ATE466016T1 - Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivats - Google Patents
Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivatsInfo
- Publication number
- ATE466016T1 ATE466016T1 AT02767405T AT02767405T ATE466016T1 AT E466016 T1 ATE466016 T1 AT E466016T1 AT 02767405 T AT02767405 T AT 02767405T AT 02767405 T AT02767405 T AT 02767405T AT E466016 T1 ATE466016 T1 AT E466016T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- hydroxynormorphinone derivative
- hydroxynormorphinone
- derivative
- Prior art date
Links
- WJZVCRUPHQAKSZ-IPOQPSJVSA-N (4r,4as,7ar,12bs)-4a,9-dihydroxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical class O=C([C@@H]1O2)C=C[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 WJZVCRUPHQAKSZ-IPOQPSJVSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203187 | 2001-08-23 | ||
| PCT/EP2002/009280 WO2003018588A2 (en) | 2001-08-23 | 2002-08-15 | Process for the preparation of a 14-hydroxynormorphinone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466016T1 true ATE466016T1 (de) | 2010-05-15 |
Family
ID=8180821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02767405T ATE466016T1 (de) | 2001-08-23 | 2002-08-15 | Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivats |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7435817B2 (de) |
| EP (1) | EP1421085B1 (de) |
| JP (1) | JP4559730B2 (de) |
| KR (1) | KR100901402B1 (de) |
| CN (1) | CN1271072C (de) |
| AR (1) | AR035289A1 (de) |
| AT (1) | ATE466016T1 (de) |
| AU (1) | AU2002331163B2 (de) |
| BR (1) | BRPI0211899B8 (de) |
| CA (1) | CA2457671C (de) |
| DE (1) | DE60236171D1 (de) |
| EC (1) | ECSP044984A (de) |
| ES (1) | ES2345327T3 (de) |
| HR (1) | HRP20040161A2 (de) |
| HU (1) | HUP0401600A3 (de) |
| IL (1) | IL160193A0 (de) |
| IS (1) | IS7153A (de) |
| MX (1) | MXPA04001647A (de) |
| NO (1) | NO328655B1 (de) |
| NZ (1) | NZ531152A (de) |
| PE (1) | PE20030460A1 (de) |
| PL (1) | PL368732A1 (de) |
| RU (1) | RU2297419C2 (de) |
| WO (1) | WO2003018588A2 (de) |
| ZA (1) | ZA200401016B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006126529A1 (ja) * | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| ATE493417T1 (de) | 2005-06-16 | 2011-01-15 | Mallinckrodt Inc | Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga |
| JP2010522189A (ja) * | 2007-03-23 | 2010-07-01 | マリンクロッド・インコーポレイテッド | オリパビンからのオキシモルホンの改善された調製 |
| CN101033228B (zh) * | 2007-04-04 | 2010-05-19 | 复旦大学 | 14-羟基-7,8-二氢降吗啡酮的制备方法 |
| MX2009010931A (es) | 2007-04-16 | 2009-10-29 | Mallinckrodt Inc | Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno. |
| EP2222642B1 (de) * | 2007-12-17 | 2014-02-12 | Mallinckrodt LLC | Verfahren und verbindungen zur herstellung von (+) opiaten |
| WO2009078988A1 (en) * | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | Sinomenine derivatives and processes for their synthesis |
| WO2009078990A1 (en) | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | N-demethylation of n-methyl morphinans |
| CN102946870A (zh) | 2010-05-10 | 2013-02-27 | 欧洲凯尔特公司 | 包含氢吗啡酮和纳洛酮的药物组合物 |
| BR112012028788A2 (pt) | 2010-05-10 | 2016-07-19 | Euro Celtique Sa | fabricação de grânulos sem ativos |
| JP5840201B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス．エイ． | 活性剤を負荷した顆粒と追加の活性剤の組合せ |
| TWI471289B (zh) | 2010-06-11 | 2015-02-01 | Rhodes Technologies | 使三級胺進行ｎ－脫烷反應之方法 |
| AU2011263417B2 (en) | 2010-06-11 | 2014-03-27 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof |
| AU2012304484B2 (en) | 2011-09-08 | 2016-07-28 | SpecGx LLC | Production of alkaloids without the isolation of intermediates |
| RU2637934C2 (ru) * | 2013-08-02 | 2017-12-08 | Джонсон Мэтти Паблик Лимитед Компани | Способ получения оксиморфона |
| CA2929909C (en) | 2013-11-13 | 2018-08-21 | Euro-Celtique S.A. | Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3581423D1 (de) | 1984-03-27 | 1991-02-28 | Mallinckrodt Inc | Herstellung von noroxymorphon aus morphin. |
| US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| WO2000066588A1 (en) * | 1999-05-05 | 2000-11-09 | The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services | Direct c-14 oxidation of opioids |
-
2002
- 2002-08-15 BR BRPI0211899A patent/BRPI0211899B8/pt not_active IP Right Cessation
- 2002-08-15 RU RU2004108210/04A patent/RU2297419C2/ru active
- 2002-08-15 KR KR1020047002513A patent/KR100901402B1/ko not_active Expired - Fee Related
- 2002-08-15 MX MXPA04001647A patent/MXPA04001647A/es active IP Right Grant
- 2002-08-15 CN CNB028163524A patent/CN1271072C/zh not_active Expired - Lifetime
- 2002-08-15 IL IL16019302A patent/IL160193A0/xx unknown
- 2002-08-15 EP EP02767405A patent/EP1421085B1/de not_active Expired - Lifetime
- 2002-08-15 PL PL02368732A patent/PL368732A1/xx not_active Application Discontinuation
- 2002-08-15 HU HU0401600A patent/HUP0401600A3/hu unknown
- 2002-08-15 NZ NZ531152A patent/NZ531152A/en not_active IP Right Cessation
- 2002-08-15 HR HR20040161A patent/HRP20040161A2/xx not_active Application Discontinuation
- 2002-08-15 WO PCT/EP2002/009280 patent/WO2003018588A2/en not_active Ceased
- 2002-08-15 DE DE60236171T patent/DE60236171D1/de not_active Expired - Lifetime
- 2002-08-15 ES ES02767405T patent/ES2345327T3/es not_active Expired - Lifetime
- 2002-08-15 AU AU2002331163A patent/AU2002331163B2/en not_active Expired
- 2002-08-15 CA CA2457671A patent/CA2457671C/en not_active Expired - Lifetime
- 2002-08-15 US US10/487,884 patent/US7435817B2/en not_active Expired - Lifetime
- 2002-08-15 AT AT02767405T patent/ATE466016T1/de active
- 2002-08-15 JP JP2003523248A patent/JP4559730B2/ja not_active Expired - Lifetime
- 2002-08-21 PE PE2002000800A patent/PE20030460A1/es not_active Application Discontinuation
- 2002-08-21 AR ARP020103130A patent/AR035289A1/es active IP Right Grant
-
2004
- 2004-02-06 ZA ZA200401016A patent/ZA200401016B/en unknown
- 2004-02-13 IS IS7153A patent/IS7153A/is unknown
- 2004-02-19 NO NO20040724A patent/NO328655B1/no not_active IP Right Cessation
- 2004-02-19 EC EC2004004984A patent/ECSP044984A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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