CO4410319A1 - Derivados de fenetanolamina - Google Patents

Derivados de fenetanolamina

Info

Publication number
CO4410319A1
CO4410319A1 CO95024914A CO95024914A CO4410319A1 CO 4410319 A1 CO4410319 A1 CO 4410319A1 CO 95024914 A CO95024914 A CO 95024914A CO 95024914 A CO95024914 A CO 95024914A CO 4410319 A1 CO4410319 A1 CO 4410319A1
Authority
CO
Colombia
Prior art keywords
atoms
carbon
alkyl
group
zch2co2h
Prior art date
Application number
CO95024914A
Other languages
English (en)
Inventor
Michael Walter Foxton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9411589A external-priority patent/GB9411589D0/en
Priority claimed from GBGB9504169.5A external-priority patent/GB9504169D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO4410319A1 publication Critical patent/CO4410319A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REIVINDICACION NUMERO UN COMPUESTO DE LA FORMULA GENERAL (I): FIGURA 1 CARACTERIZADO PORQUE R1 REPRESENTA UN GRUPO ARILO OPCIONALMENTE SUSTI- TUIDO POR UNO O MAS SUSTITUYENTES, SELECCIONADOS DE HALO, HIDROXI, ALCOXI DE 1 A 6 ATOMOS DE CAR- BONO, ALQUILO DE 1 A 6 ATOMOS DE CARBONO, NITRO, CIANO, HIDROXIMETILO Y TRIFLUOROMETILO; R2 REPRESENTA H o ALQUILO DE 1 A 6 ATOMOS DE CARBONO; R3 REPRESENTA UN GRUPO FENILO O HETEROARILO SUS- TITUIDO POR R6 Y R7; R4 Y R5 CADA UNO REPRESENTA INDEPENDIENTEMENTE H o ALQUILO DE 1 A 6 ATOMOS DE CARBONO o, R4 Y R5 CONJUNTAMENTE FORMAN UN GRUPO CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO; R6 REPRESENTA ZCH2CO2H Y R7 REPRESENTA H o ZCH2CO2H, o R6 Y R7 CONJUNTAMENTE REPRESENTAN UN GRUPO FIGURA 2 EN DONDE CADA Z PUEDE SER EL MISMO O DIFERENTE, Y SE SELECCIONA DE UN ENLACE, CH2,O, S o NR9; R8 ES H o CO2H; R9 ES H O ALQUILO DE 1 A 6 ATOMOS DE CARBONO; X REPRESENTA (CH2)n, DONDE n ES 1 o 2; Y DERIVADOS FISIOLOGICAMENTE ACEPTABLES DE LOS MISMOS".
CO95024914A 1994-06-09 1995-06-08 Derivados de fenetanolamina CO4410319A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9411589A GB9411589D0 (en) 1994-06-09 1994-06-09 Chemical compounds
GBGB9504169.5A GB9504169D0 (en) 1995-03-02 1995-03-02 Chemical compounds

Publications (1)

Publication Number Publication Date
CO4410319A1 true CO4410319A1 (es) 1997-01-09

Family

ID=26305035

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95024914A CO4410319A1 (es) 1994-06-09 1995-06-08 Derivados de fenetanolamina

Country Status (5)

Country Link
AU (1) AU2737295A (es)
CO (1) CO4410319A1 (es)
IL (1) IL114059A0 (es)
PE (1) PE14696A1 (es)
WO (1) WO1995033724A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9525121D0 (en) * 1995-12-08 1996-02-07 Glaxo Group Ltd Chemical compounds
GB9525177D0 (en) * 1995-12-08 1996-02-07 Glaxo Group Ltd Chemical compounds
US5914339A (en) * 1996-05-14 1999-06-22 American Home Products Corporation Substituted 1,3-benzodioxoles
FR2751646B1 (fr) * 1996-07-23 1999-01-22 Sanofi Sa Phenoxypropanolamine a action antagoniste beta3-adrenergique
GB9706707D0 (en) * 1997-04-02 1997-05-21 Glaxo Group Ltd Chemical compounds
GB9812709D0 (en) * 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
GB9929118D0 (en) * 1999-12-10 2000-02-02 Glaxo Group Ltd Chemical compounds
US7709677B2 (en) 2001-01-31 2010-05-04 Glaxosmithkline Llc Process of preparing arylethanoldiamines
GB0102408D0 (en) * 2001-01-31 2001-03-14 Glaxo Group Ltd Chemical compounds
GB0102407D0 (en) 2001-01-31 2001-03-14 Glaxo Group Ltd Process
US7034053B2 (en) 2001-01-31 2006-04-25 Smithkline Beecham Corporation Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors
DE60315892T2 (de) 2002-12-24 2008-08-14 Astrazeneca Ab Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung
EP1595873A1 (de) * 2004-05-13 2005-11-16 Boehringer Ingelheim Pharma GmbH & Co.KG Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen
US7423035B2 (en) 2004-05-13 2008-09-09 Boehringer Ingelheim International Gmbh Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament
ATE529111T1 (de) 2005-12-07 2011-11-15 Basilea Pharmaceutica Ag Nützliche monobactam-antibiotika
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
CN107205964A (zh) 2014-12-03 2017-09-26 威力塞帕特治疗股份有限公司 使用调节释放索拉贝隆用于下尿路症状的组合物和方法
US10065922B2 (en) 2015-10-23 2018-09-04 Velicept Therapeutics, Inc. Solabegron zwitterion and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154761A (en) * 1976-02-09 1979-05-15 Allen & Hanburys Limited Pharmacologically active compounds
DK31578A (da) * 1977-02-03 1978-08-04 Allen & Hanburys Ltd Fremgangsmaade til fremstilling af benzenderivater
US5061727A (en) * 1990-05-04 1991-10-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
GB9207964D0 (en) * 1992-04-10 1992-05-27 Ici Plc Chemical compounds

Also Published As

Publication number Publication date
IL114059A0 (en) 1995-10-31
AU2737295A (en) 1996-01-04
PE14696A1 (es) 1996-05-13
WO1995033724A1 (en) 1995-12-14

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