DE10075004I1 - N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte dafuer - Google Patents

N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte dafuer

Info

Publication number
DE10075004I1
DE10075004I1 DE2000175004 DE10075004C DE10075004I1 DE 10075004 I1 DE10075004 I1 DE 10075004I1 DE 2000175004 DE2000175004 DE 2000175004 DE 10075004 C DE10075004 C DE 10075004C DE 10075004 I1 DE10075004 I1 DE 10075004I1
Authority
DE
Germany
Prior art keywords
alkyl
group
formula
antiarrhythmic agents
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2000175004
Other languages
English (en)
Other versions
DE10075004I2 (de
Inventor
John Edmund Arrowsmith
Peter Edward Cross
Geoffrey Noel Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26290703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10075004(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB868610668A external-priority patent/GB8610668D0/en
Priority claimed from GB868630059A external-priority patent/GB8630059D0/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of DE10075004I1 publication Critical patent/DE10075004I1/de
Publication of DE10075004I2 publication Critical patent/DE10075004I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polyamides (AREA)
  • Lubricants (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
DE2000175004 1986-05-01 1987-04-29 N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte daf}r. Active DE10075004I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868610668A GB8610668D0 (en) 1986-05-01 1986-05-01 Anti-arrhythmia agents
GB868630059A GB8630059D0 (en) 1986-12-17 1986-12-17 Antiarrhythmic agents

Publications (2)

Publication Number Publication Date
DE10075004I1 true DE10075004I1 (de) 2000-04-13
DE10075004I2 DE10075004I2 (de) 2006-02-02

Family

ID=26290703

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8787303782T Expired - Lifetime DE3778201D1 (de) 1986-05-01 1987-04-29 N-substituierte p-aminoethylsulfonanilide als antiarrhythmische mittel und zwischenprodukte dafuer.
DE2000175004 Active DE10075004I2 (de) 1986-05-01 1987-04-29 N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte daf}r.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8787303782T Expired - Lifetime DE3778201D1 (de) 1986-05-01 1987-04-29 N-substituierte p-aminoethylsulfonanilide als antiarrhythmische mittel und zwischenprodukte dafuer.

Country Status (27)

Country Link
US (2) US4959366A (de)
EP (1) EP0245997B1 (de)
KR (2) KR870011084A (de)
CN (1) CN1019801B (de)
AT (1) ATE74906T1 (de)
AU (1) AU578557B2 (de)
BA (2) BA98301A (de)
CA (1) CA1289140C (de)
DE (2) DE3778201D1 (de)
DK (1) DK175096B1 (de)
EG (1) EG18188A (de)
ES (1) ES2033840T3 (de)
FI (1) FI88291C (de)
GR (1) GR3004457T3 (de)
HU (1) HU196743B (de)
IE (1) IE59366B1 (de)
IL (1) IL82373A (de)
LU (1) LU90519I2 (de)
LV (1) LV5715B4 (de)
MY (1) MY111142A (de)
NL (1) NL300002I2 (de)
NO (2) NO168527C (de)
NZ (1) NZ220151A (de)
PH (1) PH23425A (de)
PL (1) PL149924B1 (de)
PT (1) PT84782B (de)
YU (2) YU46195B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602174A (en) * 1986-02-15 1997-02-11 Beecham Wuefling Gmbh & Co. Treatment
NL8700842A (de) * 1987-04-10 1988-11-01 Duphar Int Res
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
GB8809314D0 (en) * 1988-04-20 1988-05-25 Wellcome Found Anti-hypertensive sulfonanilides
GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
US5166209A (en) * 1989-04-21 1992-11-24 Burroughs Wellcome Co. Pharmacologically active compounds
HUT58270A (en) * 1989-06-02 1992-02-28 Wyeth John & Brother Ltd Process for producing amine derivatives and pharmaceutical compositions containing them
US5084463A (en) * 1989-12-11 1992-01-28 American Home Products Corporation N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
IL106549A0 (en) * 1992-07-31 1993-12-08 Syntex Inc Heterocyclic derivatives,their preparation and pharmaceutical compositions containing them
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
DE4422517A1 (de) * 1994-06-28 1996-01-04 Dresden Arzneimittel Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ES2206508T3 (es) * 1994-08-04 2004-05-16 C & C RESEARCH LABS. Nuevo derivado aminado, procedimiento de obtencion de este derivado y su utilizacion como antiarritmico.
DE69500377T2 (de) 1994-08-19 1997-10-09 Mitsui Toatsu Chemicals Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
FR2726267B1 (fr) * 1994-10-26 1998-01-02 Smithkline Beecham Lab Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
CN1055679C (zh) * 1995-12-06 2000-08-23 中国药科大学 具有心血管活性的苯乙胺衍生物
CN1055682C (zh) * 1995-12-06 2000-08-23 中国药科大学 甲磺酰胺基苯乙胺衍生物的新制备方法
GB9722662D0 (en) * 1997-10-27 1997-12-24 Pfizer Ltd Polymorphs
HUP9702411A2 (hu) * 1997-12-11 2000-03-28 Gyógyszerkutató Intézet Kft. Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
CA2440284A1 (en) * 2001-03-08 2002-09-19 Emory University Ph-dependent nmda receptor antagonists
CN100358865C (zh) * 2001-07-30 2008-01-02 中国科学院上海药物研究所 一类磺酰胺苯烷胺类化合物及其制备方法和用途
DE10201550A1 (de) * 2002-01-17 2003-07-31 Merck Patent Gmbh Phenoxy-Piperidine
AU2002357560A1 (en) * 2002-04-26 2003-11-10 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Sulfamidophenylalkylamines and their production and use
SI2332921T1 (sl) * 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
AU2004253888B2 (en) * 2003-06-17 2010-11-11 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
DE102004025726B4 (de) * 2004-05-26 2006-07-06 Roder, Hanno, Dr. Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
US8022056B2 (en) * 2006-12-14 2011-09-20 Tautatis, Inc Compositions and methods for the treatment of cancer
CA2693032A1 (en) * 2007-06-29 2009-01-08 Emory University Nmda receptor antagonists for neuroprotection
CN101372467B (zh) * 2007-08-23 2011-09-14 明德国际仓储贸易(上海)有限公司 具有n,n-二烷氨基的桥基化合物及所应用的染料化合物
CN102015591B (zh) 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
MX2013002422A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales de lorcaserina con acidos opticamente activos.
WO2012030939A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
AU2011296033A1 (en) 2010-09-01 2013-04-04 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-HT2C agonists
CN102531946A (zh) * 2012-01-05 2012-07-04 山东大学 3-甲氧基苯甲酰胺衍生物及其制备方法与应用
AR088670A1 (es) 2012-10-09 2014-06-25 Arena Pharm Inc Metodo de control del peso
FR3029113A1 (fr) 2014-12-02 2016-06-03 Univ Paris-Sud Composes pour le traitement des maladies mitochondriales
CZ307826B6 (cs) * 2017-12-01 2019-05-29 Farmak, A.S. Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu)
US10888524B2 (en) 2018-02-05 2021-01-12 Enaltec Pharma Research Pvt. Ltd. Immediate release tablet of dofetilide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR977261A (fr) * 1948-11-04 1951-03-29 équilibrage des masses dans les moteurs à combustion interne
US3478149A (en) * 1962-01-24 1969-11-11 Mead Johnson & Co Therapeutic compositions and methods employing sulfonamidophenethanolamines
FR148F (de) * 1962-01-24
US3852468A (en) * 1967-02-27 1974-12-03 Ici Ltd Alkanolamine derivatives as {62 -adrenergic blocking agents
US3758692A (en) * 1969-04-14 1973-09-11 Mead Johnson & Co Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
US3574741A (en) * 1969-04-14 1971-04-13 Mead Johnson & Co Sulfonamidophenalkylamines
GB1263987A (en) * 1969-05-30 1972-02-16 Allen & Hanburys Ltd Phenethylamine derivatives
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
GB1301134A (en) * 1970-07-18 1972-12-29 Pfizer Ltd SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
DE2965655D1 (en) * 1978-06-28 1983-07-21 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
IL57670A (en) * 1978-07-03 1982-11-30 Lilly Co Eli Phenethanolamines,their preparation and pharmaceutical formulations comprising them
DE3061205D1 (en) * 1979-06-16 1983-01-05 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
DD202692A5 (de) * 1979-12-04 1983-09-28 Ciba Geigy Verfahren zur herstellung neuer derivate des 2-amino-aethanols
FR2541999B1 (fr) * 1983-03-04 1986-09-19 Bristol Myers Co Phenethanolamines et leurs utilisations
DE3566886D1 (en) * 1984-05-04 1989-01-26 Upjohn Co N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
US4569801A (en) * 1984-10-15 1986-02-11 Eli Lilly And Company Alkylsulfonamidophenylalkylamines

Also Published As

Publication number Publication date
NO168527C (no) 1992-03-04
US4959366A (en) 1990-09-25
NO871820L (no) 1987-11-02
EG18188A (en) 1992-09-30
DE3778201D1 (de) 1992-05-21
IL82373A0 (en) 1987-10-30
YU73588A (en) 1990-04-30
EP0245997A2 (de) 1987-11-19
FI871898A0 (fi) 1987-04-29
FI871898A (fi) 1987-11-02
HUT43558A (en) 1987-11-30
NO871820D0 (no) 1987-04-30
FI88291B (fi) 1993-01-15
FI88291C (fi) 1993-04-26
NL300002I1 (nl) 2000-04-03
IE59366B1 (en) 1994-02-09
EP0245997A3 (en) 1989-12-20
MY111142A (en) 1999-09-30
LV5715B4 (lv) 1996-02-20
ES2033840T3 (es) 1993-04-01
IL82373A (en) 1992-01-15
DK175096B1 (da) 2004-06-01
KR930001339B1 (ko) 1993-02-26
NZ220151A (en) 1989-02-24
GR3004457T3 (de) 1993-03-31
AU578557B2 (en) 1988-10-27
NO2001011I1 (no) 2001-07-16
DK220287A (da) 1987-11-02
NO168527B (no) 1991-11-25
ATE74906T1 (de) 1992-05-15
YU46195B (sh) 1993-05-28
US5079248A (en) 1992-01-07
LU90519I2 (fr) 2000-04-10
DK220287D0 (da) 1987-04-30
NL300002I2 (nl) 2000-05-01
EP0245997B1 (de) 1992-04-15
LV5715A4 (lv) 1995-10-20
CN87103300A (zh) 1987-11-11
PL149924B1 (en) 1990-04-30
CN1019801B (zh) 1992-12-30
PL265418A1 (en) 1988-07-21
KR920014397A (ko) 1992-07-30
YU78387A (en) 1988-08-31
PH23425A (en) 1989-08-07
DE10075004I2 (de) 2006-02-02
AU7226087A (en) 1987-11-19
KR870011084A (ko) 1987-12-19
CA1289140C (en) 1991-09-17
PT84782A (en) 1987-05-01
BA98211B1 (bs) 1999-08-02
YU46541B (sh) 1993-11-16
IE871165L (en) 1987-11-01
HU196743B (en) 1989-01-30
BA98301A (bs) 2001-09-14
PT84782B (pt) 1989-12-29

Similar Documents

Publication Publication Date Title
DE10075004I1 (de) N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte dafuer
TNSN86081A1 (fr) Amides derives de la quinoleine et leurs procedes de preparation
YU231790A (sh) Spirocikli koji sadrže azot
DK0409435T3 (da) Heteroarylpiperaziner som antipsykotiske midler
ATE59842T1 (de) Indanamin-derivate als antiarrhythmische mittel.
DE69112095T2 (de) 1-Phenoxycarbonyl-2-Pyrrolidon-Derivate und nootrope Wirkstoffe.