HUP0401600A3 - Process for the preparation of 14-hydroxymorphine derivatives - Google Patents
Process for the preparation of 14-hydroxymorphine derivativesInfo
- Publication number
- HUP0401600A3 HUP0401600A3 HU0401600A HUP0401600A HUP0401600A3 HU P0401600 A3 HUP0401600 A3 HU P0401600A3 HU 0401600 A HU0401600 A HU 0401600A HU P0401600 A HUP0401600 A HU P0401600A HU P0401600 A3 HUP0401600 A3 HU P0401600A3
- Authority
- HU
- Hungary
- Prior art keywords
- hydroxymorphine
- derivatives
- preparation
- hydroxymorphine derivatives
- Prior art date
Links
- WYMBHLXUDPDGQJ-BRJGLHKUSA-N (4r,4as,7s,7ar,12bs)-3-methyl-1,2,4,7,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol Chemical class O([C@H]1[C@H](C=C[C@]23O)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WYMBHLXUDPDGQJ-BRJGLHKUSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203187 | 2001-08-23 | ||
| PCT/EP2002/009280 WO2003018588A2 (en) | 2001-08-23 | 2002-08-15 | Process for the preparation of a 14-hydroxynormorphinone derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401600A2 HUP0401600A2 (hu) | 2004-11-29 |
| HUP0401600A3 true HUP0401600A3 (en) | 2008-05-28 |
Family
ID=8180821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401600A HUP0401600A3 (en) | 2001-08-23 | 2002-08-15 | Process for the preparation of 14-hydroxymorphine derivatives |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7435817B2 (hu) |
| EP (1) | EP1421085B1 (hu) |
| JP (1) | JP4559730B2 (hu) |
| KR (1) | KR100901402B1 (hu) |
| CN (1) | CN1271072C (hu) |
| AR (1) | AR035289A1 (hu) |
| AT (1) | ATE466016T1 (hu) |
| AU (1) | AU2002331163B2 (hu) |
| BR (1) | BRPI0211899B8 (hu) |
| CA (1) | CA2457671C (hu) |
| DE (1) | DE60236171D1 (hu) |
| EC (1) | ECSP044984A (hu) |
| ES (1) | ES2345327T3 (hu) |
| HK (1) | HK1063803A1 (hu) |
| HR (1) | HRP20040161A2 (hu) |
| HU (1) | HUP0401600A3 (hu) |
| IL (1) | IL160193A0 (hu) |
| IS (1) | IS7153A (hu) |
| MX (1) | MXPA04001647A (hu) |
| NO (1) | NO328655B1 (hu) |
| NZ (1) | NZ531152A (hu) |
| PE (1) | PE20030460A1 (hu) |
| PL (1) | PL368732A1 (hu) |
| RU (1) | RU2297419C2 (hu) |
| WO (1) | WO2003018588A2 (hu) |
| ZA (1) | ZA200401016B (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2610859C (en) | 2005-06-16 | 2013-11-12 | Peter Xianqi Wang | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
| EP2125824B2 (en) * | 2007-03-23 | 2023-11-15 | Mallinckrodt LLC | Improved preparation of oxymorphone from oripavine |
| CN101033228B (zh) * | 2007-04-04 | 2010-05-19 | 复旦大学 | 14-羟基-7,8-二氢降吗啡酮的制备方法 |
| WO2008130553A1 (en) | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
| CA2709862C (en) * | 2007-12-17 | 2016-03-15 | Peter X. Wang | Sinomenine derivatives and processes for their synthesis |
| CN101896487A (zh) | 2007-12-17 | 2010-11-24 | 马林克罗特公司 | N-甲基吗啡喃的n-脱甲基化 |
| EP2222642B1 (en) * | 2007-12-17 | 2014-02-12 | Mallinckrodt LLC | Process and compounds for the production of (+) opiates |
| CH705273B1 (de) | 2010-05-10 | 2016-06-15 | Euro Celtique Sa | Pharmazeutische Zusammensetzung – umfassend Hydromorphon und Naloxon. |
| AU2011252040C1 (en) | 2010-05-10 | 2015-04-02 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| CN103002881B (zh) | 2010-05-10 | 2015-09-02 | 欧洲凯尔特公司 | 载有活性剂的颗粒与额外活性剂的组合 |
| CA2802295C (en) | 2010-06-11 | 2016-09-20 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| WO2013036729A1 (en) | 2011-09-08 | 2013-03-14 | Mallinckrodt Llc | Production of alkaloids without the isolation of intermediates |
| BR112016002079A2 (pt) * | 2013-08-02 | 2017-09-05 | Johnson Matthey Plc | Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido |
| UA116405C2 (uk) | 2013-11-13 | 2018-03-12 | Євро-Селтік С.А. | Гідроморфон та налоксон для лікування болю та синдрому опіоїдної дисфункції кишечнику |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
| IT1199871B (it) | 1984-03-27 | 1989-01-05 | Mallinckrodt Inc | Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| WO2000066588A1 (en) * | 1999-05-05 | 2000-11-09 | The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services | Direct c-14 oxidation of opioids |
-
2002
- 2002-08-15 EP EP02767405A patent/EP1421085B1/en not_active Expired - Lifetime
- 2002-08-15 IL IL16019302A patent/IL160193A0/xx unknown
- 2002-08-15 RU RU2004108210/04A patent/RU2297419C2/ru active
- 2002-08-15 PL PL02368732A patent/PL368732A1/xx not_active Application Discontinuation
- 2002-08-15 ES ES02767405T patent/ES2345327T3/es not_active Expired - Lifetime
- 2002-08-15 AT AT02767405T patent/ATE466016T1/de active
- 2002-08-15 DE DE60236171T patent/DE60236171D1/de not_active Expired - Lifetime
- 2002-08-15 CA CA2457671A patent/CA2457671C/en not_active Expired - Lifetime
- 2002-08-15 AU AU2002331163A patent/AU2002331163B2/en not_active Expired
- 2002-08-15 BR BRPI0211899A patent/BRPI0211899B8/pt not_active IP Right Cessation
- 2002-08-15 WO PCT/EP2002/009280 patent/WO2003018588A2/en active IP Right Grant
- 2002-08-15 US US10/487,884 patent/US7435817B2/en not_active Expired - Lifetime
- 2002-08-15 JP JP2003523248A patent/JP4559730B2/ja not_active Expired - Lifetime
- 2002-08-15 NZ NZ531152A patent/NZ531152A/en not_active IP Right Cessation
- 2002-08-15 MX MXPA04001647A patent/MXPA04001647A/es active IP Right Grant
- 2002-08-15 CN CNB028163524A patent/CN1271072C/zh not_active Expired - Lifetime
- 2002-08-15 KR KR1020047002513A patent/KR100901402B1/ko not_active IP Right Cessation
- 2002-08-15 HU HU0401600A patent/HUP0401600A3/hu unknown
- 2002-08-21 PE PE2002000800A patent/PE20030460A1/es not_active Application Discontinuation
- 2002-08-21 AR ARP020103130A patent/AR035289A1/es active IP Right Grant
-
2004
- 2004-02-06 ZA ZA200401016A patent/ZA200401016B/en unknown
- 2004-02-13 IS IS7153A patent/IS7153A/is unknown
- 2004-02-19 HR HR20040161A patent/HRP20040161A2/xx not_active Application Discontinuation
- 2004-02-19 NO NO20040724A patent/NO328655B1/no not_active IP Right Cessation
- 2004-02-19 EC EC2004004984A patent/ECSP044984A/es unknown
- 2004-09-06 HK HK04106705.9A patent/HK1063803A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: N.V. ORGANON, NL Free format text: FORMER OWNER(S): AKZO NOBEL N.V., NL |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |