AR023565A1 - Un procedimiento para preparar una forma polimorfica de sal del acido maleico de tizazolidin-2,4 diona - Google Patents

Un procedimiento para preparar una forma polimorfica de sal del acido maleico de tizazolidin-2,4 diona

Info

Publication number
AR023565A1
AR023565A1 ARP000101867A ARP000101867A AR023565A1 AR 023565 A1 AR023565 A1 AR 023565A1 AR P000101867 A ARP000101867 A AR P000101867A AR P000101867 A ARP000101867 A AR P000101867A AR 023565 A1 AR023565 A1 AR 023565A1
Authority
AR
Argentina
Prior art keywords
maleic acid
compound
polymorphic form
salt
tizazolidin
Prior art date
Application number
ARP000101867A
Other languages
English (en)
Original Assignee
Smithkline Beecham Cork Ltd
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR023565(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9909473.2A external-priority patent/GB9909473D0/en
Priority claimed from GBGB9912196.4A external-priority patent/GB9912196D0/en
Application filed by Smithkline Beecham Cork Ltd, Smithkline Beecham Plc filed Critical Smithkline Beecham Cork Ltd
Publication of AR023565A1 publication Critical patent/AR023565A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Una forma polimorfica de sal del ácido maleico de 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]bencil-tiazolidina-2,4-diona (el Polimorfo), que proporciona:(i)un espectro infrarrojo que contiene picos a 1.763, 912, 856 y 709 cm-1; y/o (ii) un espectroR aman que contiene picos a 1.762, 1.284, 912 y 888 cm1-; y/o(iii) un espectro de resonancia magnética nuclear de 13C en estado solido que contiene picos a 111,0, 113,6, 119,8, 129,1, 130,9, 131,8, 134,7, 138,7, 146,5,152,7, 157,5, 169,5, 171,0,178,7 ppm; y/o (iv) un patron de difraccion de rayos X a través de polvo (XRPD) que da distancias reticulares calculadas a 5,87,5,30,4,69, 4,09, 3,88, 3,53 y 3,46 Angstroms; un procedimiento para preparar dicho compuesto, una composicionfarmacéutica que c ontiene dicho compuesto y eluso de dicho compuesto en medicina.
ARP000101867A 1999-04-23 2000-04-19 Un procedimiento para preparar una forma polimorfica de sal del acido maleico de tizazolidin-2,4 diona AR023565A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9909473.2A GB9909473D0 (en) 1999-04-23 1999-04-23 Novel compounds
GBGB9912196.4A GB9912196D0 (en) 1999-05-25 1999-05-25 Novel pharmaceutical

Publications (1)

Publication Number Publication Date
AR023565A1 true AR023565A1 (es) 2002-09-04

Family

ID=26315461

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP000101867A AR023565A1 (es) 1999-04-23 2000-04-19 Un procedimiento para preparar una forma polimorfica de sal del acido maleico de tizazolidin-2,4 diona
ARP000101862A AR023561A1 (es) 1999-04-23 2000-04-19 Una forma polimorfica del acido maleico de un derivado de tiazolidin-2, 4 diona, una composicion farmaceutica y el uso de dicho polimorfo para lafabricacion de un medicamento

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP000101862A AR023561A1 (es) 1999-04-23 2000-04-19 Una forma polimorfica del acido maleico de un derivado de tiazolidin-2, 4 diona, una composicion farmaceutica y el uso de dicho polimorfo para lafabricacion de un medicamento

Country Status (40)

Country Link
US (2) US6806280B1 (es)
EP (2) EP1304330A3 (es)
JP (1) JP2002543077A (es)
KR (1) KR100744360B1 (es)
CN (1) CN1167702C (es)
AP (1) AP1598A (es)
AR (2) AR023565A1 (es)
AT (1) ATE246191T1 (es)
AU (1) AU765005B2 (es)
BG (1) BG65485B1 (es)
BR (1) BR0009932A (es)
CA (1) CA2370280A1 (es)
CO (1) CO5170421A1 (es)
CZ (1) CZ20013800A3 (es)
DE (1) DE60004196T2 (es)
DK (1) DK1173435T3 (es)
DZ (1) DZ3156A1 (es)
EA (1) EA004541B1 (es)
ES (1) ES2203453T3 (es)
HK (1) HK1045153B (es)
HR (1) HRP20010772B1 (es)
HU (1) HUP0200931A3 (es)
IL (1) IL146111A0 (es)
MA (1) MA25356A1 (es)
MX (1) MXPA01010821A (es)
MY (1) MY131973A (es)
NO (1) NO320574B1 (es)
NZ (1) NZ515168A (es)
OA (1) OA11872A (es)
PE (1) PE20010044A1 (es)
PL (1) PL351684A1 (es)
PT (1) PT1173435E (es)
SK (1) SK286427B6 (es)
TR (1) TR200103062T2 (es)
TW (1) TWI283677B (es)
UA (1) UA67844C2 (es)
UY (1) UY26121A1 (es)
WO (1) WO2000064896A1 (es)
YU (1) YU75301A (es)
ZA (1) ZA200108719B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
DZ3155A1 (fr) 1999-04-23 2000-11-02 Smithkline Beecham Plc Nouvelle composition pharmaceutique.
CO5170421A1 (es) * 1999-04-23 2002-06-27 Smithkline Beecham Plc Nuevo compuesto farmaceutico maleico
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
GB0006133D0 (en) 2000-03-14 2000-05-03 Smithkline Beecham Plc Novel pharmaceutical
US7241895B2 (en) 2000-09-26 2007-07-10 Dr. Reddy's Laboratories Limited Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation
AU9123201A (en) * 2000-09-26 2002-04-08 Reddy S Res Foundation Novel polymorphic forms of 5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione maleate and process for their preparation
KR100673140B1 (ko) * 2002-04-19 2007-01-22 파에스 파마, 에스.에이. 4-[2-[4-[1-(2-에톡시에틸)-1Ｈ-벤즈이미다졸-2-일] -1-피페리디닐]에틸]- α,α-디메틸- 벤젠아세틱 애시드의 동질이상체
GB0307259D0 (en) * 2003-03-28 2003-05-07 Glaxo Group Ltd Process
EP1468997A3 (en) * 2003-04-18 2004-11-03 CHEMI S.p.A. Polymorphous forms of rosiglitazone maleate
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
WO2005073227A2 (en) * 2004-01-28 2005-08-11 Usv Limited A process for the preparation of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] phenyl methyl] thiazolidine-2, 4-dione maleate
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
US20090076093A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched rosiglitazone
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3856378T2 (de) 1987-09-04 2000-05-11 Beecham Group Plc Substituierte Thiazolidindionderivate
US6462337B1 (en) * 2000-04-20 2002-10-08 Agilent Technologies, Inc. Mass spectrometer electrospray ionization
GB9124513D0 (en) 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
GB9218830D0 (en) 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5478852C1 (en) * 1993-09-15 2001-03-13 Sankyo Co Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
UY24886A1 (es) * 1997-02-18 2001-08-27 Smithkline Beecham Plc Tiazolidindiona
US6632947B2 (en) * 1997-02-18 2003-10-14 Smithkline Beecham Plc Process for the preparation of substituted thiazolidinedione
GB9711683D0 (en) * 1997-06-05 1997-08-06 Smithkline Beecham Plc Composition
US7091359B2 (en) * 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
GB9726563D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726566D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6613785B2 (en) * 1998-07-21 2003-09-02 Smithkline Beecham Plc Use of glucose uptake enhancer for reducing post-ischemic injury of the heart
MXPA01010822A (es) 1999-04-23 2002-06-04 Smithkline Beecham Plc Composicion farmaceutica novedosa.
DZ3155A1 (fr) * 1999-04-23 2000-11-02 Smithkline Beecham Plc Nouvelle composition pharmaceutique.
CO5170421A1 (es) * 1999-04-23 2002-06-27 Smithkline Beecham Plc Nuevo compuesto farmaceutico maleico
CN1277965A (zh) 2000-06-14 2000-12-27 中国医药研究开发中心 盐酸罗格列酮及其应用
AU9123201A (en) 2000-09-26 2002-04-08 Reddy S Res Foundation Novel polymorphic forms of 5-(4-(2-(N-methyl-N-(2-pyridyl)amino)ethoxy)benzyl) thiazolidine-2,4-dione maleate and process for their preparation

Also Published As

Publication number Publication date
DE60004196D1 (de) 2003-09-04
ES2203453T3 (es) 2004-04-16
DK1173435T3 (da) 2003-11-24
AU4130800A (en) 2000-11-10
TWI283677B (en) 2007-07-11
PE20010044A1 (es) 2001-03-10
OA11872A (en) 2006-03-27
CO5170421A1 (es) 2002-06-27
YU75301A (sh) 2004-07-15
EP1173435B1 (en) 2003-07-30
HRP20010772B1 (en) 2007-05-31
ZA200108719B (en) 2002-06-21
IL146111A0 (en) 2002-07-25
KR100744360B1 (ko) 2007-07-30
AR023561A1 (es) 2002-09-04
DE60004196T2 (de) 2004-04-15
UY26121A1 (es) 2000-12-29
SK286427B6 (sk) 2008-09-05
BR0009932A (pt) 2002-04-09
CA2370280A1 (en) 2000-11-02
BG106121A (en) 2002-05-31
HK1045153A1 (en) 2002-11-15
US6806280B1 (en) 2004-10-19
NO20015147D0 (no) 2001-10-22
NO320574B1 (no) 2005-12-27
CZ20013800A3 (cs) 2002-04-17
DZ3156A1 (fr) 2000-11-02
AP2001002330A0 (en) 2000-12-31
AU765005B2 (en) 2003-09-04
PL351684A1 (en) 2003-06-02
UA67844C2 (uk) 2004-07-15
CN1356999A (zh) 2002-07-03
TR200103062T2 (tr) 2002-05-21
NZ515168A (en) 2004-02-27
HRP20010772A2 (en) 2002-10-31
EA200101121A1 (ru) 2002-04-25
AP1598A (en) 2006-04-26
NO20015147L (no) 2001-12-17
CN1167702C (zh) 2004-09-22
US20050080114A1 (en) 2005-04-14
MXPA01010821A (es) 2003-09-04
ATE246191T1 (de) 2003-08-15
HUP0200931A3 (en) 2004-03-29
JP2002543077A (ja) 2002-12-17
WO2000064896A9 (en) 2001-10-25
KR20010110797A (ko) 2001-12-13
EA004541B1 (ru) 2004-06-24
BG65485B1 (bg) 2008-09-30
EP1304330A2 (en) 2003-04-23
HUP0200931A2 (en) 2002-08-28
MA25356A1 (fr) 2001-12-31
PT1173435E (pt) 2003-12-31
WO2000064896A1 (en) 2000-11-02
MY131973A (en) 2007-09-28
HK1045153B (zh) 2004-07-09
EP1173435A1 (en) 2002-01-23
EP1304330A3 (en) 2003-11-19
SK14922001A3 (sk) 2002-02-05

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