IE59366B1 - N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor - Google Patents

N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor

Info

Publication number
IE59366B1
IE59366B1 IE116587A IE116587A IE59366B1 IE 59366 B1 IE59366 B1 IE 59366B1 IE 116587 A IE116587 A IE 116587A IE 116587 A IE116587 A IE 116587A IE 59366 B1 IE59366 B1 IE 59366B1
Authority
IE
Ireland
Prior art keywords
compound
formula
alkyl
group
methyl
Prior art date
Application number
IE116587A
Other languages
English (en)
Other versions
IE871165L (en
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26290703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE59366(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB868610668A external-priority patent/GB8610668D0/en
Priority claimed from GB868630059A external-priority patent/GB8630059D0/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of IE871165L publication Critical patent/IE871165L/en
Publication of IE59366B1 publication Critical patent/IE59366B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polyamides (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fats And Perfumes (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Cephalosporin Compounds (AREA)
IE116587A 1986-05-01 1987-05-11 N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor IE59366B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868610668A GB8610668D0 (en) 1986-05-01 1986-05-01 Anti-arrhythmia agents
GB868630059A GB8630059D0 (en) 1986-12-17 1986-12-17 Antiarrhythmic agents

Publications (2)

Publication Number Publication Date
IE871165L IE871165L (en) 1987-11-01
IE59366B1 true IE59366B1 (en) 1994-02-09

Family

ID=26290703

Family Applications (1)

Application Number Title Priority Date Filing Date
IE116587A IE59366B1 (en) 1986-05-01 1987-05-11 N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor

Country Status (27)

Country Link
US (2) US4959366A (OSRAM)
EP (1) EP0245997B1 (OSRAM)
KR (2) KR870011084A (OSRAM)
CN (1) CN1019801B (OSRAM)
AT (1) ATE74906T1 (OSRAM)
AU (1) AU578557B2 (OSRAM)
BA (2) BA98301A (OSRAM)
CA (1) CA1289140C (OSRAM)
DE (2) DE3778201D1 (OSRAM)
DK (1) DK175096B1 (OSRAM)
EG (1) EG18188A (OSRAM)
ES (1) ES2033840T3 (OSRAM)
FI (1) FI88291C (OSRAM)
GR (1) GR3004457T3 (OSRAM)
HU (1) HU196743B (OSRAM)
IE (1) IE59366B1 (OSRAM)
IL (1) IL82373A (OSRAM)
LU (1) LU90519I2 (OSRAM)
LV (1) LV5715B4 (OSRAM)
MY (1) MY111142A (OSRAM)
NL (1) NL300002I2 (OSRAM)
NO (2) NO168527C (OSRAM)
NZ (1) NZ220151A (OSRAM)
PH (1) PH23425A (OSRAM)
PL (1) PL149924B1 (OSRAM)
PT (1) PT84782B (OSRAM)
YU (2) YU46195B (OSRAM)

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US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
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GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
US5166209A (en) * 1989-04-21 1992-11-24 Burroughs Wellcome Co. Pharmacologically active compounds
HUT58270A (en) * 1989-06-02 1992-02-28 Wyeth John & Brother Ltd Process for producing amine derivatives and pharmaceutical compositions containing them
US5084463A (en) * 1989-12-11 1992-01-28 American Home Products Corporation N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
IL106549A0 (en) * 1992-07-31 1993-12-08 Syntex Inc Heterocyclic derivatives,their preparation and pharmaceutical compositions containing them
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
DE4422517A1 (de) * 1994-06-28 1996-01-04 Dresden Arzneimittel Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2630095A (en) * 1994-08-04 1996-03-04 C & C Research Laboratories Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic
EP0697407B1 (en) 1994-08-19 1997-06-25 MITSUI TOATSU CHEMICALS, Inc. Pyrimidinedione derivatives and antiarrhythmic compositions containing same
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
FR2726267B1 (fr) * 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
CN1055679C (zh) * 1995-12-06 2000-08-23 中国药科大学 具有心血管活性的苯乙胺衍生物
CN1055682C (zh) * 1995-12-06 2000-08-23 中国药科大学 甲磺酰胺基苯乙胺衍生物的新制备方法
GB9722662D0 (en) * 1997-10-27 1997-12-24 Pfizer Ltd Polymorphs
HUP9702411A2 (hu) * 1997-12-11 2000-03-28 Gyógyszerkutató Intézet Kft. Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
JP2005506292A (ja) * 2001-03-08 2005-03-03 エモリー　ユニバーシティ ｐＨに依存するＮＭＤＡレセプターアンタゴニスト
CN100358865C (zh) * 2001-07-30 2008-01-02 中国科学院上海药物研究所 一类磺酰胺苯烷胺类化合物及其制备方法和用途
DE10201550A1 (de) * 2002-01-17 2003-07-31 Merck Patent Gmbh Phenoxy-Piperidine
WO2003091205A1 (fr) * 2002-04-26 2003-11-06 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Sulfamidophenylalkylamines, production et utilisation de ces dernieres
JP4782003B2 (ja) * 2003-06-17 2011-09-28 アリーナ ファーマシューティカルズ， インコーポレイテッド ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体
DK2332921T3 (en) * 2003-06-17 2016-05-09 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3benzazepine hydrochloride
DE102004025726B4 (de) * 2004-05-26 2006-07-06 Roder, Hanno, Dr. Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
JP2010513287A (ja) * 2006-12-14 2010-04-30 トータティス， インク． 癌治療のための組成物及び方法
EP2170334B1 (en) 2007-06-29 2021-03-17 Emory University Nmda receptor antagonists for neuroprotection
CN101372467B (zh) * 2007-08-23 2011-09-14 明德国际仓储贸易(上海)有限公司 具有n,n-二烷氨基的桥基化合物及所应用的染料化合物
WO2009111004A1 (en) 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
SG10201506865WA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
NZ630494A (en) 2010-09-01 2016-05-27 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
CN102531946A (zh) * 2012-01-05 2012-07-04 山东大学 3-甲氧基苯甲酰胺衍生物及其制备方法与应用
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management
FR3029113A1 (fr) 2014-12-02 2016-06-03 Univ Paris-Sud Composes pour le traitement des maladies mitochondriales
CZ307826B6 (cs) * 2017-12-01 2019-05-29 Farmak, A.S. Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu)
US10888524B2 (en) 2018-02-05 2021-01-12 Enaltec Pharma Research Pvt. Ltd. Immediate release tablet of dofetilide

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FR977261A (fr) * 1948-11-04 1951-03-29 équilibrage des masses dans les moteurs à combustion interne
FR148F (OSRAM) * 1962-01-24
US3478149A (en) * 1962-01-24 1969-11-11 Mead Johnson & Co Therapeutic compositions and methods employing sulfonamidophenethanolamines
US3852468A (en) * 1967-02-27 1974-12-03 Ici Ltd Alkanolamine derivatives as {62 -adrenergic blocking agents
US3574741A (en) * 1969-04-14 1971-04-13 Mead Johnson & Co Sulfonamidophenalkylamines
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
GB1263987A (en) * 1969-05-30 1972-02-16 Allen & Hanburys Ltd Phenethylamine derivatives
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
GB1301134A (en) * 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
IL57670A (en) * 1978-07-03 1982-11-30 Lilly Co Eli Phenethanolamines,their preparation and pharmaceutical formulations comprising them
ATE1899T1 (de) * 1979-06-16 1982-12-15 Beecham Group Plc Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
DD157796A5 (de) * 1979-12-04 1982-12-08 Ciba Geigy Ag Verfahren zur herstellung neuer derivate des 2-amino-aethanols
FR2541999B1 (fr) * 1983-03-04 1986-09-19 Bristol Myers Co Phenethanolamines et leurs utilisations
DE3566886D1 (en) * 1984-05-04 1989-01-26 Upjohn Co N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
US4569801A (en) * 1984-10-15 1986-02-11 Eli Lilly And Company Alkylsulfonamidophenylalkylamines

Also Published As

Publication number Publication date
NO2001011I1 (no) 2001-07-16
ATE74906T1 (de) 1992-05-15
FI88291C (fi) 1993-04-26
PT84782B (pt) 1989-12-29
FI88291B (fi) 1993-01-15
YU73588A (en) 1990-04-30
LV5715A4 (lv) 1995-10-20
YU46195B (sh) 1993-05-28
EP0245997A2 (en) 1987-11-19
NL300002I1 (nl) 2000-04-03
GR3004457T3 (OSRAM) 1993-03-31
YU46541B (sh) 1993-11-16
MY111142A (en) 1999-09-30
NO168527B (no) 1991-11-25
BA98211B1 (bs) 1999-08-02
LU90519I2 (fr) 2000-04-10
HUT43558A (en) 1987-11-30
YU78387A (en) 1988-08-31
US5079248A (en) 1992-01-07
PL265418A1 (en) 1988-07-21
DE10075004I2 (de) 2006-02-02
FI871898A7 (fi) 1987-11-02
NL300002I2 (nl) 2000-05-01
DE3778201D1 (de) 1992-05-21
HU196743B (en) 1989-01-30
KR920014397A (ko) 1992-07-30
KR870011084A (ko) 1987-12-19
IE871165L (en) 1987-11-01
NZ220151A (en) 1989-02-24
PT84782A (en) 1987-05-01
PH23425A (en) 1989-08-07
DE10075004I1 (de) 2000-04-13
EP0245997A3 (en) 1989-12-20
BA98301A (bs) 2001-09-14
DK220287A (da) 1987-11-02
US4959366A (en) 1990-09-25
FI871898A0 (fi) 1987-04-29
NO871820D0 (no) 1987-04-30
CN1019801B (zh) 1992-12-30
PL149924B1 (en) 1990-04-30
EP0245997B1 (en) 1992-04-15
KR930001339B1 (ko) 1993-02-26
DK175096B1 (da) 2004-06-01
LV5715B4 (lv) 1996-02-20
AU578557B2 (en) 1988-10-27
NO168527C (no) 1992-03-04
CN87103300A (zh) 1987-11-11
EG18188A (en) 1992-09-30
IL82373A0 (en) 1987-10-30
NO871820L (no) 1987-11-02
IL82373A (en) 1992-01-15
CA1289140C (en) 1991-09-17
DK220287D0 (da) 1987-04-30
AU7226087A (en) 1987-11-19
ES2033840T3 (es) 1993-04-01

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