EP1421085A2 - Verfahren for zur herstellung eines 14-hydroxynormorphinon-derivats - Google Patents
Verfahren for zur herstellung eines 14-hydroxynormorphinon-derivatsInfo
- Publication number
- EP1421085A2 EP1421085A2 EP02767405A EP02767405A EP1421085A2 EP 1421085 A2 EP1421085 A2 EP 1421085A2 EP 02767405 A EP02767405 A EP 02767405A EP 02767405 A EP02767405 A EP 02767405A EP 1421085 A2 EP1421085 A2 EP 1421085A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- formula
- derivative
- benzyl
- hydroxynormoφhinone
- moφhine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Definitions
- an oxidizing agent effective for oxidizing allylic hydroxy groups to form keto groups, where a morphinone compound of the formula III is prepared.
- the oxidizing agent is sodium dichromate.
- Ri is ethyl. For R 2 benzyl is most preferred.
- the novel intermediates of formula II, III and IV form each another aspect of the present invention.
- the intermediates of formula II, III and IV are in particular preferred wherein is ethyl.
- Most preferred are the intermediates of formula II, III and IV wherein Ri is ethyl and R 2 is benzyl.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02767405A EP1421085B1 (de) | 2001-08-23 | 2002-08-15 | Verfahren for zur herstellung eines 14-hydroxynormorphinon-derivats |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01203187 | 2001-08-23 | ||
EP01203187 | 2001-08-23 | ||
PCT/EP2002/009280 WO2003018588A2 (en) | 2001-08-23 | 2002-08-15 | Process for the preparation of a 14-hydroxynormorphinone derivative |
EP02767405A EP1421085B1 (de) | 2001-08-23 | 2002-08-15 | Verfahren for zur herstellung eines 14-hydroxynormorphinon-derivats |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1421085A2 true EP1421085A2 (de) | 2004-05-26 |
EP1421085B1 EP1421085B1 (de) | 2010-04-28 |
Family
ID=8180821
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02767405A Expired - Lifetime EP1421085B1 (de) | 2001-08-23 | 2002-08-15 | Verfahren for zur herstellung eines 14-hydroxynormorphinon-derivats |
Country Status (26)
Country | Link |
---|---|
US (1) | US7435817B2 (de) |
EP (1) | EP1421085B1 (de) |
JP (1) | JP4559730B2 (de) |
KR (1) | KR100901402B1 (de) |
CN (1) | CN1271072C (de) |
AR (1) | AR035289A1 (de) |
AT (1) | ATE466016T1 (de) |
AU (1) | AU2002331163B2 (de) |
BR (1) | BRPI0211899B8 (de) |
CA (1) | CA2457671C (de) |
DE (1) | DE60236171D1 (de) |
EC (1) | ECSP044984A (de) |
ES (1) | ES2345327T3 (de) |
HK (1) | HK1063803A1 (de) |
HR (1) | HRP20040161A2 (de) |
HU (1) | HUP0401600A3 (de) |
IL (1) | IL160193A0 (de) |
IS (1) | IS7153A (de) |
MX (1) | MXPA04001647A (de) |
NO (1) | NO328655B1 (de) |
NZ (1) | NZ531152A (de) |
PE (1) | PE20030460A1 (de) |
PL (1) | PL368732A1 (de) |
RU (1) | RU2297419C2 (de) |
WO (1) | WO2003018588A2 (de) |
ZA (1) | ZA200401016B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2610859C (en) | 2005-06-16 | 2013-11-12 | Peter Xianqi Wang | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
EP2125824B2 (de) * | 2007-03-23 | 2023-11-15 | Mallinckrodt LLC | Verbesserte zubereitung von oxymorphon aus oripavin |
CN101033228B (zh) * | 2007-04-04 | 2010-05-19 | 复旦大学 | 14-羟基-7,8-二氢降吗啡酮的制备方法 |
WO2008130553A1 (en) | 2007-04-16 | 2008-10-30 | Mallinckrodt Inc. | Novel opiate reduction utilizing catalytic hydrogen transfer reaction |
CA2709862C (en) * | 2007-12-17 | 2016-03-15 | Peter X. Wang | Sinomenine derivatives and processes for their synthesis |
CN101896487A (zh) | 2007-12-17 | 2010-11-24 | 马林克罗特公司 | N-甲基吗啡喃的n-脱甲基化 |
EP2222642B1 (de) * | 2007-12-17 | 2014-02-12 | Mallinckrodt LLC | Verfahren und verbindungen zur herstellung von (+) opiaten |
CH705273B1 (de) | 2010-05-10 | 2016-06-15 | Euro Celtique Sa | Pharmazeutische Zusammensetzung – umfassend Hydromorphon und Naloxon. |
AU2011252040C1 (en) | 2010-05-10 | 2015-04-02 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
CN103002881B (zh) | 2010-05-10 | 2015-09-02 | 欧洲凯尔特公司 | 载有活性剂的颗粒与额外活性剂的组合 |
CA2802295C (en) | 2010-06-11 | 2016-09-20 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第3級アミンのn−脱アルキル化方法 |
WO2013036729A1 (en) | 2011-09-08 | 2013-03-14 | Mallinckrodt Llc | Production of alkaloids without the isolation of intermediates |
BR112016002079A2 (pt) * | 2013-08-02 | 2017-09-05 | Johnson Matthey Plc | Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido |
UA116405C2 (uk) | 2013-11-13 | 2018-03-12 | Євро-Селтік С.А. | Гідроморфон та налоксон для лікування болю та синдрому опіоїдної дисфункції кишечнику |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
IT1199871B (it) | 1984-03-27 | 1989-01-05 | Mallinckrodt Inc | Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento |
US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
WO2000066588A1 (en) * | 1999-05-05 | 2000-11-09 | The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services | Direct c-14 oxidation of opioids |
-
2002
- 2002-08-15 EP EP02767405A patent/EP1421085B1/de not_active Expired - Lifetime
- 2002-08-15 IL IL16019302A patent/IL160193A0/xx unknown
- 2002-08-15 RU RU2004108210/04A patent/RU2297419C2/ru active
- 2002-08-15 PL PL02368732A patent/PL368732A1/xx not_active Application Discontinuation
- 2002-08-15 ES ES02767405T patent/ES2345327T3/es not_active Expired - Lifetime
- 2002-08-15 AT AT02767405T patent/ATE466016T1/de active
- 2002-08-15 DE DE60236171T patent/DE60236171D1/de not_active Expired - Lifetime
- 2002-08-15 CA CA2457671A patent/CA2457671C/en not_active Expired - Lifetime
- 2002-08-15 AU AU2002331163A patent/AU2002331163B2/en not_active Expired
- 2002-08-15 BR BRPI0211899A patent/BRPI0211899B8/pt not_active IP Right Cessation
- 2002-08-15 WO PCT/EP2002/009280 patent/WO2003018588A2/en active IP Right Grant
- 2002-08-15 US US10/487,884 patent/US7435817B2/en not_active Expired - Lifetime
- 2002-08-15 JP JP2003523248A patent/JP4559730B2/ja not_active Expired - Lifetime
- 2002-08-15 NZ NZ531152A patent/NZ531152A/en not_active IP Right Cessation
- 2002-08-15 MX MXPA04001647A patent/MXPA04001647A/es active IP Right Grant
- 2002-08-15 CN CNB028163524A patent/CN1271072C/zh not_active Expired - Lifetime
- 2002-08-15 KR KR1020047002513A patent/KR100901402B1/ko not_active IP Right Cessation
- 2002-08-15 HU HU0401600A patent/HUP0401600A3/hu unknown
- 2002-08-21 PE PE2002000800A patent/PE20030460A1/es not_active Application Discontinuation
- 2002-08-21 AR ARP020103130A patent/AR035289A1/es active IP Right Grant
-
2004
- 2004-02-06 ZA ZA200401016A patent/ZA200401016B/en unknown
- 2004-02-13 IS IS7153A patent/IS7153A/is unknown
- 2004-02-19 HR HR20040161A patent/HRP20040161A2/xx not_active Application Discontinuation
- 2004-02-19 NO NO20040724A patent/NO328655B1/no not_active IP Right Cessation
- 2004-02-19 EC EC2004004984A patent/ECSP044984A/es unknown
- 2004-09-06 HK HK04106705.9A patent/HK1063803A1/xx not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
See references of WO03018588A2 * |
Also Published As
Similar Documents
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EP2112153B1 (de) | Verfahren zur Verminderung von Alpha, Beta-ungesättigten Ketonen in Opioidzusammensetzungen | |
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