ID23903A - Turuan tetrahidrofuran tetrasiklik tersubstitusi halogen - Google Patents

Turuan tetrahidrofuran tetrasiklik tersubstitusi halogen

Info

Publication number
ID23903A
ID23903A IDW20000646A ID20000646A ID23903A ID 23903 A ID23903 A ID 23903A ID W20000646 A IDW20000646 A ID W20000646A ID 20000646 A ID20000646 A ID 20000646A ID 23903 A ID23903 A ID 23903A
Authority
ID
Indonesia
Prior art keywords
tetrasiklik
tetrahidrofuran
turran
substituted halogen
halogen
Prior art date
Application number
IDW20000646A
Other languages
English (en)
Indonesian (id)
Inventor
J I Andres-Gil
F J Fernandez-Gadea
P Gil-Lopetegui
A Diaz-Martinez
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ID23903A publication Critical patent/ID23903A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IDW20000646A 1997-10-10 1998-10-06 Turuan tetrahidrofuran tetrasiklik tersubstitusi halogen ID23903A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97203154 1997-10-10

Publications (1)

Publication Number Publication Date
ID23903A true ID23903A (id) 2000-05-25

Family

ID=8228817

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20000646A ID23903A (id) 1997-10-10 1998-10-06 Turuan tetrahidrofuran tetrasiklik tersubstitusi halogen

Country Status (36)

Country Link
US (2) US6511976B1 (fr)
EP (1) EP1021432B1 (fr)
JP (1) JP3248902B2 (fr)
KR (1) KR100366014B1 (fr)
CN (1) CN100340554C (fr)
AP (1) AP1239A (fr)
AR (1) AR017325A1 (fr)
AT (1) ATE235479T1 (fr)
AU (1) AU737334B2 (fr)
BG (1) BG64387B1 (fr)
BR (1) BR9812871A (fr)
CA (1) CA2305612C (fr)
CZ (1) CZ296928B6 (fr)
DE (1) DE69812668T2 (fr)
DK (1) DK1021432T3 (fr)
EA (1) EA003698B1 (fr)
EE (1) EE04526B1 (fr)
ES (1) ES2195403T3 (fr)
HK (1) HK1029106A1 (fr)
HR (1) HRP20000189A2 (fr)
HU (1) HU225161B1 (fr)
ID (1) ID23903A (fr)
IL (1) IL135538A (fr)
MY (1) MY117783A (fr)
NO (1) NO317159B1 (fr)
NZ (1) NZ503294A (fr)
OA (1) OA11898A (fr)
PL (1) PL339833A1 (fr)
PT (1) PT1021432E (fr)
SI (1) SI1021432T1 (fr)
SK (1) SK284028B6 (fr)
TR (1) TR200000918T2 (fr)
TW (1) TW567186B (fr)
UA (1) UA52778C2 (fr)
WO (1) WO1999019317A1 (fr)
ZA (1) ZA989204B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
BR0214775A (pt) 2001-12-07 2004-11-09 Janssen Pharmaceutica Nv Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos
NZ532806A (en) * 2001-12-07 2006-01-27 Janssen Pharmaceutica Nv Preparation of trans-fused 3,3a,8,12b-tetrahydro-2H-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (fr) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
AR049512A1 (es) * 2004-06-14 2006-08-09 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos. composiciones farmaceuticas
JP4823221B2 (ja) * 2004-06-23 2011-11-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規な不飽和四環式テトラヒドロフラン誘導体
AU2011202995B2 (en) * 2004-12-07 2012-02-02 Janssen Pharmaceutica N.V. Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
US7799785B2 (en) 2004-12-07 2010-09-21 Janssen Pharmaceutica Nv Substituted tetracyclic tetahydrofuran, pyrrolidine and tetrahydrothiophene derivatives
WO2006079637A1 (fr) 2005-01-27 2006-08-03 Janssen Pharmaceutica N.V. Derives heterocycliques tetracycliques de tetrahydrofuranne en tant qu'inhibiteurs de 5ht2 dans le traitement de troubles du systeme nerveux central
CN101175749B (zh) * 2005-05-19 2011-05-18 詹森药业有限公司 选择的含环胺侧链的四环四氢呋喃衍生物
BRPI0611408A2 (pt) * 2005-05-26 2010-09-08 Janssen Pharmaceutica Nv derivados de tetra-hidrofurano tetracìclico substituìdo, pirrolidina e tetrahidrotiofeno, seus usos como um medicamento, composição farmacêutica e processo para o preparo da mesma
CA2611443C (fr) * 2005-06-17 2014-08-26 Janssen Pharmaceutica N.V. Nouveaux derives tetracycliques de tetrahydrofurane contenant une chaine laterale d'amine cyclique
US9125866B1 (en) 2015-01-28 2015-09-08 King Saud University Antidepressant compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL183618B1 (pl) 1994-11-02 2002-06-28 Janssen Pharmaceutica Nv Nowy związek, pochodna podstawionej tetracyklicznej oksazepiny lub tiazepiny, kompozycja farmaceutyczna i sposób wytwarzania pochodnej podstawionej tetracyklicznej oksazepiny lub tiazepiny
US5552399A (en) * 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
IL123655A (en) 1996-04-12 2001-03-19 Janssen Pharmaceutica Nv Substituted tetracyclic tetrahydrofuran derivatives and pharmaceutical compositions containing them
YU10499A (sh) 1996-08-28 2001-03-07 Eli Lilly And Company Supstituisani 1,2,3,4-tetrahidro-2-dibenzofuranamini i 2-aminociklohepta /b/benzofurani

Also Published As

Publication number Publication date
CZ296928B6 (cs) 2006-07-12
AP2000001784A0 (en) 2000-06-30
US6511976B1 (en) 2003-01-28
US6699858B2 (en) 2004-03-02
KR100366014B1 (ko) 2002-12-26
HUP0003748A3 (en) 2002-02-28
OA11898A (en) 2006-04-10
EA003698B1 (ru) 2003-08-28
DE69812668T2 (de) 2004-01-29
SI1021432T1 (en) 2003-08-31
JP3248902B2 (ja) 2002-01-21
NZ503294A (en) 2001-08-31
DK1021432T3 (da) 2003-07-14
WO1999019317A1 (fr) 1999-04-22
BG104287A (en) 2000-11-30
BG64387B1 (bg) 2004-12-30
CN1274353A (zh) 2000-11-22
DE69812668D1 (de) 2003-04-30
AU737334B2 (en) 2001-08-16
NO20001792L (no) 2000-04-06
EE200000161A (et) 2001-04-16
CN100340554C (zh) 2007-10-03
HU225161B1 (en) 2006-07-28
ES2195403T3 (es) 2003-12-01
TW567186B (en) 2003-12-21
PT1021432E (pt) 2003-08-29
TR200000918T2 (tr) 2000-07-21
EA200000400A1 (ru) 2000-10-30
HUP0003748A2 (hu) 2002-01-28
IL135538A0 (en) 2001-05-20
PL339833A1 (en) 2001-01-02
EP1021432B1 (fr) 2003-03-26
ATE235479T1 (de) 2003-04-15
HK1029106A1 (en) 2001-03-23
UA52778C2 (uk) 2003-01-15
EP1021432A1 (fr) 2000-07-26
CA2305612A1 (fr) 1999-04-22
KR20010023292A (ko) 2001-03-26
MY117783A (en) 2004-08-30
CZ20001136A3 (cs) 2000-08-16
ZA989204B (en) 2000-04-10
AU9629698A (en) 1999-05-03
JP2001519425A (ja) 2001-10-23
AP1239A (en) 2004-01-15
HRP20000189A2 (en) 2001-02-28
IL135538A (en) 2005-07-25
NO20001792D0 (no) 2000-04-06
NO317159B1 (no) 2004-08-30
EE04526B1 (et) 2005-08-15
US20030134852A1 (en) 2003-07-17
SK284028B6 (sk) 2004-08-03
CA2305612C (fr) 2007-07-31
AR017325A1 (es) 2001-09-05
BR9812871A (pt) 2000-08-08
SK4712000A3 (en) 2000-10-09

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