FR2189403A1 - Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonists - Google Patents
Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonistsInfo
- Publication number
- FR2189403A1 FR2189403A1 FR7321915A FR7321915A FR2189403A1 FR 2189403 A1 FR2189403 A1 FR 2189403A1 FR 7321915 A FR7321915 A FR 7321915A FR 7321915 A FR7321915 A FR 7321915A FR 2189403 A1 FR2189403 A1 FR 2189403A1
- Authority
- FR
- France
- Prior art keywords
- prepn
- norcodeinones
- norcodeine
- halo
- intermedi
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prepn. of norcodeins by reaction of 1-halo-norcodeinones of formula: where X is Cl or Br; and Y is CHO, -CO2Me or -CO2Et with a suitable reagent to give a cpd. of formula: which in turn is reduced to norcodeins (III): Cpds. are new. Removal of the protecting gp. Y requires mild conditions to avoid possible rearrangement of the mol. When Y = -CHO this is performed with H2O2, or aq. or alcoholic HCl or HBr. When Y is CO2Me or CO2Et alkaline hydrolysis in an inert atmos. is prefd. Norcodeine is an inter. in the prepn. of narcotic antagonists such as nalorphine or normorphine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26308372A | 1972-06-15 | 1972-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2189403A1 true FR2189403A1 (en) | 1974-01-25 |
Family
ID=23000311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7321915A Withdrawn FR2189403A1 (en) | 1972-06-15 | 1973-06-15 | Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonists |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2189403A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009078987A1 (en) * | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | Process and compounds for the production of (+) opiates |
| US8624031B2 (en) | 2011-09-08 | 2014-01-07 | Mallinckrodt Llc | Production of alkaloids without the isolation of intermediates |
-
1973
- 1973-06-15 FR FR7321915A patent/FR2189403A1/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009078987A1 (en) * | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | Process and compounds for the production of (+) opiates |
| US8252808B2 (en) | 2007-12-17 | 2012-08-28 | Mallinckrodt Llc | Process and compounds for the production of (+)opiates |
| US8624031B2 (en) | 2011-09-08 | 2014-01-07 | Mallinckrodt Llc | Production of alkaloids without the isolation of intermediates |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1241844A (en) | Penicillins | |
| FR2189403A1 (en) | Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonists | |
| ES339321A1 (en) | Olefin Oxides | |
| AU472090B2 (en) | Removal of dissolved organic matter from acidic aqueous solution | |
| CA1011055A (en) | Pool sidewall to floor connection | |
| CA969125A (en) | Distillation process for recovering substantially anhydrous formic acid from aqueous solutions | |
| YU40410B (en) | Process for producing antibacterial agents 6-d-(-)-alpha-amino-(p-hydroxyphenylacetamido)-penicillanic acid | |
| JPS51133219A (en) | Method of producing organic solution of percarboxylic acid | |
| FR2113774A1 (en) | Prepn of l-ornithine salts with org acids - using silver oxides | |
| GB1543434A (en) | Sorption of weak organic acids from water | |
| HUP9904328A2 (en) | Solvent extraction of 3-hydroxymethylcephalosporins | |
| IT1061689B (en) | PROCEDURE FOR PRODUCING PERPROPIONIC ACID SOLUTIONS | |
| SE7604889L (en) | WAY TO PREPARE PERPROPIONIC ACID SOLUTIONS | |
| AU498044B2 (en) | Purification ofan aqueous solution of zinc sulphate | |
| CA1025134A (en) | Reduction of dissolved organic lead in aqueous solutions | |
| EG12522A (en) | 6-(d-2 acylamido-2 phenylacetamido)penicillanic acid | |
| JPS532469A (en) | Production of di substituted xantone carboxylic acid compound | |
| ES457577A1 (en) | Esters of 7-sulfenyliminocephem-4-carboxylic acids | |
| JPS51131243A (en) | Car antenna | |
| AU5337673A (en) | Treatment of waste sulphuric acid | |
| AU478775B2 (en) | Novel substituted xanthone carboxylic acid compounds | |
| GB1523278A (en) | Penicillanic acid derivatives | |
| JPS53137913A (en) | Preparation of cis-epoxysuccinic acid or cis-epoxysuccinate salt | |
| JPS5379816A (en) | Urea treatment of aliphatic dicarbosylic acid-contg. | |
| JPS5350171A (en) | Production of novel di substituted xanthone carboxylic acid compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |