BR0012430A - Método papa a preparação de cloreto de 2-metóxi-4-(n-t-butilamino-carbonil)-benzenosulfoni la - Google Patents

Método papa a preparação de cloreto de 2-metóxi-4-(n-t-butilamino-carbonil)-benzenosulfoni la

Info

Publication number
BR0012430A
BR0012430A BR0012430-3A BR0012430A BR0012430A BR 0012430 A BR0012430 A BR 0012430A BR 0012430 A BR0012430 A BR 0012430A BR 0012430 A BR0012430 A BR 0012430A
Authority
BR
Brazil
Prior art keywords
acid
formula
chloride
methoxy
preparation
Prior art date
Application number
BR0012430-3A
Other languages
English (en)
Other versions
BR0012430B1 (pt
Inventor
Csaba Goenczi
Eva Csikos
Felix Hajdu
Istvan Hermecz
Gergely Heja
Gergelyne Heja
Lajos Nagy
Andrea Santane Csutor
Kalman Simon
Agota Smelkone
Tiborne Szomor
Gyoergyne Szvoboda
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR0012430A publication Critical patent/BR0012430A/pt
Publication of BR0012430B1 publication Critical patent/BR0012430B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/06—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with sulfuric acid or sulfur trioxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/57—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C07C309/60—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"MéTODO PARA A PREPARAçãO DE CLORETO DE 2-METóXI-4-(N-T-BUTILAMINO-CARBONIL)-BENZENOSULFONI LA". Processo para a preparação do cloreto de 2-metóxi-4-(N-t-butilaminocarbonil)-benzenosulfonila mediante a sulfonação do ácido m-hidroxibenzóico, metilação do grupo hidroxila do ácido sulfónico resultante ou de seu sal, transformação do grupo ácido carboxílico e do grupo ácido sulfónico para grupos cloretos ácidos e reagir o cloreto de 4-clorosulfonil-3-metoxibenzoíla com a t-butilamina, caracterizado pelo fato de que compreende realizar a sulfonação do ácido 3-metoxibenzóico de fórmula (II) com ácido sulfúrico 96%, separar o ácido 3-hidróxi-4-sulfobenzóico de fórmula (III) assim obtido, na forma de seu sal de fórmula geral (IV) , onde Z estabelece quanto a um metal alcalino ou um grupo amónio, metilar o composto de fórmula geral (IV) em presença de um catalisador de transferência de fase a um pH acima de 11,5 e transformar o sal mono do ácido 3-metóxi-4-sulfobenzóico de fórmula geral (V), onde o significado de Z é como definido acima, ao cloreto ácido de fórmula (VI), e reagir o composto de fórmula (VI), com a t-butilamina, usada em quantidade equimolar ou em um pequeno excesso, em presença de um agente ácido de ligação, em solvente aprótico, em baixa temperatura.
BRPI0012430-3A 1999-07-15 2000-07-13 método para a preparação de cloreto de 2-metóxi-4-(n-t-butilamino-carbonil)-benzenosulfoni la. BR0012430B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902375A HU225150B1 (en) 1999-07-15 1999-07-15 Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride
PCT/HU2000/000080 WO2001005754A1 (en) 1999-07-15 2000-07-13 Method for the preparation of 2-methoxy-4-(n-t-butylamino-carbonyl)-benzenesulfonyl chloride

Publications (2)

Publication Number Publication Date
BR0012430A true BR0012430A (pt) 2002-03-26
BR0012430B1 BR0012430B1 (pt) 2011-05-17

Family

ID=89998737

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0012430-3A BR0012430B1 (pt) 1999-07-15 2000-07-13 método para a preparação de cloreto de 2-metóxi-4-(n-t-butilamino-carbonil)-benzenosulfoni la.

Country Status (17)

Country Link
US (1) US6548702B1 (pt)
EP (1) EP1202960B1 (pt)
JP (1) JP4636761B2 (pt)
CN (1) CN1164571C (pt)
AT (1) ATE261430T1 (pt)
AU (1) AU6308300A (pt)
BR (1) BR0012430B1 (pt)
CA (1) CA2378337C (pt)
CZ (1) CZ2002146A3 (pt)
DE (1) DE60008884T2 (pt)
ES (1) ES2215699T3 (pt)
HR (1) HRP20020141B1 (pt)
HU (1) HU225150B1 (pt)
MX (1) MXPA01013342A (pt)
PL (1) PL199425B1 (pt)
SK (1) SK286031B6 (pt)
WO (1) WO2001005754A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL205571B1 (pl) * 2001-07-31 2010-05-31 Sanofi Synthelabo Sposób wytwarzania pochodnych 3-spiro-cykloheksano-1,3'- (3H) indolin-2'-onu
CN105621518A (zh) * 2015-12-29 2016-06-01 浙江奇彩环境科技股份有限公司 一种3,4-二氯苯磺酸废水的资源化处理方法
CN110372548A (zh) * 2018-04-12 2019-10-25 南京化学试剂股份有限公司 一种5-磺基水杨酸的精制方法
CN113402437B (zh) * 2021-06-29 2023-07-14 河北维达康生物科技有限公司 一种合成膳食补充剂褪黑素的新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953507A (en) 1973-08-31 1976-04-27 Stauffer Chemical Company N-t-butyl-α-(3,5-substituted phenoxy) alkyl amides and their use as herbicides
FR2740136B1 (fr) 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
HUP9902375A3 (en) 2002-11-28
CN1360569A (zh) 2002-07-24
HRP20020141A2 (en) 2003-10-31
JP4636761B2 (ja) 2011-02-23
CZ2002146A3 (cs) 2002-11-13
HUP9902375A2 (hu) 2001-05-28
US6548702B1 (en) 2003-04-15
CA2378337A1 (en) 2001-01-25
JP2003505366A (ja) 2003-02-12
EP1202960A1 (en) 2002-05-08
AU6308300A (en) 2001-02-05
SK286031B6 (sk) 2008-01-07
DE60008884T2 (de) 2005-02-03
EP1202960B1 (en) 2004-03-10
HRP20020141B1 (en) 2010-09-30
HU225150B1 (en) 2006-07-28
WO2001005754A1 (en) 2001-01-25
MXPA01013342A (es) 2002-08-20
PL199425B1 (pl) 2008-09-30
BR0012430B1 (pt) 2011-05-17
CN1164571C (zh) 2004-09-01
CA2378337C (en) 2008-05-20
ES2215699T3 (es) 2004-10-16
ATE261430T1 (de) 2004-03-15
HU9902375D0 (en) 1999-10-28
PL352466A1 (en) 2003-08-25
DE60008884D1 (de) 2004-04-15
SK472002A3 (en) 2003-02-04

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B25G Requested change of headquarter approved
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Owner name: SANOFI-AVENTIS (FR)

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
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