ECSP044984A - Oxidación del c-14 de derivados de la morfina - Google Patents

Oxidación del c-14 de derivados de la morfina

Info

Publication number
ECSP044984A
ECSP044984A EC2004004984A ECSP044984A ECSP044984A EC SP044984 A ECSP044984 A EC SP044984A EC 2004004984 A EC2004004984 A EC 2004004984A EC SP044984 A ECSP044984 A EC SP044984A EC SP044984 A ECSP044984 A EC SP044984A
Authority
EC
Ecuador
Prior art keywords
benzyl
morphine
oxidation
derivatives
oxidant
Prior art date
Application number
EC2004004984A
Other languages
English (en)
Inventor
Joannes Theodorus Maria Linders
Pieter Vrijhof
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ECSP044984A publication Critical patent/ECSP044984A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Abstract

La presente invención se refiere a un proceso para la preparación de un derivado de 14 hidroxinormorfinona de la fórmula IV, que comprende la reacción del compuesto de la fórmula III con un oxidante de cobalto (II) en presencia de una base suave y aire u oxígenocomo co-oxidante; en donde R1 es (1C-7C)alquilo, sustituido opcionalmente por una o más clorinas, por butenilo, vinilo, bencilo, fenilo o naftilo; y R2 es bencilo o bencilo sustituido por uno o más sustituyentes del grupo (1C-6C)alcoxi o bencilo sustituido por uno o más halógenos. El proceso es muy adecuado para la producción de noroximorfona.
EC2004004984A 2001-08-23 2004-02-19 Oxidación del c-14 de derivados de la morfina ECSP044984A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01203187 2001-08-23

Publications (1)

Publication Number Publication Date
ECSP044984A true ECSP044984A (es) 2004-04-28

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004984A ECSP044984A (es) 2001-08-23 2004-02-19 Oxidación del c-14 de derivados de la morfina

Country Status (26)

Country Link
US (1) US7435817B2 (es)
EP (1) EP1421085B1 (es)
JP (1) JP4559730B2 (es)
KR (1) KR100901402B1 (es)
CN (1) CN1271072C (es)
AR (1) AR035289A1 (es)
AT (1) ATE466016T1 (es)
AU (1) AU2002331163B2 (es)
BR (1) BRPI0211899B8 (es)
CA (1) CA2457671C (es)
DE (1) DE60236171D1 (es)
EC (1) ECSP044984A (es)
ES (1) ES2345327T3 (es)
HK (1) HK1063803A1 (es)
HR (1) HRP20040161A2 (es)
HU (1) HUP0401600A3 (es)
IL (1) IL160193A0 (es)
IS (1) IS7153A (es)
MX (1) MXPA04001647A (es)
NO (1) NO328655B1 (es)
NZ (1) NZ531152A (es)
PE (1) PE20030460A1 (es)
PL (1) PL368732A1 (es)
RU (1) RU2297419C2 (es)
WO (1) WO2003018588A2 (es)
ZA (1) ZA200401016B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2610859C (en) 2005-06-16 2013-11-12 Peter Xianqi Wang A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
EP2125824B2 (en) * 2007-03-23 2023-11-15 Mallinckrodt LLC Improved preparation of oxymorphone from oripavine
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
WO2008130553A1 (en) 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
CA2709862C (en) * 2007-12-17 2016-03-15 Peter X. Wang Sinomenine derivatives and processes for their synthesis
CN101896487A (zh) 2007-12-17 2010-11-24 马林克罗特公司 N-甲基吗啡喃的n-脱甲基化
EP2222642B1 (en) * 2007-12-17 2014-02-12 Mallinckrodt LLC Process and compounds for the production of (+) opiates
CH705273B1 (de) 2010-05-10 2016-06-15 Euro Celtique Sa Pharmazeutische Zusammensetzung – umfassend Hydromorphon und Naloxon.
AU2011252040C1 (en) 2010-05-10 2015-04-02 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
CN103002881B (zh) 2010-05-10 2015-09-02 欧洲凯尔特公司 载有活性剂的颗粒与额外活性剂的组合
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
WO2013036729A1 (en) 2011-09-08 2013-03-14 Mallinckrodt Llc Production of alkaloids without the isolation of intermediates
BR112016002079A2 (pt) * 2013-08-02 2017-09-05 Johnson Matthey Plc Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido
UA116405C2 (uk) 2013-11-13 2018-03-12 Євро-Селтік С.А. Гідроморфон та налоксон для лікування болю та синдрому опіоїдної дисфункції кишечнику

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
IT1199871B (it) 1984-03-27 1989-01-05 Mallinckrodt Inc Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
WO2000066588A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
KR100901402B1 (ko) 2009-06-05
HRP20040161A2 (en) 2004-06-30
DE60236171D1 (de) 2010-06-10
CA2457671A1 (en) 2003-03-06
US7435817B2 (en) 2008-10-14
RU2004108210A (ru) 2005-04-10
RU2297419C2 (ru) 2007-04-20
JP2005502670A (ja) 2005-01-27
WO2003018588A2 (en) 2003-03-06
BRPI0211899B8 (pt) 2021-05-25
US20050038250A1 (en) 2005-02-17
EP1421085B1 (en) 2010-04-28
CA2457671C (en) 2011-02-15
IS7153A (is) 2004-02-13
ES2345327T3 (es) 2010-09-21
PE20030460A1 (es) 2003-05-15
ZA200401016B (en) 2004-10-19
AR035289A1 (es) 2004-05-05
WO2003018588B1 (en) 2004-02-26
HUP0401600A3 (en) 2008-05-28
MXPA04001647A (es) 2004-05-31
NO20040724L (no) 2004-02-19
HK1063803A1 (en) 2005-01-14
AU2002331163B2 (en) 2008-02-21
IL160193A0 (en) 2004-07-25
CN1271072C (zh) 2006-08-23
PL368732A1 (en) 2005-04-04
HUP0401600A2 (hu) 2004-11-29
BR0211899A (pt) 2004-09-21
ATE466016T1 (de) 2010-05-15
NZ531152A (en) 2005-11-25
BR0211899B1 (pt) 2014-01-21
CN1545517A (zh) 2004-11-10
NO328655B1 (no) 2010-04-19
JP4559730B2 (ja) 2010-10-13
WO2003018588A3 (en) 2003-11-27
KR20040027950A (ko) 2004-04-01
EP1421085A2 (en) 2004-05-26

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