HRP20041048B1 - POLIMORF 4-[2-[4-[1-(2-ETOKSIETIL)-1H-BENZIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α- DIMETIL- BENZENOCTENE KISELINE - Google Patents

POLIMORF 4-[2-[4-[1-(2-ETOKSIETIL)-1H-BENZIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α- DIMETIL- BENZENOCTENE KISELINE

Info

Publication number
HRP20041048B1
HRP20041048B1 HRP20041048AA HRP20041048A HRP20041048B1 HR P20041048 B1 HRP20041048 B1 HR P20041048B1 HR P20041048A A HRP20041048A A HR P20041048AA HR P20041048 A HRP20041048 A HR P20041048A HR P20041048 B1 HRP20041048 B1 HR P20041048B1
Authority
HR
Croatia
Prior art keywords
polymorph
ethoxyethyl
piperidinyl
dimethyl
ethyl
Prior art date
Application number
HRP20041048AA
Other languages
English (en)
Inventor
Aurelio Orjales-Venero
Maravillas Bordell Martín
Gonzalo Canal Mori
Haydée Blanco Fuente
María Luisa LUCERO DE PABLO
Victor Rubio Royo
Ramón MOSQUERA PESTAÑA
Original Assignee
Faes Farma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29225789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20041048(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Faes Farma, S.A. filed Critical Faes Farma, S.A.
Publication of HRP20041048A2 publication Critical patent/HRP20041048A2/xx
Publication of HRP20041048A9 publication Critical patent/HRP20041048A9/hr
Publication of HRP20041048B1 publication Critical patent/HRP20041048B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Opisan je polimorf 1 4-[2-[4-[1-(2-etoksietil)-1H-benzimidazol-2-il]-1-piperidinil]etil]- α, α-dimetil-benzenoctene kiseline s formulom (I), procedure za njegovu pripravu, farmaceutske formule koje sadržavaju polimorf 1 i upotreba polimorfa 1 za tretiranje alergijskih reakcija i patoloških procesa posredovanih histaminom kod sisavaca kakav je čovjek.
HRP20041048AA 2002-04-19 2004-11-09 POLIMORF 4-[2-[4-[1-(2-ETOKSIETIL)-1H-BENZIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α- DIMETIL- BENZENOCTENE KISELINE HRP20041048B1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2002/000194 WO2003089425A1 (es) 2002-04-19 2002-04-19 POLIMORFO DEL ÁCIDO 4-[2-[4-[1-(2-ETOXIETIL)-1H-BENCIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α-DIMETIL-BENCENOACÉTICO

Publications (3)

Publication Number Publication Date
HRP20041048A2 HRP20041048A2 (en) 2005-02-28
HRP20041048A9 HRP20041048A9 (hr) 2013-01-31
HRP20041048B1 true HRP20041048B1 (hr) 2013-04-30

Family

ID=29225789

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20041048AA HRP20041048B1 (hr) 2002-04-19 2004-11-09 POLIMORF 4-[2-[4-[1-(2-ETOKSIETIL)-1H-BENZIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α- DIMETIL- BENZENOCTENE KISELINE

Country Status (31)

Country Link
US (2) US7612095B2 (hr)
EP (1) EP1505066B1 (hr)
JP (1) JP5142448B2 (hr)
KR (1) KR100673140B1 (hr)
CN (1) CN1290843C (hr)
AR (1) AR039423A1 (hr)
AT (1) ATE347550T1 (hr)
AU (1) AU2002255017B2 (hr)
BG (1) BG66302B1 (hr)
BR (1) BRPI0215703B8 (hr)
CA (1) CA2484460C (hr)
CY (2) CY1107564T1 (hr)
CZ (1) CZ305162B6 (hr)
DE (1) DE60216641T2 (hr)
DK (1) DK1505066T3 (hr)
ES (1) ES2278018T3 (hr)
HK (1) HK1072772A1 (hr)
HR (1) HRP20041048B1 (hr)
HU (1) HU230032B1 (hr)
IL (1) IL164645A (hr)
MX (1) MXPA04010313A (hr)
NO (1) NO329327B1 (hr)
NZ (1) NZ536551A (hr)
PA (1) PA8571201A1 (hr)
PE (1) PE20040086A1 (hr)
PT (1) PT1505066E (hr)
SI (1) SI1505066T1 (hr)
SK (1) SK288052B6 (hr)
UA (1) UA76866C2 (hr)
UY (1) UY27762A1 (hr)
WO (1) WO2003089425A1 (hr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
JP6023054B2 (ja) * 2011-06-30 2016-11-09 パナソニック インテレクチュアル プロパティ コーポレーション オブ アメリカＰａｎａｓｏｎｉｃ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｃｏｒｐｏｒａｔｉｏｎ ｏｆ Ａｍｅｒｉｃａ 通信システム、ユーザ端末並びに通信装置
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103356616A (zh) * 2013-06-29 2013-10-23 北京万全德众医药生物技术有限公司 一种含有比拉斯汀的药物组合物及其制备方法
CN104447682A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 比拉斯汀化合物
CN104398481A (zh) * 2014-10-29 2015-03-11 万全万特制药江苏有限公司 比拉斯汀口崩片及其制备方法
JP7168447B2 (ja) * 2015-07-24 2022-11-09 ウルキマ，ソシエダッド アノニマ ビラスチンの結晶形態及びそれらの調製方法
EP3170817A1 (en) * 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) * 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center SOLID STATE FORMS OF 2- [4- (2- {4- [1- (2-ETHOXYETHYL) -1H-BENZIMIDAZOL-2-YL] -1-PIPERIDINYL} ETHYL) PHENYL] -2-METHYLPROPANOIC ACID AND PREPARATION METHOD THEREOF
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
PL3641735T3 (pl) 2017-12-18 2021-09-06 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Kompozycja farmaceutyczna tabletki zawierająca bilastynę w postaci 3 i rozpuszczalny w wodzie wypełniacz
PT3740191T (pt) 2018-01-18 2021-07-09 Faes Farma Sa Composições oftálmicas compreendendo bilastina, uma beta-ciclodextrina e pelo menos um agente gelificante
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0818454A1 (en) * 1996-06-04 1998-01-14 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) Benzimidazole derivatives with antihistaminic activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
EP1171430A1 (en) * 1999-04-16 2002-01-16 Dr. Reddy's Research Foundation Novel polymorphic forms of an antidiabetic agent: process for their preparation and pharmaceutical compositions containing them
AP1598A (en) * 1999-04-23 2006-04-26 Smithkline Beecham Plc Polymorph of 5-[4-[2-(N-methyl-N-(2-pyridyl) amino) ethoxy]benzyl] thiazolidine-2,4-dione, maleic acid salt.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0818454A1 (en) * 1996-06-04 1998-01-14 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) Benzimidazole derivatives with antihistaminic activity

Also Published As

Publication number Publication date
CY2013015I2 (el) 2015-08-05
PT1505066E (pt) 2007-03-30
CZ20041122A3 (cs) 2005-03-16
NZ536551A (en) 2006-08-31
KR20050005448A (ko) 2005-01-13
MXPA04010313A (es) 2005-06-08
US20100004285A1 (en) 2010-01-07
UA76866C2 (uk) 2006-09-15
US20050203141A1 (en) 2005-09-15
JP2005529120A (ja) 2005-09-29
CA2484460A1 (en) 2003-10-30
EP1505066A1 (en) 2005-02-09
EP1505066B1 (en) 2006-12-06
DK1505066T3 (da) 2007-03-19
CN1628112A (zh) 2005-06-15
AU2002255017A1 (en) 2003-11-03
BG108941A (en) 2005-12-30
AU2002255017B2 (en) 2008-11-13
WO2003089425A1 (es) 2003-10-30
US7612095B2 (en) 2009-11-03
JP5142448B2 (ja) 2013-02-13
NO329327B1 (no) 2010-09-27
CZ305162B6 (cs) 2015-05-27
CA2484460C (en) 2009-09-29
SK288052B6 (sk) 2013-03-01
SI1505066T1 (sl) 2007-04-30
BRPI0215703B8 (pt) 2021-05-25
DE60216641D1 (de) 2007-01-18
IL164645A (en) 2010-11-30
BRPI0215703B1 (pt) 2017-06-27
AR039423A1 (es) 2005-02-16
HUP0500241A2 (hu) 2005-06-28
CY2013015I1 (el) 2015-08-05
CY1107564T1 (el) 2013-03-13
HRP20041048A2 (en) 2005-02-28
KR100673140B1 (ko) 2007-01-22
SK50202004A3 (sk) 2005-05-05
HRP20041048A9 (hr) 2013-01-31
HU230032B1 (hu) 2015-05-28
IL164645A0 (en) 2005-12-18
BG66302B1 (bg) 2013-03-29
ATE347550T1 (de) 2006-12-15
CN1290843C (zh) 2006-12-20
PA8571201A1 (es) 2003-12-10
PE20040086A1 (es) 2004-04-27
UY27762A1 (es) 2003-09-30
ES2278018T3 (es) 2007-08-01
HK1072772A1 (en) 2005-09-09
BR0215703A (pt) 2005-02-01
DE60216641T2 (de) 2007-09-27
NO20044999L (no) 2005-01-14

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