BR0215703A - Polimorfo de ácido 4-[2-[1-(2-etoxietil)-1h-benzidimazol-2-il]-1-piperidinil]e til]-aa-dimetil-benzenoacético, procedimento para sua preparação, preparado farmacêutico e seu uso - Google Patents

Polimorfo de ácido 4-[2-[1-(2-etoxietil)-1h-benzidimazol-2-il]-1-piperidinil]e til]-aa-dimetil-benzenoacético, procedimento para sua preparação, preparado farmacêutico e seu uso

Info

Publication number
BR0215703A
BR0215703A BR0215703-9A BR0215703A BR0215703A BR 0215703 A BR0215703 A BR 0215703A BR 0215703 A BR0215703 A BR 0215703A BR 0215703 A BR0215703 A BR 0215703A
Authority
BR
Brazil
Prior art keywords
preparation
benzidimazol
ethoxyethyl
piperidinyl
polymorph
Prior art date
Application number
BR0215703-9A
Other languages
English (en)
Other versions
BRPI0215703B1 (pt
BRPI0215703B8 (pt
Inventor
Aurelio Orjales Venero
Mosquera Pesta A Ramon
Maravillas Bordell Martin
Gonzalo Canal Mori
Haydee Blanco Fuente
Maria Luisa Lucero De Pablo
Victor Rubio Royo
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29225789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0215703(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Publication of BR0215703A publication Critical patent/BR0215703A/pt
Publication of BRPI0215703B1 publication Critical patent/BRPI0215703B1/pt
Publication of BRPI0215703B8 publication Critical patent/BRPI0215703B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"POLIMORFO DE áCIDO 4-[2-[1-(2-ETOXIETIL)-1H-BENZIDIMAZOL-2IL]-1-PIPERIDINIL]ET IL]-<244><244>-DIMETIL-BENZENOACéTICO, PROCEDIMENTO PARA SUA PREPARAçãO, PREPARADO FARMACêUTICO E SEU USO". Trata-se do polimorfo de ácido 4-[2-[1-(2-etoxietil)-1H-benzidimazol-2-il]-1-piperidiniletil]-<244><244> dimetil-benzenoacético da fórmula (I), dos procedimentos para a sua preparação, de fórmulas farmacêuticas que contêm o polimorfo 1 e do uso do polimorfo 1 para o tratamento de reações alérgicas e os processos patológicos mediados pela histamina em mamíferos, tal como o homem.
BRPI0215703A 2002-04-19 2002-04-19 polimorfo de ácido 4-[2-[1-(2-etoxietil)-1h-benzidimazol-2-il]-1-piperidinil]etil]-a, a-dimetil-benzenoacético, preparado farmacêutico, e seu uso do polimorfo 1 BRPI0215703B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2002/000194 WO2003089425A1 (es) 2002-04-19 2002-04-19 POLIMORFO DEL ÁCIDO 4-[2-[4-[1-(2-ETOXIETIL)-1H-BENCIMIDAZOL-2-IL]-1-PIPERIDINIL]ETIL]-α, α-DIMETIL-BENCENOACÉTICO

Publications (3)

Publication Number Publication Date
BR0215703A true BR0215703A (pt) 2005-02-01
BRPI0215703B1 BRPI0215703B1 (pt) 2017-06-27
BRPI0215703B8 BRPI0215703B8 (pt) 2021-05-25

Family

ID=29225789

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0215703A BRPI0215703B8 (pt) 2002-04-19 2002-04-19 polimorfo de ácido 4-[2-[1-(2-etoxietil)-1h-benzidimazol-2-il]-1-piperidinil]etil]-a, a-dimetil-benzenoacético, preparado farmacêutico, e seu uso do polimorfo 1

Country Status (31)

Country Link
US (2) US7612095B2 (pt)
EP (1) EP1505066B1 (pt)
JP (1) JP5142448B2 (pt)
KR (1) KR100673140B1 (pt)
CN (1) CN1290843C (pt)
AR (1) AR039423A1 (pt)
AT (1) ATE347550T1 (pt)
AU (1) AU2002255017B2 (pt)
BG (1) BG66302B1 (pt)
BR (1) BRPI0215703B8 (pt)
CA (1) CA2484460C (pt)
CY (2) CY1107564T1 (pt)
CZ (1) CZ305162B6 (pt)
DE (1) DE60216641T2 (pt)
DK (1) DK1505066T3 (pt)
ES (1) ES2278018T3 (pt)
HK (1) HK1072772A1 (pt)
HR (1) HRP20041048B1 (pt)
HU (1) HU230032B1 (pt)
IL (1) IL164645A (pt)
MX (1) MXPA04010313A (pt)
NO (1) NO329327B1 (pt)
NZ (1) NZ536551A (pt)
PA (1) PA8571201A1 (pt)
PE (1) PE20040086A1 (pt)
PT (1) PT1505066E (pt)
SI (1) SI1505066T1 (pt)
SK (1) SK288052B6 (pt)
UA (1) UA76866C2 (pt)
UY (1) UY27762A1 (pt)
WO (1) WO2003089425A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
US20140194111A1 (en) * 2011-06-30 2014-07-10 Panasonic Corporation Communication system, user terminal, and communication device
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103356616A (zh) * 2013-06-29 2013-10-23 北京万全德众医药生物技术有限公司 一种含有比拉斯汀的药物组合物及其制备方法
CN104447682A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 比拉斯汀化合物
CN104398481A (zh) * 2014-10-29 2015-03-11 万全万特制药江苏有限公司 比拉斯汀口崩片及其制备方法
WO2017017301A1 (es) * 2015-07-24 2017-02-02 Urquima, S.A Formas cristalinas de bilastina y procedimientos para su preparación
EP3170817A1 (en) * 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) * 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
WO2019097091A1 (en) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
WO2019141563A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
IL145958A0 (en) * 1999-04-16 2002-07-25 Reddy Research Foundation Polymorphic form of arginine salt of (2s)-3-[4-[2-phenoxazin-10-yl)ethoxy] phenyl]2-ethoxypropanoic acid, processes for the preparation thereof and pharmaceutical compositions containing the same
PE20010044A1 (es) * 1999-04-23 2001-03-10 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona

Also Published As

Publication number Publication date
AU2002255017A1 (en) 2003-11-03
HK1072772A1 (en) 2005-09-09
DE60216641T2 (de) 2007-09-27
NZ536551A (en) 2006-08-31
KR100673140B1 (ko) 2007-01-22
CA2484460A1 (en) 2003-10-30
AU2002255017B2 (en) 2008-11-13
JP5142448B2 (ja) 2013-02-13
PT1505066E (pt) 2007-03-30
WO2003089425A1 (es) 2003-10-30
CY2013015I1 (el) 2015-08-05
CZ20041122A3 (cs) 2005-03-16
HRP20041048B1 (hr) 2013-04-30
CZ305162B6 (cs) 2015-05-27
PA8571201A1 (es) 2003-12-10
HUP0500241A2 (hu) 2005-06-28
BG108941A (en) 2005-12-30
IL164645A0 (en) 2005-12-18
CN1290843C (zh) 2006-12-20
DE60216641D1 (de) 2007-01-18
CY2013015I2 (el) 2015-08-05
US20100004285A1 (en) 2010-01-07
HRP20041048A2 (en) 2005-02-28
AR039423A1 (es) 2005-02-16
HU230032B1 (hu) 2015-05-28
UY27762A1 (es) 2003-09-30
HRP20041048A9 (hr) 2013-01-31
IL164645A (en) 2010-11-30
US7612095B2 (en) 2009-11-03
KR20050005448A (ko) 2005-01-13
BRPI0215703B1 (pt) 2017-06-27
EP1505066B1 (en) 2006-12-06
CN1628112A (zh) 2005-06-15
US20050203141A1 (en) 2005-09-15
CY1107564T1 (el) 2013-03-13
JP2005529120A (ja) 2005-09-29
SK50202004A3 (sk) 2005-05-05
CA2484460C (en) 2009-09-29
PE20040086A1 (es) 2004-04-27
NO329327B1 (no) 2010-09-27
ATE347550T1 (de) 2006-12-15
DK1505066T3 (da) 2007-03-19
NO20044999L (no) 2005-01-14
ES2278018T3 (es) 2007-08-01
EP1505066A1 (en) 2005-02-09
SI1505066T1 (sl) 2007-04-30
SK288052B6 (sk) 2013-03-01
BRPI0215703B8 (pt) 2021-05-25
BG66302B1 (bg) 2013-03-29
MXPA04010313A (es) 2005-06-08
UA76866C2 (uk) 2006-09-15

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