HUP9902375A2 - Eljárás 2-metoxi-4(N-t-butilamino-karbonil)-benzolszulfoklorid előállítására - Google Patents

Eljárás 2-metoxi-4(N-t-butilamino-karbonil)-benzolszulfoklorid előállítására

Info

Publication number
HUP9902375A2
HUP9902375A2 HU9902375A HUP9902375A HUP9902375A2 HU P9902375 A2 HUP9902375 A2 HU P9902375A2 HU 9902375 A HU9902375 A HU 9902375A HU P9902375 A HUP9902375 A HU P9902375A HU P9902375 A2 HUP9902375 A2 HU P9902375A2
Authority
HU
Hungary
Prior art keywords
acid
formula
methoxy
resulting
chloride
Prior art date
Application number
HU9902375A
Other languages
English (en)
Inventor
Csaba Gönczi
Lajos Nagy
Gergely Héja
Éva Csikós
Félix Hajdú
Tiborné Szomor
Györgyné Szvoboda
Csutor Andrea Sántáné
Gergelyné Héja
István Hermecz
Kálmán Simon
Esek Ágota Smelkóné
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Priority to HU9902375A priority Critical patent/HU225150B1/hu
Publication of HU9902375D0 publication Critical patent/HU9902375D0/hu
Priority to EP00949824A priority patent/EP1202960B1/en
Priority to AU63083/00A priority patent/AU6308300A/en
Priority to BRPI0012430-3A priority patent/BR0012430B1/pt
Priority to SK47-2002A priority patent/SK286031B6/sk
Priority to PL352466A priority patent/PL199425B1/pl
Priority to MXPA01013342A priority patent/MXPA01013342A/es
Priority to SI200030355T priority patent/SI1202960T1/xx
Priority to US10/030,655 priority patent/US6548702B1/en
Priority to DE60008884T priority patent/DE60008884T2/de
Priority to CA002378337A priority patent/CA2378337C/en
Priority to ES00949824T priority patent/ES2215699T3/es
Priority to CNB008102945A priority patent/CN1164571C/zh
Priority to PCT/HU2000/000080 priority patent/WO2001005754A1/en
Priority to CZ2002146A priority patent/CZ2002146A3/cs
Priority to HU0201573A priority patent/HU225237B1/hu
Priority to AT00949824T priority patent/ATE261430T1/de
Priority to JP2001511415A priority patent/JP4636761B2/ja
Publication of HUP9902375A2 publication Critical patent/HUP9902375A2/hu
Priority to HR20020141A priority patent/HRP20020141B1/xx
Publication of HUP9902375A3 publication Critical patent/HUP9902375A3/hu
Publication of HU225150B1 publication Critical patent/HU225150B1/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/06Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/57Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C07C309/60Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya eljárás (I) képletű 2-metoxi-4-(N-t-butilamino-karbonil)-benzolszulfoklorid előállítására m-hidroxi-benzoesav szulfonálásával, a kapottszulfonsav vagy sója hidroxi-csoportjának metilezésével, a karboxil- és szulfonsavcsoportsavkloriddá való alakításával és a 4-klórszulfonil-3-metoxi-benzoilklorid t-butilaminnal való reagáltatásával, azzal jellemezve,hogy az m-hidroxi-benzoesav szulfonálását 96 t%-os kénsavban hajtjákvégre, a kapott 3-hidroxi-4-szulfo-benzoesavat (IV) általános képletűsója - mely képletben Z jelentése alkálifém vagy ammóniumcsoport -formájában elkülönítik, majd fázistranszfer-katalizátor jelenlétében11,5 fölötti pH értéken metilezik, a kapott 3-metoxi-4-szulfo-benzoesav-monosót (VI) képletű savkloriddá alakítják, majd savmegkötőszer jelenlétében alacsony hőmérsékleten, poláris oldószeres közegbenmoláris vagy kis feleslegben alkalmazott t-butilaminnal reagáltatják. Ó
HU9902375A 1999-07-15 1999-07-15 Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride HU225150B1 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
HU9902375A HU225150B1 (en) 1999-07-15 1999-07-15 Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride
JP2001511415A JP4636761B2 (ja) 1999-07-15 2000-07-13 2−メトキシ−4−(N−t−ブチルアミノカルボニル)ベンゼンスルホニルクロリドの製造方法
CA002378337A CA2378337C (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride
CNB008102945A CN1164571C (zh) 1999-07-15 2000-07-13 制备2-甲氧基-4-(n-叔丁基氨基羰基)苯磺酰氯的方法
BRPI0012430-3A BR0012430B1 (pt) 1999-07-15 2000-07-13 método para a preparação de cloreto de 2-metóxi-4-(n-t-butilamino-carbonil)-benzenosulfoni la.
SK47-2002A SK286031B6 (sk) 1999-07-15 2000-07-13 Spôsob prípravy 2-metoxy-4-(N-terc- butylaminokarbonyl)benzénsulfonylchloridu
PL352466A PL199425B1 (pl) 1999-07-15 2000-07-13 Nowy sposób wytwarzania chlorku 2-metoksy-4-(N-t-butyloaminokarbonylo)-benzenosulfonylu
MXPA01013342A MXPA01013342A (es) 1999-07-15 2000-07-13 Metodo para la preparacion de cloruro de 2-metoxi-4-(n-t-butilamino-carbonil)-bencensulfonilo.
SI200030355T SI1202960T1 (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride
US10/030,655 US6548702B1 (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(N-t-butylamino-carbonyl)-benzenesulfonyl chloride
DE60008884T DE60008884T2 (de) 1999-07-15 2000-07-13 Verfahren zur herstellung von 2-methoxy-4-(n-t-butylamino-carbonyl)-benzolsulfonsaürechlorid
EP00949824A EP1202960B1 (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride
ES00949824T ES2215699T3 (es) 1999-07-15 2000-07-13 Proceso para la preparacion de cloruro de 2-metoxi-4-(n-t-butilaminocarbonil)bencenosulfonilo.
AU63083/00A AU6308300A (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride
PCT/HU2000/000080 WO2001005754A1 (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride
CZ2002146A CZ2002146A3 (cs) 1999-07-15 2000-07-13 Způsob přípravy 2-methoxy-4-(N-terc-butylaminokarbonyl)-benzensulfonylchloridu
HU0201573A HU225237B1 (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(t-butylamino-carbonyl)-benzenesulfonyl chloride
AT00949824T ATE261430T1 (de) 1999-07-15 2000-07-13 Verfahren zur herstellung von 2-methoxy-4-(n-t- butylamino-carbonyl)-benzolsulfonsaürechlorid
HR20020141A HRP20020141B1 (en) 1999-07-15 2002-02-14 METHOD FOR THE PREPARATION OF 2-METHOXY-4-(N-t-BUTYLAMINO-CARBONYL)-BENZENESULFONYL CHLORIDE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902375A HU225150B1 (en) 1999-07-15 1999-07-15 Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride

Publications (4)

Publication Number Publication Date
HU9902375D0 HU9902375D0 (en) 1999-10-28
HUP9902375A2 true HUP9902375A2 (hu) 2001-05-28
HUP9902375A3 HUP9902375A3 (en) 2002-11-28
HU225150B1 HU225150B1 (en) 2006-07-28

Family

ID=89998737

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902375A HU225150B1 (en) 1999-07-15 1999-07-15 Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride

Country Status (17)

Country Link
US (1) US6548702B1 (hu)
EP (1) EP1202960B1 (hu)
JP (1) JP4636761B2 (hu)
CN (1) CN1164571C (hu)
AT (1) ATE261430T1 (hu)
AU (1) AU6308300A (hu)
BR (1) BR0012430B1 (hu)
CA (1) CA2378337C (hu)
CZ (1) CZ2002146A3 (hu)
DE (1) DE60008884T2 (hu)
ES (1) ES2215699T3 (hu)
HR (1) HRP20020141B1 (hu)
HU (1) HU225150B1 (hu)
MX (1) MXPA01013342A (hu)
PL (1) PL199425B1 (hu)
SK (1) SK286031B6 (hu)
WO (1) WO2001005754A1 (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2240781T3 (es) * 2001-07-31 2005-10-16 Sanofi-Aventis Procedimiento para la preparacion de derivados de 3-spiro(ciclohexan-1,3'-(3h)indolin-2'-ona).
CN105621518A (zh) * 2015-12-29 2016-06-01 浙江奇彩环境科技股份有限公司 一种3,4-二氯苯磺酸废水的资源化处理方法
CN110372548A (zh) * 2018-04-12 2019-10-25 南京化学试剂股份有限公司 一种5-磺基水杨酸的精制方法
CN113402437B (zh) * 2021-06-29 2023-07-14 河北维达康生物科技有限公司 一种合成膳食补充剂褪黑素的新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953507A (en) * 1973-08-31 1976-04-27 Stauffer Chemical Company N-t-butyl-α-(3,5-substituted phenoxy) alkyl amides and their use as herbicides
FR2740136B1 (fr) * 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
CA2378337C (en) 2008-05-20
CZ2002146A3 (cs) 2002-11-13
CN1164571C (zh) 2004-09-01
CN1360569A (zh) 2002-07-24
HU225150B1 (en) 2006-07-28
ATE261430T1 (de) 2004-03-15
DE60008884T2 (de) 2005-02-03
BR0012430A (pt) 2002-03-26
AU6308300A (en) 2001-02-05
BR0012430B1 (pt) 2011-05-17
PL352466A1 (en) 2003-08-25
WO2001005754A1 (en) 2001-01-25
JP4636761B2 (ja) 2011-02-23
HRP20020141B1 (en) 2010-09-30
HU9902375D0 (en) 1999-10-28
ES2215699T3 (es) 2004-10-16
EP1202960B1 (en) 2004-03-10
EP1202960A1 (en) 2002-05-08
HRP20020141A2 (en) 2003-10-31
CA2378337A1 (en) 2001-01-25
MXPA01013342A (es) 2002-08-20
DE60008884D1 (de) 2004-04-15
SK286031B6 (sk) 2008-01-07
SK472002A3 (en) 2003-02-04
PL199425B1 (pl) 2008-09-30
HUP9902375A3 (en) 2002-11-28
US6548702B1 (en) 2003-04-15
JP2003505366A (ja) 2003-02-12

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