PL2125824T5 - Ulepszony sposób wytwarzania oksymorfonu z oripawiny - Google Patents

Ulepszony sposób wytwarzania oksymorfonu z oripawiny

Info

Publication number
PL2125824T5
PL2125824T5 PL08732176.6T PL08732176T PL2125824T5 PL 2125824 T5 PL2125824 T5 PL 2125824T5 PL 08732176 T PL08732176 T PL 08732176T PL 2125824 T5 PL2125824 T5 PL 2125824T5
Authority
PL
Poland
Prior art keywords
oripavine
improved method
oxymorphone
making
making oxymorphone
Prior art date
Application number
PL08732176.6T
Other languages
English (en)
Other versions
PL2125824T3 (pl
Inventor
Peter X. Wang
Tao Jiang
Gary L. Cantrell
David Wayne Berberich
Original Assignee
SpecGx LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39477545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2125824(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SpecGx LLC filed Critical SpecGx LLC
Publication of PL2125824T3 publication Critical patent/PL2125824T3/pl
Publication of PL2125824T5 publication Critical patent/PL2125824T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL08732176.6T 2007-03-23 2008-03-14 Ulepszony sposób wytwarzania oksymorfonu z oripawiny PL2125824T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89653707P 2007-03-23 2007-03-23
PCT/US2008/056929 WO2008118654A1 (en) 2007-03-23 2008-03-14 Improved preparation of oxymorphone from oripavine
EP08732176.6A EP2125824B2 (en) 2007-03-23 2008-03-14 Improved preparation of oxymorphone from oripavine

Publications (2)

Publication Number Publication Date
PL2125824T3 PL2125824T3 (pl) 2014-05-30
PL2125824T5 true PL2125824T5 (pl) 2024-11-04

Family

ID=39477545

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08732176.6T PL2125824T5 (pl) 2007-03-23 2008-03-14 Ulepszony sposób wytwarzania oksymorfonu z oripawiny

Country Status (8)

Country Link
US (1) US8217175B2 (pl)
EP (1) EP2125824B2 (pl)
JP (1) JP2010522189A (pl)
AU (1) AU2008231127B2 (pl)
CA (1) CA2681740A1 (pl)
ES (1) ES2438997T5 (pl)
PL (1) PL2125824T5 (pl)
WO (1) WO2008118654A1 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602007003197D1 (de) * 2006-03-02 2009-12-24 Mallinckrodt Inc Verfahren zur herstellung von morphinan-6-on-produkten mit geringen konzentrationen von alpha-, beta-ungesättigten ketonverbindungen
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
JP2013529595A (ja) 2010-06-11 2013-07-22 ローズ テクノロジーズ 第３級アミンのｎ−脱アルキル化方法
US8563571B2 (en) 2010-07-22 2013-10-22 Noramco, Inc. Crystalline forms of oxymorphone hydrochloride
EP2420503A1 (en) * 2010-07-27 2012-02-22 Universität Innsbruck Process for the synthesis of 14-oxygenated morphinan-6-ones
JP6121988B2 (ja) 2011-05-06 2017-04-26 ブロック ユニバーシティ 金属触媒ｎ−脱メチル化／官能基化および分子内基移動によるモルヒネ類似体の調製のための方法
PL2812336T3 (pl) 2012-02-08 2017-07-31 Mallinckrodt Llc Sposób wytwarzania 6-hydroksyIowej pochodnej opiatu nal w jednym naczyniu
US10316042B2 (en) 2012-07-16 2019-06-11 Rhodes Technologies Process for improved opioid synthesis
UA117226C2 (uk) 2012-07-16 2018-07-10 Родес Текнолоджіс Спосіб покращеного синтезу опіоїду
GB201313915D0 (en) * 2013-08-02 2013-09-18 Johnson Matthey Plc Process
EP3027622B8 (en) * 2013-08-02 2019-06-12 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
CN106029669B (zh) 2014-01-15 2018-04-13 罗德科技公司 改进的羟二氢吗啡酮合成的方法
CN106029670A (zh) 2014-01-15 2016-10-12 罗德科技公司 改进的羟考酮合成的方法
WO2016187522A1 (en) 2015-05-20 2016-11-24 Noramco, Inc. Process for the preparation of oxymorphone freebase
US20160340362A1 (en) * 2015-05-20 2016-11-24 Noramco, Inc. Process For The Preparation Of Oxymorphone Freebase
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) * 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
BE638369A (pl) * 1962-10-10
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1123768A (en) * 1966-07-29 1968-08-14 Smith Kline French Lab New thebaine and oripavine derivatives and processes for preparing the same
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
US4277604A (en) * 1980-01-25 1981-07-07 The United States Of America As Represented By The Department Of Health And Human Services Facile synthesis of codeine precursors from thebaine
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
FR2636330B1 (fr) * 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
US6067749A (en) * 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
AUPQ968300A0 (en) * 2000-08-25 2000-09-21 Glaxo Wellcome Australia Ltd Chemical methods
HUP0401600A3 (en) * 2001-08-23 2008-05-28 Organon Nv Process for the preparation of 14-hydroxymorphine derivatives
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
JP4879740B2 (ja) 2003-09-22 2012-02-22 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー モルヒナン化合物およびその中間体の合成法
TWI365880B (en) * 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
SK286087B6 (sk) † 2004-08-18 2008-03-05 Zentiva, A. S. Spôsob prípravy oxykodonu
EP2073636B1 (en) † 2006-10-17 2012-09-05 Penick Corporation Process for preparing oxymorphone
GB0624880D0 (en) † 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Also Published As

Publication number Publication date
CA2681740A1 (en) 2008-10-02
WO2008118654A1 (en) 2008-10-02
JP2010522189A (ja) 2010-07-01
US20100113787A1 (en) 2010-05-06
PL2125824T3 (pl) 2014-05-30
EP2125824A1 (en) 2009-12-02
AU2008231127B2 (en) 2013-05-02
EP2125824B1 (en) 2013-11-20
ES2438997T5 (es) 2024-09-03
ES2438997T3 (es) 2014-01-21
AU2008231127A1 (en) 2008-10-02
EP2125824B2 (en) 2023-11-15
US8217175B2 (en) 2012-07-10

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