FR1602610A - 10.10.62.-17.4.63. 38445-15209 thebaine derivs - Google Patents

10.10.62.-17.4.63. 38445-15209 thebaine derivs

Info

Publication number
FR1602610A
FR1602610A FR1602610DA FR1602610A FR 1602610 A FR1602610 A FR 1602610A FR 1602610D A FR1602610D A FR 1602610DA FR 1602610 A FR1602610 A FR 1602610A
Authority
FR
France
Prior art keywords
derivs
thebaine
lower alkyl
substd
cyclobutylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3844462A external-priority patent/GB1049789A/en
Application filed filed Critical
Application granted granted Critical
Publication of FR1602610A publication Critical patent/FR1602610A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Thebaine derivs. of the general formula (I), quaternary ammonium salts, acid addition salts and N-oxide derivs. thereof:- (I) R1 = lower alkyl R2 = H, lower alkyl, or (1-8C) acyl R = where R3, R4 and R5 are H, Hal, Me. or R = cyclopropylmethyl; cyclobutylmethyl; cyclopentylmethyl; or cyclohexylmethyl, all opt. substd. by one or more Me radicals; or propargyl. The dotted line indicates a single or double bond. Central nervous depressant and analgesic activity. Morphine antagonist.
FR1602610D 1962-10-10 1963-10-10 10.10.62.-17.4.63. 38445-15209 thebaine derivs Expired FR1602610A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB3844562 1962-10-10
GB3844462A GB1049789A (en) 1963-04-17 1962-10-10 New thebaine derivatives and methods of preparing the same
GB1520963 1963-04-17

Publications (1)

Publication Number Publication Date
FR1602610A true FR1602610A (en) 1971-01-04

Family

ID=27257232

Family Applications (2)

Application Number Title Priority Date Filing Date
FR1602610D Expired FR1602610A (en) 1962-10-10 1963-10-10 10.10.62.-17.4.63. 38445-15209 thebaine derivs
FR44344A Active FR3195M (en) 1962-10-10 1964-01-09 Pharmaceutical compositions comprising derivatives of theban.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR44344A Active FR3195M (en) 1962-10-10 1964-01-09 Pharmaceutical compositions comprising derivatives of theban.

Country Status (1)

Country Link
FR (2) FR1602610A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546688A (en) * 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド Synthetic route to 14-hydroxyl opiates via 1-halo-thebaine or analogs
WO2009078987A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Process and compounds for the production of (+) opiates
WO2009078990A1 (en) 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of n-methyl morphinans
US8624031B2 (en) 2011-09-08 2014-01-07 Mallinckrodt Llc Production of alkaloids without the isolation of intermediates

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546688A (en) * 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド Synthetic route to 14-hydroxyl opiates via 1-halo-thebaine or analogs
WO2009078987A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Process and compounds for the production of (+) opiates
WO2009078990A1 (en) 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of n-methyl morphinans
US7671204B2 (en) 2007-12-17 2010-03-02 Mallinckrodt Inc. N-demethylation of N-methyl morphinans
US8252808B2 (en) 2007-12-17 2012-08-28 Mallinckrodt Llc Process and compounds for the production of (+)opiates
US8624031B2 (en) 2011-09-08 2014-01-07 Mallinckrodt Llc Production of alkaloids without the isolation of intermediates

Also Published As

Publication number Publication date
FR3195M (en) 1965-03-15

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Legal Events

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