ES2000705A6 - Procedimiento de preparacion de nuevas benzamidas y sus sales - Google Patents

Procedimiento de preparacion de nuevas benzamidas y sus sales

Info

Publication number
ES2000705A6
ES2000705A6 ES8600430A ES8600430A ES2000705A6 ES 2000705 A6 ES2000705 A6 ES 2000705A6 ES 8600430 A ES8600430 A ES 8600430A ES 8600430 A ES8600430 A ES 8600430A ES 2000705 A6 ES2000705 A6 ES 2000705A6
Authority
ES
Spain
Prior art keywords
group
hydrogen
salts
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600430A
Other languages
English (en)
Inventor
Armando Vega Noverola
Jose Manuel Prieto Soto
Fernando Pujol Noguera
Jacinto Moragues Mauri
Robert Geoffrey Willi Spickett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fordonal SA
Original Assignee
Fordonal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fordonal SA filed Critical Fordonal SA
Publication of ES2000705A6 publication Critical patent/ES2000705A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE NUEVAS BENZAMIDAS Y SUS SALES DE FORMULA I: EN DONDE: R REPRESENTA UN GRUPO ALCOXI, ALQUENOXI O ALQUINILOXI. R1 ES HIDROGENO O UN GRUPO NR4R5 O NR6COR7 EN DONDE R4, R5 Y R6 QUE OPCIONALMENTE SON IGUALES O DISTINTOS ENTRE SI, SON HIDROGENO O UN GRUPO ALQUILO, Y R7 ES UN GRUPO ALQUILO O TRIFLUOROMETILO. R2 ES HIDROGENO, HALOGENO O UN GRUPO NITRO O SULFAMOILO. R3 ES HIDROGENO O UN GRUPO METILO. X ES UNA CADENA HIDROCARBONADA CONTENIENDO DE 1 A 4 ATOMOS DE CARBONO, UNO DE LOS CUALES ESTA OPCIONALMENTE REEMPLAZADO POR UN ATOMO DE OXIGENO. Y ES UN GRUPO ETER CICLICO NO AROMATICO O UN GRUPO TIOETER CICLICO NO AROMATICO.
ES8600430A 1985-08-06 1986-07-21 Procedimiento de preparacion de nuevas benzamidas y sus sales Expired ES2000705A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858519707A GB8519707D0 (en) 1985-08-06 1985-08-06 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2000705A6 true ES2000705A6 (es) 1988-03-16

Family

ID=10583372

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8600430A Expired ES2000705A6 (es) 1985-08-06 1986-07-21 Procedimiento de preparacion de nuevas benzamidas y sus sales
ES8600431A Expired ES2000706A6 (es) 1985-08-06 1986-07-21 Procedimiento de preparacion de nuevas benzamidas y su sales

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES8600431A Expired ES2000706A6 (es) 1985-08-06 1986-07-21 Procedimiento de preparacion de nuevas benzamidas y su sales

Country Status (28)

Country Link
US (1) US4772618A (es)
EP (1) EP0213775B1 (es)
JP (1) JPH0662614B2 (es)
KR (1) KR920001763B1 (es)
CN (1) CN1022830C (es)
AR (2) AR243521A1 (es)
AT (1) ATE49206T1 (es)
AU (1) AU596110B2 (es)
CA (1) CA1300154C (es)
DD (1) DD287502A5 (es)
DE (1) DE3667975D1 (es)
DK (1) DK370586A (es)
EG (1) EG18154A (es)
ES (2) ES2000705A6 (es)
FI (1) FI89168C (es)
GB (1) GB8519707D0 (es)
GR (1) GR862060B (es)
HU (1) HU201060B (es)
IE (1) IE58751B1 (es)
IL (1) IL79469A0 (es)
MX (1) MX3375A (es)
MY (1) MY101352A (es)
NO (1) NO168706C (es)
NZ (1) NZ217078A (es)
PH (1) PH25019A (es)
PL (1) PL150228B1 (es)
PT (2) PT83147B (es)
ZA (1) ZA865537B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640139A1 (fr) * 1988-12-14 1990-06-15 Delagrange Laboratoires Application de benzamides substitues comme gastromoteurs
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
JP2999669B2 (ja) * 1993-08-24 2000-01-17 株式会社三和化学研究所 ベンゾ［ｂ］フランカルボキサミド誘導体、その製法及び用途
JPH0820586A (ja) 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
JPH0873463A (ja) 1994-07-05 1996-03-19 Sanwa Kagaku Kenkyusho Co Ltd ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
CN1052228C (zh) * 1996-01-17 2000-05-10 中国科学院大连化学物理研究所 N-甲酰基哌啶及其同系物的制备方法
CN1091104C (zh) * 1998-04-02 2002-09-18 中国科学院大连化学物理研究所 一种n－甲酰基哌啶的制备方法
CN1649766A (zh) 2002-06-11 2005-08-03 安芸电器株式会社 自行车的前照灯以及前照灯电路
JP5200288B2 (ja) * 2004-01-07 2013-06-05 アルメテオン、インコーポレイテッド 胃腸疾患および中枢神経系疾患の治療のための立体異性体化合物と方法
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
JP5845263B2 (ja) * 2010-09-01 2016-01-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ ５−ｈｔ２ｂ受容体アンタゴニスト
CN110950843B (zh) * 2019-11-28 2022-12-27 广东东阳光药业有限公司 取代的苯酰胺衍生物及其用途
CN119679732B (zh) * 2024-12-11 2025-10-10 北京阳光诺和药物研究股份有限公司 一种胃肠促动力片剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1019781A (es) 1963-03-05
US3342826A (en) 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
GB1507462A (en) * 1974-03-21 1978-04-12 Gallardo Antonio Sa N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
GB1574418A (en) * 1976-11-16 1980-09-03 Anphar Sa Piperidine derivatives
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives

Also Published As

Publication number Publication date
AR242793A1 (es) 1993-05-31
CA1300154C (en) 1992-05-05
IE58751B1 (en) 1993-11-03
JPS62129279A (ja) 1987-06-11
US4772618A (en) 1988-09-20
HUT44782A (en) 1988-04-28
AU6075886A (en) 1987-02-12
KR920001763B1 (ko) 1992-03-02
DD287502A5 (de) 1991-02-28
AU596110B2 (en) 1990-04-26
NZ217078A (en) 1989-01-27
AR243521A1 (es) 1993-08-31
PH25019A (en) 1991-01-28
GB8519707D0 (en) 1985-09-11
ES2000706A6 (es) 1988-03-16
FI89168C (fi) 1993-08-25
PT83147B (pt) 1988-07-29
NO168706C (no) 1992-03-25
PT83146A (en) 1986-09-01
MY101352A (en) 1991-09-05
CN1022830C (zh) 1993-11-24
PT83146B (pt) 1988-07-29
PL150228B1 (en) 1990-05-31
NO863139D0 (no) 1986-08-04
JPH0662614B2 (ja) 1994-08-17
IL79469A0 (en) 1986-10-31
EP0213775A1 (en) 1987-03-11
PL260921A1 (en) 1988-01-07
NO863139L (no) 1987-02-09
DE3667975D1 (en) 1990-02-08
PT83147A (en) 1986-09-01
EP0213775B1 (en) 1990-01-03
EG18154A (en) 1992-11-30
DK370586A (da) 1987-03-27
HU201060B (en) 1990-09-28
ATE49206T1 (de) 1990-01-15
FI863179A7 (fi) 1987-02-07
ZA865537B (en) 1987-03-25
GR862060B (en) 1986-12-24
DK370586D0 (da) 1986-08-04
FI863179A0 (fi) 1986-08-04
KR870002071A (ko) 1987-03-28
NO168706B (no) 1991-12-16
IE862073L (en) 1987-02-06
CN86105972A (zh) 1987-04-01
MX3375A (es) 1993-12-01
FI89168B (fi) 1993-05-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980504