HUP0500241A2 - Polimorf 4-{2-[4-[1-(2-etoxietil)-1H-benzimidazol-2-il]-1-piperidinil]etil}-alfa,alfa-dimetil-benzenoecetsav, eljárás előállításukra, az ezt tartalmazó gyógyszerkészítmények és alkalmazása - Google Patents
Polimorf 4-{2-[4-[1-(2-etoxietil)-1H-benzimidazol-2-il]-1-piperidinil]etil}-alfa,alfa-dimetil-benzenoecetsav, eljárás előállításukra, az ezt tartalmazó gyógyszerkészítmények és alkalmazásaInfo
- Publication number
- HUP0500241A2 HUP0500241A2 HU0500241A HUP0500241A HUP0500241A2 HU P0500241 A2 HUP0500241 A2 HU P0500241A2 HU 0500241 A HU0500241 A HU 0500241A HU P0500241 A HUP0500241 A HU P0500241A HU P0500241 A2 HUP0500241 A2 HU P0500241A2
- Authority
- HU
- Hungary
- Prior art keywords
- alpha
- polymorph
- ethoxyethyl
- piperidinyl
- ethyl
- Prior art date
Links
- ACCMWZWAEFYUGZ-UHFFFAOYSA-N bilastine Chemical compound N=1C2=CC=CC=C2N(CCOCC)C=1C(CC1)CCN1CCC1=CC=C(C(C)(C)C(O)=O)C=C1 ACCMWZWAEFYUGZ-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000037273 Pathologic Processes Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000009054 pathological process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány tárgyát az (I) képletű 4-{2-[4-[1-(2-etoxietil)-1H-benzimidazol-2-il]-1-piperidinil]etil}-a,a-dimetil-benzenoecetsav(<bilasztin<) új polimorf kristályos formája képezi. A találmányhoztartoznak továbbá ezen vegyület előállítási eljárásai, az újpolimorfot tartalmazó gyógyászati készítmények és az új polimorfalkalmazása allergiás reakciók és hisztamin által mediált patológiásfolyamatok kezelésére használható gyógyszerkészítmények előállítására. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ES2002/000194 WO2003089425A1 (es) | 2002-04-19 | 2002-04-19 | POLIMORFO DEL ÁCIDO 4-[2-[4-[1-(2-ETOXIETIL)-1H-BENCIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α-DIMETIL-BENCENOACÉTICO |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0500241A2 true HUP0500241A2 (hu) | 2005-06-28 |
HU230032B1 HU230032B1 (hu) | 2015-05-28 |
Family
ID=29225789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500241A HU230032B1 (hu) | 2002-04-19 | 2002-04-19 | Polimorf 4-{2-[4-[1-(2-etoxietil)-1H-benzimidazol-2-il]-1-piperidinil]etil}-alfa,alfa-dimetil-benzenoecetsav |
Country Status (31)
Country | Link |
---|---|
US (2) | US7612095B2 (hu) |
EP (1) | EP1505066B1 (hu) |
JP (1) | JP5142448B2 (hu) |
KR (1) | KR100673140B1 (hu) |
CN (1) | CN1290843C (hu) |
AR (1) | AR039423A1 (hu) |
AT (1) | ATE347550T1 (hu) |
AU (1) | AU2002255017B2 (hu) |
BG (1) | BG66302B1 (hu) |
BR (1) | BRPI0215703B8 (hu) |
CA (1) | CA2484460C (hu) |
CY (2) | CY1107564T1 (hu) |
CZ (1) | CZ305162B6 (hu) |
DE (1) | DE60216641T2 (hu) |
DK (1) | DK1505066T3 (hu) |
ES (1) | ES2278018T3 (hu) |
HK (1) | HK1072772A1 (hu) |
HR (1) | HRP20041048B1 (hu) |
HU (1) | HU230032B1 (hu) |
IL (1) | IL164645A (hu) |
MX (1) | MXPA04010313A (hu) |
NO (1) | NO329327B1 (hu) |
NZ (1) | NZ536551A (hu) |
PA (1) | PA8571201A1 (hu) |
PE (1) | PE20040086A1 (hu) |
PT (1) | PT1505066E (hu) |
SI (1) | SI1505066T1 (hu) |
SK (1) | SK288052B6 (hu) |
UA (1) | UA76866C2 (hu) |
UY (1) | UY27762A1 (hu) |
WO (1) | WO2003089425A1 (hu) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010013472A (ja) * | 2009-09-09 | 2010-01-21 | Faes Farma Sa | 4−[2−[1−(2−エトキシエチル)−1H−ベンズイミダゾール−2−イル]−1−ピペリジニル]エチル]−α,α−ジメチルベンゼノ酢酸の多形体 |
WO2013001731A1 (ja) * | 2011-06-30 | 2013-01-03 | パナソニック株式会社 | 通信システム、ユーザ端末並びに通信装置 |
CN102675101B (zh) * | 2012-05-16 | 2014-01-29 | 王蕾 | 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法 |
CZ307500B6 (cs) | 2012-08-15 | 2018-10-24 | Zentiva, K.S. | Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty |
CN103214454A (zh) * | 2013-03-30 | 2013-07-24 | 北京万全德众医药生物技术有限公司 | 一种比拉斯汀晶型及制备方法 |
WO2014188453A2 (en) * | 2013-05-24 | 2014-11-27 | Msn Laboratories Private Limited | Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid |
CN103356616A (zh) * | 2013-06-29 | 2013-10-23 | 北京万全德众医药生物技术有限公司 | 一种含有比拉斯汀的药物组合物及其制备方法 |
CN104447682A (zh) * | 2013-09-12 | 2015-03-25 | 天津市汉康医药生物技术有限公司 | 比拉斯汀化合物 |
CN104398481A (zh) * | 2014-10-29 | 2015-03-11 | 万全万特制药江苏有限公司 | 比拉斯汀口崩片及其制备方法 |
CA2993134A1 (en) * | 2015-07-24 | 2017-02-02 | Urquima, S.A. | Crystalline forms of bilastine and preparation methods thereof |
EP3170817A1 (en) | 2015-11-20 | 2017-05-24 | Faes Farma, S.A. | Co-crystals of benzimidazole compounds |
EP3170816A1 (en) * | 2015-11-20 | 2017-05-24 | Faes Farma, S.A. | Supersaturated compositions of benzimidazole compounds |
WO2017167949A1 (en) | 2016-04-01 | 2017-10-05 | Krka, D.D., Novo Mesto | Crystalline forms of bilastine |
WO2017191651A1 (en) * | 2016-05-05 | 2017-11-09 | Msn Laboratories Private Limited, R & D Center | Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof |
EP3453384B1 (en) | 2017-09-07 | 2020-05-27 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine |
EP3641735B1 (en) * | 2017-12-18 | 2021-02-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler |
EP3470062B1 (en) | 2017-12-18 | 2020-10-28 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate |
WO2019141563A1 (en) | 2018-01-18 | 2019-07-25 | Faes Farma, S.A. | Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent |
CA3200779A1 (en) | 2020-12-23 | 2022-06-30 | Strusi ORAZIO LUCA | A non-micronized bilastine composition |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4810789A (en) * | 1987-08-28 | 1989-03-07 | Bristol-Myers Company | Process for buspirone hydrochloride polymorphic crystalline form conversion |
ES2124167B1 (es) * | 1996-06-04 | 1999-09-16 | Espanola Prod Quimicos | Nuevos derivados del bencimidazol con actividad antihistaminica. |
BR0010683A (pt) * | 1999-04-16 | 2003-07-01 | Reddy Research Foundation | Formas polimórficas de um agente antidiabético: processo para seu preparo e composições farmacêuticas contendo o mesmo |
CO5170421A1 (es) * | 1999-04-23 | 2002-06-27 | Smithkline Beecham Plc | Nuevo compuesto farmaceutico maleico |
-
2002
- 2002-04-19 KR KR1020047016676A patent/KR100673140B1/ko active IP Right Grant
- 2002-04-19 SK SK5020-2004A patent/SK288052B6/sk not_active IP Right Cessation
- 2002-04-19 SI SI200230485T patent/SI1505066T1/sl unknown
- 2002-04-19 ES ES02724323T patent/ES2278018T3/es not_active Expired - Lifetime
- 2002-04-19 AT AT02724323T patent/ATE347550T1/de active
- 2002-04-19 WO PCT/ES2002/000194 patent/WO2003089425A1/es active IP Right Grant
- 2002-04-19 UA UA20041109444A patent/UA76866C2/uk unknown
- 2002-04-19 MX MXPA04010313A patent/MXPA04010313A/es active IP Right Grant
- 2002-04-19 CN CNB028289870A patent/CN1290843C/zh not_active Ceased
- 2002-04-19 HU HU0500241A patent/HU230032B1/hu unknown
- 2002-04-19 CZ CZ2004-1122A patent/CZ305162B6/cs not_active IP Right Cessation
- 2002-04-19 CA CA002484460A patent/CA2484460C/en not_active Expired - Fee Related
- 2002-04-19 NZ NZ536551A patent/NZ536551A/en not_active IP Right Cessation
- 2002-04-19 EP EP02724323A patent/EP1505066B1/en not_active Expired - Lifetime
- 2002-04-19 JP JP2003586146A patent/JP5142448B2/ja not_active Expired - Lifetime
- 2002-04-19 PT PT02724323T patent/PT1505066E/pt unknown
- 2002-04-19 AU AU2002255017A patent/AU2002255017B2/en not_active Expired
- 2002-04-19 US US10/511,822 patent/US7612095B2/en active Active
- 2002-04-19 DE DE60216641T patent/DE60216641T2/de not_active Expired - Lifetime
- 2002-04-19 DK DK02724323T patent/DK1505066T3/da active
- 2002-04-19 BR BRPI0215703A patent/BRPI0215703B8/pt active IP Right Grant
-
2003
- 2003-04-14 PE PE2003000376A patent/PE20040086A1/es active IP Right Grant
- 2003-04-14 UY UY27762A patent/UY27762A1/es not_active Application Discontinuation
- 2003-04-15 AR ARP030101325A patent/AR039423A1/es not_active Application Discontinuation
- 2003-04-16 PA PA20038571201A patent/PA8571201A1/es unknown
-
2004
- 2004-10-17 IL IL164645A patent/IL164645A/en active IP Right Grant
- 2004-11-09 HR HRP20041048AA patent/HRP20041048B1/hr not_active IP Right Cessation
- 2004-11-17 NO NO20044999A patent/NO329327B1/no not_active IP Right Cessation
- 2004-11-18 BG BG108941A patent/BG66302B1/bg unknown
-
2005
- 2005-07-27 HK HK05106418A patent/HK1072772A1/xx not_active IP Right Cessation
-
2007
- 2007-02-23 CY CY20071100259T patent/CY1107564T1/el unknown
-
2009
- 2009-09-16 US US12/561,148 patent/US20100004285A1/en not_active Abandoned
-
2013
- 2013-04-24 CY CY2013015C patent/CY2013015I1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0500241A2 (hu) | Polimorf 4-{2-[4-[1-(2-etoxietil)-1H-benzimidazol-2-il]-1-piperidinil]etil}-alfa,alfa-dimetil-benzenoecetsav, eljárás előállításukra, az ezt tartalmazó gyógyszerkészítmények és alkalmazása | |
JP6483146B2 (ja) | アルツハイマー病治療用のbace1阻害剤としての2−アミノ−3,5,5−トリフルオロ−3,4,5,6−テトラヒドロピリジン | |
NO20055068L (no) | Kjemiske forbindelser | |
NO20075365L (no) | 3,4-substituerte pyrrolidinderivater for behandling av hypertensjon | |
DE60315323D1 (de) | Piperidinderivate zur verwendung bei der behandlung von durch chemokins vermittelten leiden | |
MXPA03011484A (es) | Heteroarilos multiciclicos sustituidos con quinuclidinas para el tratamiento de enfermedades. | |
BRPI0514865A (pt) | processo para preparar um composto | |
MXPA04003007A (es) | Compuestos azabiciclico sustituidos condensados con heteroarilo para el tratamiento de enfermedades. | |
HUP0402043A2 (hu) | Rimonabant polimorf formája, eljárás ezen forma előállítására és ilyen polimorf formát tartalmazó gyógyászati készítmények | |
EP2423207A3 (en) | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | |
NO20050741L (no) | Ny fremgangsmate for syntesen og ny krystallinsk form av agomelatin og farmasoytiske sammensetninger inneholdende den | |
PE20050078A1 (es) | Derivados de pirrolidona como inhibidores de maob | |
CA2753434A1 (en) | Soluble guanylate cyclase activators | |
SE0301368D0 (sv) | Chemical compounds | |
HUP0401886A2 (hu) | Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
TW200740779A (en) | Intermediate compound for synthesizing pharmaceutical agent and production method thereof | |
EP2412707A3 (en) | 3-[2-(3-Amino-2-oxo-2H-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors | |
NO20073839L (no) | Kinolinderivat, fremgangsmate for fremstilling og anvendelse av dette, og legemiddel inneholdende dette | |
NO20063268L (no) | Fremgangsmate til fremstilling av 1-(2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-metoksybenzyl)quinuklidin-3-amin | |
NO20060417L (no) | Fremgangsmate til fremstilling av 1-okten fra krakk-C4 | |
CA2524900A1 (en) | 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines | |
MA27133A1 (fr) | Nouvelles formes polymorphes cristallines d'hydrochlorure de lercanidipine et procede de fabrication associe | |
HUP0303928A2 (hu) | Omeprazol kristályos formája, eljárás az előállítására és ezt tartalmazó gyógyszerkészítmények | |
AU2003208686A1 (en) | Alkylammonium salts of omeprazole and esomeprazole | |
DE60210977D1 (de) | Immunmodulierende verbindungen |