BR0009932A - Polimorfo de sal de ácido maléico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etóxi]benzil]tiazolidi na-2,4-diona - Google Patents

Polimorfo de sal de ácido maléico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etóxi]benzil]tiazolidi na-2,4-diona

Info

Publication number
BR0009932A
BR0009932A BR0009932-5A BR0009932A BR0009932A BR 0009932 A BR0009932 A BR 0009932A BR 0009932 A BR0009932 A BR 0009932A BR 0009932 A BR0009932 A BR 0009932A
Authority
BR
Brazil
Prior art keywords
amino
methyl
polymorph
maleic acid
acid salt
Prior art date
Application number
BR0009932-5A
Other languages
English (en)
Inventor
Paul David James Blackler
Christine Marie Browne
Timothy G Coakley
Robert Gordon Giles
Gillian Morrissey
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Cork Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26315461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0009932(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9909473.2A external-priority patent/GB9909473D0/en
Priority claimed from GBGB9912196.4A external-priority patent/GB9912196D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Cork Ltd filed Critical Smithkline Beecham Plc
Publication of BR0009932A publication Critical patent/BR0009932A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"POLIMORFO DE SAL DE áCIDO MALéICO DE 5- [4- [2- (N-METIL-N-(2-PIRIDIL)AMINO)ETóXI]BENZIL)TIAZOLIDINA-2,4- DIONA". A presente invenção refere-se a uma forma polimórfica de sal de ácido maléico de 5-[4-[2-(N-metil-N-(2piridil)amino)etóxilbenzilltiazolidina-2,4-diona (o "Polimorfo") caracterizado pelo fato de que ele provê: (i) um espectro infravermelho contendo picos em 1763, 912, 856 e 709 cm^ -1^ e/ou (ii) um espectro Raman contendo picos em 1762, 1284, 912 e 888 cm^ -1^, e/ou (iii) um espectro de ressonância magnética nuclear ^ 13^C em estado sólido contendo picos em 111,0, 113,6, 119,8, 129,1, 130,9, 131,8, 134,7, 138,7, 146,5, 152,7, 157,5, 169,5, 171,0, 178,7 ppm, e/ou (iv) um padrão de difração em pó de raio X (XRPD), que rende espaçamentos de látice em 5,87, 5,30, 4,69, 4,09, 3,88, 3,61, 3,53 e 3,46 A, a um processo para preparar tal composto, a uma composição farmacêutica contendo tal composto e ao uso do composto em medicina.
BR0009932-5A 1999-04-23 2000-04-19 Polimorfo de sal de ácido maléico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etóxi]benzil]tiazolidi na-2,4-diona BR0009932A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9909473.2A GB9909473D0 (en) 1999-04-23 1999-04-23 Novel compounds
GBGB9912196.4A GB9912196D0 (en) 1999-05-25 1999-05-25 Novel pharmaceutical
PCT/GB2000/001520 WO2000064896A1 (en) 1999-04-23 2000-04-19 Polymorph of 5-[4-[2- (n-methyl-n-( 2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2,4-dione, maleic acid salt

Publications (1)

Publication Number Publication Date
BR0009932A true BR0009932A (pt) 2002-04-09

Family

ID=26315461

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009932-5A BR0009932A (pt) 1999-04-23 2000-04-19 Polimorfo de sal de ácido maléico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etóxi]benzil]tiazolidi na-2,4-diona

Country Status (40)

Country Link
US (2) US6806280B1 (pt)
EP (2) EP1173435B1 (pt)
JP (1) JP2002543077A (pt)
KR (1) KR100744360B1 (pt)
CN (1) CN1167702C (pt)
AP (1) AP1598A (pt)
AR (2) AR023561A1 (pt)
AT (1) ATE246191T1 (pt)
AU (1) AU765005B2 (pt)
BG (1) BG65485B1 (pt)
BR (1) BR0009932A (pt)
CA (1) CA2370280A1 (pt)
CO (1) CO5170421A1 (pt)
CZ (1) CZ20013800A3 (pt)
DE (1) DE60004196T2 (pt)
DK (1) DK1173435T3 (pt)
DZ (1) DZ3156A1 (pt)
EA (1) EA004541B1 (pt)
ES (1) ES2203453T3 (pt)
HK (1) HK1045153B (pt)
HR (1) HRP20010772B1 (pt)
HU (1) HUP0200931A3 (pt)
IL (1) IL146111A0 (pt)
MA (1) MA25356A1 (pt)
MX (1) MXPA01010821A (pt)
MY (1) MY131973A (pt)
NO (1) NO320574B1 (pt)
NZ (1) NZ515168A (pt)
OA (1) OA11872A (pt)
PE (1) PE20010044A1 (pt)
PL (1) PL351684A1 (pt)
PT (1) PT1173435E (pt)
SK (1) SK286427B6 (pt)
TR (1) TR200103062T2 (pt)
TW (1) TWI283677B (pt)
UA (1) UA67844C2 (pt)
UY (1) UY26121A1 (pt)
WO (1) WO2000064896A1 (pt)
YU (1) YU75301A (pt)
ZA (1) ZA200108719B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137940A1 (en) * 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
BR0009934A (pt) 1999-04-23 2002-06-04 Smithkline Beecham Plc Produto farmacêutico
PE20010044A1 (es) * 1999-04-23 2001-03-10 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
GB0006133D0 (en) 2000-03-14 2000-05-03 Smithkline Beecham Plc Novel pharmaceutical
US7241895B2 (en) 2000-09-26 2007-07-10 Dr. Reddy's Laboratories Limited Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation
IL155036A0 (en) * 2000-09-26 2003-10-31 Reddy Research Foundation Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] benzyl] thiazolidine-2,4-dione maleate and pharmaceutical compositions containing the same
CN1290843C (zh) * 2002-04-19 2006-12-20 费斯制药股份有限公司 4－[2－[4－[1－(2－乙氧基乙基)－1H－苯并咪唑－2－基]－1－哌啶基]乙基]－α,α－二甲基苯乙酸的多晶型物
GB0307259D0 (en) * 2003-03-28 2003-05-07 Glaxo Group Ltd Process
EP1468997A3 (en) * 2003-04-18 2004-11-03 CHEMI S.p.A. Polymorphous forms of rosiglitazone maleate
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
WO2005073227A2 (en) * 2004-01-28 2005-08-11 Usv Limited A process for the preparation of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] phenyl methyl] thiazolidine-2, 4-dione maleate
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
US20090076093A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched rosiglitazone
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137915T3 (es) 1987-09-04 2000-01-01 Beecham Group Plc Derivados de tiazolidindiona sustituida.
US6462337B1 (en) * 2000-04-20 2002-10-08 Agilent Technologies, Inc. Mass spectrometer electrospray ionization
GB9124513D0 (en) 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
US5457109A (en) * 1993-09-15 1995-10-10 Warner-Lambert Company Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
US6632947B2 (en) * 1997-02-18 2003-10-14 Smithkline Beecham Plc Process for the preparation of substituted thiazolidinedione
UY24886A1 (es) * 1997-02-18 2001-08-27 Smithkline Beecham Plc Tiazolidindiona
GB9711683D0 (en) 1997-06-05 1997-08-06 Smithkline Beecham Plc Composition
US7091359B2 (en) * 1997-11-04 2006-08-15 Smithkline Beecham Plc Process for the preparation of thiazolidinedione derivatives
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
GB9726566D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9726563D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6613785B2 (en) * 1998-07-21 2003-09-02 Smithkline Beecham Plc Use of glucose uptake enhancer for reducing post-ischemic injury of the heart
BR0009934A (pt) 1999-04-23 2002-06-04 Smithkline Beecham Plc Produto farmacêutico
MXPA01010822A (es) 1999-04-23 2002-06-04 Smithkline Beecham Plc Composicion farmaceutica novedosa.
PE20010044A1 (es) * 1999-04-23 2001-03-10 Smithkline Beecham Plc Polimorfo de sal del acido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]-tiazolidina-2,4-diona
CN1277965A (zh) 2000-06-14 2000-12-27 中国医药研究开发中心 盐酸罗格列酮及其应用
IL155036A0 (en) 2000-09-26 2003-10-31 Reddy Research Foundation Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] benzyl] thiazolidine-2,4-dione maleate and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
BG65485B1 (bg) 2008-09-30
MXPA01010821A (es) 2003-09-04
CO5170421A1 (es) 2002-06-27
UY26121A1 (es) 2000-12-29
NO20015147D0 (no) 2001-10-22
YU75301A (sh) 2004-07-15
TWI283677B (en) 2007-07-11
AP1598A (en) 2006-04-26
DE60004196D1 (de) 2003-09-04
PE20010044A1 (es) 2001-03-10
EP1304330A2 (en) 2003-04-23
IL146111A0 (en) 2002-07-25
WO2000064896A9 (en) 2001-10-25
ATE246191T1 (de) 2003-08-15
PL351684A1 (en) 2003-06-02
HRP20010772B1 (en) 2007-05-31
EA004541B1 (ru) 2004-06-24
HUP0200931A2 (en) 2002-08-28
CZ20013800A3 (cs) 2002-04-17
SK14922001A3 (sk) 2002-02-05
AR023565A1 (es) 2002-09-04
NO320574B1 (no) 2005-12-27
AR023561A1 (es) 2002-09-04
HRP20010772A2 (en) 2002-10-31
EP1173435B1 (en) 2003-07-30
OA11872A (en) 2006-03-27
US20050080114A1 (en) 2005-04-14
DE60004196T2 (de) 2004-04-15
DK1173435T3 (da) 2003-11-24
EA200101121A1 (ru) 2002-04-25
JP2002543077A (ja) 2002-12-17
NZ515168A (en) 2004-02-27
AU765005B2 (en) 2003-09-04
MY131973A (en) 2007-09-28
WO2000064896A1 (en) 2000-11-02
ZA200108719B (en) 2002-06-21
CA2370280A1 (en) 2000-11-02
KR100744360B1 (ko) 2007-07-30
SK286427B6 (sk) 2008-09-05
AP2001002330A0 (en) 2000-12-31
ES2203453T3 (es) 2004-04-16
MA25356A1 (fr) 2001-12-31
NO20015147L (no) 2001-12-17
EP1304330A3 (en) 2003-11-19
CN1356999A (zh) 2002-07-03
KR20010110797A (ko) 2001-12-13
US6806280B1 (en) 2004-10-19
TR200103062T2 (tr) 2002-05-21
UA67844C2 (uk) 2004-07-15
HK1045153B (zh) 2004-07-09
DZ3156A1 (fr) 2000-11-02
HUP0200931A3 (en) 2004-03-29
HK1045153A1 (en) 2002-11-15
CN1167702C (zh) 2004-09-22
AU4130800A (en) 2000-11-10
PT1173435E (pt) 2003-12-31
EP1173435A1 (en) 2002-01-23
BG106121A (en) 2002-05-31

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 10(VIII), 11, 13, 24 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.