IL105048A - Cyclic peptide antifungal agents and process for preparation thereof - Google Patents
Cyclic peptide antifungal agents and process for preparation thereofInfo
- Publication number
- IL105048A IL105048A IL10504893A IL10504893A IL105048A IL 105048 A IL105048 A IL 105048A IL 10504893 A IL10504893 A IL 10504893A IL 10504893 A IL10504893 A IL 10504893A IL 105048 A IL105048 A IL 105048A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- alkyl
- phenyl
- substituted
- hydrogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 39
- 230000008569 process Effects 0.000 title claims description 13
- 238000002360 preparation method Methods 0.000 title claims description 9
- 229940121375 antifungal agent Drugs 0.000 title description 29
- 108010069514 Cyclic Peptides Proteins 0.000 title description 12
- 102000001189 Cyclic Peptides Human genes 0.000 title description 12
- 239000003429 antifungal agent Substances 0.000 title description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 89
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 42
- 239000001257 hydrogen Substances 0.000 claims abstract description 41
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 30
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 23
- 125000002252 acyl group Chemical group 0.000 claims abstract description 22
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 18
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims abstract description 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 11
- 150000002431 hydrogen Chemical group 0.000 claims abstract description 11
- 150000003839 salts Chemical class 0.000 claims abstract description 6
- 231100000252 nontoxic Toxicity 0.000 claims abstract description 5
- 230000003000 nontoxic effect Effects 0.000 claims abstract description 5
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 claims abstract description 3
- -1 C7-C14 tricycloalkyl Chemical group 0.000 claims description 106
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 40
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 30
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 21
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims description 20
- 244000045947 parasite Species 0.000 claims description 14
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 12
- AQRLNPVMDITEJU-UHFFFAOYSA-N triethylsilane Chemical compound CC[SiH](CC)CC AQRLNPVMDITEJU-UHFFFAOYSA-N 0.000 claims description 12
- 230000002401 inhibitory effect Effects 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 10
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 150000001602 bicycloalkyls Chemical group 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 6
- 230000002538 fungal effect Effects 0.000 claims description 6
- 229910052736 halogen Inorganic materials 0.000 claims description 6
- 150000002367 halogens Chemical class 0.000 claims description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 6
- 230000003071 parasitic effect Effects 0.000 claims description 6
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims description 5
- 239000003638 chemical reducing agent Substances 0.000 claims description 5
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 claims description 4
- 241000233872 Pneumocystis carinii Species 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 4
- 125000001624 naphthyl group Chemical group 0.000 claims description 4
- 125000005493 quinolyl group Chemical group 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 3
- 208000001388 Opportunistic Infections Diseases 0.000 claims description 3
- 125000003282 alkyl amino group Chemical group 0.000 claims description 3
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- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 2
- 125000002346 iodo group Chemical group I* 0.000 claims description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical group [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims description 2
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
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- 239000000243 solution Substances 0.000 description 22
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- 241001465754 Metazoa Species 0.000 description 10
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- 125000004122 cyclic group Chemical group 0.000 description 8
- FAUOJMHVEYMQQG-HVYQDZECSA-N echinocandin B Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](C)O)=CC=C(O)C=C1 FAUOJMHVEYMQQG-HVYQDZECSA-N 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 7
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
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- 241000222122 Candida albicans Species 0.000 description 3
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- 239000012981 Hank's balanced salt solution Substances 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- 208000005384 Pneumocystis Pneumonia Diseases 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 3
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- 125000003118 aryl group Chemical group 0.000 description 3
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- WZRJTRPJURQBRM-UHFFFAOYSA-N 4-amino-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 WZRJTRPJURQBRM-UHFFFAOYSA-N 0.000 description 2
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- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/66—Gramicidins S, C; Tyrocidins A, B, C; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12231593A IL122315A (en) | 1992-03-19 | 1993-03-15 | Cyclic peptides and antifungal pharmaceutical compositions containing them |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85411792A | 1992-03-19 | 1992-03-19 | |
| US99239092A | 1992-12-16 | 1992-12-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL105048A0 IL105048A0 (en) | 1993-07-08 |
| IL105048A true IL105048A (en) | 2001-06-14 |
Family
ID=27127211
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12231593A IL122315A (en) | 1992-03-19 | 1993-03-15 | Cyclic peptides and antifungal pharmaceutical compositions containing them |
| IL10504893A IL105048A (en) | 1992-03-19 | 1993-03-15 | Cyclic peptide antifungal agents and process for preparation thereof |
| IL12231597A IL122315A0 (en) | 1992-03-19 | 1997-11-27 | Cyclic peptide antifungal agents |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12231593A IL122315A (en) | 1992-03-19 | 1993-03-15 | Cyclic peptides and antifungal pharmaceutical compositions containing them |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12231597A IL122315A0 (en) | 1992-03-19 | 1997-11-27 | Cyclic peptide antifungal agents |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0561639B1 (OSRAM) |
| JP (3) | JP3519754B2 (OSRAM) |
| KR (1) | KR100256036B1 (OSRAM) |
| CN (1) | CN1036715C (OSRAM) |
| AT (1) | ATE217635T1 (OSRAM) |
| AU (2) | AU3534193A (OSRAM) |
| BR (1) | BR9301232A (OSRAM) |
| CA (1) | CA2091663C (OSRAM) |
| CZ (1) | CZ288974B6 (OSRAM) |
| DE (2) | DE69331922T2 (OSRAM) |
| DK (1) | DK0561639T3 (OSRAM) |
| ES (1) | ES2174843T3 (OSRAM) |
| FI (1) | FI118768B (OSRAM) |
| HU (2) | HU225783B1 (OSRAM) |
| IL (3) | IL122315A (OSRAM) |
| LU (1) | LU91406I2 (OSRAM) |
| MX (1) | MX9301457A (OSRAM) |
| MY (1) | MY136593A (OSRAM) |
| NL (1) | NL300334I2 (OSRAM) |
| NO (1) | NO930948L (OSRAM) |
| NZ (3) | NZ247149A (OSRAM) |
| PT (1) | PT561639E (OSRAM) |
| RU (1) | RU2129562C1 (OSRAM) |
| TW (1) | TW264477B (OSRAM) |
| YU (1) | YU49108B (OSRAM) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430018A (en) * | 1991-10-17 | 1995-07-04 | Merck & Co., Inc. | Cyclohexapeptide with basic nitrogen containing alkylamide groups |
| US6743777B1 (en) | 1992-03-19 | 2004-06-01 | Eli Lilly And Company | Cyclic peptide antifungal agents and process for preparation thereof |
| NZ247149A (en) * | 1992-03-19 | 1996-10-28 | Lilly Co Eli | Cyclic peptide antifungal agents and compositions thereof |
| US5378804A (en) * | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| JPH09500103A (ja) * | 1993-05-04 | 1997-01-07 | メルク エンド カンパニー インコーポレーテッド | シクロヘキサペプチジルアミノアルキルエーテル |
| US5948753A (en) * | 1993-05-04 | 1999-09-07 | Merck & Co., Inc. | Cyclohexapeptidyl propanolamine compounds |
| WO1995008341A1 (en) * | 1993-09-22 | 1995-03-30 | Merck & Co., Inc. | Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use |
| US5514651A (en) * | 1994-09-16 | 1996-05-07 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| US5516757A (en) * | 1994-09-16 | 1996-05-14 | Merck & Co., Inc. | Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use |
| WO1996008266A1 (en) * | 1994-09-16 | 1996-03-21 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| RU2165423C2 (ru) * | 1994-10-07 | 2001-04-20 | Фудзисава Фармасьютикал Ко., Лтд. | Полипептидное соединение, способ его получения и фармацевтическая композиция |
| US5516756A (en) * | 1994-10-31 | 1996-05-14 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| DE69615535T2 (de) * | 1995-01-26 | 2002-05-02 | Merck & Co., Inc. | Neue fungizide cyclohexapeptide |
| US5646111A (en) * | 1995-04-07 | 1997-07-08 | Eli Lilly And Company | Cyclic peptide antifungal Agents |
| US5786325A (en) * | 1995-05-26 | 1998-07-28 | Eli Lilly And Company | Cyclic peptide antifungal agents and methods of making and using |
| US5629290A (en) * | 1995-05-26 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5618787A (en) * | 1995-05-26 | 1997-04-08 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5652213A (en) * | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5629289A (en) * | 1995-07-25 | 1997-05-13 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| CA2244238A1 (en) * | 1996-02-01 | 1997-08-07 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| US5693611A (en) * | 1996-02-01 | 1997-12-02 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| JPH09227422A (ja) * | 1996-02-12 | 1997-09-02 | Rolic Ag | シクロペンチル誘導体 |
| US5696084A (en) * | 1996-08-16 | 1997-12-09 | Abbott Laboratories | Amino-lipopetide antifungal agents |
| AUPO381496A0 (en) * | 1996-11-25 | 1996-12-19 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| UA72200C2 (uk) * | 1997-12-10 | 2005-02-15 | Авентіс Фарма С.А. | Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція |
| FR2784993B1 (fr) * | 1998-10-26 | 2002-10-31 | Hoechst Marion Roussel Inc | Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme fongicides |
| AU2003200556B2 (en) * | 1997-12-10 | 2005-12-01 | Novexel | Echinocandin derivative and their preparation method |
| AUPP172898A0 (en) * | 1998-02-09 | 1998-03-05 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| EP1064299A1 (en) * | 1998-03-16 | 2001-01-03 | Fujisawa Pharmaceutical Co., Ltd. | Cyclohexapeptide wf14573 or its salt, production thereof and use thereof |
| ATE287899T1 (de) | 1998-08-20 | 2005-02-15 | Lilly Co Eli | Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen |
| JP2003511345A (ja) | 1998-12-09 | 2003-03-25 | イーライ リリー アンド カンパニー | Ｅｃｈｉｎｏｃａｎｄｉｎシクロペプチド化合物の精製 |
| DE19907904A1 (de) | 1999-02-24 | 2000-08-31 | Clariant Gmbh | Verfahren zur Herstellung von [1,1':4',1"]-Terphenylverbindungen |
| RU2250763C2 (ru) | 1999-03-03 | 2005-04-27 | Эли Лилли Энд Компани | Фармацевтические препараты эхинокандина, содержащие мицелообразующие поверхностно-активные вещества |
| IL145186A0 (en) | 1999-03-03 | 2002-06-30 | Lilly Co Eli | Formation and anion-exchange of crystalline echinocandin ammonium salts |
| KR20020003864A (ko) | 1999-03-03 | 2002-01-15 | 피터 지. 스트링거 | 에키노칸딘/탄수화물 착물 |
| BR0008713A (pt) | 1999-03-03 | 2001-12-26 | Lilly Co Eli | Processos para preparar formulações ecomposições farmacêuticas orais com ecb |
| AU3231901A (en) | 2000-02-18 | 2001-08-27 | Meiji Seika Kaisha | Phenoxyalkylamine derivatives useful as opioid delta receptor agonists |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| US6991800B2 (en) | 2002-06-13 | 2006-01-31 | Vicuron Pharmaceuticals Inc. | Antifungal parenteral products |
| EA200501713A1 (ru) * | 2003-04-30 | 2006-06-30 | ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи | Фенилзамещённые карбоновые кислоты |
| KR101551207B1 (ko) * | 2008-09-04 | 2015-09-08 | 롬엔드하스전자재료코리아유한회사 | 신규한 유기 발광 화합물 및 이를 발광재료로서 채용하고 있는 유기 발광 소자 |
| CN102464704B (zh) * | 2010-11-05 | 2013-12-11 | 上海医药工业研究院 | 一种化合物及其制备方法和用途 |
| PL3677252T3 (pl) * | 2012-03-19 | 2024-01-08 | Cidara Therapeutics, Inc. | Schematy dawkowania dla związków z klasy echinokandyn |
| PL3058958T3 (pl) | 2015-02-23 | 2019-02-28 | Selectchemie Ag | Kompozycja anidulafunginy |
| JP6866583B2 (ja) * | 2016-07-05 | 2021-04-28 | Dic株式会社 | 液晶化合物 |
| CN116903706B (zh) * | 2023-06-13 | 2024-05-17 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE886576A (fr) * | 1979-12-13 | 1981-06-10 | Lilly Co Eli | Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques |
| BE886575A (fr) * | 1979-12-13 | 1981-06-10 | Lilly Co Eli | Derives de noyaux peptidiques cycliques, leur preparation et leur utilisation comme agents antifongiques |
| CA2037957A1 (en) * | 1990-03-12 | 1991-09-13 | Merck & Co., Inc. | N-acylated cyclohexapeptide compounds |
| GB2241956A (en) | 1990-03-16 | 1991-09-18 | Merck & Co Inc | N-acylated cyclohexapeptide compounds |
| IL97347A0 (en) * | 1990-03-19 | 1992-05-25 | Merck & Co Inc | Lipopeptide derivatives and antimicrobial compositions containing them |
| US5330973A (en) * | 1990-03-19 | 1994-07-19 | Merck & Co., Inc. | Lipopeptide derivatives |
| US5310726A (en) * | 1990-03-19 | 1994-05-10 | Merck & Co., Inc. | Lipopeptide compounds |
| NZ247149A (en) * | 1992-03-19 | 1996-10-28 | Lilly Co Eli | Cyclic peptide antifungal agents and compositions thereof |
-
1993
- 1993-03-15 NZ NZ247149A patent/NZ247149A/en not_active IP Right Cessation
- 1993-03-15 CZ CZ1993416A patent/CZ288974B6/cs not_active IP Right Cessation
- 1993-03-15 CA CA002091663A patent/CA2091663C/en not_active Expired - Lifetime
- 1993-03-15 NZ NZ512085A patent/NZ512085A/en not_active IP Right Cessation
- 1993-03-15 IL IL12231593A patent/IL122315A/en not_active IP Right Cessation
- 1993-03-15 IL IL10504893A patent/IL105048A/en active Protection Beyond IP Right Term
- 1993-03-15 NZ NZ299314A patent/NZ299314A/en not_active IP Right Cessation
- 1993-03-15 MY MYPI93000458A patent/MY136593A/en unknown
- 1993-03-15 TW TW082101890A patent/TW264477B/zh not_active IP Right Cessation
- 1993-03-16 NO NO93930948A patent/NO930948L/no not_active Application Discontinuation
- 1993-03-16 MX MX9301457A patent/MX9301457A/es unknown
- 1993-03-17 KR KR1019930004076A patent/KR100256036B1/ko not_active Expired - Lifetime
- 1993-03-18 BR BR9301232A patent/BR9301232A/pt not_active Application Discontinuation
- 1993-03-18 ES ES93302064T patent/ES2174843T3/es not_active Expired - Lifetime
- 1993-03-18 CN CN93103587A patent/CN1036715C/zh not_active Expired - Lifetime
- 1993-03-18 YU YU18593A patent/YU49108B/sh unknown
- 1993-03-18 RU RU93004787A patent/RU2129562C1/ru active
- 1993-03-18 HU HU9300785A patent/HU225783B1/hu unknown
- 1993-03-18 DE DE69331922T patent/DE69331922T2/de not_active Expired - Lifetime
- 1993-03-18 AT AT93302064T patent/ATE217635T1/de active
- 1993-03-18 DE DE200812000006 patent/DE122008000006I2/de active Active
- 1993-03-18 FI FI931202A patent/FI118768B/fi not_active IP Right Cessation
- 1993-03-18 JP JP05852993A patent/JP3519754B2/ja not_active Expired - Lifetime
- 1993-03-18 EP EP93302064A patent/EP0561639B1/en not_active Expired - Lifetime
- 1993-03-18 DK DK93302064T patent/DK0561639T3/da active
- 1993-03-18 PT PT93302064T patent/PT561639E/pt unknown
- 1993-03-19 AU AU35341/93A patent/AU3534193A/en not_active Abandoned
-
1995
- 1995-06-22 HU HU95P/P00378P patent/HU211562A9/hu active Protection Beyond IP Right Term
-
1996
- 1996-09-09 AU AU65529/96A patent/AU689391B2/en not_active Expired
-
1997
- 1997-11-27 IL IL12231597A patent/IL122315A0/xx unknown
-
2002
- 2002-01-10 JP JP2002003969A patent/JP3520071B2/ja not_active Expired - Lifetime
-
2003
- 2003-12-10 JP JP2003412638A patent/JP2004115540A/ja active Pending
-
2008
- 2008-01-09 LU LU91406C patent/LU91406I2/fr unknown
- 2008-01-21 NL NL300334C patent/NL300334I2/nl unknown
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