ECSP044984A - Oxidación del c-14 de derivados de la morfina - Google Patents

Oxidación del c-14 de derivados de la morfina

Info

Publication number
ECSP044984A
ECSP044984A EC2004004984A ECSP044984A ECSP044984A EC SP044984 A ECSP044984 A EC SP044984A EC 2004004984 A EC2004004984 A EC 2004004984A EC SP044984 A ECSP044984 A EC SP044984A EC SP044984 A ECSP044984 A EC SP044984A
Authority
EC
Ecuador
Prior art keywords
benzyl
morphine
oxidation
derivatives
oxidant
Prior art date
Application number
EC2004004984A
Other languages
English (en)
Inventor
Joannes Theodorus Maria Linders
Pieter Vrijhof
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ECSP044984A publication Critical patent/ECSP044984A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a un proceso para la preparación de un derivado de 14 hidroxinormorfinona de la fórmula IV, que comprende la reacción del compuesto de la fórmula III con un oxidante de cobalto (II) en presencia de una base suave y aire u oxígenocomo co-oxidante; en donde R1 es (1C-7C)alquilo, sustituido opcionalmente por una o más clorinas, por butenilo, vinilo, bencilo, fenilo o naftilo; y R2 es bencilo o bencilo sustituido por uno o más sustituyentes del grupo (1C-6C)alcoxi o bencilo sustituido por uno o más halógenos. El proceso es muy adecuado para la producción de noroximorfona.
EC2004004984A 2001-08-23 2004-02-19 Oxidación del c-14 de derivados de la morfina ECSP044984A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01203187 2001-08-23

Publications (1)

Publication Number Publication Date
ECSP044984A true ECSP044984A (es) 2004-04-28

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004004984A ECSP044984A (es) 2001-08-23 2004-02-19 Oxidación del c-14 de derivados de la morfina

Country Status (25)

Country Link
US (1) US7435817B2 (es)
EP (1) EP1421085B1 (es)
JP (1) JP4559730B2 (es)
KR (1) KR100901402B1 (es)
CN (1) CN1271072C (es)
AR (1) AR035289A1 (es)
AT (1) ATE466016T1 (es)
AU (1) AU2002331163B2 (es)
BR (1) BRPI0211899B8 (es)
CA (1) CA2457671C (es)
DE (1) DE60236171D1 (es)
EC (1) ECSP044984A (es)
ES (1) ES2345327T3 (es)
HR (1) HRP20040161A2 (es)
HU (1) HUP0401600A3 (es)
IL (1) IL160193A0 (es)
IS (1) IS7153A (es)
MX (1) MXPA04001647A (es)
NO (1) NO328655B1 (es)
NZ (1) NZ531152A (es)
PE (1) PE20030460A1 (es)
PL (1) PL368732A1 (es)
RU (1) RU2297419C2 (es)
WO (1) WO2003018588A2 (es)
ZA (1) ZA200401016B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP1893616B1 (en) 2005-06-16 2010-12-29 Mallinckrodt, Inc. A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
US8217175B2 (en) * 2007-03-23 2012-07-10 Mallinckrodt Llc Preparation of oxymorphone from oripavine
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
ES2423180T3 (es) 2007-04-16 2013-09-18 Mallinckrodt Llc Nueva reducción de opiáceos mediante reacción de transferencia de hidrógeno catalítica
AU2008338970B2 (en) * 2007-12-17 2013-08-22 SpecGx LLC Sinomenine derivatives and processes for their synthesis
JP5688974B2 (ja) * 2007-12-17 2015-03-25 マリンクロッド エルエルシー （＋）−オピエートの生成のためのプロセスおよび化合物
EP2222677A1 (en) 2007-12-17 2010-09-01 Mallinckrodt Inc. N-demethylation of n-methyl morphinans
AU2011252039B2 (en) 2010-05-10 2014-06-12 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
EP2568965A1 (en) 2010-05-10 2013-03-20 Euro-Celtique S.A. Combination of active loaded granules with additional actives
BR112012028788A2 (pt) 2010-05-10 2016-07-19 Euro Celtique Sa fabricação de grânulos sem ativos
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
JP5736040B2 (ja) 2010-06-11 2015-06-17 ローズ テクノロジーズ Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用
RU2014112493A (ru) 2011-09-08 2015-10-20 МАЛЛИНКРОДТ Эл-Эл-Си Получения алкалоидов без выделения промежуточных продуктов
BR112016002079A2 (pt) * 2013-08-02 2017-09-05 Johnson Matthey Plc Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido
KR20160060768A (ko) 2013-11-13 2016-05-30 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손
CN114621238B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种制备纳呋拉啡的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
EP0158476B1 (en) 1984-03-27 1991-01-23 Mallinckrodt, Inc. (a Delaware corporation) Preparation of noroxymorphone from morphine
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
AU4823900A (en) * 1999-05-05 2000-11-17 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
RU2004108210A (ru) 2005-04-10
RU2297419C2 (ru) 2007-04-20
NO328655B1 (no) 2010-04-19
KR100901402B1 (ko) 2009-06-05
EP1421085B1 (en) 2010-04-28
BR0211899B1 (pt) 2014-01-21
CN1271072C (zh) 2006-08-23
HK1063803A1 (en) 2005-01-14
CA2457671A1 (en) 2003-03-06
CA2457671C (en) 2011-02-15
HUP0401600A2 (hu) 2004-11-29
US20050038250A1 (en) 2005-02-17
MXPA04001647A (es) 2004-05-31
ATE466016T1 (de) 2010-05-15
IS7153A (is) 2004-02-13
WO2003018588B1 (en) 2004-02-26
JP2005502670A (ja) 2005-01-27
EP1421085A2 (en) 2004-05-26
NO20040724L (no) 2004-02-19
CN1545517A (zh) 2004-11-10
AR035289A1 (es) 2004-05-05
KR20040027950A (ko) 2004-04-01
BR0211899A (pt) 2004-09-21
HRP20040161A2 (en) 2004-06-30
WO2003018588A2 (en) 2003-03-06
AU2002331163B2 (en) 2008-02-21
US7435817B2 (en) 2008-10-14
NZ531152A (en) 2005-11-25
PE20030460A1 (es) 2003-05-15
ES2345327T3 (es) 2010-09-21
BRPI0211899B8 (pt) 2021-05-25
ZA200401016B (en) 2004-10-19
DE60236171D1 (de) 2010-06-10
WO2003018588A3 (en) 2003-11-27
JP4559730B2 (ja) 2010-10-13
HUP0401600A3 (en) 2008-05-28
PL368732A1 (en) 2005-04-04
IL160193A0 (en) 2004-07-25

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