ATE466016T1 - Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivats - Google Patents
Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivatsInfo
- Publication number
- ATE466016T1 ATE466016T1 AT02767405T AT02767405T ATE466016T1 AT E466016 T1 ATE466016 T1 AT E466016T1 AT 02767405 T AT02767405 T AT 02767405T AT 02767405 T AT02767405 T AT 02767405T AT E466016 T1 ATE466016 T1 AT E466016T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- hydroxynormorphinone derivative
- hydroxynormorphinone
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203187 | 2001-08-23 | ||
| PCT/EP2002/009280 WO2003018588A2 (en) | 2001-08-23 | 2002-08-15 | Process for the preparation of a 14-hydroxynormorphinone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466016T1 true ATE466016T1 (de) | 2010-05-15 |
Family
ID=8180821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02767405T ATE466016T1 (de) | 2001-08-23 | 2002-08-15 | Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivats |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7435817B2 (de) |
| EP (1) | EP1421085B1 (de) |
| JP (1) | JP4559730B2 (de) |
| KR (1) | KR100901402B1 (de) |
| CN (1) | CN1271072C (de) |
| AR (1) | AR035289A1 (de) |
| AT (1) | ATE466016T1 (de) |
| AU (1) | AU2002331163B2 (de) |
| BR (1) | BRPI0211899B8 (de) |
| CA (1) | CA2457671C (de) |
| DE (1) | DE60236171D1 (de) |
| EC (1) | ECSP044984A (de) |
| ES (1) | ES2345327T3 (de) |
| HK (1) | HK1063803A1 (de) |
| HR (1) | HRP20040161A2 (de) |
| HU (1) | HUP0401600A3 (de) |
| IL (1) | IL160193A0 (de) |
| IS (1) | IS7153A (de) |
| MX (1) | MXPA04001647A (de) |
| NO (1) | NO328655B1 (de) |
| NZ (1) | NZ531152A (de) |
| PE (1) | PE20030460A1 (de) |
| PL (1) | PL368732A1 (de) |
| RU (1) | RU2297419C2 (de) |
| WO (1) | WO2003018588A2 (de) |
| ZA (1) | ZA200401016B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008546688A (ja) | 2005-06-16 | 2008-12-25 | マリンクロッド・インコーポレイテッド | １−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路 |
| WO2008118654A1 (en) * | 2007-03-23 | 2008-10-02 | Mallinckrodt Inc. | Improved preparation of oxymorphone from oripavine |
| CN101033228B (zh) * | 2007-04-04 | 2010-05-19 | 复旦大学 | 14-羟基-7,8-二氢降吗啡酮的制备方法 |
| MX2009010931A (es) | 2007-04-16 | 2009-10-29 | Mallinckrodt Inc | Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno. |
| JP2011506605A (ja) | 2007-12-17 | 2011-03-03 | マリンクロッド・インコーポレイテッド | Ｎ−メチルモルフィナンのｎ−脱メチル化 |
| CA2709858C (en) * | 2007-12-17 | 2016-03-29 | Peter X. Wang | Process and compounds for the production of (+)opiates |
| PL2222643T3 (pl) * | 2007-12-17 | 2019-12-31 | SpecGx LLC | Pochodne synomeniny i sposób ich wytwarzania |
| PE20130657A1 (es) | 2010-05-10 | 2013-06-15 | Euro Celtique Sa | Composiciones farmaceuticas que comprenden hidromorfona y naloxona |
| EP2568968B1 (de) | 2010-05-10 | 2017-07-12 | Euro-Celtique S.A. | Herstellung von Wirkstoff-freiem Granulat und dieses enthaltende Tabletten |
| JP5840201B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス．エイ． | 活性剤を負荷した顆粒と追加の活性剤の組合せ |
| TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| ES2666404T3 (es) | 2010-06-11 | 2018-05-04 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
| CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
| EP3027622B8 (de) * | 2013-08-02 | 2019-06-12 | Johnson Matthey Public Limited Company | Verfahren zur herstellung von oxymorphon |
| JP6232135B2 (ja) | 2013-11-13 | 2017-11-15 | ユーロ−セルティーク エス．エイ． | 疼痛およびオピオイドによる腸機能障害症候群の治療のためのヒドロモルホンおよびナロキソン |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
| DE3581423D1 (de) | 1984-03-27 | 1991-02-28 | Mallinckrodt Inc | Herstellung von noroxymorphon aus morphin. |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| AU4823900A (en) * | 1999-05-05 | 2000-11-17 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Direct c-14 oxidation of opioids |
-
2002
- 2002-08-15 KR KR1020047002513A patent/KR100901402B1/ko not_active IP Right Cessation
- 2002-08-15 HU HU0401600A patent/HUP0401600A3/hu unknown
- 2002-08-15 BR BRPI0211899A patent/BRPI0211899B8/pt not_active IP Right Cessation
- 2002-08-15 JP JP2003523248A patent/JP4559730B2/ja not_active Expired - Lifetime
- 2002-08-15 MX MXPA04001647A patent/MXPA04001647A/es active IP Right Grant
- 2002-08-15 NZ NZ531152A patent/NZ531152A/en not_active IP Right Cessation
- 2002-08-15 CA CA2457671A patent/CA2457671C/en not_active Expired - Lifetime
- 2002-08-15 AT AT02767405T patent/ATE466016T1/de active
- 2002-08-15 ES ES02767405T patent/ES2345327T3/es not_active Expired - Lifetime
- 2002-08-15 PL PL02368732A patent/PL368732A1/xx not_active Application Discontinuation
- 2002-08-15 US US10/487,884 patent/US7435817B2/en not_active Expired - Lifetime
- 2002-08-15 WO PCT/EP2002/009280 patent/WO2003018588A2/en active IP Right Grant
- 2002-08-15 DE DE60236171T patent/DE60236171D1/de not_active Expired - Lifetime
- 2002-08-15 RU RU2004108210/04A patent/RU2297419C2/ru active
- 2002-08-15 IL IL16019302A patent/IL160193A0/xx unknown
- 2002-08-15 CN CNB028163524A patent/CN1271072C/zh not_active Expired - Lifetime
- 2002-08-15 EP EP02767405A patent/EP1421085B1/de not_active Expired - Lifetime
- 2002-08-15 AU AU2002331163A patent/AU2002331163B2/en not_active Expired
- 2002-08-21 AR ARP020103130A patent/AR035289A1/es active IP Right Grant
- 2002-08-21 PE PE2002000800A patent/PE20030460A1/es not_active Application Discontinuation
-
2004
- 2004-02-06 ZA ZA200401016A patent/ZA200401016B/en unknown
- 2004-02-13 IS IS7153A patent/IS7153A/is unknown
- 2004-02-19 NO NO20040724A patent/NO328655B1/no not_active IP Right Cessation
- 2004-02-19 EC EC2004004984A patent/ECSP044984A/es unknown
- 2004-02-19 HR HR20040161A patent/HRP20040161A2/xx not_active Application Discontinuation
- 2004-09-06 HK HK04106705.9A patent/HK1063803A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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