso do mesmo, e, composição farmacêutica. | |
HUP9902721A2 (hu) | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
WO1999030739A1 (fr) * | 1997-12-16 | 1999-06-24 | Sankyo Company, Limited | Remede contre la leucemie |
EP1132087A4 (en) * | 1998-11-13 | 2002-06-26 | Fujisawa Pharmaceutical Co | MEDICINE AGAINST POLYCYSTIC OVARY SYNDROME |
US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
WO2000043006A1 (fr) * | 1999-01-19 | 2000-07-27 | Sankyo Company, Limited | Inhibiteur de la mort des cellules nerveuses imputable à la cytotoxicité de l'acide glutamique |
BR0009593A (pt) * | 1999-04-06 | 2002-06-18 | Sankyo Co | Agente melhorador de resistência à insulina, agente hipoglicêmico, agente imunorregulador, inibidor de aldose redutase, inibidor de 5-lipoxigenase, supressor de produção de lipìdios peroxidados, ativador de ppar, antagonista de leucotrienos, promotor de formação hidroxiadipocelular ou antagonista de cálcio, agente preventivo e/ou terapêutico, derivados de ácido carboxìlico, medicamento, composição farmacêutica, e, uso de um composto |
IL145759A0 (en) * | 1999-04-07 | 2002-07-25 | Sankyo Co | Amine derivatives and pharmaceutical compositions containing the same |
WO2000061582A1 (fr) * | 1999-04-08 | 2000-10-19 | Sankyo Company, Limited | Derives imidazole condenses substitues |
TWI284533B (en) | 1999-05-24 | 2007-08-01 | Sankyo Co | Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant |
JP2001072671A (ja) * | 1999-06-28 | 2001-03-21 | Sankyo Co Ltd | ベンズイミダゾール化合物の合成中間体およびその製造方法 |
EP1191019B1 (en) * | 1999-06-28 | 2006-08-16 | Sankyo Company, Limited | Intermediates for the synthesis of benzimidazole compounds and process for the preparation thereof |
CZ2002178A3 (cs) * | 1999-07-19 | 2002-05-15 | Sankyo Company Limited | Terapeutické a profylaktické látky pro nádorová onemocnění |
AU7559200A (en) * | 1999-10-12 | 2001-04-23 | Japan Tobacco Inc. | Hypertriglyceridemia remedies and antiobestics |
US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
CA2352937C (en) | 2000-07-13 | 2009-12-22 | Tomoyasu Yoshida | Process for producing n-acylnitroaniline derivative |
JP2002088048A (ja) * | 2000-07-13 | 2002-03-27 | Sumitomo Chem Co Ltd | N−t−ブトキシカルボニルニトロアニリン誘導体の製造法 |
US6452014B1 (en) * | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
ATE341343T1 (de) * | 2000-12-26 | 2006-10-15 | Sankyo Co | Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel |
GB0112363D0 (en) | 2001-05-21 | 2001-07-11 | Allied Therapeutics Ltd | Method and apparatus for treating biological fluids |
FR2829765A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique |
AU2002336657B2 (en) * | 2001-10-24 | 2008-01-03 | The Regents Of The University Of California | Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis |
JP2004002365A (ja) * | 2002-04-05 | 2004-01-08 | Sankyo Co Ltd | Acat阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物 |
AU2003236365A1 (en) * | 2002-04-05 | 2003-10-20 | Sankyo Company, Limited | Medicinal composition comprising acat inhibitor and insuline resistance improving agent |
US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
JP2004083574A (ja) * | 2002-06-25 | 2004-03-18 | Sankyo Co Ltd | 利尿剤及びペルオキシソーム増殖因子活性化受容体(PPAR)γ活性化剤を含有する医薬組成物 |
TW200403055A (en) * | 2002-06-25 | 2004-03-01 | Sankyo Co | Pharmaceutical composition of a peroxisome proliferator-activated receptor (PPAR) gamma atcivetor and a diuretic |
TW200408628A (en) * | 2002-08-02 | 2004-06-01 | Sankyo Co | Resorcinol and its derivatives |
US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
TW200502395A (en) * | 2002-10-18 | 2005-01-16 | Sankyo Co | Method for evaluating an agent for improving beta cell dysfunction |
US20040198800A1 (en) * | 2002-12-19 | 2004-10-07 | Geoffrey Allan | Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents |
US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
PL1679074T3 (pl) * | 2003-10-24 | 2011-05-31 | Santen Pharmaceutical Co Ltd | Środek terapeutyczny do leczenia chorób zapalnych rogówki i spojówki |
CA2543555A1 (en) | 2003-10-29 | 2005-05-06 | Santen Pharmaceutical Co., Ltd. | Therapeutic agent for keratoconjunctival disorder |
BRPI0509305A (pt) * | 2004-03-29 | 2007-09-04 | Sankyo Co | uso de um sensibilizador insulìnico, composição farmecêutica, e , kit |
RU2246945C1 (ru) * | 2004-05-11 | 2005-02-27 | Аверин Константин Михайлович | Суппозитории притововоспалительного, антисептического и регенерационного действия |
TW200608967A (en) * | 2004-07-29 | 2006-03-16 | Sankyo Co | Pharmaceutical compositions containing with diabetic agent |
WO2006022450A1 (ja) * | 2004-08-26 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | 皮膚疾患治療剤 |
BRPI0516192A (pt) | 2004-09-28 | 2008-08-26 | Sankyo Co | composto, e, método para a preparação de um composto |
JP4789180B2 (ja) * | 2004-09-28 | 2011-10-12 | 第一三共株式会社 | 6−置換−1−メチル−1−h−ベンズイミダゾール誘導体の製造方法及びその製造中間体 |
US20060106014A1 (en) * | 2004-10-14 | 2006-05-18 | Sekhar Boddupalli | Methods for treating diabetes |
TW200633702A (en) * | 2004-12-15 | 2006-10-01 | Sankyo Co | Medicinal composition containing fbpase inhibitor |
JP2006225382A (ja) * | 2005-01-24 | 2006-08-31 | Sankyo Co Ltd | チアゾリジンジオン化合物の製造方法及びその製造中間体 |
TW200637856A (en) * | 2005-01-24 | 2006-11-01 | Sankyo Co | Process for producing thiazolidinedion compound and intermediate thereof |
TW200722088A (en) * | 2005-05-27 | 2007-06-16 | Sankyo Co | Diabetes remedy |
TWI418350B (zh) * | 2005-06-24 | 2013-12-11 | Sankyo Co | 含有ppar調節劑之醫藥組成物的用途 |
TW200740802A (en) * | 2005-07-08 | 2007-11-01 | Sankyo Co | Pharmaceutical composition containing thiazolidinedione compound |
CA2615118A1 (en) * | 2005-07-12 | 2007-01-18 | Daiichi Sankyo Company, Limited | Pharmaceutical composition containing ppar.gamma. agonist |
TW200738266A (en) * | 2005-09-29 | 2007-10-16 | Sankyo Co | Pharmaceutical agent containing insulin resistance improving agent |
TW200730173A (en) * | 2005-12-16 | 2007-08-16 | Sankyo Co | Pharmaceutical composition enhancing production of adiponectin |
JP2008044932A (ja) * | 2006-07-21 | 2008-02-28 | Daiichi Sankyo Co Ltd | チアゾリジンジオン化合物を含有する組成物 |
AU2007293885A1 (en) | 2006-09-07 | 2008-03-13 | Takeda Gmbh | Combination treatment for diabetes mellitus |
KR100811100B1 (ko) * | 2006-09-27 | 2008-03-06 | 한국생명공학연구원 | 벤즈아졸 유도체를 유효성분으로 함유하는 대사성 질환예방 및 치료용 약학적 조성물 |
CN101679298B (zh) * | 2007-04-05 | 2013-10-23 | 第一三共株式会社 | 稠合二环杂芳基衍生物 |
AU2008259342B2 (en) | 2007-06-04 | 2014-07-10 | Ben-Gurion University Of The Negev Research And Development Authority | Tri-aryl compounds and compositions comprising the same |
JP2009227668A (ja) | 2008-02-25 | 2009-10-08 | Santen Pharmaceut Co Ltd | 角膜上皮バリア機能亢進剤 |
TW201124411A (en) | 2009-11-26 | 2011-07-16 | Daiichi Sankyo Co Ltd | The manufacturing method of 6-substituted-1-methy-1H-benzimidazol derivatives and the synthesis intermediates thereof |
WO2013101911A2 (en) | 2011-12-28 | 2013-07-04 | Allergan, Inc. | Benzimidazole derivatives as selective blockers of persistent sodium current |
CA2928725A1 (en) | 2013-11-05 | 2015-05-14 | Esther Priel | Compounds for the treatment of diabetes and disease complications arising from same |
CN104083364B (zh) * | 2014-07-18 | 2015-12-09 | 泰山医学院附属医院 | 一种治疗阴沟肠杆菌引起的小儿呼吸道感染的药物组合物 |
CN104086541B (zh) * | 2014-07-18 | 2016-01-20 | 高中设 | 一种治疗小儿呼吸道感染的药物组合物 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPS60226873A (ja) * | 1984-03-28 | 1985-11-12 | Sankyo Co Ltd | 1,3−ベンゾオキサチオ−ル誘導体及びその製法 |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
DK173350B1 (da) * | 1985-02-26 | 2000-08-07 | Sankyo Co | Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
US4873255A (en) * | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
JP2826379B2 (ja) * | 1990-01-22 | 1998-11-18 | 三共株式会社 | チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤 |
US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
EP0839812A1 (en) * | 1990-04-27 | 1998-05-06 | Sankyo Company Limited | Preparation of benzylthiazolidine derivatives |
GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
EP0544696B1 (en) * | 1990-08-23 | 1995-01-11 | Pfizer Inc. | Hypoglycemic hydroxyurea derivatives |
GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
GB9023585D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
US5614544A (en) * | 1993-09-14 | 1997-03-25 | Takeda Chemical Industries, Ltd. | Oxazolidinedione derivatives and their use |
IL113084A (en) * | 1994-03-23 | 1999-01-26 | Sankyo Co | Derivatives of thiazolidine and oxazolidine, processes for their preparation and pharmaceutical preparations containing them |
NO305987B1 (no) * | 1994-04-11 | 1999-08-30 | Sankyo Co | Heterosykliske forbindelser med antidiabetisk aktivitet, deres anvendelse og farmasoeytisk preparat inneholdende disse |
US5420146A (en) * | 1994-05-10 | 1995-05-30 | American Home Products Corporation | Di-oxadiazolidine derivatives as antihyperglycemic agents |
JPH08143556A (ja) * | 1994-11-15 | 1996-06-04 | Terumo Corp | ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物 |
JPH08143568A (ja) * | 1994-11-22 | 1996-06-04 | Terumo Corp | ピリドピリミジン誘導体及びそれを含有する医薬組成物 |
JPH08143566A (ja) * | 1994-11-25 | 1996-06-04 | Terumo Corp | キナゾリン誘導体及びそれを含有する医薬組成物 |
JP3929512B2 (ja) * | 1995-06-02 | 2007-06-13 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
JP3144624B2 (ja) * | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
-
1996
- 1996-05-30 IL IL11847496A patent/IL118474A/en not_active IP Right Cessation
- 1996-05-30 CZ CZ19961567A patent/CZ293016B6/cs not_active IP Right Cessation
- 1996-05-31 TW TW085106495A patent/TW449594B/zh not_active IP Right Cessation
- 1996-05-31 PT PT96303940T patent/PT745600E/pt unknown
- 1996-05-31 ES ES96303940T patent/ES2164841T3/es not_active Expired - Lifetime
- 1996-05-31 AT AT96303940T patent/ATE207489T1/de active
- 1996-05-31 CA CA2177858A patent/CA2177858C/en not_active Expired - Fee Related
- 1996-05-31 JP JP8137930A patent/JP2976885B2/ja not_active Expired - Fee Related
- 1996-05-31 NZ NZ286716A patent/NZ286716A/xx not_active IP Right Cessation
- 1996-05-31 NO NO962239A patent/NO308744B1/no not_active IP Right Cessation
- 1996-05-31 HU HU9601492A patent/HU225778B1/hu not_active IP Right Cessation
- 1996-05-31 EP EP96303940A patent/EP0745600B1/en not_active Expired - Lifetime
- 1996-05-31 DE DE69616151T patent/DE69616151T2/de not_active Expired - Lifetime
- 1996-05-31 DK DK96303940T patent/DK0745600T3/da active
- 1996-05-31 AU AU54627/96A patent/AU712390B2/en not_active Ceased
- 1996-05-31 RU RU96110410A patent/RU2125048C1/ru not_active IP Right Cessation
- 1996-05-31 US US08/657,041 patent/US5886014A/en not_active Expired - Lifetime
- 1996-06-01 KR KR1019960019481A patent/KR100485425B1/ko not_active IP Right Cessation
- 1996-06-01 CN CN96110937A patent/CN1066729C/zh not_active Expired - Fee Related
- 1996-06-03 MX MX9602122A patent/MX9602122A/es unknown
-
1998
- 1998-02-19 HK HK98101291A patent/HK1002280A1/xx not_active IP Right Cessation
- 1998-12-04 HK HK98112833A patent/HK1011683A1/xx not_active IP Right Cessation
-
1999
- 1999-05-28 JP JP15031299A patent/JP3249490B2/ja not_active Expired - Fee Related
-
2004
- 2004-06-05 KR KR1020040041157A patent/KR100493772B1/ko not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL118474A (en) | Benzimideol derivatives and pharmaceutical preparations containing them | |
US5756525A (en) | Compounds for treating eating disorders | |
US5002953A (en) | Novel compounds | |
US5260445A (en) | 2,4-thiazolidinediones | |
US5194443A (en) | Compounds | |
US5232925A (en) | Compounds | |
KR930011300B1 (ko) | 옥시인돌유도체 | |
US6706746B2 (en) | Thiazolidine-2,4-dione hydrochloride salt, pharmaceutical compositions thereof and treatment method therewith | |
EP0555251A1 (en) | Thiazolidine dione derivatives | |
US4918091A (en) | Novel thiazolidinediones | |
US7521465B2 (en) | Diphenyl ether derivatives | |
KR20080081099A (ko) | 치환된 티아졸리딘디온 유도체 | |
JPH11503762A (ja) | 2−アルキルピロリジン類 | |
US5925656A (en) | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | |
EP0555264A1 (en) | Novel compounds | |
EP0549366B1 (en) | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | |
FR2754258A1 (fr) | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant | |
KR960012206B1 (ko) | 티아졸리딘-2,4-디온 유도체 및 이의 염, 이의 제조방법 및 이의 용도 | |
US5063240A (en) | Novel compounds | |
EP0549365A1 (en) | Thiazolidine compounds, their preparation and their therapeutic uses | |
AU1559599A (en) | Process for the preparation of thiazolidinedione derivatives | |
EP1682539B1 (en) | Process for preparing thiazolidinediones | |
US20080319031A1 (en) | Novel Tyrosine Derivatives | |
EP0593348B1 (fr) | Dérivés de thiazolidin-2,4-dione, leur procédé de préparation et les compositions pharmaceutiques les contenant | |
JPS61286359A (ja) | N−〔〔5−(トリフルオロメチル)−6−メトキシ−1−ナフタレニル〕チオキソメチルまたはカルボニル〕−n−メチルグリシンアミド |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |