IL112081A - Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them - Google Patents

Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them

Info

Publication number
IL112081A
IL112081A IL11208194A IL11208194A IL112081A IL 112081 A IL112081 A IL 112081A IL 11208194 A IL11208194 A IL 11208194A IL 11208194 A IL11208194 A IL 11208194A IL 112081 A IL112081 A IL 112081A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
preparation
compositions containing
independently
tetrahydrofuran derivatives
Prior art date
Application number
IL11208194A
Other languages
English (en)
Other versions
IL112081A0 (en
Original Assignee
Schering Plough Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22622452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL112081(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Plough Corp filed Critical Schering Plough Corp
Publication of IL112081A0 publication Critical patent/IL112081A0/xx
Publication of IL112081A publication Critical patent/IL112081A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11208194A 1993-12-21 1994-12-20 Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them IL112081A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21

Publications (2)

Publication Number Publication Date
IL112081A0 IL112081A0 (en) 1995-03-15
IL112081A true IL112081A (en) 2001-08-26

Family

ID=22622452

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11208194A IL112081A (en) 1993-12-21 1994-12-20 Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them

Country Status (28)

Country Link
EP (1) EP0736030B1 (cs)
JP (1) JP2834889B2 (cs)
KR (1) KR0179990B1 (cs)
CN (1) CN1064685C (cs)
AT (1) ATE204875T1 (cs)
AU (1) AU681753B2 (cs)
BR (1) BR1100154B1 (cs)
CA (1) CA2179396C (cs)
CO (1) CO4520281A1 (cs)
CZ (1) CZ294823B6 (cs)
DE (2) DE122006000004I2 (cs)
DK (1) DK0736030T3 (cs)
ES (1) ES2159623T3 (cs)
FI (1) FI118470B (cs)
FR (1) FR06C0009I2 (cs)
HU (1) HU225062B1 (cs)
IL (1) IL112081A (cs)
LU (1) LU91216I2 (cs)
MY (1) MY130217A (cs)
NL (1) NL300219I2 (cs)
NO (2) NO316173B1 (cs)
NZ (1) NZ278713A (cs)
PL (1) PL181193B1 (cs)
PT (1) PT736030E (cs)
SK (1) SK283035B6 (cs)
TW (1) TW377349B (cs)
WO (1) WO1995017407A1 (cs)
ZA (1) ZA9410142B (cs)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
CZ59497A3 (en) * 1995-06-02 1997-08-13 Schering Corp Tetrahydrofuran derivative and pharmaceutical composition containing thereof
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
WO1997022579A1 (en) * 1995-12-20 1997-06-26 Schering Corporation Process for preparation of hydrazides
ES2169440T3 (es) * 1996-05-24 2002-07-01 Schering Corp Composiciones antifungicas con biodisponibilidad mejorada.
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
ES2224256T3 (es) * 1996-06-28 2005-03-01 Schering Corporation Disolucion solida de un agente antifungico con biodisponibilidad mejorada.
JP2000514059A (ja) * 1996-06-28 2000-10-24 シェーリング コーポレイション トリアゾール抗真菌化合物を含む経口組成物
CN1102592C (zh) * 1996-11-12 2003-03-05 塞普拉科公司 2r,4s,s,s－和2s,4r,s,s－羟基伊曲康唑
AU5251398A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. (2r,4s,r,r-) and (2s,4r,r,r-)hydroxyitraconazole
CN1237174A (zh) * 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,s,r－和2s,4r,s,r－羟基伊曲康唑
CN1237172A (zh) * 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,r,s－和2s,4r,r,s－羟基伊曲康唑－和羟基沙波康唑衍生物
US5684197A (en) * 1996-12-12 1997-11-04 Schering Corporation Process for preparation of hydrazides
RU2197489C2 (ru) 1997-02-11 2003-01-27 Жансен Фармасетика Н.В. Сложные эфиры аминокислот, способы их получения, промежуточные продукты, фармацевтическая композиция и способ ее получения
PT1027349E (pt) * 1997-09-25 2005-05-31 Schering Corp Fosfato de tetra-hidrofurano e esteres hidroxilo, como pro-farmacos para os correspondentes agentes antifungicos
US6043245A (en) * 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
AU9592998A (en) * 1997-10-07 1999-04-27 Schering Corporation Crystalline antifungal glycine ester polymorph
PL189317B1 (pl) * 1997-10-07 2005-07-29 Schering Corp Krystaliczny przeciwgrzybiczy polimorf (-)-4-[4-[4-[4-[(2R-cis)-5-(2,4-difluorofenylo)tetrahydro-5-(1H-1,2,4-triazol-1-ilo-metylo)furan-3-ilo]metoksy]fenylo]-1-piperazynylo]fenylo-2,4-dihydro-2-[(S)-1-etylo-2(S)-hydroksypropylo]-3H-1,2,4-triazol-3-onu
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
ES2194723T3 (es) * 1999-05-04 2003-12-01 Janssen Pharmaceutica Nv Eteres antifungicos.
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
WO2002080678A1 (en) * 2001-04-03 2002-10-17 Schering Corporation Antifungal composition with enhanced bioavailability
US7078526B2 (en) 2002-05-31 2006-07-18 Transform Pharmaceuticals, Inc. CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
AU2003243699B2 (en) 2002-06-21 2009-01-15 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
KR101289115B1 (ko) * 2004-08-13 2013-07-23 엠에스디 인터내셔널 홀딩즈 게엠베하 항생제인 트리아졸 및 코르티코스테로이드를 포함하는약제학적 제형
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
WO2011158248A2 (en) * 2010-05-12 2011-12-22 Glenmark Generics Limited Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole
EP2571847B1 (en) 2010-05-19 2016-09-21 Sandoz AG Process for the preparation of chiral hydrazides
EP2571869B1 (en) 2010-05-19 2015-09-23 Sandoz AG Purification of posaconazole and posaconazole intermediates
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
MX338514B (es) * 2010-05-19 2016-04-20 Sandoz Ag Preparacion de intermediarios de posaconazol.
AU2011276680B2 (en) 2010-06-29 2014-07-17 Merck Sharp & Dohme Llc Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin
CN108329303A (zh) * 2011-06-16 2018-07-27 桑多斯股份公司 制备手性化合物的方法
EP2789610A1 (en) 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
CA2919290A1 (en) 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
WO2016087878A1 (en) 2014-12-05 2016-06-09 Pulmocide Limited Antimycotic compound
HUE048843T2 (hu) * 2015-05-21 2020-08-28 Pulmocide Ltd Gombaölõ szer 4-(4-(4-(((3R,5R)-5-((1H -1,2,4-triazol-1-YL)metil)-5-(2,4-difluor-fenil)tetra-hidro-furán-3-YL)metoxi)-3 metilfenil)piperazin-1-il)-n -(2-hidroxi-ciklohexil)benzamid, vagy annak gyógyszerészetileg elfogadható sója
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
CA2999422A1 (en) * 2015-09-23 2017-03-30 Biocon Limited Crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
KR102434471B1 (ko) * 2016-03-04 2022-08-19 저장 아우선 파마슈티칼 씨오., 엘티디. 포사코나졸, 조성물, 중간체, 제조방법 및 그의 용도
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
EP3558304A2 (en) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
EP0318214B1 (en) * 1987-11-20 1994-12-14 Schering Corporation Tri- and tetra-substituted-oxetanes and -tetrahydrofurans and intermediates thereof
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals

Also Published As

Publication number Publication date
EP0736030A1 (en) 1996-10-09
ATE204875T1 (de) 2001-09-15
JP2834889B2 (ja) 1998-12-14
NO2006002I1 (no) 2006-02-20
FR06C0009I2 (cs) 2006-12-29
SK283035B6 (sk) 2003-02-04
FI962577A0 (fi) 1996-06-20
PL315169A1 (en) 1996-10-14
PL181193B1 (pl) 2001-06-29
DE122006000004I2 (de) 2007-03-29
AU681753B2 (en) 1997-09-04
KR0179990B1 (en) 1999-03-20
CN1142828A (zh) 1997-02-12
CZ180596A3 (en) 1997-01-15
BR1100154B1 (pt) 2013-11-26
FR06C0009I1 (cs) 2006-05-19
WO1995017407A1 (en) 1995-06-29
NZ278713A (en) 1997-12-19
DE69428125T2 (de) 2002-05-02
JPH09500658A (ja) 1997-01-21
NL300219I1 (nl) 2006-04-03
CZ294823B6 (cs) 2005-03-16
SK82696A3 (en) 1997-03-05
HK1008820A1 (en) 1999-05-21
DE69428125D1 (de) 2001-10-04
NO962616D0 (no) 1996-06-20
NL300219I2 (nl) 2006-05-01
PT736030E (pt) 2002-01-30
ZA9410142B (en) 1996-05-02
HU225062B1 (en) 2006-05-29
DK0736030T3 (da) 2001-10-29
MY130217A (en) 2007-06-29
HU9601709D0 (en) 1996-08-28
FI118470B (fi) 2007-11-30
TW377349B (en) 1999-12-21
CO4520281A1 (es) 1997-10-15
ES2159623T3 (es) 2001-10-16
LU91216I2 (en) 2006-03-27
CA2179396A1 (en) 1995-06-29
CA2179396C (en) 2001-04-17
IL112081A0 (en) 1995-03-15
CN1064685C (zh) 2001-04-18
DE122006000004I1 (de) 2006-04-27
EP0736030B1 (en) 2001-08-29
HUT75879A (en) 1997-05-28
NO2006002I2 (no) 2011-03-07
FI962577L (fi) 1996-06-20
AU1512795A (en) 1995-07-10
NO962616L (no) 1996-08-07
NO316173B1 (no) 2003-12-22

Similar Documents

Publication Publication Date Title
IL112081A (en) Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them
MX9701229A (es) Antifungicos de tetrahidrofurano.
IL133627A0 (en) Antithrombotic agents
MX9804046A (es) 6-0-metil eritromicina d y proceso para hacerla.
AU3583989A (en) New cephem compounds and processes for preparation thereof
AU560980B2 (en) New vitro alphatic compounds
AU6257396A (en) Tetrahydrofuran antifungals
AU8226891A (en) Benzopyran derivative, production thereof, and pharmaceutical composition containing the same
AU8889998A (en) Water soluble analogs and prodrugs of paclitaxel
WO1990012577A3 (en) Topical anti-angiogenic as hair growth inhibitors
CA2511753A1 (en) Phospholipid derivatives
CA2304624A1 (en) Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent
NZ290236A (en) Inhibition ofleucotriene biosynthesis and pharmaceutical compositions comprising aryl-urea derivatives

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXTF Application for patent extension filed
KB Patent renewed
EXTF Application for patent extension filed
EXTF Application for patent extension filed
KB Patent renewed
PEL Intention of commissioner to extend period of protection
EXTN Extension order renewed