BR112014005421A2 - produção de alcaloides sem o isolamento de intermediários - Google Patents

produção de alcaloides sem o isolamento de intermediários

Info

Publication number
BR112014005421A2
BR112014005421A2 BR112014005421A BR112014005421A BR112014005421A2 BR 112014005421 A2 BR112014005421 A2 BR 112014005421A2 BR 112014005421 A BR112014005421 A BR 112014005421A BR 112014005421 A BR112014005421 A BR 112014005421A BR 112014005421 A2 BR112014005421 A2 BR 112014005421A2
Authority
BR
Brazil
Prior art keywords
intermediates
isolation
alkaloid production
alkaloid
production
Prior art date
Application number
BR112014005421A
Other languages
English (en)
Inventor
W Berberich David
X Wang Peter
Jiang Tao
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of BR112014005421A2 publication Critical patent/BR112014005421A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

resumo patente de invenção: "produção de alcaloides sem o isolamento de intermediários". a presente invenção refere-se a processos para a produção de alcaloides sem o isolamento de intermediários.
BR112014005421A 2011-09-08 2012-09-07 produção de alcaloides sem o isolamento de intermediários BR112014005421A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161532253P 2011-09-08 2011-09-08
PCT/US2012/054099 WO2013036729A1 (en) 2011-09-08 2012-09-07 Production of alkaloids without the isolation of intermediates

Publications (1)

Publication Number Publication Date
BR112014005421A2 true BR112014005421A2 (pt) 2017-04-04

Family

ID=46982922

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014005421A BR112014005421A2 (pt) 2011-09-08 2012-09-07 produção de alcaloides sem o isolamento de intermediários

Country Status (14)

Country Link
US (1) US8624031B2 (pt)
EP (1) EP2753622B1 (pt)
JP (1) JP2014526467A (pt)
KR (1) KR20140063763A (pt)
CN (1) CN103917543A (pt)
AU (1) AU2012304484B2 (pt)
BR (1) BR112014005421A2 (pt)
CA (1) CA2845187A1 (pt)
ES (1) ES2566620T3 (pt)
IL (1) IL231292A0 (pt)
MX (1) MX2014002630A (pt)
PL (1) PL2753622T3 (pt)
RU (1) RU2014112493A (pt)
WO (1) WO2013036729A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014270109B2 (en) 2013-05-24 2017-05-25 Rhodes Technologies Opioid ketal compounds and uses thereof

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Also Published As

Publication number Publication date
KR20140063763A (ko) 2014-05-27
AU2012304484A1 (en) 2014-02-27
CN103917543A (zh) 2014-07-09
US20130066080A1 (en) 2013-03-14
IL231292A0 (en) 2014-04-30
EP2753622A1 (en) 2014-07-16
EP2753622B1 (en) 2016-01-20
ES2566620T3 (es) 2016-04-14
AU2012304484B2 (en) 2016-07-28
JP2014526467A (ja) 2014-10-06
RU2014112493A (ru) 2015-10-20
WO2013036729A1 (en) 2013-03-14
US8624031B2 (en) 2014-01-07
MX2014002630A (es) 2014-04-14
PL2753622T3 (pl) 2016-07-29
CA2845187A1 (en) 2013-03-14

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]