NO962239L - Benzimidazolderivater, deres fremstilling og terapeutiske anvendelse - Google Patents

Benzimidazolderivater, deres fremstilling og terapeutiske anvendelse

Info

Publication number
NO962239L
NO962239L NO962239A NO962239A NO962239L NO 962239 L NO962239 L NO 962239L NO 962239 A NO962239 A NO 962239A NO 962239 A NO962239 A NO 962239A NO 962239 L NO962239 L NO 962239L
Authority
NO
Norway
Prior art keywords
ylmethyl
preparation
dioxothiazolidin
therapeutic use
benzimidazole derivatives
Prior art date
Application number
NO962239A
Other languages
English (en)
Other versions
NO962239D0 (no
NO308744B1 (no
Inventor
Takashi Fujita
Kunio Wada
Minoru Oguchi
Hiroaki Yanagisawa
Koichi Fujimoto
Toshihiko Fujiwara
Hiroyoshi Horikoshi
Takao Yoshioka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26385935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO962239(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO962239D0 publication Critical patent/NO962239D0/no
Publication of NO962239L publication Critical patent/NO962239L/no
Publication of NO308744B1 publication Critical patent/NO308744B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO962239A 1995-06-01 1996-05-31 Benzimidazolderivater, deres anvendelse, og farmasøytisk preparat inneholdende disse NO308744B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13509795 1995-06-01
JP4584596 1996-03-04

Publications (3)

Publication Number Publication Date
NO962239D0 NO962239D0 (no) 1996-05-31
NO962239L true NO962239L (no) 1996-12-02
NO308744B1 NO308744B1 (no) 2000-10-23

Family

ID=26385935

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962239A NO308744B1 (no) 1995-06-01 1996-05-31 Benzimidazolderivater, deres anvendelse, og farmasøytisk preparat inneholdende disse

Country Status (21)

Country Link
US (1) US5886014A (no)
EP (1) EP0745600B1 (no)
JP (2) JP2976885B2 (no)
KR (2) KR100485425B1 (no)
CN (1) CN1066729C (no)
AT (1) ATE207489T1 (no)
AU (1) AU712390B2 (no)
CA (1) CA2177858C (no)
CZ (1) CZ293016B6 (no)
DE (1) DE69616151T2 (no)
DK (1) DK0745600T3 (no)
ES (1) ES2164841T3 (no)
HK (2) HK1002280A1 (no)
HU (1) HU225778B1 (no)
IL (1) IL118474A (no)
MX (1) MX9602122A (no)
NO (1) NO308744B1 (no)
NZ (1) NZ286716A (no)
PT (1) PT745600E (no)
RU (1) RU2125048C1 (no)
TW (1) TW449594B (no)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
US6127367A (en) * 1996-02-29 2000-10-03 Pfizer, Inc. Method of reducing tissue damage associated with non-cardiac ischemia
NZ314406A (en) * 1996-03-18 2000-12-22 Sankyo Co Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
AU710249B2 (en) * 1996-05-31 1999-09-16 Sankyo Company Limited Autoimmune disease therapeutic agent
CA2257284C (en) * 1996-05-31 2005-10-04 Sankyo Company Limited Remedy for autoimmune diseases
BR9711098B1 (pt) * 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
WO1997041121A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
PT1022272E (pt) * 1997-10-08 2004-08-31 Sankyo Co Compostos heterociclicos fundidos substituidos
HUP9902721A2 (hu) 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
AU1507799A (en) * 1997-12-16 1999-07-05 Sankyo Company Limited Leukemia remedy
EP1132087A4 (en) * 1998-11-13 2002-06-26 Fujisawa Pharmaceutical Co MEDICINE AGAINST POLYCYSTIC OVARY SYNDROME
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
AU3073600A (en) * 1999-01-19 2000-08-07 Sankyo Company Limited Inhibitor for nerve cell death due to glutamic acid cytotoxicity
CZ20013593A3 (cs) * 1999-04-06 2002-03-13 Sankyo Company, Limited Alfa-Substituované deriváty karboxylových kyselin
HUP0200996A3 (en) * 1999-04-07 2003-01-28 Sankyo Company Ltd Chuo Ku Amine derivatives, pharmaceutical compositions containing them and their use
WO2000061582A1 (fr) * 1999-04-08 2000-10-19 Sankyo Company, Limited Derives imidazole condenses substitues
TWI284533B (en) 1999-05-24 2007-08-01 Sankyo Co Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant
JP2001072671A (ja) * 1999-06-28 2001-03-21 Sankyo Co Ltd ベンズイミダゾール化合物の合成中間体およびその製造方法
IL146916A0 (en) 1999-06-28 2002-08-14 Sankyo Co Nitrobenzene and aminobenzene derivatives and a process utilizing the same
KR20020015383A (ko) * 1999-07-19 2002-02-27 가와무라 요시부미 암의 예방제 및 치료제
AU7559200A (en) * 1999-10-12 2001-04-23 Japan Tobacco Inc. Hypertriglyceridemia remedies and antiobestics
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
JP2002088048A (ja) * 2000-07-13 2002-03-27 Sumitomo Chem Co Ltd N−t−ブトキシカルボニルニトロアニリン誘導体の製造法
US6630598B2 (en) 2000-07-13 2003-10-07 Sumitomo Chemical Company, Limited Process for producing N-acylnitroaniline derivative
US6452014B1 (en) * 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
EP1695716A2 (en) * 2000-12-26 2006-08-30 Sankyo Company, Limited Medicinal compositions containing diuretics and insulin sensitizers
GB0112363D0 (en) 2001-05-21 2001-07-11 Allied Therapeutics Ltd Method and apparatus for treating biological fluids
FR2829765A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
JP2005538679A (ja) * 2001-10-24 2005-12-22 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ アテローム性動脈硬化症に寄与する主要遺伝子としての5−リポキシゲナーゼの同定
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
JP2004002365A (ja) * 2002-04-05 2004-01-08 Sankyo Co Ltd Acat阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物
WO2003084572A1 (fr) * 2002-04-05 2003-10-16 Sankyo Company, Limited Composition médicale comprenant un inhibiteur de l'acat et agent améliorant la résistance à l'insuline
JP2004083574A (ja) * 2002-06-25 2004-03-18 Sankyo Co Ltd 利尿剤及びペルオキシソーム増殖因子活性化受容体(PPAR)γ活性化剤を含有する医薬組成物
WO2004000356A1 (ja) * 2002-06-25 2003-12-31 Sankyo Company, Limited 利尿剤及びペルオキシソーム増殖因子活性化受容体(PPAR)γ活性化剤を含有する医薬組成物
WO2004013109A1 (ja) * 2002-08-02 2004-02-12 Sankyo Company, Limited レゾルシノール誘導体
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
AU2003273041A1 (en) * 2002-10-18 2004-05-04 Sankyo Company, Limited METHOD OF EVALUATING Beta-CELL HYPOFUNCTION IMPROVING AGENT
US20040198800A1 (en) * 2002-12-19 2004-10-07 Geoffrey Allan Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents
US6794401B2 (en) * 2003-01-17 2004-09-21 Bexel Pharmaceuticals, Inc. Amino acid phenoxy ethers
US7358255B2 (en) * 2003-10-24 2008-04-15 Santen Pharmaceutical Co., Ltd. Therapeutic agent for keratoconjunctival disorder
WO2005039571A1 (ja) 2003-10-29 2005-05-06 Santen Pharmaceutical Co., Ltd. 角結膜障害治療剤
KR20070011329A (ko) * 2004-03-29 2007-01-24 상꾜 가부시키가이샤 인슐린 저항성 개선제를 함유하는 당뇨병 치료제
RU2246945C1 (ru) * 2004-05-11 2005-02-27 Аверин Константин Михайлович Суппозитории притововоспалительного, антисептического и регенерационного действия
TW200608967A (en) * 2004-07-29 2006-03-16 Sankyo Co Pharmaceutical compositions containing with diabetic agent
WO2006022450A1 (ja) * 2004-08-26 2006-03-02 Santen Pharmaceutical Co., Ltd. 皮膚疾患治療剤
JP4789180B2 (ja) * 2004-09-28 2011-10-12 第一三共株式会社 6−置換−1−メチル−1−h−ベンズイミダゾール誘導体の製造方法及びその製造中間体
CN101068770B (zh) 2004-09-28 2012-01-04 三共株式会社 制备6-取代的-1-甲基-1-h-苯并咪唑衍生物的方法及其合成中间体
WO2006044556A2 (en) * 2004-10-14 2006-04-27 Galileo Pharmaceuticals, Inc. Dual inhibitors of lipoxygenase for treating diabetes
EP1825854A1 (en) * 2004-12-15 2007-08-29 Daiichi Sankyo Company, Limited MEDICINAL COMPOSITION CONTAINING FBPase INHIBITOR
TW200637856A (en) * 2005-01-24 2006-11-01 Sankyo Co Process for producing thiazolidinedion compound and intermediate thereof
JP2006225382A (ja) * 2005-01-24 2006-08-31 Sankyo Co Ltd チアゾリジンジオン化合物の製造方法及びその製造中間体
WO2006126673A1 (ja) * 2005-05-27 2006-11-30 Daiichi Sankyo Company, Limited 組み合わせによる糖尿病治療薬
TWI418350B (zh) * 2005-06-24 2013-12-11 Sankyo Co 含有ppar調節劑之醫藥組成物的用途
EP1902713A4 (en) * 2005-07-08 2009-05-13 Daiichi Sankyo Co Ltd A PHIAZEUTIC COMPOSITION CONTAINING A THIAZOLIDINDEIDE COMPOUND
JPWO2007007757A1 (ja) * 2005-07-12 2009-01-29 第一三共株式会社 PPARγアゴニストを含有する医薬組成物
TW200738266A (en) * 2005-09-29 2007-10-16 Sankyo Co Pharmaceutical agent containing insulin resistance improving agent
TW200730173A (en) * 2005-12-16 2007-08-16 Sankyo Co Pharmaceutical composition enhancing production of adiponectin
JP2008044932A (ja) * 2006-07-21 2008-02-28 Daiichi Sankyo Co Ltd チアゾリジンジオン化合物を含有する組成物
EP2213289A1 (en) 2006-09-07 2010-08-04 Nycomed GmbH Combination treatment for diabetes mellitus
KR100811100B1 (ko) * 2006-09-27 2008-03-06 한국생명공학연구원 벤즈아졸 유도체를 유효성분으로 함유하는 대사성 질환예방 및 치료용 약학적 조성물
BRPI0809643A2 (pt) * 2007-04-05 2014-11-11 Daiichi Sankyo Co Ltd Derivados de heteroarila bicíclica fundida
SI2152663T1 (sl) 2007-06-04 2014-08-29 Ben Gurion University Of The Negev Research And Development Authority Tri-arilne spojine in sestavki, ki vsebujejo isto
CA2716418A1 (en) 2008-02-25 2009-09-03 Santen Pharmaceutical Co., Ltd. Agent for enhancing corneal epithelial barrier function
KR20120101017A (ko) 2009-11-26 2012-09-12 다이이찌 산쿄 가부시키가이샤 6-치환 1-메틸-1h-벤즈이미다졸 유도체의 제조법 및 그 제조 중간체
US8859780B2 (en) * 2011-12-28 2014-10-14 Allergan, Inc. Benzimidazole derivatives as selective blockers of persistent sodium current
MX2016005995A (es) 2013-11-05 2016-08-17 Ben-Gurion Univ Of The Negev Res And Dev Authority Compuestos para el tratamiento de diabetes y complicaciones de la enfermedad derivadas de la misma.
CN104083364B (zh) * 2014-07-18 2015-12-09 泰山医学院附属医院 一种治疗阴沟肠杆菌引起的小儿呼吸道感染的药物组合物
CN104086541B (zh) * 2014-07-18 2016-01-20 高中设 一种治疗小儿呼吸道感染的药物组合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
JPS60226873A (ja) * 1984-03-28 1985-11-12 Sankyo Co Ltd 1,3−ベンゾオキサチオ−ル誘導体及びその製法
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物,其制备方法和用途
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US4681940A (en) * 1985-11-19 1987-07-21 American Home Products Corporation 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles
US4873255A (en) * 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
SG59988A1 (en) * 1987-09-04 1999-02-22 Beecham Group Plc Substituted thiazolidinedione derivatives
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
JP2826379B2 (ja) * 1990-01-22 1998-11-18 三共株式会社 チアゾリジン誘導体を有効成分とする肥満性高血圧症治療剤
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
EP0454501B1 (en) * 1990-04-27 2001-09-05 Sankyo Company Limited Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
EP0544696B1 (en) * 1990-08-23 1995-01-11 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023585D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat
US5614544A (en) * 1993-09-14 1997-03-25 Takeda Chemical Industries, Ltd. Oxazolidinedione derivatives and their use
CA2145257A1 (en) * 1994-03-23 1995-09-24 Takashi Fujita Thiazolidine and oxazolidine derivatives, their preparation and their medical use
RU2151145C1 (ru) * 1994-04-11 2000-06-20 Санкио Компани Лимитед Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью
US5420146A (en) * 1994-05-10 1995-05-30 American Home Products Corporation Di-oxadiazolidine derivatives as antihyperglycemic agents
JPH08143556A (ja) * 1994-11-15 1996-06-04 Terumo Corp ジオキソチアゾリジン誘導体及びそれを含有する医薬組成物
JPH08143568A (ja) * 1994-11-22 1996-06-04 Terumo Corp ピリドピリミジン誘導体及びそれを含有する医薬組成物
JPH08143566A (ja) * 1994-11-25 1996-06-04 Terumo Corp キナゾリン誘導体及びそれを含有する医薬組成物
JP3144624B2 (ja) * 1995-06-02 2001-03-12 杏林製薬株式会社 N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
JP3929512B2 (ja) * 1995-06-02 2007-06-13 杏林製薬株式会社 N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法

Also Published As

Publication number Publication date
KR100493772B1 (ko) 2005-06-08
CA2177858C (en) 2010-07-06
KR100485425B1 (ko) 2005-10-27
ATE207489T1 (de) 2001-11-15
DK0745600T3 (da) 2001-11-12
ES2164841T3 (es) 2002-03-01
DE69616151D1 (de) 2001-11-29
TW449594B (en) 2001-08-11
HUP9601492A3 (en) 1998-10-28
NZ286716A (en) 1997-08-22
HU225778B1 (en) 2007-08-28
JP2000001487A (ja) 2000-01-07
HU9601492D0 (en) 1996-07-29
US5886014A (en) 1999-03-23
AU5462796A (en) 1996-12-12
IL118474A0 (en) 1996-09-12
KR970001349A (ko) 1997-01-24
CN1157288A (zh) 1997-08-20
MX9602122A (es) 1997-06-28
JPH09295970A (ja) 1997-11-18
CZ293016B6 (cs) 2004-01-14
EP0745600B1 (en) 2001-10-24
PT745600E (pt) 2002-02-28
NO962239D0 (no) 1996-05-31
EP0745600A1 (en) 1996-12-04
HK1011683A1 (en) 1999-07-16
IL118474A (en) 2001-08-08
HK1002280A1 (en) 1998-08-14
CZ156796A3 (en) 1996-12-11
AU712390B2 (en) 1999-11-04
HUP9601492A2 (hu) 1998-08-28
JP3249490B2 (ja) 2002-01-21
NO308744B1 (no) 2000-10-23
DE69616151T2 (de) 2002-07-11
JP2976885B2 (ja) 1999-11-10
CA2177858A1 (en) 1996-12-02
CN1066729C (zh) 2001-06-06
RU2125048C1 (ru) 1999-01-20

Similar Documents

Publication Publication Date Title
DK0745600T3 (da) Benzimidazolderivater, deres fremstilling og deres terapeutiske anvendelse
ES2094308T3 (es) Derivados de aminoalcohol aromatico con propiedades antidiabeticas y antiobesidad, su preparacion y utilizacion terapeutica.
DK0708098T3 (da) Oximderivater, deres fremstilling og deres terapeutiske anvendelse
NO970892L (no) Isoksazolderivater
NO20020968L (no) Glukopyranosyloksypyrazolderivater, medisinske sammensetninger inneholdende det samme og intermediater forfremstillingen derav
DK0508740T3 (da) Thiazolidindionderivater, deres fremstilling og anvendelse.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees