YU46541B - Postupak za dobijanje antiaritmičkih agenasa - Google Patents
Postupak za dobijanje antiaritmičkih agenasaInfo
- Publication number
- YU46541B YU46541B YU73588A YU73588A YU46541B YU 46541 B YU46541 B YU 46541B YU 73588 A YU73588 A YU 73588A YU 73588 A YU73588 A YU 73588A YU 46541 B YU46541 B YU 46541B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- group
- formula
- compounds
- antiarrhythmic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
- Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
- Saccharide Compounds (AREA)
- Pyrrole Compounds (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Plant Substances (AREA)
- Cephalosporin Compounds (AREA)
- Polyamides (AREA)
- Lubricants (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
POSTUPAK ZA DOBIJANJE ANTIARITMIČKIH AGENASA, formule (I): ili njihove farmaceutski primenljive adicione soli, gde su R i R1 svaki nezavisno C1-C4 akil, X je O, S ili direktna veza, Y je etilenska grupa proizvoljno supstituisana metil grupom, "alk" je etilenska, trimerilenska ili tetrametilenska grupa, "alk" je proizvoljno supstituisana metil grupa R2 je H, halogen, CF3 ili C1-C4 alkil grupa, i R3 je grupa formule -NHSO2 (C1-C4 alkil) ili -CONR4R5 gde su R4 i R5 svaki nezavisno H, ili C1-C4 alkil ili zajedno a atomom azota za koji su pričvršćeni, predstavljaju 1-pirolidinil, piperidino, morfolino ili N-metilpiperazin-1-il grupa, naznačen time, što reaguje jedinjenje formule: sa jedinjenjem formule gde R1, R2, R3, X, Y i alk su kao što je definisano formulom (I), i R6 je odlazeća grupa i R7 je grupa formule -NHR, gde je R definisano formulom (I), ili je R6 grupa formule -NHR, gde je R definisano formulom (I) i R7 je odlazeća grupa, u organskom rastvaraču kao što je etanol na temperaturi refluksa, i što se po potrebi dobijeni proizvod formule (I) prevodi u farmaceutski prihvatljivu so. Prijava sadrži još tri zavisna patentna zahteva.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BA980301A BA98301A (bs) | 1986-05-01 | 1998-03-30 | Postupak za dobijanje antiaritmickih agenasa |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868610668A GB8610668D0 (en) | 1986-05-01 | 1986-05-01 | Anti-arrhythmia agents |
GB868630059A GB8630059D0 (en) | 1986-12-17 | 1986-12-17 | Antiarrhythmic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
YU73588A YU73588A (en) | 1990-04-30 |
YU46541B true YU46541B (sh) | 1993-11-16 |
Family
ID=26290703
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU78387A YU46195B (sh) | 1986-05-01 | 1987-04-30 | Postupak za dobijanje antiaritmičkih agenasa |
YU73588A YU46541B (sh) | 1986-05-01 | 1988-04-12 | Postupak za dobijanje antiaritmičkih agenasa |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU78387A YU46195B (sh) | 1986-05-01 | 1987-04-30 | Postupak za dobijanje antiaritmičkih agenasa |
Country Status (27)
Country | Link |
---|---|
US (2) | US4959366A (sh) |
EP (1) | EP0245997B1 (sh) |
KR (2) | KR870011084A (sh) |
CN (1) | CN1019801B (sh) |
AT (1) | ATE74906T1 (sh) |
AU (1) | AU578557B2 (sh) |
BA (2) | BA98301A (sh) |
CA (1) | CA1289140C (sh) |
DE (2) | DE3778201D1 (sh) |
DK (1) | DK175096B1 (sh) |
EG (1) | EG18188A (sh) |
ES (1) | ES2033840T3 (sh) |
FI (1) | FI88291C (sh) |
GR (1) | GR3004457T3 (sh) |
HU (1) | HU196743B (sh) |
IE (1) | IE59366B1 (sh) |
IL (1) | IL82373A (sh) |
LU (1) | LU90519I2 (sh) |
LV (1) | LV5715B4 (sh) |
MY (1) | MY111142A (sh) |
NL (1) | NL300002I2 (sh) |
NO (2) | NO168527C (sh) |
NZ (1) | NZ220151A (sh) |
PH (1) | PH23425A (sh) |
PL (1) | PL149924B1 (sh) |
PT (1) | PT84782B (sh) |
YU (2) | YU46195B (sh) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602174A (en) * | 1986-02-15 | 1997-02-11 | Beecham Wuefling Gmbh & Co. | Treatment |
NL8700842A (sh) * | 1987-04-10 | 1988-11-01 | Duphar Int Res | |
SE8705150D0 (sv) * | 1987-12-23 | 1987-12-23 | Haessle Ab | Novel antiarrhythmic agents |
US4906634A (en) * | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
GB8809314D0 (en) * | 1988-04-20 | 1988-05-25 | Wellcome Found | Anti-hypertensive sulfonanilides |
GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
US5086073A (en) * | 1989-06-02 | 1992-02-04 | John Wyeth & Brother Limited | Composition for treating depression with aralkyl amines |
US5166209A (en) * | 1989-04-21 | 1992-11-24 | Burroughs Wellcome Co. | Pharmacologically active compounds |
US5084463A (en) * | 1989-12-11 | 1992-01-28 | American Home Products Corporation | N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity |
WO1994003425A2 (en) * | 1992-07-31 | 1994-02-17 | Syntex (U.S.A.) Inc. | Carbostyril derivatives for the treatment of arrhythmia |
US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
GB9404485D0 (en) * | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
CA2196672A1 (en) * | 1994-08-04 | 1996-02-15 | You Sup Chung | Amine derivatives, processes for producing same, and use thereof as antiarrhythmic drugs |
DE69500377T2 (de) | 1994-08-19 | 1997-10-09 | Mitsui Toatsu Chemicals | Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen |
US5679706A (en) * | 1994-09-30 | 1997-10-21 | Bristol-Myers Squibb Company | Combination of a potassium channel activator and an antiarrhythmic agent |
FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
CN1055682C (zh) * | 1995-12-06 | 2000-08-23 | 中国药科大学 | 甲磺酰胺基苯乙胺衍生物的新制备方法 |
CN1055679C (zh) * | 1995-12-06 | 2000-08-23 | 中国药科大学 | 具有心血管活性的苯乙胺衍生物 |
GB9722662D0 (en) * | 1997-10-27 | 1997-12-24 | Pfizer Ltd | Polymorphs |
HUP9702411A2 (hu) * | 1997-12-11 | 2000-03-28 | Gyógyszerkutató Intézet Kft. | Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények |
WO2002072542A2 (en) * | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
CN100358865C (zh) * | 2001-07-30 | 2008-01-02 | 中国科学院上海药物研究所 | 一类磺酰胺苯烷胺类化合物及其制备方法和用途 |
DE10201550A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
AU2002357560A1 (en) * | 2002-04-26 | 2003-11-10 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Sulfamidophenylalkylamines and their production and use |
CN101274911B (zh) * | 2003-06-17 | 2011-01-26 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物 |
SI2332921T1 (sl) * | 2003-06-17 | 2016-06-30 | Arena Pharmaceuticals, Inc. | 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid |
DE102004025726B4 (de) * | 2004-05-26 | 2006-07-06 | Roder, Hanno, Dr. | Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit |
JP2010513287A (ja) * | 2006-12-14 | 2010-04-30 | トータティス, インク. | 癌治療のための組成物及び方法 |
KR20100045983A (ko) * | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 nmda 수용체 길항물질 |
CN101372467B (zh) * | 2007-08-23 | 2011-09-14 | 明德国际仓储贸易(上海)有限公司 | 具有n,n-二烷氨基的桥基化合物及所应用的染料化合物 |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ht2c 수용체 아고니스트의 제조 방법 |
NZ630494A (en) | 2010-09-01 | 2016-05-27 | Arena Pharm Inc | Administration of lorcaserin to individuals with renal impairment |
SG10201506870PA (en) | 2010-09-01 | 2015-10-29 | Arena Pharm Inc | Salts of lorcaserin with optically active acids |
SG188361A1 (en) | 2010-09-01 | 2013-04-30 | Arena Pharm Inc | Non-hygroscopic salts of 5-ht2c agonists |
CN102531946A (zh) * | 2012-01-05 | 2012-07-04 | 山东大学 | 3-甲氧基苯甲酰胺衍生物及其制备方法与应用 |
KR20150070249A (ko) | 2012-10-09 | 2015-06-24 | 아레나 파마슈티칼스, 인크. | 체중 관리 방법 |
FR3029113A1 (fr) | 2014-12-02 | 2016-06-03 | Univ Paris-Sud | Composes pour le traitement des maladies mitochondriales |
CZ2017772A3 (cs) * | 2017-12-01 | 2019-05-29 | Farmak, A.S. | Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu) |
US10888524B2 (en) | 2018-02-05 | 2021-01-12 | Enaltec Pharma Research Pvt. Ltd. | Immediate release tablet of dofetilide |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR977261A (fr) * | 1948-11-04 | 1951-03-29 | équilibrage des masses dans les moteurs à combustion interne | |
GB993584A (sh) * | 1962-01-24 | |||
US3478149A (en) * | 1962-01-24 | 1969-11-11 | Mead Johnson & Co | Therapeutic compositions and methods employing sulfonamidophenethanolamines |
US3852468A (en) * | 1967-02-27 | 1974-12-03 | Ici Ltd | Alkanolamine derivatives as {62 -adrenergic blocking agents |
US3574741A (en) * | 1969-04-14 | 1971-04-13 | Mead Johnson & Co | Sulfonamidophenalkylamines |
US3758692A (en) * | 1969-04-14 | 1973-09-11 | Mead Johnson & Co | Ylamines sympathomimetic process and compositions employing sulfonamidophenalk |
GB1263987A (en) * | 1969-05-30 | 1972-02-16 | Allen & Hanburys Ltd | Phenethylamine derivatives |
BE757005A (fr) * | 1969-10-02 | 1971-04-02 | Bristol Myers Co | Phenethanolamines substituees et procede pour leur preparation |
GB1301134A (en) * | 1970-07-18 | 1972-12-29 | Pfizer Ltd | SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES |
EP0006735B1 (en) * | 1978-06-28 | 1983-06-15 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
DK268579A (da) * | 1978-07-03 | 1980-01-04 | Lilly Co Eli | Fremgangsmaade til fremstilling af phenetamolaminer |
ATE1899T1 (de) * | 1979-06-16 | 1982-12-15 | Beecham Group Plc | Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen. |
DD202692A5 (de) * | 1979-12-04 | 1983-09-28 | Ciba Geigy | Verfahren zur herstellung neuer derivate des 2-amino-aethanols |
FR2541999B1 (fr) * | 1983-03-04 | 1986-09-19 | Bristol Myers Co | Phenethanolamines et leurs utilisations |
EP0164865B1 (en) * | 1984-05-04 | 1988-12-21 | The Upjohn Company | N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use |
US4569801A (en) * | 1984-10-15 | 1986-02-11 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamines |
-
1987
- 1987-04-19 EG EG230/87A patent/EG18188A/xx active
- 1987-04-24 PH PH35179A patent/PH23425A/en unknown
- 1987-04-27 MY MYPI87000548A patent/MY111142A/en unknown
- 1987-04-29 PT PT84782A patent/PT84782B/pt unknown
- 1987-04-29 US US07/044,086 patent/US4959366A/en not_active Expired - Lifetime
- 1987-04-29 FI FI871898A patent/FI88291C/fi not_active IP Right Cessation
- 1987-04-29 DE DE8787303782T patent/DE3778201D1/de not_active Expired - Lifetime
- 1987-04-29 DE DE2000175004 patent/DE10075004I2/de active Active
- 1987-04-29 EP EP87303782A patent/EP0245997B1/en not_active Expired - Lifetime
- 1987-04-29 AT AT87303782T patent/ATE74906T1/de active
- 1987-04-29 CA CA000535897A patent/CA1289140C/en not_active Expired - Lifetime
- 1987-04-29 ES ES198787303782T patent/ES2033840T3/es not_active Expired - Lifetime
- 1987-04-29 PL PL1987265418A patent/PL149924B1/pl unknown
- 1987-04-29 IL IL82373A patent/IL82373A/xx not_active IP Right Cessation
- 1987-04-30 KR KR870004213A patent/KR870011084A/ko not_active Application Discontinuation
- 1987-04-30 NO NO871820A patent/NO168527C/no not_active IP Right Cessation
- 1987-04-30 HU HU871971A patent/HU196743B/hu unknown
- 1987-04-30 YU YU78387A patent/YU46195B/sh unknown
- 1987-04-30 NZ NZ220151A patent/NZ220151A/xx unknown
- 1987-04-30 DK DK198702202A patent/DK175096B1/da active Protection Beyond IP Right Term
- 1987-04-30 AU AU72260/87A patent/AU578557B2/en not_active Expired
- 1987-05-01 CN CN87103300A patent/CN1019801B/zh not_active Expired
- 1987-05-11 IE IE116587A patent/IE59366B1/en not_active IP Right Cessation
-
1988
- 1988-04-12 YU YU73588A patent/YU46541B/sh unknown
-
1990
- 1990-06-20 US US07/541,232 patent/US5079248A/en not_active Expired - Lifetime
- 1990-12-07 KR KR1019900020068A patent/KR930001339B1/ko not_active IP Right Cessation
-
1992
- 1992-04-29 GR GR920400823T patent/GR3004457T3/el unknown
-
1995
- 1995-03-15 LV LV950058A patent/LV5715B4/xx unknown
-
1998
- 1998-03-30 BA BA980301A patent/BA98301A/bs unknown
- 1998-03-30 BA BA980211A patent/BA98211B1/bs active
-
2000
- 2000-02-01 NL NL300002C patent/NL300002I2/nl unknown
- 2000-02-09 LU LU90519C patent/LU90519I2/fr unknown
-
2001
- 2001-06-26 NO NO2001011C patent/NO2001011I1/no unknown
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