ES2033840T3 - P-aminoetilsulfonanilidas n-sustituidas como agentes antiarritmicos; e intermedios para los mismos. - Google Patents
P-aminoetilsulfonanilidas n-sustituidas como agentes antiarritmicos; e intermedios para los mismos.Info
- Publication number
- ES2033840T3 ES2033840T3 ES198787303782T ES87303782T ES2033840T3 ES 2033840 T3 ES2033840 T3 ES 2033840T3 ES 198787303782 T ES198787303782 T ES 198787303782T ES 87303782 T ES87303782 T ES 87303782T ES 2033840 T3 ES2033840 T3 ES 2033840T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- group
- formula
- antiarrhythmic agents
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
- Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
- Lubricants (AREA)
- Cephalosporin Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
COMPUESTOS DE LA FORMULA (A) Y SUS SALES, EN LOS QUE LOS SUSTITUYENTES SON COMO SE HAN DEFINIDO EN LAS REIVINDICACIONES Y EN LA MEMORIA. LOS COMPUESTOS DE LA FORMULA (A) EN LOS QUE RA ES -NHSO2R1 Y RB ES R3, SON AGENTES ANTIARRITMICOS. LOS RESTANTES COMPUESTOS DE LA FORMULA (A) SON COMPUESTOS INTERMEDIOS DE SINTESIS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868610668A GB8610668D0 (en) | 1986-05-01 | 1986-05-01 | Anti-arrhythmia agents |
GB868630059A GB8630059D0 (en) | 1986-12-17 | 1986-12-17 | Antiarrhythmic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2033840T3 true ES2033840T3 (es) | 1993-04-01 |
Family
ID=26290703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787303782T Expired - Lifetime ES2033840T3 (es) | 1986-05-01 | 1987-04-29 | P-aminoetilsulfonanilidas n-sustituidas como agentes antiarritmicos; e intermedios para los mismos. |
Country Status (27)
Country | Link |
---|---|
US (2) | US4959366A (es) |
EP (1) | EP0245997B1 (es) |
KR (2) | KR870011084A (es) |
CN (1) | CN1019801B (es) |
AT (1) | ATE74906T1 (es) |
AU (1) | AU578557B2 (es) |
BA (2) | BA98211B1 (es) |
CA (1) | CA1289140C (es) |
DE (2) | DE3778201D1 (es) |
DK (1) | DK175096B1 (es) |
EG (1) | EG18188A (es) |
ES (1) | ES2033840T3 (es) |
FI (1) | FI88291C (es) |
GR (1) | GR3004457T3 (es) |
HU (1) | HU196743B (es) |
IE (1) | IE59366B1 (es) |
IL (1) | IL82373A (es) |
LU (1) | LU90519I2 (es) |
LV (1) | LV5715B4 (es) |
MY (1) | MY111142A (es) |
NL (1) | NL300002I2 (es) |
NO (2) | NO168527C (es) |
NZ (1) | NZ220151A (es) |
PH (1) | PH23425A (es) |
PL (1) | PL149924B1 (es) |
PT (1) | PT84782B (es) |
YU (2) | YU46195B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602174A (en) * | 1986-02-15 | 1997-02-11 | Beecham Wuefling Gmbh & Co. | Treatment |
NL8700842A (es) * | 1987-04-10 | 1988-11-01 | Duphar Int Res | |
SE8705150D0 (sv) * | 1987-12-23 | 1987-12-23 | Haessle Ab | Novel antiarrhythmic agents |
US4906634A (en) * | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
GB8809314D0 (en) * | 1988-04-20 | 1988-05-25 | Wellcome Found | Anti-hypertensive sulfonanilides |
GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
US5166209A (en) * | 1989-04-21 | 1992-11-24 | Burroughs Wellcome Co. | Pharmacologically active compounds |
AU641394B2 (en) * | 1989-06-02 | 1993-09-23 | John Wyeth & Brother Limited | Amines |
US5084463A (en) * | 1989-12-11 | 1992-01-28 | American Home Products Corporation | N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity |
AU4787593A (en) * | 1992-07-31 | 1994-03-03 | Syntex (U.S.A.) Inc. | Heterocyclic derivatives useful in the treatment of cardiovascular diseases |
US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
GB9404485D0 (en) * | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP3904599B2 (ja) * | 1994-08-04 | 2007-04-11 | シー・アンド・シー・リサーチ・ラブズ | 新規なアミン誘導体、その製造方法及び抗不整脈剤としての用途 |
DE69500377T2 (de) | 1994-08-19 | 1997-10-09 | Mitsui Toatsu Chemicals | Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen |
US5679706A (en) * | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
CN1055682C (zh) * | 1995-12-06 | 2000-08-23 | 中国药科大学 | 甲磺酰胺基苯乙胺衍生物的新制备方法 |
CN1055679C (zh) * | 1995-12-06 | 2000-08-23 | 中国药科大学 | 具有心血管活性的苯乙胺衍生物 |
GB9722662D0 (en) * | 1997-10-27 | 1997-12-24 | Pfizer Ltd | Polymorphs |
HUP9702411A2 (hu) * | 1997-12-11 | 2000-03-28 | Gyógyszerkutató Intézet Kft. | Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények |
EP1436258A4 (en) * | 2001-03-08 | 2005-03-23 | Univ Emory | ANTAGONISTS OF THE NMDA RECEPTOR DEPENDENT OF PH |
CN100358865C (zh) * | 2001-07-30 | 2008-01-02 | 中国科学院上海药物研究所 | 一类磺酰胺苯烷胺类化合物及其制备方法和用途 |
DE10201550A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
AU2002357560A1 (en) * | 2002-04-26 | 2003-11-10 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Sulfamidophenylalkylamines and their production and use |
DK2332921T3 (en) * | 2003-06-17 | 2016-05-09 | Arena Pharm Inc | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3benzazepine hydrochloride |
CN1805938B (zh) * | 2003-06-17 | 2010-06-16 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
ATE544455T1 (de) * | 2006-12-14 | 2012-02-15 | Tautatis Inc | Zusammensetzungen und verfahren für die krebsbehandlung |
NZ582917A (en) | 2007-06-29 | 2013-01-25 | Univ Emory | Nmda receptor antagonists for neuroprotection |
CN101372467B (zh) * | 2007-08-23 | 2011-09-14 | 明德国际仓储贸易(上海)有限公司 | 具有n,n-二烷氨基的桥基化合物及所应用的染料化合物 |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
WO2011153206A1 (en) | 2010-06-02 | 2011-12-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
US8999970B2 (en) | 2010-09-01 | 2015-04-07 | Arena Pharmaceuticals, Inc. | Administration of an anti-obesity compound to individuals with renal impairment |
SG188361A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
CA2808909A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
CN102531946A (zh) * | 2012-01-05 | 2012-07-04 | 山东大学 | 3-甲氧基苯甲酰胺衍生物及其制备方法与应用 |
UY34436A (es) | 2012-10-09 | 2014-07-31 | Arena Pharm Inc | Metodo de control del peso |
FR3029113A1 (fr) | 2014-12-02 | 2016-06-03 | Univ Paris-Sud | Composes pour le traitement des maladies mitochondriales |
CZ2017772A3 (cs) * | 2017-12-01 | 2019-05-29 | Farmak, A.S. | Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu) |
US10888524B2 (en) | 2018-02-05 | 2021-01-12 | Enaltec Pharma Research Pvt. Ltd. | Immediate release tablet of dofetilide |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR977261A (fr) * | 1948-11-04 | 1951-03-29 | équilibrage des masses dans les moteurs à combustion interne | |
GB993584A (es) * | 1962-01-24 | |||
US3478149A (en) * | 1962-01-24 | 1969-11-11 | Mead Johnson & Co | Therapeutic compositions and methods employing sulfonamidophenethanolamines |
US3852468A (en) * | 1967-02-27 | 1974-12-03 | Ici Ltd | Alkanolamine derivatives as {62 -adrenergic blocking agents |
US3758692A (en) * | 1969-04-14 | 1973-09-11 | Mead Johnson & Co | Ylamines sympathomimetic process and compositions employing sulfonamidophenalk |
US3574741A (en) * | 1969-04-14 | 1971-04-13 | Mead Johnson & Co | Sulfonamidophenalkylamines |
GB1263987A (en) * | 1969-05-30 | 1972-02-16 | Allen & Hanburys Ltd | Phenethylamine derivatives |
BE757005A (fr) * | 1969-10-02 | 1971-04-02 | Bristol Myers Co | Phenethanolamines substituees et procede pour leur preparation |
GB1301134A (en) * | 1970-07-18 | 1972-12-29 | Pfizer Ltd | SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES |
EP0006735B1 (en) * | 1978-06-28 | 1983-06-15 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
DK268579A (da) * | 1978-07-03 | 1980-01-04 | Lilly Co Eli | Fremgangsmaade til fremstilling af phenetamolaminer |
ATE1899T1 (de) * | 1979-06-16 | 1982-12-15 | Beecham Group Plc | Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen. |
DD202692A5 (de) * | 1979-12-04 | 1983-09-28 | Ciba Geigy | Verfahren zur herstellung neuer derivate des 2-amino-aethanols |
FR2541999B1 (fr) * | 1983-03-04 | 1986-09-19 | Bristol Myers Co | Phenethanolamines et leurs utilisations |
DE3566886D1 (en) * | 1984-05-04 | 1989-01-26 | Upjohn Co | N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use |
US4569801A (en) * | 1984-10-15 | 1986-02-11 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamines |
-
1987
- 1987-04-19 EG EG230/87A patent/EG18188A/xx active
- 1987-04-24 PH PH35179A patent/PH23425A/en unknown
- 1987-04-27 MY MYPI87000548A patent/MY111142A/en unknown
- 1987-04-29 DE DE8787303782T patent/DE3778201D1/de not_active Expired - Lifetime
- 1987-04-29 DE DE2000175004 patent/DE10075004I2/de active Active
- 1987-04-29 IL IL82373A patent/IL82373A/xx not_active IP Right Cessation
- 1987-04-29 CA CA000535897A patent/CA1289140C/en not_active Expired - Lifetime
- 1987-04-29 FI FI871898A patent/FI88291C/fi not_active IP Right Cessation
- 1987-04-29 ES ES198787303782T patent/ES2033840T3/es not_active Expired - Lifetime
- 1987-04-29 PT PT84782A patent/PT84782B/pt unknown
- 1987-04-29 EP EP87303782A patent/EP0245997B1/en not_active Expired - Lifetime
- 1987-04-29 US US07/044,086 patent/US4959366A/en not_active Expired - Lifetime
- 1987-04-29 PL PL1987265418A patent/PL149924B1/pl unknown
- 1987-04-29 AT AT87303782T patent/ATE74906T1/de active
- 1987-04-30 NZ NZ220151A patent/NZ220151A/xx unknown
- 1987-04-30 KR KR870004213A patent/KR870011084A/ko not_active Application Discontinuation
- 1987-04-30 NO NO871820A patent/NO168527C/no not_active IP Right Cessation
- 1987-04-30 DK DK198702202A patent/DK175096B1/da active Protection Beyond IP Right Term
- 1987-04-30 AU AU72260/87A patent/AU578557B2/en not_active Expired
- 1987-04-30 HU HU871971A patent/HU196743B/hu unknown
- 1987-04-30 YU YU78387A patent/YU46195B/sh unknown
- 1987-05-01 CN CN87103300A patent/CN1019801B/zh not_active Expired
- 1987-05-11 IE IE116587A patent/IE59366B1/en not_active IP Right Cessation
-
1988
- 1988-04-12 YU YU73588A patent/YU46541B/sh unknown
-
1990
- 1990-06-20 US US07/541,232 patent/US5079248A/en not_active Expired - Lifetime
- 1990-12-07 KR KR1019900020068A patent/KR930001339B1/ko not_active IP Right Cessation
-
1992
- 1992-04-29 GR GR920400823T patent/GR3004457T3/el unknown
-
1995
- 1995-03-15 LV LV950058A patent/LV5715B4/xx unknown
-
1998
- 1998-03-30 BA BA980211A patent/BA98211B1/bs active
- 1998-03-30 BA BA980301A patent/BA98301A/bs unknown
-
2000
- 2000-02-01 NL NL300002C patent/NL300002I2/nl unknown
- 2000-02-09 LU LU90519C patent/LU90519I2/fr unknown
-
2001
- 2001-06-26 NO NO2001011C patent/NO2001011I1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 245997 Country of ref document: ES |
|
SPCF | Request for supplementary protection certificate filed |
Free format text: DOFETILIDA (TIKOSYN) Spc suppl protection certif: C200000007 Filing date: 20000310 |
|
SPCG | Supplementary protection certificate granted |
Free format text: DOFETILIDA (TIKOSYN) Spc suppl protection certif: C200000007 Filing date: 20000310 Expiry date: 20120429 Effective date: 20030703 |