NO20075365L - 3,4-substituerte pyrrolidinderivater for behandling av hypertensjon - Google Patents

3,4-substituerte pyrrolidinderivater for behandling av hypertensjon

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Publication number
NO20075365L
NO20075365L NO20075365A NO20075365A NO20075365L NO 20075365 L NO20075365 L NO 20075365L NO 20075365 A NO20075365 A NO 20075365A NO 20075365 A NO20075365 A NO 20075365A NO 20075365 L NO20075365 L NO 20075365L
Authority
NO
Norway
Prior art keywords
substituted pyrrolidine
treatment
compounds
pyrrolidine compounds
disease
Prior art date
Application number
NO20075365A
Other languages
English (en)
Inventor
Claus Ehrhardt
Holger Sellner
Osamu Irie
Edwige Liliane Jeann Lorthiois
Juergen Klaus Maibaum
Nils Ostermann
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20075365L publication Critical patent/NO20075365L/no

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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  • Pyrrole Compounds (AREA)

Abstract

Oppfinnelsen vedrører anvendelse av (3,4-di-, 3,3,4-tri-, 3,4,4-tri- eller 3,3,4,4-tetra-)-substituerte pyrrolidinforbindelser for fremstilling av en farmasøytisk formulering for behandling av en sykdom som avhenger av reninaktivitet; anvendelse av en forbindelse av denne klasse ved behandling av en sykdom som avhenger av reninaktivitet; forbindelser som er del av en underklasse av disse substituerte pyrrolidinforbindelser, for anvendelse i diagnostisk og terapeutisk behandling av et varmblodig dyr, spesielt for behandling av en sykdom som avhenger av reninaktivitet; nye forbindelser som er del av en underklasse av disse substituerte pyrrolidinforbindelser; farmasøytiske formuleringer som innbefatter disse substituerte pyrrolidinforbindelser, og/eller en fremgangsmåte for behandling innbefattende å administrere disse substituerte pyrrolidinforbindelser, en fremgangsmåte for fremstilling spesielt av disse nye substituerte pyrrolidinforbindelser, samt nye mellomprodukter, utgangsstoffer og/eller deltrinn for deres syntese. De substituerte pyrrolidinforbindelsene har formel (I), (I) hvor R1, R2, R3, R4, R5 og T defineres i beskrivelsen.
NO20075365A 2005-03-23 2007-10-19 3,4-substituerte pyrrolidinderivater for behandling av hypertensjon NO20075365L (no)

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GBGB0505969.6A GB0505969D0 (en) 2005-03-23 2005-03-23 Organic compounds
PCT/EP2006/002578 WO2006100036A1 (en) 2005-03-23 2006-03-21 3, 4-substituted pyrrolidine derivatives for the treatment of hypertension

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ATE486597T1 (de) 2010-11-15
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WO2006100036A1 (en) 2006-09-28
CN101146530B (zh) 2011-05-18
IL185242A0 (en) 2008-06-05
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PL1863477T3 (pl) 2011-04-29
BRPI0609671A2 (pt) 2010-04-20
ZA200706697B (en) 2008-10-29

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