ES2036674T3 - Derivados de aminoindanos utiles como agentes antiarritmicos. - Google Patents

Derivados de aminoindanos utiles como agentes antiarritmicos.

Info

Publication number
ES2036674T3
ES2036674T3 ES198888302600T ES88302600T ES2036674T3 ES 2036674 T3 ES2036674 T3 ES 2036674T3 ES 198888302600 T ES198888302600 T ES 198888302600T ES 88302600 T ES88302600 T ES 88302600T ES 2036674 T3 ES2036674 T3 ES 2036674T3
Authority
ES
Spain
Prior art keywords
aminoindanes
derivatives
useful
antiarrhythmic agents
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888302600T
Other languages
English (en)
Inventor
Peter Edward Dr. Cross
John Edmund Dr. Arrowsmith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of ES2036674T3 publication Critical patent/ES2036674T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

COMPUESTOS DE LA FORNULA (A) Y SUS SALES DONDE CADA R, QUE ES EL MISMO, ES -NHSO2 (C1-C4 ALQUILO, C1-C4 ALCOXI O HALOGENO Y N ES 1 O 2 CON LA CONDICION DE QUE, CUANDO X ES 0 N ES 2. LOS COMPUESTOS DE LA FORMULA (A) EN LA CUAL CADA R ES -NHSO2 (C1-C4 ALQUILO) SON AGENTES ANTIARRITMICOS. LOS COMPUESTOS EN LOS CUALES R ES -NH2 O -NO2 SON PRODUCTOS INTERMEDIOS DE LA SINTESIS.
ES198888302600T 1987-03-25 1988-03-24 Derivados de aminoindanos utiles como agentes antiarritmicos. Expired - Lifetime ES2036674T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878707123A GB8707123D0 (en) 1987-03-25 1987-03-25 Antiarrhythmic agents

Publications (1)

Publication Number Publication Date
ES2036674T3 true ES2036674T3 (es) 1993-06-01

Family

ID=10614609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888302600T Expired - Lifetime ES2036674T3 (es) 1987-03-25 1988-03-24 Derivados de aminoindanos utiles como agentes antiarritmicos.

Country Status (12)

Country Link
US (1) US5006561A (es)
EP (1) EP0286278B1 (es)
JP (1) JPS63264556A (es)
AT (1) ATE59842T1 (es)
AU (1) AU593739B2 (es)
DE (1) DE3861484D1 (es)
DK (1) DK160788A (es)
ES (1) ES2036674T3 (es)
GB (1) GB8707123D0 (es)
GR (1) GR3001665T3 (es)
IE (1) IE61071B1 (es)
PT (1) PT87051B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809314D0 (en) * 1988-04-20 1988-05-25 Wellcome Found Anti-hypertensive sulfonanilides
JP2931986B2 (ja) * 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体
US5166209A (en) * 1989-04-21 1992-11-24 Burroughs Wellcome Co. Pharmacologically active compounds
CA2071897A1 (en) * 1989-12-28 1991-06-29 Richard A. Glennon Sigma receptor ligands and the use thereof
WO1995000131A1 (en) * 1993-06-23 1995-01-05 Cambridge Neuroscience, Incorporated Sigma receptor ligands and the use thereof
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5475139A (en) * 1993-10-22 1995-12-12 Yung Shin Pharm. Ind. Co., Ltd. Method for the preparation of substituted derivatives of diphenyl amine
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
FR2717175B1 (fr) * 1994-03-11 1996-06-14 Adir Nouveaux composés alkylaminoindanes, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
US6083986A (en) * 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
US6303637B1 (en) 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors
US6632836B1 (en) 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
AU781365B2 (en) 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
BR0110519A (pt) * 2000-05-04 2003-04-08 Warner Lambert Co Método para inibir a agregação de proteìnas amilóides e formar imagens dos depósitos de amilóides usando derivados de aminoindano
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6620849B2 (en) 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518652A1 (de) * 1965-05-29 1969-04-10 Albert Ag Chem Werke Verfahren zur Herstellung von pharmazeutisch wirksamen Derivaten des 2-Aminoindans
US3923813A (en) * 1969-12-19 1975-12-02 Christiaens Sa A Derivatives of 2-aminoindanes
DE3566886D1 (en) * 1984-05-04 1989-01-26 Upjohn Co N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
US4959500A (en) * 1989-05-23 1990-09-25 Ethyl Corporation Polybrominated bis sulfonamides

Also Published As

Publication number Publication date
PT87051B (pt) 1992-07-31
DE3861484D1 (de) 1991-02-14
IE880887L (en) 1988-09-25
GR3001665T3 (en) 1992-11-23
EP0286278B1 (en) 1991-01-09
JPH0480019B2 (es) 1992-12-17
DK160788A (da) 1988-12-22
DK160788D0 (da) 1988-03-24
GB8707123D0 (en) 1987-04-29
ATE59842T1 (de) 1991-01-15
AU593739B2 (en) 1990-02-15
US5006561A (en) 1991-04-09
IE61071B1 (en) 1994-09-21
PT87051A (pt) 1988-04-01
EP0286278A1 (en) 1988-10-12
JPS63264556A (ja) 1988-11-01
AU1642488A (en) 1989-11-23

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