HUP0401458A2 - Eljárás 4-metilamino-4-fenilpiperidin előállítására - Google Patents
Eljárás 4-metilamino-4-fenilpiperidin előállításáraInfo
- Publication number
- HUP0401458A2 HUP0401458A2 HU0401458A HUP0401458A HUP0401458A2 HU P0401458 A2 HUP0401458 A2 HU P0401458A2 HU 0401458 A HU0401458 A HU 0401458A HU P0401458 A HUP0401458 A HU P0401458A HU P0401458 A2 HUP0401458 A2 HU P0401458A2
- Authority
- HU
- Hungary
- Prior art keywords
- phenylpiperidine
- benzyl
- methylamino
- formula
- preparing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- UORMPYQLQRCWRN-UHFFFAOYSA-N n-methyl-4-phenylpiperidin-4-amine Chemical compound C=1C=CC=CC=1C1(NC)CCNCC1 UORMPYQLQRCWRN-UHFFFAOYSA-N 0.000 title abstract 2
- AUBONLVMDCVPQE-UHFFFAOYSA-N 1-benzyl-4-phenylpiperidine-4-carbonitrile Chemical compound C1CC(C#N)(C=2C=CC=CC=2)CCN1CC1=CC=CC=C1 AUBONLVMDCVPQE-UHFFFAOYSA-N 0.000 abstract 1
- LTUVVZKXVNALKM-UHFFFAOYSA-N 1-benzyl-4-phenylpiperidine-4-carboxamide Chemical compound C1CC(C(=O)N)(C=2C=CC=CC=2)CCN1CC1=CC=CC=C1 LTUVVZKXVNALKM-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal alkoxide Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány (I) általános képletű 4-alkoxikarbonilamino-l-benzil-4-fenilpiperidin előállítására alkalmas eljárásra vonatkozik, amelyszerint a (II) képletű 1-benzil-4-ciano-4fenilpiperidint savasközegben hidrolizálják, és a hidrolízissel kapott 1-benzil-4-fenil-4-piperidinkarboxamidot alkálífémalkoxid jelenlétében brómmalreagáltatják. A találmány tárgyát képezi a 4-metilamino-4-fenilpiperidin (II) képletű vegyületből való előállítására alkalmaseljárás is. Alk jelentése 1-3 szénatomos alkilcsoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0109575A FR2827281B1 (fr) | 2001-07-16 | 2001-07-16 | Procede pour la preparation de la 4-methylamino-4-phenylpiperidine |
| PCT/FR2002/002498 WO2003008381A1 (fr) | 2001-07-16 | 2002-07-15 | Procede pour la preparation de la 4-methylamino-4-phenylpiperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0401458A2 true HUP0401458A2 (hu) | 2004-12-28 |
Family
ID=8865643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401458A HUP0401458A2 (hu) | 2001-07-16 | 2002-07-15 | Eljárás 4-metilamino-4-fenilpiperidin előállítására |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6916929B2 (hu) |
| EP (1) | EP1409457B1 (hu) |
| JP (1) | JP4307996B2 (hu) |
| CN (1) | CN1254467C (hu) |
| AT (1) | ATE334963T1 (hu) |
| BR (1) | BR0211135A (hu) |
| CA (1) | CA2450362A1 (hu) |
| DE (1) | DE60213603T2 (hu) |
| ES (1) | ES2269766T3 (hu) |
| FR (1) | FR2827281B1 (hu) |
| HR (1) | HRP20040032A2 (hu) |
| HU (1) | HUP0401458A2 (hu) |
| MX (1) | MXPA04000513A (hu) |
| PL (1) | PL368938A1 (hu) |
| WO (1) | WO2003008381A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2305666B1 (en) * | 2004-07-30 | 2014-06-25 | AbbVie Inc. | Preparation of pyridonecarboxylic acid antibacterials |
| US7576216B2 (en) | 2004-07-30 | 2009-08-18 | Abbott Laboratories | Preparation of pyridonecarboxylic acid antibacterials |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
-
2001
- 2001-07-16 FR FR0109575A patent/FR2827281B1/fr not_active Expired - Fee Related
-
2002
- 2002-07-15 US US10/483,475 patent/US6916929B2/en not_active Expired - Fee Related
- 2002-07-15 DE DE60213603T patent/DE60213603T2/de not_active Expired - Lifetime
- 2002-07-15 WO PCT/FR2002/002498 patent/WO2003008381A1/fr active IP Right Grant
- 2002-07-15 EP EP02770025A patent/EP1409457B1/fr not_active Expired - Lifetime
- 2002-07-15 CA CA002450362A patent/CA2450362A1/en not_active Abandoned
- 2002-07-15 BR BR0211135-7A patent/BR0211135A/pt not_active IP Right Cessation
- 2002-07-15 AT AT02770025T patent/ATE334963T1/de not_active IP Right Cessation
- 2002-07-15 HU HU0401458A patent/HUP0401458A2/hu unknown
- 2002-07-15 JP JP2003513941A patent/JP4307996B2/ja not_active Expired - Fee Related
- 2002-07-15 CN CNB028140966A patent/CN1254467C/zh not_active Expired - Fee Related
- 2002-07-15 ES ES02770025T patent/ES2269766T3/es not_active Expired - Lifetime
- 2002-07-15 MX MXPA04000513A patent/MXPA04000513A/es not_active Application Discontinuation
- 2002-07-15 PL PL02368938A patent/PL368938A1/xx unknown
-
2004
- 2004-01-14 HR HR20040032A patent/HRP20040032A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL368938A1 (en) | 2005-04-04 |
| BR0211135A (pt) | 2004-06-29 |
| EP1409457B1 (fr) | 2006-08-02 |
| JP4307996B2 (ja) | 2009-08-05 |
| DE60213603T2 (de) | 2007-10-11 |
| JP2004536130A (ja) | 2004-12-02 |
| CN1527817A (zh) | 2004-09-08 |
| CN1254467C (zh) | 2006-05-03 |
| CA2450362A1 (en) | 2003-01-30 |
| FR2827281A1 (fr) | 2003-01-17 |
| US20040181071A1 (en) | 2004-09-16 |
| US6916929B2 (en) | 2005-07-12 |
| DE60213603D1 (de) | 2006-09-14 |
| EP1409457A1 (fr) | 2004-04-21 |
| ATE334963T1 (de) | 2006-08-15 |
| WO2003008381A1 (fr) | 2003-01-30 |
| MXPA04000513A (es) | 2004-07-23 |
| FR2827281B1 (fr) | 2003-12-19 |
| HRP20040032A2 (en) | 2004-06-30 |
| ES2269766T3 (es) | 2007-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |