MXPA04000949A - Proceso para la preparacion de derivados de 3-espiroæciclohexam-1,3æ-æ3h!indolin-2æ-ona!. - Google Patents
Proceso para la preparacion de derivados de 3-espiroæciclohexam-1,3æ-æ3h!indolin-2æ-ona!.Info
- Publication number
- MXPA04000949A MXPA04000949A MXPA04000949A MXPA04000949A MXPA04000949A MX PA04000949 A MXPA04000949 A MX PA04000949A MX PA04000949 A MXPA04000949 A MX PA04000949A MX PA04000949 A MXPA04000949 A MX PA04000949A MX PA04000949 A MXPA04000949 A MX PA04000949A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- preparation
- cyclohexam
- indolin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000003444 phase transfer catalyst Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion se relaciona con un proceso para la preparacion de un compuesto de la formula (I) haciendo reaccionar un compuesto de la formula (II) con un compuesto de la formula (III), caracterizado porque se disuelven los compuestos de la formula (II) y de la formula (III) en un disolvente organico inmiscible en agua en presencia de un catalizador de transferencia de fase, y se hacen reaccionar con a) una solucion acuosa de una base, o b) una base en forma solida directamente, y si se desea, transformar el compuesto de formula (I) asi obtenido en su sal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0103122A HU0103122D0 (en) | 2001-07-31 | 2001-07-31 | Chemical process chemical process chemical process |
| HU0202193A HUP0202193A2 (hu) | 2002-07-04 | 2002-07-04 | Eljárás egy spiro[ciklohexán-1,3'-[3'H]indolin]-2'-on-származék előállítására |
| PCT/HU2002/000075 WO2003011827A1 (en) | 2001-07-31 | 2002-07-25 | Process for the preparation of 3-spiro'cyclohexam-1,3'-'3h!indolin-2'-one! derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04000949A true MXPA04000949A (es) | 2004-06-25 |
Family
ID=89980593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04000949A MXPA04000949A (es) | 2001-07-31 | 2002-07-25 | Proceso para la preparacion de derivados de 3-espiroæciclohexam-1,3æ-æ3h!indolin-2æ-ona!. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7619082B2 (es) |
| EP (1) | EP1421064B1 (es) |
| JP (1) | JP4520145B2 (es) |
| CN (1) | CN1243736C (es) |
| AT (1) | ATE295350T1 (es) |
| BR (1) | BR0211445A (es) |
| CA (1) | CA2453946C (es) |
| DE (1) | DE60204154T2 (es) |
| DK (1) | DK1421064T3 (es) |
| ES (1) | ES2240781T3 (es) |
| HR (1) | HRP20040200A2 (es) |
| MX (1) | MXPA04000949A (es) |
| PL (1) | PL205571B1 (es) |
| PT (1) | PT1421064E (es) |
| WO (1) | WO2003011827A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2740136B1 (fr) | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
| HU225150B1 (en) * | 1999-07-15 | 2006-07-28 | Sanofi Aventis | Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride |
| HUP9902376A3 (en) * | 1999-07-15 | 2002-11-28 | Sanofi Aventis | Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts |
-
2002
- 2002-07-25 JP JP2003517019A patent/JP4520145B2/ja not_active Expired - Fee Related
- 2002-07-25 CN CNB028150589A patent/CN1243736C/zh not_active Expired - Fee Related
- 2002-07-25 PT PT02755383T patent/PT1421064E/pt unknown
- 2002-07-25 PL PL367292A patent/PL205571B1/pl not_active IP Right Cessation
- 2002-07-25 DK DK02755383T patent/DK1421064T3/da active
- 2002-07-25 DE DE60204154T patent/DE60204154T2/de not_active Expired - Lifetime
- 2002-07-25 BR BR0211445-3A patent/BR0211445A/pt not_active IP Right Cessation
- 2002-07-25 EP EP02755383A patent/EP1421064B1/en not_active Expired - Lifetime
- 2002-07-25 CA CA002453946A patent/CA2453946C/en not_active Expired - Fee Related
- 2002-07-25 WO PCT/HU2002/000075 patent/WO2003011827A1/en active IP Right Grant
- 2002-07-25 ES ES02755383T patent/ES2240781T3/es not_active Expired - Lifetime
- 2002-07-25 US US10/485,133 patent/US7619082B2/en not_active Expired - Fee Related
- 2002-07-25 MX MXPA04000949A patent/MXPA04000949A/es active IP Right Grant
- 2002-07-25 AT AT02755383T patent/ATE295350T1/de not_active IP Right Cessation
-
2004
- 2004-02-27 HR HR20040200A patent/HRP20040200A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2240781T3 (es) | 2005-10-16 |
| BR0211445A (pt) | 2004-07-20 |
| PL205571B1 (pl) | 2010-05-31 |
| DE60204154T2 (de) | 2006-01-19 |
| ATE295350T1 (de) | 2005-05-15 |
| JP2005501053A (ja) | 2005-01-13 |
| EP1421064A1 (en) | 2004-05-26 |
| DK1421064T3 (da) | 2005-08-29 |
| PL367292A1 (en) | 2005-02-21 |
| DE60204154D1 (de) | 2005-06-16 |
| US7619082B2 (en) | 2009-11-17 |
| JP4520145B2 (ja) | 2010-08-04 |
| CN1537099A (zh) | 2004-10-13 |
| CA2453946A1 (en) | 2003-02-13 |
| US20040225124A1 (en) | 2004-11-11 |
| CA2453946C (en) | 2008-12-09 |
| PT1421064E (pt) | 2005-08-31 |
| CN1243736C (zh) | 2006-03-01 |
| HRP20040200A2 (en) | 2005-06-30 |
| EP1421064B1 (en) | 2005-05-11 |
| WO2003011827A1 (en) | 2003-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of company name or juridical status | ||
| FG | Grant or registration |