PE20010044A1 - Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona - Google Patents
Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-dionaInfo
- Publication number
- PE20010044A1 PE20010044A1 PE2000000365A PE0003652000A PE20010044A1 PE 20010044 A1 PE20010044 A1 PE 20010044A1 PE 2000000365 A PE2000000365 A PE 2000000365A PE 0003652000 A PE0003652000 A PE 0003652000A PE 20010044 A1 PE20010044 A1 PE 20010044A1
- Authority
- PE
- Peru
- Prior art keywords
- polymorph
- diona
- pyridyl
- ethoxy
- benzyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UNA FORMA POLIMORFICA DE LA SAL DEL ACIDO MALEICO DE 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]-TIAZOLIDINA-2,4-DIONA AISLADO EN FORMA PURA, CRISTALINA CARACTERIZADO POR SUS PROPIEDADES FISICAS: ESPECTRO INFRARROJO, ESPECTRO RAMAN, ESPECTRO DE RESONANCIA MAGNETICA NUCLEAR, PATRON DE DIFRACCION DE RAYOS X. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE: a) EL COMPUESTO SE SUSPENDE EN ACETONA Y SE AGITA A UNA TEMPERATURA ELEVADA DURANTE UN PERIODO DE TIEMPO PROLONGADO; b) SE SIEMBRA EL COMPUESTO EN ETANOL DESNATURALIZADO A UNA TEMPERATURA ELEVADA CON CRISTALES DEL POLIMORFO, ENTONCES SE ENFRIA LA MEZCLA DE REACCION PARA PROPORCIONAR EL POLIMORFO, DESPUES DE LO CUAL SE RECUPERA EL POLIMORFO DEL ETANOL DESNATURALIZADO. EL POLIMORFO DE LA SAL DEL ACIDO MALEICO DE 5-[4-[2-(N-METIL-N-(2-PIRIDIL)AMINO)ETOXI]BENCIL]-TIAZOLIDINA-2,4-DIONA ES UTIL PARA EL TRATAMIENTO DE DIABETES MELLITUS Y SUS COMPLICACIONES
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9909473.2A GB9909473D0 (en) | 1999-04-23 | 1999-04-23 | Novel compounds |
GBGB9912196.4A GB9912196D0 (en) | 1999-05-25 | 1999-05-25 | Novel pharmaceutical |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010044A1 true PE20010044A1 (es) | 2001-03-10 |
Family
ID=26315461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000365A PE20010044A1 (es) | 1999-04-23 | 2000-04-19 | Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona |
Country Status (40)
Country | Link |
---|---|
US (2) | US6806280B1 (es) |
EP (2) | EP1304330A3 (es) |
JP (1) | JP2002543077A (es) |
KR (1) | KR100744360B1 (es) |
CN (1) | CN1167702C (es) |
AP (1) | AP1598A (es) |
AR (2) | AR023561A1 (es) |
AT (1) | ATE246191T1 (es) |
AU (1) | AU765005B2 (es) |
BG (1) | BG65485B1 (es) |
BR (1) | BR0009932A (es) |
CA (1) | CA2370280A1 (es) |
CO (1) | CO5170421A1 (es) |
CZ (1) | CZ20013800A3 (es) |
DE (1) | DE60004196T2 (es) |
DK (1) | DK1173435T3 (es) |
DZ (1) | DZ3156A1 (es) |
EA (1) | EA004541B1 (es) |
ES (1) | ES2203453T3 (es) |
HK (1) | HK1045153B (es) |
HR (1) | HRP20010772B1 (es) |
HU (1) | HUP0200931A3 (es) |
IL (1) | IL146111A0 (es) |
MA (1) | MA25356A1 (es) |
MX (1) | MXPA01010821A (es) |
MY (1) | MY131973A (es) |
NO (1) | NO320574B1 (es) |
NZ (1) | NZ515168A (es) |
OA (1) | OA11872A (es) |
PE (1) | PE20010044A1 (es) |
PL (1) | PL351684A1 (es) |
PT (1) | PT1173435E (es) |
SK (1) | SK286427B6 (es) |
TR (1) | TR200103062T2 (es) |
TW (1) | TWI283677B (es) |
UA (1) | UA67844C2 (es) |
UY (1) | UY26121A1 (es) |
WO (1) | WO2000064896A1 (es) |
YU (1) | YU75301A (es) |
ZA (1) | ZA200108719B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020137940A1 (en) * | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
GB9726568D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
ATE247653T1 (de) | 1999-04-23 | 2003-09-15 | Smithkline Beecham Plc | Thiazolidindionderivat und seine verwendung als antidiabetikum |
ATE246191T1 (de) * | 1999-04-23 | 2003-08-15 | Smithkline Beecham Plc | Polymorph von 5-(4-(2-(n-methyl-n-(2- pyrdyl)amino)äthoxy)benzyl)thiazolidin-2,4-dion maleinsäuresalz |
US20040248945A1 (en) | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
GB0006133D0 (en) | 2000-03-14 | 2000-05-03 | Smithkline Beecham Plc | Novel pharmaceutical |
US7241895B2 (en) | 2000-09-26 | 2007-07-10 | Dr. Reddy's Laboratories Limited | Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation |
MXPA03002580A (es) * | 2000-09-26 | 2003-10-15 | Cord Janet I | Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion. |
CA2484460C (en) * | 2002-04-19 | 2009-09-29 | Faes Farma, S.A. | Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-yl]-1-piperidinyl]ethyl]-.alpha..alpha. dimethyl-benzeneacetic acid |
GB0307259D0 (en) * | 2003-03-28 | 2003-05-07 | Glaxo Group Ltd | Process |
EP1468997A3 (en) * | 2003-04-18 | 2004-11-03 | CHEMI S.p.A. | Polymorphous forms of rosiglitazone maleate |
GB2405403A (en) * | 2003-08-29 | 2005-03-02 | Cipla Ltd | Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base |
EP1709038A2 (en) * | 2004-01-28 | 2006-10-11 | Usv Limited | A process for the preparation of 5- 4- 2- n-methyl -n-(2-pyridyl) amino ethoxy phenyl methyl thiaz olidine-2, 4-dione maleate |
ITMI20041537A1 (it) * | 2004-07-28 | 2004-10-28 | Chemi Spa | Nuova forma polimorfa del rosiglitazone maleato |
CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
US20090076093A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched rosiglitazone |
EP2184055A1 (en) | 2008-11-07 | 2010-05-12 | LEK Pharmaceuticals d.d. | Process for preparing solid dosage forms of rosiglitazone maleate |
JP2010013472A (ja) * | 2009-09-09 | 2010-01-21 | Faes Farma Sa | 4−[2−[1−(2−エトキシエチル)−1H−ベンズイミダゾール−2−イル]−1−ピペリジニル]エチル]−α,α−ジメチルベンゼノ酢酸の多形体 |
JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Jak激酶家族之小分子抑制劑 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10199003I1 (de) | 1987-09-04 | 2003-06-12 | Beecham Group Plc | Substituierte Thiazolidinionderivate |
GB9124513D0 (en) | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
US6462337B1 (en) * | 2000-04-20 | 2002-10-08 | Agilent Technologies, Inc. | Mass spectrometer electrospray ionization |
US5741803A (en) | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
US5478852C1 (en) * | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
DE4404198A1 (de) | 1994-02-10 | 1995-08-17 | Henkel Kgaa | 2-Fluor-6-nitroaniline |
UY24886A1 (es) * | 1997-02-18 | 2001-08-27 | Smithkline Beecham Plc | Tiazolidindiona |
US6632947B2 (en) * | 1997-02-18 | 2003-10-14 | Smithkline Beecham Plc | Process for the preparation of substituted thiazolidinedione |
GB9711683D0 (en) * | 1997-06-05 | 1997-08-06 | Smithkline Beecham Plc | Composition |
US7091359B2 (en) * | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
GB9726563D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US6664278B2 (en) | 1997-12-16 | 2003-12-16 | Smithkline Beecham P.L.C. | Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt |
GB9726566D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
US6613785B2 (en) * | 1998-07-21 | 2003-09-02 | Smithkline Beecham Plc | Use of glucose uptake enhancer for reducing post-ischemic injury of the heart |
ATE246191T1 (de) * | 1999-04-23 | 2003-08-15 | Smithkline Beecham Plc | Polymorph von 5-(4-(2-(n-methyl-n-(2- pyrdyl)amino)äthoxy)benzyl)thiazolidin-2,4-dion maleinsäuresalz |
ATE247653T1 (de) | 1999-04-23 | 2003-09-15 | Smithkline Beecham Plc | Thiazolidindionderivat und seine verwendung als antidiabetikum |
JP2002543076A (ja) | 1999-04-23 | 2002-12-17 | スミスクライン ビーチャム パブリック リミテッド カンパニー | チアゾリジンジオン誘導体および抗糖尿病薬としてのその使用 |
CN1277965A (zh) | 2000-06-14 | 2000-12-27 | 中国医药研究开发中心 | 盐酸罗格列酮及其应用 |
MXPA03002580A (es) | 2000-09-26 | 2003-10-15 | Cord Janet I | Nuevas formas polimorficas de maleato de 5-(4-(2-(n-metil-n-(2-piridil) amino)etoxi)bencil) tiazolidin-2, 4-diona y proceso para su preparacion. |
-
2000
- 2000-04-19 AT AT00920892T patent/ATE246191T1/de not_active IP Right Cessation
- 2000-04-19 AR ARP000101862A patent/AR023561A1/es unknown
- 2000-04-19 HU HU0200931A patent/HUP0200931A3/hu unknown
- 2000-04-19 CA CA002370280A patent/CA2370280A1/en not_active Abandoned
- 2000-04-19 ES ES00920892T patent/ES2203453T3/es not_active Expired - Lifetime
- 2000-04-19 DZ DZ003156A patent/DZ3156A1/xx active
- 2000-04-19 EP EP02080321A patent/EP1304330A3/en not_active Withdrawn
- 2000-04-19 DK DK00920892T patent/DK1173435T3/da active
- 2000-04-19 EP EP00920892A patent/EP1173435B1/en not_active Expired - Lifetime
- 2000-04-19 DE DE60004196T patent/DE60004196T2/de not_active Expired - Fee Related
- 2000-04-19 TR TR2001/03062T patent/TR200103062T2/xx unknown
- 2000-04-19 KR KR1020017013540A patent/KR100744360B1/ko not_active IP Right Cessation
- 2000-04-19 AP APAP/P/2001/002330A patent/AP1598A/en active
- 2000-04-19 EA EA200101121A patent/EA004541B1/ru not_active IP Right Cessation
- 2000-04-19 CZ CZ20013800A patent/CZ20013800A3/cs unknown
- 2000-04-19 MX MXPA01010821A patent/MXPA01010821A/es active IP Right Grant
- 2000-04-19 YU YU75301A patent/YU75301A/sh unknown
- 2000-04-19 JP JP2000614248A patent/JP2002543077A/ja active Pending
- 2000-04-19 AU AU41308/00A patent/AU765005B2/en not_active Ceased
- 2000-04-19 NZ NZ515168A patent/NZ515168A/xx unknown
- 2000-04-19 WO PCT/GB2000/001520 patent/WO2000064896A1/en not_active Application Discontinuation
- 2000-04-19 CN CNB008091463A patent/CN1167702C/zh not_active Expired - Fee Related
- 2000-04-19 PT PT00920892T patent/PT1173435E/pt unknown
- 2000-04-19 AR ARP000101867A patent/AR023565A1/es unknown
- 2000-04-19 PL PL00351684A patent/PL351684A1/xx not_active Application Discontinuation
- 2000-04-19 CO CO00028929A patent/CO5170421A1/es not_active Application Discontinuation
- 2000-04-19 SK SK1492-2001A patent/SK286427B6/sk not_active IP Right Cessation
- 2000-04-19 OA OA1200100276A patent/OA11872A/en unknown
- 2000-04-19 IL IL14611100A patent/IL146111A0/xx unknown
- 2000-04-19 US US10/048,123 patent/US6806280B1/en not_active Expired - Fee Related
- 2000-04-19 BR BR0009932-5A patent/BR0009932A/pt not_active Application Discontinuation
- 2000-04-19 PE PE2000000365A patent/PE20010044A1/es not_active Application Discontinuation
- 2000-04-19 UA UA2001117939A patent/UA67844C2/uk unknown
- 2000-04-21 MY MYPI20001708A patent/MY131973A/en unknown
- 2000-04-24 UY UY26121A patent/UY26121A1/es not_active Application Discontinuation
- 2000-05-11 TW TW089108962A patent/TWI283677B/zh not_active IP Right Cessation
-
2001
- 2001-10-22 HR HR20010772A patent/HRP20010772B1/xx not_active IP Right Cessation
- 2001-10-22 NO NO20015147A patent/NO320574B1/no unknown
- 2001-10-22 MA MA26378A patent/MA25356A1/fr unknown
- 2001-10-23 ZA ZA200108719A patent/ZA200108719B/en unknown
- 2001-11-20 BG BG106121A patent/BG65485B1/bg unknown
-
2002
- 2002-06-28 HK HK02104879.6A patent/HK1045153B/zh not_active IP Right Cessation
-
2004
- 2004-09-08 US US10/935,939 patent/US20050080114A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |