PE20030460A1 - Oxidacion c-14 de derivados de morfina - Google Patents

Oxidacion c-14 de derivados de morfina

Info

Publication number
PE20030460A1
PE20030460A1 PE2002000800A PE2002000800A PE20030460A1 PE 20030460 A1 PE20030460 A1 PE 20030460A1 PE 2002000800 A PE2002000800 A PE 2002000800A PE 2002000800 A PE2002000800 A PE 2002000800A PE 20030460 A1 PE20030460 A1 PE 20030460A1
Authority
PE
Peru
Prior art keywords
formula
oxidizing
morphine
benzil
compound
Prior art date
Application number
PE2002000800A
Other languages
English (en)
Inventor
Pieter Vrijhof
Joannes Theodorus Maria Linders
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20030460A1 publication Critical patent/PE20030460A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

DONDE LOS DERIVADOS SON 14-HIDROXINORMORFINONA DE FORMULA IV, Y LA OXIDACION COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA III CON UN OXIDANTE DE COBALTO (II) EN PRESENCIA DE UNA BASE SUAVE Y AIRE U OXIGENO COMO CO-OXIDANTE, SIENDO R1 UN ALQUIL C1-C7 OPCIONALMENTE SUSTITUIDO CON UNO O MAS CLOROS, BUTENIL, VINIL, BENZIL, FENIL O NAFTIL; Y R2 ES BENZIL O BENZIL SUSTITUIDO CON UNO O MAS ALCOXI C1-C6 o CON UNO O MAS HALOGENOS. EL COMPUESTO DE FORMULA III SE PREPARA CONTACTANDO EN FORMA REACTIVA UN DERIVADO DE MORFINA DE FORMULA II CON UN AGENTE OXIDANTE EFECTIVO, TAL COMO DICROMATO DE SODIO, PARA OXIDAR GRUPOS HIDOXILOS ALILICOS Y FORMAR CETO GRUPOS. ADEMAS SE REFIERE A LA CONVERSION DE UNA MORFINA DE FORMULA I EN NOROXIMORFONA, QUE INCLUYE REACCIONAR LA MORFINA CON UN ESTER HALOFORMATO, OXIDAR LA MORFINA PARA FORMAR LA MORFINONA DE FORMULA III, OXIDAR LA MORFINONA PARA FORMAR EL COMPUESTO DE FORMULA IV, DESPROTEGER LA POSICION 3 Y REDUCIR EL ENLACE DOBLE EN LA POSICION 7,8 DEL COMPUESTO DE FORMULA IV PARA FORMAR UN DERIVADO 3,14-HIDROXINORMORFINONA DE FORMULA V, E HIDROLIZAR ESTE DERIVADO EN NOROXIMORFONA DE FORMULA VI
PE2002000800A 2001-08-23 2002-08-21 Oxidacion c-14 de derivados de morfina PE20030460A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01203187 2001-08-23

Publications (1)

Publication Number Publication Date
PE20030460A1 true PE20030460A1 (es) 2003-05-15

Family

ID=8180821

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000800A PE20030460A1 (es) 2001-08-23 2002-08-21 Oxidacion c-14 de derivados de morfina

Country Status (26)

Country Link
US (1) US7435817B2 (es)
EP (1) EP1421085B1 (es)
JP (1) JP4559730B2 (es)
KR (1) KR100901402B1 (es)
CN (1) CN1271072C (es)
AR (1) AR035289A1 (es)
AT (1) ATE466016T1 (es)
AU (1) AU2002331163B2 (es)
BR (1) BRPI0211899B8 (es)
CA (1) CA2457671C (es)
DE (1) DE60236171D1 (es)
EC (1) ECSP044984A (es)
ES (1) ES2345327T3 (es)
HK (1) HK1063803A1 (es)
HR (1) HRP20040161A2 (es)
HU (1) HUP0401600A3 (es)
IL (1) IL160193A0 (es)
IS (1) IS7153A (es)
MX (1) MXPA04001647A (es)
NO (1) NO328655B1 (es)
NZ (1) NZ531152A (es)
PE (1) PE20030460A1 (es)
PL (1) PL368732A1 (es)
RU (1) RU2297419C2 (es)
WO (1) WO2003018588A2 (es)
ZA (1) ZA200401016B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2610859C (en) 2005-06-16 2013-11-12 Peter Xianqi Wang A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
CA2681740A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
CN101033228B (zh) * 2007-04-04 2010-05-19 复旦大学 14-羟基-7,8-二氢降吗啡酮的制备方法
MX2009010931A (es) 2007-04-16 2009-10-29 Mallinckrodt Inc Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
JP5688974B2 (ja) * 2007-12-17 2015-03-25 マリンクロッド エルエルシー （＋）−オピエートの生成のためのプロセスおよび化合物
AU2008338970B2 (en) * 2007-12-17 2013-08-22 SpecGx LLC Sinomenine derivatives and processes for their synthesis
AU2008338972A1 (en) 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of N-methyl morphinans
EA201291211A1 (ru) 2010-05-10 2013-05-30 Эро-Селтик С.А. Фармацевтические композиции, содержащие гидроморфон и налоксон
US9901540B2 (en) 2010-05-10 2018-02-27 Euro-Celtique S.A. Combination of active loaded granules with additional actives
CN103002882B (zh) 2010-05-10 2016-03-02 欧洲凯尔特公司 不含活性剂之颗粒及包含其之片剂的制备
ES2537610T3 (es) 2010-06-11 2015-06-10 Rhodes Technologies Proceso para la N-desalquilación de aminas terciarias
AU2011263417B2 (en) 2010-06-11 2014-03-27 Rhodes Technologies Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
EP2753622B1 (en) 2011-09-08 2016-01-20 Mallinckrodt LLC Production of alkaloids without the isolation of intermediates
WO2015015146A1 (en) * 2013-08-02 2015-02-05 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
KR102194174B1 (ko) 2013-11-13 2020-12-23 유로-셀티큐 에스.에이. 통증 및 오피오이드 장 기능장애 증후군의 치료를 위한 히드로모르폰 및 날록손

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
FR2562072B1 (fr) 1984-03-27 1989-07-07 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
AU4823900A (en) 1999-05-05 2000-11-17 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Direct c-14 oxidation of opioids

Also Published As

Publication number Publication date
US7435817B2 (en) 2008-10-14
KR20040027950A (ko) 2004-04-01
HRP20040161A2 (en) 2004-06-30
BR0211899B1 (pt) 2014-01-21
CN1271072C (zh) 2006-08-23
WO2003018588A2 (en) 2003-03-06
BRPI0211899B8 (pt) 2021-05-25
CN1545517A (zh) 2004-11-10
HK1063803A1 (en) 2005-01-14
WO2003018588B1 (en) 2004-02-26
JP4559730B2 (ja) 2010-10-13
JP2005502670A (ja) 2005-01-27
CA2457671A1 (en) 2003-03-06
HUP0401600A2 (hu) 2004-11-29
NO328655B1 (no) 2010-04-19
ES2345327T3 (es) 2010-09-21
US20050038250A1 (en) 2005-02-17
NZ531152A (en) 2005-11-25
AU2002331163B2 (en) 2008-02-21
WO2003018588A3 (en) 2003-11-27
RU2297419C2 (ru) 2007-04-20
CA2457671C (en) 2011-02-15
PL368732A1 (en) 2005-04-04
EP1421085B1 (en) 2010-04-28
ECSP044984A (es) 2004-04-28
ZA200401016B (en) 2004-10-19
RU2004108210A (ru) 2005-04-10
MXPA04001647A (es) 2004-05-31
EP1421085A2 (en) 2004-05-26
BR0211899A (pt) 2004-09-21
IL160193A0 (en) 2004-07-25
IS7153A (is) 2004-02-13
AR035289A1 (es) 2004-05-05
ATE466016T1 (de) 2010-05-15
HUP0401600A3 (en) 2008-05-28
NO20040724L (no) 2004-02-19
DE60236171D1 (de) 2010-06-10
KR100901402B1 (ko) 2009-06-05

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