PL2222642T3 - Sposób i związki do wytwarzania (+) opiatów - Google Patents

Sposób i związki do wytwarzania (+) opiatów

Info

Publication number
PL2222642T3
PL2222642T3 PL08861695T PL08861695T PL2222642T3 PL 2222642 T3 PL2222642 T3 PL 2222642T3 PL 08861695 T PL08861695 T PL 08861695T PL 08861695 T PL08861695 T PL 08861695T PL 2222642 T3 PL2222642 T3 PL 2222642T3
Authority
PL
Poland
Prior art keywords
opiates
compounds
production
Prior art date
Application number
PL08861695T
Other languages
English (en)
Inventor
Peter X Wang
Tao Jiang
Gary L Cantrell
David W Berberich
Bobby N Trawick
Todd Osiek
Subo Liao
Frank W Moser
Joseph P Mcclurg
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of PL2222642T3 publication Critical patent/PL2222642T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
PL08861695T 2007-12-17 2008-12-17 Sposób i związki do wytwarzania (+) opiatów PL2222642T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1409407P 2007-12-17 2007-12-17
PCT/US2008/013776 WO2009078987A1 (en) 2007-12-17 2008-12-17 Process and compounds for the production of (+) opiates
EP08861695.8A EP2222642B1 (en) 2007-12-17 2008-12-17 Process and compounds for the production of (+) opiates

Publications (1)

Publication Number Publication Date
PL2222642T3 true PL2222642T3 (pl) 2014-07-31

Family

ID=40405079

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08861695T PL2222642T3 (pl) 2007-12-17 2008-12-17 Sposób i związki do wytwarzania (+) opiatów

Country Status (10)

Country Link
US (1) US8252808B2 (pl)
EP (1) EP2222642B1 (pl)
JP (2) JP5688974B2 (pl)
CN (1) CN101896463B (pl)
AU (1) AU2008338969B2 (pl)
CA (1) CA2709858C (pl)
ES (1) ES2455718T3 (pl)
NZ (1) NZ586203A (pl)
PL (1) PL2222642T3 (pl)
WO (1) WO2009078987A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101896464B (zh) * 2007-12-17 2014-12-10 马林克罗特有限公司 青藤碱衍生物和它们的合成方法
EP2328899B1 (en) 2008-09-16 2018-01-24 Mallinckrodt LLC Processes for the synthesis of five and six membered heterocyclic rings
US8367827B2 (en) 2008-12-02 2013-02-05 Mallinckrodt Llc Process for preparing hydrocodone using a super acid
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
NO2453895T3 (pl) * 2009-07-16 2018-10-20
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US9213776B1 (en) 2009-07-17 2015-12-15 Open Invention Network, Llc Method and system for searching network resources to locate content
US9645996B1 (en) 2010-03-25 2017-05-09 Open Invention Network Llc Method and device for automatically generating a tag from a conversation in a social networking website
JP5736040B2 (ja) * 2010-06-11 2015-06-17 ローズ テクノロジーズ Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用
ES2728701T3 (es) 2010-07-16 2019-10-28 Mallinckrodt Llc (+)-Morfinanos como antagonistas del receptor 9 de tipo Toll y aplicaciones terapéuticas de los mismos
US9746968B1 (en) 2010-11-10 2017-08-29 Open Invention Network Llc Touch screen display with tactile feedback using transparent actuator assemblies
JP2014526467A (ja) 2011-09-08 2014-10-06 マリンクロッド エルエルシー 中間体の単離なしでのアルカロイドの調製
CN102532024B (zh) * 2011-12-28 2016-08-03 赵爱国 青藤碱衍生物
US8987287B2 (en) 2012-12-14 2015-03-24 Purdue Pharma L.P. Spirocyclic morphinans and their use
TW201434836A (zh) 2012-12-14 2014-09-16 Purdue Pharma Lp 包含氮之嗎啡喃衍生物及其用途
EP2931724B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Pyridonemorphinan analogs and biological activity on opioid receptors
US8957084B2 (en) 2012-12-28 2015-02-17 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
TW201441199A (zh) 2012-12-28 2014-11-01 Purdue Pharma Lp 經取代之嗎啡喃類及其用途
EP3087073B1 (en) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituted morphinan hydantoins
EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
GB201513203D0 (en) * 2015-07-27 2015-09-09 Cambrex Charles City Inc New process
EP4165235A1 (en) 2020-06-10 2023-04-19 Research Center Pharmaceutical Engineering GmbH Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical n-demethylation

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
BE638369A (pl) * 1962-10-10
FR1602610A (en) 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3438989A (en) * 1967-03-10 1969-04-15 Warner Lambert Pharmaceutical Process for the production of ( ) dihydrothebainone
FR2189403A1 (en) 1972-06-15 1974-01-25 Merck & Co Inc Norcodeine prepn - by reduction of 1-halo-norcodeinones, novel intermedi-ates for narcotic antagonists
US4410700A (en) * 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
WO1982000144A1 (en) * 1980-07-03 1982-01-21 Us Commerce A short total synthesis of dihydrothebainone,dihydrocodeinone,and nordihydrocodeinone
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
IT1199871B (it) * 1984-03-27 1989-01-05 Mallinckrodt Inc Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
HU197750B (en) 1984-07-17 1989-05-29 Alkaloida Vegyeszeti Gyar Process for n-demethylation of morphine alkaloids
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
DK0496830T3 (da) * 1989-10-16 1999-10-11 Us Health Total syntese af northebain, normorphin, noroxymorphonenantiomerer og derivater via N-nor-mellemprodukter
EP1056455A4 (en) 1998-02-20 2000-12-06 Avmax Inc EPIMORPHIN COMPOUND AND USE OF THE SAME
ES2345327T3 (es) * 2001-08-23 2010-09-21 N.V. Organon Proceso para la preparacion de un derivado de 14-hidroxinormorfinona.
US7932264B2 (en) * 2005-12-15 2011-04-26 Naturemed Group Corporation Sinomenine derivatives and preparation and uses thereof
RU2009112685A (ru) 2006-09-20 2010-10-27 Маллинкродт Инк. (Us) Получение замещенных морфинан-6-онов и их солей и промежуточных соединений
CN101896464B (zh) * 2007-12-17 2014-12-10 马林克罗特有限公司 青藤碱衍生物和它们的合成方法
NO2453895T3 (pl) * 2009-07-16 2018-10-20

Also Published As

Publication number Publication date
CA2709858A1 (en) 2009-06-25
CN101896463B (zh) 2016-08-24
CN101896463A (zh) 2010-11-24
JP2011506602A (ja) 2011-03-03
EP2222642A1 (en) 2010-09-01
US20090156818A1 (en) 2009-06-18
CA2709858C (en) 2016-03-29
NZ586203A (en) 2012-10-26
WO2009078987A1 (en) 2009-06-25
EP2222642B1 (en) 2014-02-12
JP2013227349A (ja) 2013-11-07
AU2008338969A1 (en) 2009-06-25
ES2455718T3 (es) 2014-04-16
JP5688974B2 (ja) 2015-03-25
AU2008338969B2 (en) 2013-08-01
US8252808B2 (en) 2012-08-28

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