HUP0401600A2 - Eljárás 14-hidroximorfin-származékok előállítására - Google Patents

Eljárás 14-hidroximorfin-származékok előállítására

Info

Publication number
HUP0401600A2
HUP0401600A2 HU0401600A HUP0401600A HUP0401600A2 HU P0401600 A2 HUP0401600 A2 HU P0401600A2 HU 0401600 A HU0401600 A HU 0401600A HU P0401600 A HUP0401600 A HU P0401600A HU P0401600 A2 HUP0401600 A2 HU P0401600A2
Authority
HU
Hungary
Prior art keywords
benzyl
hydroxymorphine
derivatives
preparation
production
Prior art date
Application number
HU0401600A
Other languages
English (en)
Inventor
Joannes Theodorus Maria Linders
Pieter Vrijhof
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of HUP0401600A2 publication Critical patent/HUP0401600A2/hu
Publication of HUP0401600A3 publication Critical patent/HUP0401600A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Abstract

A találmány tárgya eljárás egy (IV) általános képletű 14-hidroxinormorfinon előállítására. A találmány szerinti eljárást úgyvégzik, hogy a (III) általános képletű vegyületet egy kobalt(II)-oxidálószerrel egy enyhe bázis jelenlétében és társ-oxidálószerkéntlevegő vagy oxigén jelenlétében reagáltatják; ahol képletben RIjelentése 1-7 szénatomos alkilcsoport, ami adott esetben egy vagy többklóratommal, butenil-, vinil-, benzil-, fenil- vagy naftilcsoporttalhelyettesített; és R2 jelentése benzilcsoport vagy egy vagy több 1-6szénatomos alkoxicsoporttal helyettesített benzilcsoport vagy egy vagytöbb halogénatommal helyettesített benzilcsoport. A találmány tárgyátképezik továbbá a találmány szerinti eljárásban alkalmazottintermedierek és eljárás azok előállítására. Ó
HU0401600A 2001-08-23 2002-08-15 Process for the preparation of 14-hydroxymorphine derivatives HUP0401600A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01203187 2001-08-23
PCT/EP2002/009280 WO2003018588A2 (en) 2001-08-23 2002-08-15 Process for the preparation of a 14-hydroxynormorphinone derivative

Publications (2)

Publication Number Publication Date
HUP0401600A2 true HUP0401600A2 (hu) 2004-11-29
HUP0401600A3 HUP0401600A3 (en) 2008-05-28

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401600A HUP0401600A3 (en) 2001-08-23 2002-08-15 Process for the preparation of 14-hydroxymorphine derivatives

Country Status (26)

Country Link
US (1) US7435817B2 (hu)
EP (1) EP1421085B1 (hu)
JP (1) JP4559730B2 (hu)
KR (1) KR100901402B1 (hu)
CN (1) CN1271072C (hu)
AR (1) AR035289A1 (hu)
AT (1) ATE466016T1 (hu)
AU (1) AU2002331163B2 (hu)
BR (1) BRPI0211899B8 (hu)
CA (1) CA2457671C (hu)
DE (1) DE60236171D1 (hu)
EC (1) ECSP044984A (hu)
ES (1) ES2345327T3 (hu)
HK (1) HK1063803A1 (hu)
HR (1) HRP20040161A2 (hu)
HU (1) HUP0401600A3 (hu)
IL (1) IL160193A0 (hu)
IS (1) IS7153A (hu)
MX (1) MXPA04001647A (hu)
NO (1) NO328655B1 (hu)
NZ (1) NZ531152A (hu)
PE (1) PE20030460A1 (hu)
PL (1) PL368732A1 (hu)
RU (1) RU2297419C2 (hu)
WO (1) WO2003018588A2 (hu)
ZA (1) ZA200401016B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1893616B1 (en) 2005-06-16 2010-12-29 Mallinckrodt, Inc. A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
PL2125824T3 (pl) * 2007-03-23 2014-05-30 SpecGx LLC Ulepszony sposób wytwarzania oksymorfonu z oripawiny
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
MX2009010931A (es) 2007-04-16 2009-10-29 Mallinckrodt Inc Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
NZ586187A (en) * 2007-12-17 2013-07-26 Mallinckrodt Llc Processes for the synthesis of sinomenine derivatives and their intermediate
WO2009078990A1 (en) 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of n-methyl morphinans
WO2009078987A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Process and compounds for the production of (+) opiates
NZ603170A (en) 2010-05-10 2015-04-24 Euro Celtique Sa Combination of active loaded granules with additional actives
ES2408343B2 (es) 2010-05-10 2014-07-17 Euro-Celtique, Sa Composiciones farmacéuticas que comprenden hidromorfona y naloxona
ES2642788T3 (es) 2010-05-10 2017-11-20 Euro-Celtique S.A. Fabricación de gránulos sin principio activo y de comprimidos que comprenden los mismos
ES2666404T3 (es) 2010-06-11 2018-05-04 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
CA2845187A1 (en) 2011-09-08 2013-03-14 Peter X. Wang Production of alkaloids without the isolation of intermediates
EP3027622B8 (en) * 2013-08-02 2019-06-12 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
KR102194174B1 (ko) 2013-11-13 2020-12-23 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
FR2562072B1 (fr) 1984-03-27 1989-07-07 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
WO2000066588A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
ZA200401016B (en) 2004-10-19
HRP20040161A2 (en) 2004-06-30
BR0211899B1 (pt) 2014-01-21
NO20040724L (no) 2004-02-19
IL160193A0 (en) 2004-07-25
NO328655B1 (no) 2010-04-19
IS7153A (is) 2004-02-13
EP1421085B1 (en) 2010-04-28
HK1063803A1 (en) 2005-01-14
AU2002331163B2 (en) 2008-02-21
WO2003018588A3 (en) 2003-11-27
HUP0401600A3 (en) 2008-05-28
KR100901402B1 (ko) 2009-06-05
DE60236171D1 (de) 2010-06-10
NZ531152A (en) 2005-11-25
WO2003018588B1 (en) 2004-02-26
JP2005502670A (ja) 2005-01-27
AR035289A1 (es) 2004-05-05
RU2004108210A (ru) 2005-04-10
PE20030460A1 (es) 2003-05-15
EP1421085A2 (en) 2004-05-26
US7435817B2 (en) 2008-10-14
US20050038250A1 (en) 2005-02-17
PL368732A1 (en) 2005-04-04
BRPI0211899B8 (pt) 2021-05-25
WO2003018588A2 (en) 2003-03-06
JP4559730B2 (ja) 2010-10-13
ES2345327T3 (es) 2010-09-21
RU2297419C2 (ru) 2007-04-20
CN1271072C (zh) 2006-08-23
ATE466016T1 (de) 2010-05-15
KR20040027950A (ko) 2004-04-01
BR0211899A (pt) 2004-09-21
MXPA04001647A (es) 2004-05-31
CA2457671A1 (en) 2003-03-06
ECSP044984A (es) 2004-04-28
CN1545517A (zh) 2004-11-10
CA2457671C (en) 2011-02-15

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: N.V. ORGANON, NL

Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL

FD9A Lapse of provisional protection due to non-payment of fees